Box-type houses often use asymmetric cold-formed thin-walled steel columns with complex edges to meet structural requirements. However, there is a need to clarify the mechanical properties of eccentric loading in this section of the steel column. This study conducted eccentric compression tests on 24 asymmetric cold-formed thin-walled steel columns with complex edges, clarifying the specimens' ultimate load-bearing capacity and buckling mode. The results showed that the resistance to pressure provided by the corner was higher than that provided by the two crimped edges. Subsequently, a finite element model was established, and its accuracy was verified by comparing it with experimental results. Finally, based on the formula for calculating the nominal axial strength in AISI, the direct strength method formula for the stable bearing capacity of asymmetric cold-formed thin-walled steel columns with complex edges under in-plane eccentric compression was proposed. This method takes into account the local-global interactive buckling and distortional-global interactive buckling. The comparison between the theoretical calculation results and numerical simulation results demonstrated that the design method proposed in this study is effective and conservative. It can provide a reference for future engineering applications.