It has been observed for several years that fusiform bacilli, usually associated with long spirilla,f are present in many pathological conditions. They were first demonstrated in cases of ulceromembranous angina (Vincent's or Plaut-Vincent's) and later in cases of ulceromembranous stomatitis, hospital gangrene, noma, pyorrhea alveolaris, appendicitis, subpectoral, brain, and thigh abscesses, and some other morbid processes. Both organisms have been observed in the healthy mouth and genitalia. In the majority of cases the bacilli and spirilla have been recognized in smear preparations, made from the seat of the disease, or in stained sections of tissues. Both organisms have been grown in mixed cultures. Fusiform bacilli have been isolated in pure culture by Veillon and Zuber, Ellermann and Weaver. The fusiform bacilli isolated by Dr. Weaver, and described in an article by Dr. Weaver and myself,1 appeared to be the same as those described by Ellermann, and compared quite closely with those found in smear preparations made from the seat of the disease. Although spirilla resembling those from the tissues have been grown in mixed cultures with fusiform bacilli and other organisms, all efforts to obtain them in pure culture have up to this time been unsuccessful. Most authors have believed that the fusiform bacilli and spirilla are entirely distinct organisms and that they act in symbiosis, the spirilla serving to increase the virulence of the bacillus. Some observers have maintained that they are different forms of one organism (Seiffert, Perthes, Sobel, and Herrman). As until recently no pure cultures of the bacilli and none of the spirilla have been obtained, it has been impossible to prove whether they were distinct organisms or not.
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