Three-week Follow-up Research Articles

Effect of the ActivaMotricidad Program on Improvements in Executive Functions and Interpersonal Relationships in Early Childhood Education

Background: The objective of this study was to analyze the impacts of a comprehensive physical exercise program with cognitive involvement during the school day on the executive functions and interpersonal skills of 5- and 6-year-old children. Methods: A total of 68 children participated in a 3-week pre–post intervention. Results: The results showed significant improvements in executive functions and interpersonal skills under the experimental conditions compared to the control group. These positive effects were observed to persist after a three-week follow-up. Conclusions: Therefore, the ActivaMotricidad program, which focuses on developing fundamental motor skills through cognitive, cooperative, and coordinative challenges, can serve as a useful and low-cost tool to achieve the objectives of comprehensive development and sustainability for children in early childhood education.

Metabolic stress in patients with acute severe ulcerative colitis - a single-center cohort study

Background and aimsAcute severe ulcerative colitis (ASUC) is characterized by systemic inflammation, which may initiate an acute-phase response leading to hypercatabolism. Patients with ASUC are usually treated with high-dose steroids that may further accelerate the metabolic response and lead to hyperglycemia and insulin resistance. Nevertheless, the degree of synergy between inflammation and steroid treatment and their influence on the insulin resistance remains unknown. We aimed to measure the degree of metabolic stress including insulin resistance in patients with ASUC during admission and three weeks after discharge.MethodsThis single-center cohort study was conducted in adult patients with ASUC, defined and assessed by Truelove and Witt’s criteria. Indirect calorimetry, bioelectrical impedance analysis, and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were applied at baseline and at follow-up three weeks after discharge.ResultsAmong the 22 patients admitted during the project period, 15 provided consent for participation in the study. Median C-reactive protein at inclusion was 37.6 [4; 154.7]. Both median HOMA-IR and fasting plasma glucose were markedly increased at inclusion (median 8.6 [3.8; 14.1] and 7.1 [6; 8.7], respectively), and both had decreased significantly three weeks after discharge (p=0.0036 and p=0.0039, respectively). No significant differences were observed in resting energy expenditure or anthropometric measurements from baseline to follow-up.ConclusionPatients with ASUC presented with marked insulin resistance, indicating that the days following admission and high-dose steroid treatment are particularly vulnerable. Despite improvement at three-week follow-up, patients still exhibited insulin resistance compared with relevant control groups.Clinical trial registrationClinicalTrials.gov, identifier NCT0527183.

Language sentiment predicts changes in depressive symptoms

The prevalence of depression is a major societal health concern, and there is an ongoing need to develop tools that predict who will become depressed. Past research suggests that depression changes the language we use, but it is unclear whether language is predictive of worsening symptoms. Here, we test whether the sentiment of brief written linguistic responses predicts changes in depression. Across two studies (N = 467), participants provided responses to neutral open-ended questions, narrating aspects of their lives relevant to depression (e.g., mood, motivation, sleep). Participants also completed the Patient Health Questionnaire (PHQ-9) to assess depressive symptoms and a risky decision-making task with periodic measurements of momentary happiness to quantify mood dynamics. The sentiment of written responses was evaluated by human raters (N = 470), Large Language Models (LLMs; ChatGPT 3.5 and 4.0), and the Linguistic Inquiry and Word Count (LIWC) tool. We found that language sentiment evaluated by human raters and LLMs, but not LIWC, predicted changes in depressive symptoms at a three-week follow-up. Using computational modeling, we found that language sentiment was associated with current mood, but language sentiment predicted symptom changes even after controlling for current mood. In summary, we demonstrate a scalable tool that combines brief written responses with sentiment analysis by AI tools that matches human performance in the prediction of future psychiatric symptoms.

Laser Forced Dehydration of Benign Vascular Lesions of the Oral Cavity: A Valid Alternative to Surgical Techniques.

Background and Objectives: Low-flow vascular lesions are commonly encountered in the oral cavity and may require removal due to aesthetic concerns, repeated bleeding or a cluttering sensation. Laser devices represent an excellent aid due to their affinity with blood and to their biostimulating properties and have been substituting traditional excision in selected cases. Materials and Methods: In this study, 30 patients presenting with low-flow oral vascular lesions were included. The lesions were clinically evaluated as follows: lesion's site, reason for treatment, lesion's dimensions, confirmation of positive diascopy via compression with a glass slide and photograph. The lesions were treated with laser forced dehydration (LFD) and then followed-up after 3 weeks, 6 months and 1 year. The laser source was a K-Laser Blu Derma (Eltech, K-Laser S.r.l., Via Castagnole, 20/H, Treviso, Italy). In the case of incomplete healing, a further protocol was performed at the three-week follow-up, and a further follow-up was scheduled for three weeks after. The following aspects were evaluated at each appointment: pain, using a Numeric Rating Scale (NRS) from 0 to 10 (0 = no pain, 10 = worst pain ever); the need to take painkillers (day of intervention and during follow-up); bleeding (yes/no); scar formation. Results: Complete regression was obtained in all patients, with no side effects. Only one patient required a second LFD protocol. NRS was 0 for all patients for the whole duration of the follow-up. None of the patients took painkillers on the day of the intervention and during the follow-up. One patient declared slight bleeding the day of the intervention, which she easily managed at home. One patient showed a small non-retracting and non-painful scar at the three-week follow-up. No recurrences were found after six months and one year. Conclusions: LFD targets endogenous chromophores, minimizing damage to adjacent tissue and limiting side effects. LFD is effective and could be considered a conservative alternative to traditional excision in low-flow lesions.

Preoperative ultrasound radiomics for predicting clinically relevant postoperative pancreatic fistula after pancreatectomy.

To evaluate the efficacy of the radiomics model based on preoperative B-mode ultrasound (BMUS) and shear wave elastography (SWE) for predicting the occurrence of clinically relevant-postoperative pancreatic fistula (CR-POPF). Patients who were scheduled to undergo pancreatectomy were prospectively enrolled and received ultrasound assessment within one week before surgery. The risk factors of POPF (grades B and grades C) were analyzed. Preoperative BMUS images, SWE values of pancreatic lesions and surrounding parenchyma were used to build preoperative prediction radiomics models. Radiomic signatures were extracted and constructed using a minimal Redundancy Maximal Relevance (mRMR) algorithm and an L1 penalized logistic regression. A combined model was built using multivariate regression which incorporated radiomics signatures and clinical data. From January 2020 to November 2021, a total of 147 patients (85 distal pancreatectomies and 62 pancreaticoduodenectomies) were enrolled. During the three-week follow-up after pancreatectomy, the incidence rates of grade B/C POPF were 28.6% (42/147). Radiomic signatures constructed from BMUS of pancreas parenchymal regions (panRS) achieved an area under the receiver operating characteristic curve (AUC) of 0.75, accuracy of 68.7%, sensitivity of 85.7 %, and specificity of 61.9 % in preoperative noninvasive prediction of CR-POPF. The AUC of the radiomics model increased to 0.81 when panRS was used for the prediction of CR-POPF after pancreaticoduodenectomy. Radiomics model based on ultrasound images was potentially useful for predicting CR-POPF. Patients with high-risk factors should be closely monitored when postoperation.

Comparison between six-week exergaming, conventional balance and no exercise training program on older adults’ balance and gait speed

Abstract We evaluated differences between a six-week exergame-training and a conventional balance training program on the balance and gait speed of older adults’ (>65 years). Forty-two healthy participants were recruited from independent living and community centers and randomized to one of three groups: exergaming balance training (EBT), conventional balance training (CBT), or control (no training). The participants completed two balance measurements (Fullerton Advanced Balance Scale (FAB) and center of pressure (COP) excursion), and gait speed at pre, post-intervention, and after a three-week follow-up. Both EBT and CBT groups improved their scores on the FAB, COP displacement, and gait speed post-intervention (p<0.05) and these changes were maintained and did not return to pre-training values after three weeks of detraining. The control group scores for FAB and gait velocity values declined (p<0.001) but not COP excursions during the study. This six-week exergame training program improved balance control and gait speed in community-dwelling seniors in a similar fashion to conventional training. Participants’ physical abilities scores improved and were maintained following three weeks of detraining. Exergame-based training therefore may be considered as an intervention that can address balance control and gait speed in older adults. As well improved scores can be maintained with transient or sporadic activity.

1064 nm Q-Switched Fractional Laser for Transcutaneous Delivery of a Biostimulator: Efficacy and Safety Outcomes of a Split-Face Study

Background: Laser-assisted drug delivery is a promising strategy that enhances topical treatment by increasing cutaneous permeation and reducing side effects. In cosmetic settings, the efficacy and safety profiles of a treatment must meet the need of a painless procedure with fast recovery. In this context, Q-switched laser appears promising as it can open cutaneous pores without creating a carbonisation barrier. Methods: A split-face study on patients presenting for cosmetic procedures at IDI-IRCCS, Rome (30 September–18 October 2023), was conducted. Pan-facial Q-Switched laser was followed by a topical biostimulator applied on half of the face. Post-procedure local reactions were recorded together with patients’ perceptions. Cutaneous elasticity and hydration were assessed at baseline and three-week follow-up. The Skindex17 questionnaire evaluated the procedure’s impact on patients’ life quality. Also, participants and physicians expressed satisfaction with the treatment. Results: The procedure was well tolerated by patients; local reactions include transitory erythema, superficial bleeding, and oedema, none of which had an impact on daily life. An improvement in skin quality was documented objectively and subjectively by patients and physicians. Conclusion: Q-switched lasers emerge as promising devices for drug delivery, especially for cosmetic reasons. Indeed, the low risk of local reactions together with a remarkable increase in cutaneous permeation make this a suitable strategy for cosmetic procedures.

Evaluation of video visit appropriateness for common symptoms seen in primary care: A retrospective cohort study.

Little is known about which conditions seen in primary care are appropriate for video visits. This study evaluated video visits compared to office visits for six conditions: abdominal pain, joint pain, back pain, headache, chest pain, and dizziness. Six hundred charts of adult patients from our institution's same-day outpatient clinic were reviewed in this study. Charts for video visits evaluating the aforementioned chief complaints that occurred between August and October 2020 were reviewed and compared with charts for office visits that occurred from August to September 2019. Frequencies of 3-week follow-up visits, Emergency Room visits, imaging, and referrals for office and video visits were measured. Reasons for in-person evaluation for patients seen by video were determined by review of clinician notes. Three-week in-person follow-up was more frequent for patients presenting with chest pain (52% vs 18%, p = 0.0007) and joint pain (24% vs 8%, p = 0.05) after video evaluation, relative to an office evaluation. Three-week in-person follow-up was also more frequent for patients presenting with dizziness (38% vs 28%) and low back pain (24% vs 14%); however, this difference was not statistically significant. Patients presenting with headache and abdominal pain did not have a higher rate of follow-up. Based on the frequency of in-person follow-up, this study suggests that video visits are generally adequate for evaluating headache and abdominal pain. Patients with dizziness and chest pain have the highest frequency of in-person and Emergency Room follow-up within 3 weeks when first seen by video compared to other conditions evaluated and may be less suitable for an initial video visit. Institutions can consider these findings when scheduling and providing guidance to patients on what type of visit is most appropriate for their symptoms.

The outcomes of healthcare chaplaincy on hospitalized patients. A quasi-experimental study in Belgium

ABSTRACT Research on the effects of chaplaincy care is scarce and hampered by methodological limitations. Our quasi-experimental study (n = 256 at baseline) aimed to gain insight into the immediate and intermediate impact of chaplaincy care on inpatients’ existential anxiety, peace, anxiety and depressive symptoms. Multilevel modeling was used to analyze the data. After controlling for age, gender, education, (non)religion/(non)belief and religiosity, participants receiving chaplaincy care demonstrated greater immediate improvement in peace compared to the control group at posttest. This was not found for anxiety, depressive symptoms or existential anxiety, nor for any of the outcomes at the three-week follow-up assessment.

Branch Retinal Vein Occlusion Occurring After Second Dose of Sinopharm COVID-19 Vaccine: A Case Report

: An old-aged woman was evaluated with branch retinal vein occlusion (BRVO) vision reduction in his left eye three weeks after the Sinopharm coronavirus disease 2019 (COVID-19) vaccination. Her best-corrected visual acuity (BCVA) was 1m counting finger in the left eye and 10/10 in the right eye. Initial retinal findings were superior retinal hemorrhage with prominent retinal vein dilation and tortuosity in the left eye. Fluorescein angiography (FA) and optical coherence tomography (OCT) confirmed a BRVO diagnosis. Blood reports showed no abnormalities. Antithrombotic treatment of 80 mg/d low-dose entrocoated ASA was administered. In addition, an intravitreal Aflibercept (Eylea) injection, monthly and ongoing, was prescripted, which led to a decrease in macular edema, retinal hemorrhage, and height of serous retinal detachment. Moreover, the BCVA improved to 2/10 after a three-week follow-up.

The Effect of Mirror Visual Feedback on Spatial Neglect for Patients after Stroke: A Preliminary Randomized Controlled Trial.

We investigated the effects of mirror visual feedback (MVF), with reference to using a glass wall or a covered mirror, on the reduction of spatial neglect for patients with stroke. A total of 21 subacute patients with left spatial neglect after right-hemispheric stroke were randomly assigned to 3 groups: MVF, sham 1 (viewing the hemiparetic arm through the transparent glass during bilateral arm movement) and sham 2 (using a covered mirror). The 3-week treatment program for all groups consisted of 12 sessions of movement tasks for the hemiparetic arm graded according to the severity of arm impairments. Blinded assessments were administered at pre/post and a three-week follow-up. The results showed that there was no significant advantage for MVF than sham 1; however, MVF was more beneficial than sham 2, as shown by the line crossing (p = 0.022). Improvement in discriminating the left-gap figures on the left and right side of the page in the Gap Detection Test was greater in MVF than using the covered mirror (p = 0.013; p = 0.010), showing a slight advantage of MVF in alleviating allocentric symptoms. Our study confirms that MVF was superior to using a covered mirror as a method for reducing spatial neglect and in alleviating its allocentric symptoms, but no significant advantage over bilateral arm movement through transparent glass was found. Further research in comparing their therapeutic effects is warranted.

Repeated transcranial photobiomodulation improves working memory of healthy older adults: behavioral outcomes of poststimulation including a three-week follow-up.

.SignificanceDecline in cognitive ability is a significant issue associated with healthy aging. Transcranial photobiomodulation (tPBM) is an emerging non-invasive neuromodulation technique and has shown promise to overcome this challenge.AimThis study aimed to investigate the effects of seven-day repeated tPBM, compared to those of single tPBM and baseline, on improving -back working memory in healthy older adults and to evaluate the persistent efficacy of repeated tPBM.ApproachIn a sham-controlled and within-subject design, 61 healthy older adults were recruited to participate in a longitudinal study involving an experimental baseline, seven days of tPBM treatment (12 min daily, 1064-nm laser, ) in the left dorsolateral prefrontal cortex and three weeks of follow-ups. Behavioral performance in the -back () was recorded poststimulation during the baseline, the first and seventh days of the tPBM session, and the three weekly follow-ups. A control group with 25 participants was included in this study to rule out the practice and placebo effects. The accuracy rate and response time were used in the statistical analysis.ResultsRepeated and single tPBM significantly improved accuracy rate in 1- and 3-back tasks and decreased response time in 3-back compared to the baseline. Moreover, the repeated tPBM resulted in a significantly higher improvement in accuracy rate than the single tPBM. These improvements in accuracy rate and response time lasted at least three weeks following repeated tPBM. In contrast, the control group showed no significant improvement in behavioral performance.ConclusionsThis study demonstrated that seven-day repeated tPBM improved the working memory of healthy older adults more efficiently, with the beneficial effect lasting at least three weeks. These findings provide fundamental evidence that repeated tPBM may be a potential intervention for older individuals with memory decline.

Comparison of the efficacy of mud-pack and hot-pack treatments in chronic non-specific neck pain: A single-blind, randomized-controlled study.

This study aims to compare the short-term efficacy of mud-pack (MP) and hot-pack (HP) treatments with the same temperature and duration on sleep, function, depression, and quality of life for chronic non-specific neck pain (CNNP) patients. Between December 2018 and September 2019, a total of 70 patients with CNNP diagnosis (12 males, 58 females; mean age: 50.2±9.4 years; range, 24 to 65 years) were included. The patients were divided into two groups. The MP group (n=35) had a total of 15 sessions of MP for 20 min + transcutaneous electrical nerve stimulation (TENS) for 20 min + home exercise (HE) on five days per week for three weeks. The HP group (n=35) had 15 similar sessions of HP for 20 min + TENS for 20 min + HE. The patients were assessed with the Visual Analog Scale (VAS-pain), VAS physician's and patient's global assessments, modified Neck Disability Index (mNDI), Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), and Short Form-36 (SF-36) measures before treatment, at the end of post-treatment third week and one month later. In the MP group, there were statistically significant improvements in all parameters at the end of treatment three-week and one-month follow-up (p<0.05), apart from SF-36 Vitality/Energy (SF-36V/E) at the end of treatment and SF-36 General Health (SF-36GH) at one month. In the HP group, there were statistically significant improvements observed for all parameters (p<0.05), apart from the SF-36 Physical Role and SF-36GH at the end of treatment third week and SF-36V/E at the first-month assessment. The VAS-pain(p<0.001), mNDI (p=0.019), BDI (p=0.002), SF-36GH (p<0.001), SF-36V/E (p<0.001) and SF-36 mental health (p<0.001) showed statistically significantly superior improvements in the MP group (p<0.05). In CNNP patients, both MP and HP treatments are effective. However, MP therapy has more positive effects on pain, function, depression, and quality of life parameters. The MP treatment may be used in addition to TENS treatment for CNNP patients.

Feasibility of video/audio monitoring in the analysis of motion and treatment effects on night-time seizures – Interventional study

The aim of the studyThis pilot study assessed the ability of a video/audio-based seizure monitoring system to evaluate (I) baseline frequency and severity of nocturnal seizures with motor features in patients with drug-resistant epilepsy (DRE) and (II) the individual effect of brivaracetam (BRV) treatment on number, duration and movement intensity of these seizure types. Algorithmic feature analysis was developed for assessment of qualitative changes in movement intensity measurements within seizure types before and after BRV intervention. Materials and methodsNight-time motor seizures of recruited patients were recorded in two separate four-week monitoring periods. The first period defined a prescreening phase (n = 13 patients) to establish a baseline, and the second period defined the intervention phase (n = 9 patients), with BRV initiated during the second week of the second monitoring period. All recorded nights were analyzed by an expert video reviewer, and all unequivocal seizures were classified by an epileptologist.Seizure frequencies using both seizure diaries and video monitoring were compared.The effect of BRV on both seizure duration and movement intensity was assessed by numerical comparison of visual features calculated from motion characteristics of the video, as well as spectral features from the recorded audio. The statistical significance of changes in seizure duration and intensity before and after the intervention were investigated by Wilcoxon rank-sum test and visual inspection of Kernel density estimation. Results8 patients marked seizures in their seizure diaries during the prescreening phase. During the three-week follow-up, three patients achieved > 50% seizure decrease, four patients did not respond to treatment, and two patients experienced worsening of seizures. Five patients were able to document 40–70% of their seizures compared to the video/audio monitoring system. According to the signal feature analysis the intervention decreased movement intensity with clear clinical significance in three patients, whereas statistically significant differences in features appeared in 8 out of 9 patients. ConclusionsThe novel video/audio monitoring system improved the evaluation of treatment effect compared to the seizure diaries and succeeded in providing a comparative intra-patient assessment of the movement intensity and duration of the recorded seizures.

Determine the Effectiveness of Intranasal Splints in Preventing Nasal Adhesion

Objective: The aim of this study is to determine the effectiveness of intranasal splints in preventing nasal adhesion. Study Design: Descriptive case series Place and Duration: The study was conducted at ENT department of Lady Reading Hospital Peshawar and Chaudhary Muhammad Akram Teaching and Research Hospital, Lahore for the duration of six months April 2021 to September 2021. Methods: There were 120 participants of both sexes in this research. In this study, the patients ranged in age from 16 to 50 years old. Patient demographics, such as gender, age, and height/weight were logged with their informed written consent. During general anesthesia, a patient with a deviated nasal septum and septoplasty was selected for the procedure. Immediately following the septoplasty treatment, the patient had intra-nasal splints and nasal packing placed. The nasal packing was removed on the second postoperative day, while the nasal splints were removed on the 15th day after surgery. After a three-week follow-up, frequency of nasal adhesion was calculated. Data were analyzed 24.0. Results: Among 120 cases, 75 patients, 59.2% were between the ages of 26 and 40.The mean age of the patients was 26.34±7.51 years with mean BMI 23.07±9.44 kg/m2. Most of the cases were 67 (55.8%) male and 53 (44.2%) were females. Nasal obstruction was found among 53 (44.2%) patients, frequency of rhinorrhea was 33 (27.5%) and mixed symptoms were found in 20 (16.7%). At final follow up prevalence of nasal adhesion was found in 9 (7.5%). Conclusion: According to the findings of this study, intranasal splints were an efficient and safe treatment for preventing nasal adhesion after septoplasty. Keywords: Septoplasty, Intra nasal adhesions, Deviated nasal septum, Intra nasal splints

Self-guided online therapeutic assessment in substance abuse care: A Conflict Analysis implementation and feasibility case study

“Michael” is a 60-year-old Black male receiving substance abuse treatment at a Veterans Affairs hospital. As part of Michael's care, he participated in an implementation and feasibility trial evaluating Conflict Analysis (CA), a self-guided online therapeutic assessment. CA leverages innovative diagnostic and therapeutic resources to improve client engagement and therapeutic achievement. CA employs narrative formats, encouraging patients to frame experiences within personal vocabulary, and provides personalized feedback automatically extracted from patient responses. CA is self-guided, widely accessible, and has few costs. Paper presents Michael's protocol, associated therapeutic outcome measures, and psychologist's evaluation of CA benefits. Michael completed brief online CA deployment containing a wellness-based personality inventory, four narrative tasks, and an interactive feedback template. Michael completed insight, stress, depression, wellbeing, and perceived diagnostic and therapeutic benefit measures at baseline, post, and three-week follow-up. Interventions took 2.5 h. Attending psychologist reviewed CA protocols and completed diagnostic and therapeutic questionnaires. Michael's record identifies elevated dominance. Protocol highlights Michael's drinking as mechanism to lessen social anxieties, anger, and competitiveness. Results suggest CA encouraged increased motivation to change, treatment engagement, and reduced depression. Psychologist rated benefit at maximum threshold. Implications include improving assessment efficacy, increasing online care opportunities, and expanding CA research.

An implementation and effectiveness study evaluating Conflict Analysis in VA residential substance abuse services: Whole Health informed self-guided online care

ContextWhole Health is an emerging healthcare framework that emphasizes wellbeing in place of illness. Conflict Analysis (CA), an online self-guided assessment, leverages innovative diagnostic and therapeutic resources that shares Whole Health objectives, including helping users explore their identity and develop a personalized health plan and helping users develop resources to optimize their health. ObjectivesPaper presents CA implementation-effectiveness study in a Veteran Affairs inpatient substance recovery care. DesignPatients were randomized to CA or mindfulness control. Patients completed Whole Health outcomes measures at baseline, completion (post), and three-week follow-up. Interventions took 2.5 h. Attending psychologist assessed CA protocols and completed outcome evaluation. Due to Coronavirus, recruitment and follow-up were curtailed. SettingStudy took place in a rural northern New England Veteran Affairs inpatient substance recovery unit. Outcome MeasuresMeasures include The Personal Growth Initiative Scale, The Beck Cognitive Insight Scale, Perceived Stress Scale, The Patient Health Questionnaire, Perceived Psychological Wellbeing, and Perceived Therapeutic and Diagnostic Benefit. Results12 patients were randomized, 11 completed post measures (CA=5; Mindfulness = 6), and 7 completed follow-up measures (CA=3; Mindfulness=4). CA offered significant Whole Health benefits when compared to control. Additionally, participant and clinician evaluations indicated that CA can be personally relevant, meaningful, and motivate therapeutic growth. Implications include extending CA research and expanding Whole Health related interventions. Although initial results suggest implementation feasibility and Whole Health benefit, more research is necessary to establish CA's utility within inpatient substance recovery care in particular and psychiatric rehabilitation in general.

Morphosemantic treatment of inflection of verb tense in Persian-speaking aphasic patients with agrammatism: a single-subject study

ABSTRACT Background The production of verb inflection, especially tense marking, is commonly impaired in persons with agrammatic aphasia. In Persian, verbs are inflected in three tenses the past, present, and future, and play a key role in the sentence.A group of theories attributes verb inflection errors to syntactic or semantic deficits in sentence formulation. Aims The present study intends to investigate the effect of morphosemantic treatment on the inflection of regular and irregular verbs in the past, present, and future tenses in Persian-speaking agrammatic participants. Methods & Procedure A single-subject study with an ABA design was performed to evaluate the effect of morphosemantic treatment on four Persian-speaking agrammatic participants. In the current study, in addition to presenting descriptive statistics and visual analysis, percent of non-overlapping data (PND) was used to determine whether there was an effect of intervention during the treatment phase, and d1 statistics of effect size analysis was used to determine whether there was a maintenance effect during the withdrawal phase. Outcomes & Results All participants demonstrated significant improvement in the trained regular and irregular tenses and generalized to the production of tense morphology on untrained regular and irregular verbs. The effect of therapy was maintained for a three-week follow-up. Also, the morphosemantic intervention was associated with an increase in most narrative measures and language tests scores. Conclusions Therapy for verb inflection in spontaneous speech is clinically important. The current study demonstrated that morphosemantic intervention could be successfully used for tense marker deficits in Persian-speaking participants with aphasia and agrammatism.

Effect of drops containing Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) on plaque acidogenicity and other caries-related variables in orthodontic patients

BackgroundThe purpose of the study was to investigate the effect of probiotics on biofilm acidogenicity and on the number of salivary Streptococcus mutans and lactobacilli in orthodontic patients.MethodsThis RCT was conducted on 28 young adults who were undergoing orthodontic treatment. The short-term prospective clinical trial lasted for three weeks. The test group rinsed daily with drops containing two Lactobacillus reuteri strains diluted in water, while the placebo group used drops without probiotics. The subjects were enrolled eight months since the beginning of orthodontic treatment. Plaque-pH, saliva and dental biofilm samples were obtained at baseline, one week and three weeks post intervention.ResultsTwenty-seven subjects successfully completed the trial period, only one drop out in the test group. No side effects were reported. A statistically significant increase in plaque pH at three weeks post-intervention was found for the test group (p < 0.05), while insignificant changes in the pH value were found for the placebo group in comparison to baseline (p > 0.05). In addition, the AUC7.0 showed a significant difference at three weeks between the test and placebo (p = 0.00002). The three-week samples of stimulated whole saliva showed a statistically insignificant difference in the number of S. mutans and lactobacilli between the two groups (p > 0.05). The qPCR analysis showed the ability of the two strains to get colonized in the dental biofilm without a significant effect on the microbial counts.Conclusion/clinical implicationsA mixture of Lactobacillus reuteri has the ability to reduce the pH fall at the three-week follow-up. However, the short-term use of probiotics does not appear to have an effect on the number of salivary Streptococcus mutans and lactobacilli in saliva and on the dental biofilm.Trial registrationClinicaltrial.gov (Identifier: NCT04593017/ (19/10/2020)).

Successful venous thromboprophylaxis in a patient with vaccine-induced immune thrombotic thrombocytopenia (VITT): a case report of the first reported case in Thailand

BackgroundVaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but fatal complication of the Coronavirus Disease 2019 vaccine. The many reports of VITT have mostly been in the Caucasian population. Here, we present the first reported case in an Asian population.Case presentationA 26-year-old female had severe headache and severe thrombocytopenia 8 days after administration of the ChAdOx1 nCoV-19 vaccine developed by AstraZeneca. Although no thrombosis was demonstrated by imaging studies, she had very highly elevated d-dimer levels during hospitalization. Serology for antibodies against platelet factor 4 was positive on several days with very high optical density readings. We found that the antibody could induce spontaneous platelet aggregation without the presence of heparin. We decided to treat her with intravenous immunoglobulin, high-dose dexamethasone, and a prophylactic dose of apixaban. She improved rapidly and was discharged from the hospital 6 days after admission. Neither thrombocytopenia nor thrombosis was subsequently detected at the three-week follow-up.ConclusionsDespite the lower rate of thrombosis, VITT can occur in the Asian population. Early detection and prompt treatment of VITT can improve the patient’s clinical outcome. Thromboprophylaxis with nonheparin anticoagulants also prevents clot formation.