A series of quinoline–thiazolidinone–isonicotinamide hybrids (SK-1 to SK-12) was design, synthesized and characterized for their potential as antitubercular agent. The hybrid compounds were synthesized through a cyclization reaction using thioglycolic acid, affording yields of 63-76% with high stereoselectivity and their structure were confirmed by IR, 1H, 13C NMR, MS and elemental analysis. Molecular docking studies against M. tuberculosis Enoyl-ACP Reductase (InhA) revealed high binding affinities (-9.3 to -7.5 kcal/mol) significantly better than that of isoniazid (-7.5 kcal/mol) primarily mediated by hydrogen bonds with active-site residues such as ASP54, PHE149 and TYR158. ADMET prediction indicated drug-likeness, effective gastrointestinal absorption, low blood–brain barrier permeability and reduced risk of mutagenicity and carcinogenicity. In vitro antitubercular assay was performed by Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA) methods, results showed that derivatives SK-3, SK-5 and SK-6 exhibited significant antitubercular activity as compared to isoniazid.

We report a case of nonsurgical management of lash ptosis using eyelash lamination. A 36-year-old male presented with persistent foreign body sensation and visual obscuration. Slit lamp examination revealed elongated, ptotic upper eyelashes that rested on the cornea and extended into the pupillary axis. After thorough consultation, the patient declined surgical correction and instead elected to undergo a semipermanent eyelash lamination procedure, which relies on thioglycolic acid and polyacrylamide. This chemical treatment lifted and reshaped the lashes, which redirected them away from the corneal surface. At the 3-month follow-up visit, the patient reported significant improvement in visual function and ocular comfort. He also reported marked satisfaction with the cosmetic outcome. This case highlights the potential of eyelash lamination as a low-risk, noninvasive, and cosmetically favorable alternative for managing lash ptosis, particularly in patients who are poor surgical candidates or prefer to avoid operative procedures.

Molybdenite and chalcopyrite closely coexist and have good natural floatability. During the Cu-Mo separation process, it is necessary to enhance the inhibition of chalcopyrite to reduce its influence on molybdenite. In this paper, a combined inhibitor, sodium thioglycollate (HSCH2COONa) and sodium sulfide (Na2S), with a molar ratio of 2:1, was obtained through pure mineral flotation experiments. It could reduce the impact on molybdenite while maintaining a good inhibitory effect on chalcopyrite. In the artificial mixed minerals test, the use of the combined inhibitor (80 mg/L) can achieve good indicators with Mo grade and recovery rate of 54.34% and 88.12%, respectively, and Cu grade of 2.15%. The contact angle test shows that the combined inhibitor can significantly reduce the wettability of the chalcopyrite surface while having a relatively small effect on molybdenite. The infrared spectroscopy and SEM-EDS energy spectrum indicated that the combined inhibitor C = O and S-H groups underwent chemical reactions on the surface of chalcopyrite and squeezed out kerosene on the surface of chalcopyrite. Molecular dynamics simulations indicate that the HS−, S2−, and HSCH2COO− components in the combined inhibitor are more likely to act on the surface of chalcopyrite, exerting an enhanced inhibitory effect on chalcopyrite.

Synthesis, structural features, computational study along with molecular docking examination of organosulfur mercaptoacetic acid based compound

In this study, we report a green and efficient method for the synthesis of aromatic imine intermediates via acid-catalyzed condensation of substituted aromatic amines and aldehyde using an ethanol extract of Caralluma fimbriata (Wall) as a natural bio-catalyst. The plant extract, which possesses a pH range of 4.57–5.0 and contains flavonoids, saponins, and phenolic acids, facilitated the imine formation in significantly reduced reaction time (10 min) and with high yield (up to 94%). This method represents an eco-friendly alternative to conventional acid-catalyzed condensations. The synthesized imines were further utilized in a conventional, catalyst-free reaction with thioglycolic acid to obtain 2,3-bis(2-chlorophenyl)thiazolidin-4-one derivatives. Structural confirmation was achieved using IR,1H NMR, LC-MS, and melting point analysis. The work highlights the potential of Caralluma fimbriata as a viable green catalyst in heterocyclic precursor synthesis.

Quantum-confined perovskite nanoplatelets (NPLs) with ultra-narrow emission linewidths represent promising blue-emission materials for ultrahigh-definition displays. However, their practical applications have been severely hindered by material instability and poor charge transport properties. Herein, we employed thioglycolic acid (TA) and anilinium bromide (AnHBr) as dual short-chain ligands, successfully synthesizing monodisperse CsPbBr3 NPLs with an emission peak at 463nm and a remarkable photoluminescence quantum yield (PLQY) of 89%. This approach involves introducing TA into the perovskite precursor solution, where its carboxyl groups strongly coordinate with uncoordinated Pb2+ on the surface to form TA-modified NPLs (TA-NPLs). Subsequently, the introduced Br- from AnHBr effectively fills existing Br- vacancies on initial NPLs' surface to form TA- and AnHBr-modified NPLs (TA+AnHBr-NPLs). Both ligands enhance structural stability through strong interactions with the [PbBr6]4- octahedra. The resulting solution maintains stable blue emission when stored in air for 21 days and exhibits excellent photostability. The fabricated TA+AnHBr-NPLs-based light-emitting diodes demonstrate efficient deep-blue electroluminescence at 461nm, with an external quantum efficiency (EQE) of 1.00%, CIE color coordinates of (0.146, 0.085), and remarkable spectral stability. This study offers a method for synthesizing high-stability perovskite materials and further fabricating high-performance devices.

Substitution reactions of 1-halo-1-nitrocyclohexanes with thioglycolic acid and cysteine derivatives were investigated. Readily available 1-bromo-1-nitrocompounds exhibit good stability and superior reactivity compared to other halogenides, enabling the formation of corresponding α-nitrosulfides and disulfides.

The synthesis of effective biomaterial works as antimicrobial agent. A series of -thiazolidin-4-one and -oxoazetidin-2-yl- derivatives were easily obtained commencing from α-naphthol and ethyl acetoacetate to form coumarin and then converted into -quinolin-2(1H)-one using hydrazine hydrate followed by subsequent reaction of quinolin-2(1H)-one and p-hydroxy benzaldehyde oxazine-6-carbaldehyde Thereafter carbaldehyde and aromatic primary amine were condensed from imines. Final cyclized derivatives were achieved by the reaction of imine with thioglycollic acid and chloroacetyl chloride. The structure elucidation of all the novel derivatives was accomplished through PMR, Mass and IR studies. The antimicrobial activity was assessed in vitro by serial dilution method. The activity of 5(b,d,g) and 6(b,f,g)derivatives showed noticeable antimicrobial activity against the tested microbes.

Since the beginning of this century, esthetic cosmetology has witnessed unprecedented growth, with a variety of procedures offered to enhance the customer’s appearance in a fast and non-surgical way. However, the growing demand has been paralleled by a rise in complications (particularly, ocular ones). These include allergic, mechanical and chemical lesions following eyelash extension and tinting, permanent make-up, microblading, laser-assisted eyebrow treatment and tattooing in the periocular region. Of special concern is lash and/or brow lamination, a procedure that involves the use of chemically active substances (e.g., thioglycolic acid) potentially causing inflammation, allergy, dry eye, burns and even autoimmune-like reactions. We present a case of a woman who developed allergic blepharitis and dry eye after having her first brow lamination session. Prompt diagnosis and adequate therapy including a liposomal eye spray (containing hyaluronic acid and Perilla frutescens seed extract 0.5%) led to full recovery. This case highlights the need for greater awareness among beauticians and their customers regarding potential hazards and importance of pre-procedural allergy screening and strict adherence to application protocols. It also points to the necessity for standardized post-procedural aftercare protocols.

Electrochemiluminescence (ECL) efficiency depends on charge transfer between emitters and coreactants, but random collisions often make this transfer uncontrolled. Herein, we demonstrate that chirality-directed assembly could modulate the morphology of hierarchically organized particles (Au-Cys HOPs), generating an intense local electric field that accelerates electron transfer and enhances ECL. Using L/d-cysteine (Cys) as chiral ligands, we synthesize Au-Cys HOPs from polydisperse gold thiolate nanoplatelets, yielding radially organized twisted spikes. These spiky architectures exhibit a stronger built-in electric field (BIEF) than spherical Au-TGA particles (synthesized with achiral thioglycolic acid), facilitating rapid electron transfer and significantly improved ECL. In contrast, kayak-shaped Au-dl-Cys HOPs synthesized with racemic dl-Cys exhibit a smooth morphology devoid of spiky features, whereas Au-TGA particles entirely lack hierarchical organization. Thus, the Au-Cys HOPs exhibit strong anodic ECL emission with high efficiency (25.52%) with on-electrode preoxidation of radical ions (using TPrA as a coreactant), surpassing Au-dl-Cys HOPs and Au-TGA particles by 3.6- and 170.1-fold, respectively. An efficient ECL sensing platform is constructed using Au-Cys HOPs for achieving enantioselective recognition of tryptophan (Trp) isomers (Id-Trp/Il-Trp = 2.29), with a detection limit of 0.16 nM for l-Trp. This work demonstrates chirality's critical role in nanostructure design for efficient ECL and chiral sensing applications.

Thiolated chitin nanocrystals: Colloidal-chemical properties, toxicity, emulsion stabilization and UV sensitivity.

Smartphone-assisted array sensor constructed with Cu, Ni doped ZIF-67 nanozyme for specific identification of sulfur-containing compounds and detection of thioglycolic acid

Engineered thioglycolate-activated carbon composites via ambient alcohol esterification for enhanced mercury(II) adsorption performance: The role of alcohols in thioglycolic acid esterification

This research includes the synthesis of some new heterocyclic derivatives (pyridine derivatives), firstly reaction of (2-amino-5-chloropyridine, 2-amino-4- methyl pyridine) With aromatics benzaldehydes (p-bromobenzaldehyde, dimethyl amino benzaldehyde , p-chlorobenzaldehyde, Salicylic aldehyde, p- amino benzaldehyde) to form different derivatives of schiff bases, secondly reaction of Schiff base derivatives with thioglycolic acid to form thiazolidinone derivatives, all resulting compounds characterized by FT-IR.

Much of research on developing chemically circular alternatives to nondegradable/recycle polyolefins has focused on polyethylene-like materials with cleavable bonds, but it is more challenging to create a circular alternative of matched high-performance properties to isotactic polypropylene (iPP) that accounts for 40% of polyolefins produced worldwide. Here, we introduce high–molecular-weight poly(thioglycolic acid) (PTGA) that exhibits not only closed-loop recyclability but also iPP-like thermal properties, even superior mechanical and barrier properties, and processability well suited for common processing techniques such as blow molding into bottles. To circumvent long-standing challenges of extensive transthioesterification side reactions in the ring-opening polymerization (ROP) of thioglycolide, which typically yielded only oligomers, we developed the interfacial chain-growth ROP occurring at the interface between the semicrystalline polymer surface and the monomer–organocatalyst solution phase, enabling the synthesis of high–molecular-weight PTGA. Overall, we show that PTGA is a scalable circular polymer that provides iPP-like properties and that the interfacial ROP method solves the challenges in typical solution-phase polymerization.

This study reportsthe design and solvothermal synthesisof a novelternary nanocomposite named UiO-66/Fe3O4@CNCs.The material was developed for the selective adsorption and magneticrecovery of oxytetracycline (OTC) from water. The composite combinesthree functional components. CNCs derived from Neptuniaoleracea serve as a fibrous scaffold. Fe3O4 nanoparticles provide magnetic separation, while UiO-66contributes high surface area and active binding sites as a porousMOF. The Fe3O4@CNCs hybrid was prefunctionalizedwith mercaptoacetic acid to enhance interfacial interactions and promoteuniform UiO-66 crystallization, yielding a well-defined core–shellporous architecture. The resulting UiO-66/Fe3O4@CNCs composite exhibited a high specific surface area (360.68 ±1.82 m2/g), mesoporous structure (2–14 nm), andexcellent magnetic responsiveness. Under optimized conditions (pH6, 303 K), the composite demonstrated a maximum OTC adsorption capacityof 48.55 mg/g. Kinetic analysis followed a pseudo-second-order model,confirming chemisorption. Langmuir isotherm fitting (R2 = 0.9932) indicated a monolayer capacity of 110.13 mg/g,with uniform and high-affinity sites. Thermodynamic parameters (ΔG < 0, ΔH = −62.32 kJ/mol,ΔS = −168.06 J/mol·K) confirmedthe spontaneous and exothermic nature of the process. The compositealso showed high selectivity for OTC compared to other antibiotics.It retained good adsorption performance after several reuse cycles.These findings highlight the potential of UiO-66/Fe3O4@CNCs as a sustainable, efficient, and recyclable adsorbentplatform for emerging contaminant removal in wastewater treatment.

Enhancing the separation of galena from sphalerite by the synergistic effect of calcium oxide and sodium thioglycolate

Mechanistic interpretation of thioglycolic acid as a depressant in the differential flotation of molybdenite from chalcopyrite

Abstract As a wide‐bandgap light‐harvesting material, antimony sulfide (Sb2S3) is considered one of the optimal candidates for top cells in tandem photovoltaics. However, the development of Sb2S3‐based two‐terminal (2T) tandem solar cells has been relatively slow due to the limited performance of Sb2S3 single‐junction devices. Because of the complex deep defects, high‐quality growth of Sb2S3 thin films plays a crucial role in Sb2S3 single‐junction devices and 2T tandem devices. In this study, we introduced a bidentate coupling small molecule additive, sodium thioglycolate (ST), into the precursor solution to regulate the nucleation and growth process. Experimental results demonstrated that ST formed a synergistic complexion with Sb3+ via ‐SH and ‐COO− ligands, which effectively inhibited the homogeneous nucleation in the precursor solution and stabilized the growth process of Sb2S3 thin films. As a result, the ST‐regulated Sb2S3 (ST‐Sb2S3) achieved a champion power conversion efficiency (PCE) of 8.36%. The corresponding Sb2S3/PbS‐quantum‐dots (PbS‐QDs) 2T tandem devices obtained a record certified efficiency of 12.09%. This work presents a novel additive strategy for film growth and further demonstrates the broad prospects of Sb2S3‐based 2T tandem devices.

Flash-Lamp and Thermal Annealing of Ternary Ag–In–S Quantum Dots Stabilized with Thioglycolic Acid