Till Date Research Articles

Clinicomycological Profile of Dermatophytosis in Tripura – An Institution Based Cross Sectional Study

Abstract Background: In a small state like Tripura, a surge in prevalence of superficial dermatophytosis has been observed from April to September among the population of both tribal and non-tribal groups having different lifestyle, different food habit, and different socioeconomic status. Studies from different region reveal varying pattern of etiological distribution of the disease. But till date no research study has been initiated in Tripura on clinicomycological profile of dermatophytosis. Objectives: This study was undertaken with the objectives to estimate the proportion of different fungal species associated with dermatophytosis among the patients attending Dermatology Outpatient Department of a Tertiary care hospital of Tripura and also to determine possible association of different clinical parameters with fungal species if any. Materials and Methods: A total of three hundred and ninety-one (391) new cases of dermatophytosis attending Dermatology Outpatient Department of a Tertiary care teaching hospital of Tripura were included in this study from June, 2021 to May, 2022. All the specimens were assessed by direct microscopic examination and in vitro culture. Fungi were identified on the basis of their macroscopic and microscopic features with the help of lactophenol cotton blue staining and urease test. Results: There was a male preponderance among cases and maximum patients belonged to 21-40 years age group. Trichophyton schoenleinii was the most common fungal species (52.1%) grown in culture followed by Trichophyton rubrum (26.9%). Conclusion: In contrast to previous study results from different parts of India, Trichophyton schoenleinii was the most common isolated fungal species from this part of northeast India, and Tinea corporis (41.3%) was the most prominent clinical manifestation of dermatophytosis.

Insight of recent artificial intelligence-based strategy to effectively screen COVID-19

<p><span lang="EN-US">The recent era of pandemic by corona virus disease (COVID-19) has witnessed a faster evolution of various technological solution to thwart the life-threating situation. The most important step was to select a faster mode of screening COVID-19 using chest x-ray (CXR) which could be actually ten folds faster than conventional invasive screening methods. However, the method of determining the presence of COVID-19 from CXR is critically challenging owing to the dynamic and complex nature of disease. Such problem is attempted to be solved by harnessing the potential of artificial intelligence (AI). Hence, this paper contributes towards discussion of most recent and current implementation strategies formulated by AI models towards diagnosing COVID-19. The study outcome of this paper yields an interesting learning outcome to show that AI models’ adoption is increasing in faster pace and yet challenges do exist till date. The outcome of study will assist in better adoption of AI models towards screening COVID-19.</span></p>

Dark Matter: Existential Analysis

Abstract: The Existence of Dark Matter has remained a mystery till date due to its elusive nature of its unseen physical form and how the universe is in fact affected by Dark Matter. This research paper hopes to analyze the importance of Dark Matter despite not having direct proof of its existence.

Bone Marrow Morphology: A Key Diagnostic Tool in Various Hematological and Non Hematological Disorders

Bone marrow morphology means microscopic examination of bone marrow cells and tissue samples obtained by aspirate and trephine biopsy. An invaluable tool for diagnosis of many hematological and non-hematological disorders, various types of cancer staging and metastases detection. Different kinds of anemia and leukemia can be accurately diagnosed and monitored. Objective: To check the spectrum of diseases which could be identified and diagnosed with the help of bone marrow morphology examination thus demonstrating its diagnostic utility and to check diagnostic concordance between aspirate and core biopsy. Methods: Cross sectional study with consecutive sampling technique conducted over period of one year. Samples of both Bone Marrow Aspiration (BMA) and trephine biopsy (BMB) were collected from all patients included in study after consent using standard protocols. Air dried smears were prepared from bone marrow aspiration samples while trephine biopsy tissues were processed by histopathological techniques. Routine staining such as Wright Giemsa stain, H and E stain and special cytochemistry were used to visualize the cellular architecture of bone marrow. Results: Out of 471 samples, males were predominant with the frequency of 63.9% and maximum patients (31.8%) were from the age group of 35-40 years. Most common clinical indication to conduct bone marrow examination was unexplained Cytopenia which accounted for 35.2% cases, followed by suspicion of Leukemia (28.5%). Malignant hematological disorders were more common as compared to benign disorders (64% vs 17.5%). Acute leukemia was the most commonly identified cancer with frequency of 27.6%. Conclusions: Bone marrow morphology till date remains low risk, economical, crucial diagnostic tool in especially in under resource country like Pakistan. It can guide physicians to plan proper and timely management of patients.

Co60 May be the Acceptable Alternative Radionuclides of Ir192 used in HDR Brachytherapy for the Treatment of Inoperable Carcinoma Cervix in the Treatment Modality of Concurrent Chemoradiation

Background: Cancer of the uterine cervix is the eighth most common cancer among women worldwide and third among all malignancies and the second most common cancers in female in Bangladesh. The treatment of cervical cancer requires multidisciplinary approaches Concurrent chemoradiation is the treatment of choice in locally advanced carcinoma cervix uteri. Radiotherapy is the primary local treatment for most patients having FIGO stage IIB to IVA diseases. The success of treatment depends on a careful balance between EBRT and Brachytherapy that optimizes the dose to tumor. Iridium192 is highly used radionuclide for modern remote after loading HDR brachytherapy till date. Recently Co60 source is available with miniature size and identical physical properties for remote after loaders. Methods: 60 patients with biopsy proven locally advanced carcinoma of the uterine cervix were enrolled in the study. Arm A was formed comprising 30 patients who were treated by Ir192 HDR brachytherapy and Arm B formed with equal number of 30 patients who received HDR brachytherapy treated with Co60 radionuclide. This prospective observational study was carried out to compare the treatment effect between two Arm. Results: 60 patients were enrolled in this study with age range from 35 to 63 years. Most of the patients presented with stage IIB disease, consisting of 39 patients (65.3%). Among them 48 patients had squamous cell carcinoma (80.60%), adenocarcinoma trailing with 9 patients (15.3%) and rest were adenoidsquamous carcinoma 2 and small cell carcinoma. In all three insertions, urinary bladder dose distribution was slightly smaller by HDR Co60 irradiation than HDR Ir192 exposure. These differences were statistically significant in first two insertions but not in third one Conclusion: In this study radiation dose distribution at OARs i.e. urinary bladder and rectum were compared between Arm A and Arm B. In all three insertions in urinary bladder the mean dose distribution was slightly smaller in HDR Co60 irradiation than HDR Iridium192 exposure. These differences were statistically significant in first two insertions but not in third one. In case of rectum point, the mean dose distribution was significantly lower in all three insertions of Co60 exposure than Ir192 exposure.

Caesalpinia bonducella Seeds Extracts are Non-toxic to the Gut Bacteria Lactobacillus rhamnosus, as Substantiated by In vitro and In silico Studies

The seed kernels of Caesalpinia bonducella, a traditional medicinal plant in India, are widely used to treat various disorders, including polycystic ovary syndrome. The seed kernel possesses anti-bacterial properties against many pathogenic bacteria. However, their impact on Lactobacillus spp., a prominent gram-positive gut bacterium, has not been studied till date. The present study employed both in vitro and in silico methods to illustrate the effect of seed extract of C. bonducella against Lactobacillus rhamnosus GG. For this, disc diffusion assay was performed with 100, 500, and 1000 µg/ml of aqueous and methanolic seed extract against L. rhamnosus and E. coli, and the zone of inhibition was measured. While both the extracts inhibited the growth of E. coli, it did not show any zone of inhibition against L. rhamnosus. The latter possess surface layer proteins, SlpX and SlpA, which prevented the influx of the phytocompounds of C. bonducella, as demonstrated by molecular docking using Autodock Vina. Docking results showed that the binding of the phytocompounds to the SlpX and SlpA proteins was not in the active pockets. These findings conclude that C. bonducella seed kernel extracts are safe against the gut bacteria L. rhamnosus.

Stability of Envelope Proteins of SARS-CoV-2 Variants Could Be a Choice of New Drug Target

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has emerged as one of the worst viral pandemics during the past few years. As reported by the World Health Organization, around 77,56 49 520 cases and 70 51 720 deaths were reported from all over the world, which includes approximately 3500 patients reported during the recent past only. Currently, circulating variants of SARS-CoV-2 are KP.3, JN.1, BA.2.86 and KP.2. Mass vaccinations have been provided since the end of December 2020, which led to 5.47 billion people vaccinated till date. However, the disease continues in small foci all over the world. Development of an effective drug target and mutation independent vaccine thus becomes essential research priorities. Owing to the unavailability of a specific drug molecule, the present study has focused on the development of an effective drug target to treat COVID-19. In-house primers were designed for four essential structural genes viz., Spike protein, ORF1ab, Nucleocapsid gene, and Envelope gene. Samples of different waves were amplified using these primers employing the Polymerase Chain Reaction (PCR) assay. A total number of 86 SARS-CoV-2 RT PCR positive samples were studied, and results showed the most frequent appearance (80.2%) of Envelope (E) protein in all the samples. This suggests that during transmission across numbers of human hosts, it is the Envelope protein that was the most stable one. The most severe Delta variant showed the presence of E proteins in all the samples assayed. Blocking E protein as a new drug target to intervene intracellular replication of virus could be an effective drug development strategy.

Structural characterization of DNA-binding domain of essential mammalian protein TTF 1.

Transcription Termination Factor 1 (TTF1) is a multifunctional mammalian protein with vital roles in various cellular processes, including Pol I-mediated transcription initiation and termination, pre-rRNA processing, chromatin remodelling, DNA damage repair, and polar replication fork arrest. It comprises two distinct functional regions; the N-terminal regulatory region (1-445 aa), and the C-terminal catalytic region (445-859 aa). The Myb domain located at the C-terminal region is a conserved DNA binding domain spanning from 550 to 732 aa (183 residues). Despite its critical role in various cellular processes, the physical structure of TTF1 remains unsolved. Attempts to purify the functional TTF1 protein have been unsuccessful till date. Therefore, we focused on characterizing the Myb domain of this essential protein. We started with predicting a 3-D model of the Myb domain using homology modelling, and ab-initio method. We then determined its stability through MD simulation in an explicit solvent. The model predicted is highly stable, which stabilizes at 200ns. To experimentally validate the computational model, we cloned and expressed the codon optimized Myb domain into a bacterial expression vector and purified the protein to homogeneity. Further, characterization of the protein shows that, Myb domain is predominantly helical (65%) and is alone sufficient to bind the Sal Box DNA. This is the first-ever study to report a complete in silico model of the Myb domain, which is physically characterized. The above study will pave the way towards solving the atomic structure of this essential mammalian protein.

Carcinoma esophagus with small bowel metastasis: a case report with review of literature.

Small intestinal metastasis is extremely rare and only 13 cases have been reported till date and almost all such patients have presented with intestinal obstruction. The 5-year overall survival for metastatic esophageal cancer is as low as 5% while the patients with small intestinal metastasis have a median survival of only 3months (range 1-12months) despite undergoing radical resection of the small bowel. We present a case of a male in his 50's who presented with difficulty in swallowing for 4months. On evaluation, he was found to have squamous cell carcinoma in the mid thoracic esophagus. He underwent radical chemo-radiation up to 60Gy in 25 fractions over 5weeks. One week after completion of treatment he presented with ileal obstruction and omental nodules and surgical resection and evaluation of the respective ileal segment and omental biopsy revealed a metastatic squamous cell carcinoma. The patient expired 3months post-surgery. Carcinoma esophagus with small bowel metastasis has a very grave prognosis that patients rarely survive beyond 1year despite undergoing resection. Hence it is imperative to consider a small bowel metastasis when such patients present with clinical features of intestinal obstruction for early diagnosis and aggressive management.

A Rare Case of Epitheloid Hemangioma Cheek: Case Report.

Epithelioid hemangioma is a very rare lesion arising from vascular structures. We encountered a case in very atypical location i.e. on the anterior maxillary wall. The underwent excision of tumour twice elsewhere and presented in our hospital with reccurence of mass. Patient was managed in our hospital with good cosmetic outcome with no disease recurrence till date.

Exploring the reality of seafarers' deaths and injuries and preventive measures from the cases of overwork-related disorders

Till date, only few studies have detailed the reality of overwork-related disorders among seafarers. Therefore, in this study, we aimed to evaluate the prevalence of overwork-related disorders among seafarers and assess factors such as patient attributes, diseases diagnosed at the time of determination, workload factors, and other aspects, thereby suggesting relevant preventative measures. Among all the patients identified with overwork-related disorders from April 2010 to March 2017, 2,280 cases of cerebrovascular and cardiovascular diseases and 3,517 cases of mental disorders were selected. To identify seafarer-related cases, keywords related to seafarers were extracted. Subsequently, 33 cases of cardiovascular disease and 19 cases of mental disorders were obtained. The average age of the patients with cerebrovascular and cardiovascular diseases was 56.7 years; for those with mental disorders, it was 45.2 years. The patients were most commonly engaged in fishing, transportation, and postal services. Most patients were employed in the deck department or were captains. The most common types of vessels were fishing and cargo ships. Among the diseases diagnosed at the time of determination, cerebrovascular diseases accounted for 20 cases (60.6%) and cardiovascular diseases accounted for 13 cases (39.4%), with cerebral and myocardial infarctions being the most frequent conditions. Among mental disorders, "mood disorders" accounted for 7 cases (36.8%), and "neurotic disorders, stress-related disorders, and somatoform disorders" accounted for 12 cases (63.2%), with major depressive episodes, post-traumatic stress disorder, and adjustment disorders being the most common. The most common workload factor for patients with cerebrovascular and cardiovascular diseases was "long-term excessive work," and among non-workload factors, "long working hours" and "irregular working hours" were prevalent. For mental disorders, 8 cases were attributed to "extreme psychological stress." Specific events leading to these diseases included "interpersonal relationships," "experiencing accidents or disasters," and "work quantity and quality." Both cerebrovascular and cardiovascular diseases, as well as mental disorders, showed a notable aging trend among seafarers. Thus, measures that consider the characteristics of elderly workers, such as their physical function, are important. Additionally, as seafarers are distributed across various industries and occupations, measures should be specifically tailored to their industry and job type. Our study confirmed that long working hours and irregular working hours were prevalent in both cases. Therefore, there is an urgent need for further efforts to prevent and mitigate overwork-related deaths among seafarers, including organizational support from onshore workplaces and enhancement of medical and operational support using information and communication technology.

AN EXAMINATION OF FINANCIAL PERFORMANCE: A REVIEW STUDY

In order to undertake any research a strong background study is always required. Research always stands on a strong footing in the form of comprehensive and extensive research review. A researcher has to always get conversant with the prevailing research domains, methods, instruments used by previous researchers for undertaking similar type of studies. Only then the researcher will be able to diagnose the vacuum in the research conducted till date and what addition to existing knowledge can be made by him/ her. Financial performance analysis of firms in similar industries has always been a hot favourite topic of researchers and its never ending as firms might perform well in one year and in other year might even experience depression. Hence, while undertaking research in financial performance analysis a strong base of deep review of existing knowledge is inevitably required. This paper has attempted to summarise the findings of some literature on performance analysis in finance terms already existing in research domain to facilitate research community to take such research ahead in future. KEYWORDS: Financial performance analysis, literature review

Requirement of a Wnt5A-microbiota axis in the maintenance of gut B-cell repertoire and protection from infection.

We investigated the influence of a Wnt5A-gut microbiota axis on gut B-cell repertoire and protection from infection, having previously demonstrated that Wnt5A in association with gut commensals helps shape gut T-cell repertoire. Accordingly, Wnt5A heterozygous mice, which express less than wild-type level of Wnt5A, and their isolated Peyer's patches (PPs) were studied in comparison with the wild-type counterparts. The percentages of IgM- and IgA-expressing B cells were quite similar in the PP of both sets of mice. However, the PP of the Wnt5A heterozygous mice harbored significantly higher than wild-type levels of microbiota-bound B cell-secreted IgA, indicating the prevalence of a microbial population therein, which is significantly altered from that of wild-type. Additionally, the percentage of PP IgG1-expressing B cells was appreciably depressed in the Wnt5A heterozygous mice in comparison to wild-type. Wnt5A heterozygous mice, furthermore, exhibited notably higher than the wild-type levels of morbidity and mortality following infection with Salmonella typhimurium, a common gut pathogen. Differences in morbidity/mortality correlated with considerable disparity between the PP-B-cell repertoires of the Salmonella-infected Wnt5A heterozygous and wild-type mice, in which the percentage of IgG1-expressing B1b cells in the PP of heterozygous mice remains significantly low as compared to wild-type. Overall, these results suggest that a gut Wnt5A-microbiota axis is intrinsically associated with the maintenance of gut B-cell repertoire and protection from infection.IMPORTANCEAlthough it is well accepted that B cells and microbiota are required for protection from infection and preservation of gut health, a lot remains unknown about how the optimum B-cell repertoire and microbiota are maintained in the gut. The importance of this study lies in the fact that it unveils a potential role of a growth factor termed Wnt5A in the safeguarding of the gut B-cell population and microbiota, thereby protecting the gut from the deleterious effect of infections by common pathogens. Documentation of the involvement of a Wnt5A-microbiota axis in the shaping of a protective gut B-cell repertoire, furthermore, opens up new avenues of investigations for understanding gut disorders related to microbial dysbiosis and B-cell homeostasis that, till date, are considered incurable.

MATLAB Implementation of Physics Informed Deep Neural Networks for Forward and Inverse Structural Vibration Problems

In this work, we illustrate the implementation of physics informed neural networks (PINNs) for solving forward and inverse problems in structural vibration. Physics informed deep learning has lately proven to be a powerful tool for the solution and data-driven discovery of physical systems governed by differential equations. In spite of the popularity of PINNs, their application in structural vibrations is limited. This motivates the extension of the application of PINNs in yet another new domain and leverages from the available knowledge in the form of governing physical laws. On investigating the performance of conventional PINNs in vibrations, it is mostly found that it suffers from a very recently pointed out similar scaling or regularization issue, leading to inaccurate predictions. It is thereby demonstrated that a simple strategy of modifying the loss function helps to combat the situation and enhance the approximation accuracy significantly without adding any extra computational cost. In addition to the above two contributing factors of this work, the implementation of the conventional and modified PINNs is performed in the MATLAB environment owing to its recently developed rich deep learning library. Since all the developments of PINNs till date is Python based, this is expected to diversify the field and reach out to greater scientific audience who are more proficient in MATLAB but are interested to explore the prospect of deep learning in computational science and engineering. As a bonus, complete executable codes of all four representative (both forward and inverse) problems in structural vibrations have been provided along with their line-by-line lucid explanation and well-interpreted results for better understanding.

Examining representation of women in leadership of professional medical associations in India.

Women constitute 70% of the global health workforce but are significantly underrepresented in leadership positions. In India, professional medical associations (PMAs) play a crucial role in shaping policy agenda in the health sector, but very little is known about gender diversity in their leadership. Therefore, we analysed the gender representation of current and past leaderships of Indian PMAs. Data of the current and past national leadership and leadership committees of 46 leading PMAs representing general, specialities, and super-specialities were extracted from their official websites. Gender composition of leadership was analysed using a sequential approach. For Indian Medical Association (IMA), the largest Indian PMA, an analysis of its 32 sub-chapters was also undertaken. The findings revealed that only 9 (19.5%) out of 46 associations are currently led by a woman. Leadership committees of half the associations have less than 20% women, while there were no women in the central committee of nine PMAs. Among past presidents, information was publicly available for 31 associations and all of them have had less than 20% of women presidents till date. Among the 64 individuals currently serving as presidents and secretaries of 32 sub-chapters of IMA, only three (4.6%) are women. Even in associations closely related to women's health, such as obstetrics and gynecology, pediatrics, and neonatology, unequal representation persists, highlighting male dominance. These results demonstrate significant gender disparities in PMA leadership in India, necessitating urgent efforts to promote gender equality. Gender-transformative leadership is crucial to develop gender-sensitive health care policies and practices which can serve as a catalyst for broader societal change.

Ligand-selective turn-off sensing, harvesting and post-adsorptive use of Dy(III) and Yb(III) by intrinsically fluorescent flower-shaped Gum Acacia-grafted hydrogels

Rare earth metals (REMs), such as Dysprosium (Dy) and Ytterbium (Yb), have experienced unprecedented demand in recent times due to their applications in high-end technologies. REMs are found only in select geographic locations placing tremendous economic constraints on their use. In this work, we have developed Gum Acacia-grafted hydrogels (GmAc-FluoroTerPs) that are capable of selective detection and capture of Dy and Yb. The intrinsically blue fluorescent polymer hydrogel GmAc-FluoroTerP has been optimized for Dy(III) and Yb(III) specific quenching, enabling limit of detection of the REMs at 0.13 nM and 60.8 pM, respectively. A comprehensive structural characterization of the fluorescent hydrogel has been performed via NMR, FTIR, XPS, EPR, TGA, XRD, TEM, SEM, EDX, TCSPC, and DLS. In addition to an in situ generated fluorophore, GmAc-FluoroTerP displays a distinctive aggregation induced emission enhancement in mixed solvents. The complexation of Dy(III)/Yb(III) with GmAc-FluoroTerP hydrogel has been characterized by XPS, TCSPC, and logic gate analyses, and the adsorptive capacity for Dy(III) and Yb(III) are found to be best reported till date as 125.57 mg g−1 and 102.27 mg g−1, respectively. Desorption at acidic pH allows recovery of the REMs. We also report semiconducting behaviour of the native fluorescent hydrogel, that is enhanced upon adsorptive capture of Dy(III) and Yb(III), with calculated band gaps at 1.37, 0.77, and 0.49 eV, respectively. The convergent sensing, capture, and reuse of Dy(III) and Yb(III) presented in this work promises a hitherto unreported template for application on other REMs.

Artificial Intelligence-Based Cloud Planning and Migration to Cut the Cost of Cloud Sasibhushan Rao Chanthati

The paper titled “Artificial Intelligence-Based Cloud Planning and Migration to Cut the Cost of Cloud” aims to examine how AI can be implemented to improve cloud planning and migration in a bid to reduce their costs. The proposal is concerned with the utilization of multiple AI techniques, such as machine learning models, natural language processing, and reinforcement learning, to manage the migration process in the cloud. In incorporating AI within the transitions, the paper establishes how organizations improve productivity, stability, and security during Cloud transitions. It provides a detailed pseudocode of the scenario, making the content sufficiently intelligible to the IT professionals who wish to implement these AI algorithms. In this regard, this paper helps to fill the gap that has been demonstrated in the current literature regarding the link between theoretical uses of AI and its application in cloud migration towards enhancing the deployment efficacy and cost-efficiency of cloud services. The article was first completed in 2021 and later I have modified the article with latest updates till date 2024.

Elucidating the conformational change of dengue envelope protein using the Markov state model

ABSTRACT Dengue virus, an arbovirus of genus flavivirus, is one of the most prevalent infectious disease causing organisms in the tropical environment leading to numerous deaths every year. The envelope protein plays a crucial role in the viral genome entry into the host cell. This is achieved through structure and oligomeric status change in the dengue envelope protein. The pre-fusion and post-fusion states’ structures of the dengue envelope protein are known although the pathway and intermediate structures involved in this process have remained in the dark till date. In this study, we have used targeted molecular dynamics (MD) simulation followed by conventional MD simulation and the Markov state model analysis to elucidate this pathway of change in conformation from the pre-fusion state to the post-fusion state. Intermediate conformations which may in the future serve as therapeutic targets have also been deduced from the Markov state model. This pathway determination may pave the way for the design of transition state analog inhibitors which prevent the dengue virus envelope protein from changing its conformation and thus establishing infection. The results obtained could lead to development of novel drugs to combat the viral infection.

Product Colour Variation Management with Artificial Intelligence

This research focuses on the topic of using AI in color variant management in products to enhance the appeal and performance of the products in the marketplace by incorporating artificial intelligence, deep learning, and neural network systems. Real-time consumer and product information, preferences, buying history, and sales history; I created an AI model to predict and change product colors in real-time. The complete workflow used comprises data gathering, processing, and feature extraction, model training, integration of the color adjustment software tools, and finally, testing and validation. The efficiency of such AI-driven interventions was analyzed through the consumer satisfaction indices, the sales results, and the engagement data based on the consumption of digital platforms. This study demonstrates valuable potential of AI to improve product design application and development while providing valuable suggestions for Businesses adapting and improving market outcomes according to the changing consumer trends. Such an application of AI implements a new best practice in ways of enhancing futuristic consumer-oriented marketing approaches. The paper was first completed in 2021 and later I have modified the paper with latest updates till date 2024.

Sexual dysfunction in dichlorvos-exposed male Wistar rat is ameliorated by curcumin and associated with the upregulation of testosterone.

Dichlorvos is an organophosphate pesticide that is commonly used for agricultural and domestic control of pests and insects. Despite its usefulness, it exerts reproductive toxicity and induces male sexual dysfunction. On the other hand, curcumin has been reported to improve sexual dysfunction. However, till date, no study has reported the impact of curcumin on dichlorvos-induced sexual dysfunction. This study investigated the effect and associated mechanism of curcumin on dichlorvos-induced sexual dysfunction. Thirty-two male Wistar rats were randomized into four groups; the control (1mL of olive oil), curcumin-treated (100mg/kg), DDVP-treated (98.54g/m3 of dichlorvos by inhalation), and DDVP + Curcumin-treated. Dichlorvos induced sexual dysfunction as depicted by reduced motivation to mate (8.38 ± 0.18 vs. 4.00 ± 0.33, P < 0.0001), prolonged latencies (46.63 ± 1.30 vs. 98.75 ± 1.32, P < 0.0001) and reduced frequencies of mount (14.88 ± 0.52 vs. 8.63 ± 0.38), intromission (9.38 ± 0.50 vs. 3.75 ± 0.31, P < 0.0001), and ejaculation (7.63 ± 0.38 vs. 1.50 ± 0.19, P < 0.0001). These findings were accompanied by suppression of hypothalamic-pituitary-testicular axis, evidenced by marked reductions in circulating FSH (60.00 ± 1.04 vs. 21.13 ± 0.52, P < 0.0001), LH (46.38 ± 1.38 vs. 19.00 ± 0.46, P < 0.0001), and testosterone (6.01 ± 0.50 vs. 0.74 ± 0.05, P < 0.0001). Nonetheless, the administration of curcumin in dichlorvos-exposed rats significantly attenuated dichlorvos-induced sexual dysfunction by improving the assessed indices of male sexual act. Also, curcumin significantly increased serum levels of FSH (21.13 ± 0.52 vs. 47.25 ± 0.10, P < 0.0001), LH (19.00 ± 0.46 vs. 43.00 ± 1.49), and testosterone (0.74 ± 0.05 vs. 3.98 ± 0.08, P < 0.0001). This study revealed that curcumin attenuated dichlorvos-induced sexual dysfunction by activating the hypothalamic-pituitary-testicular axis and upregulating circulating testosterone.