: The idea of the current investigation is to study the two-dimensional unsteady mixed convection MHD flow of a micro-polar nanofluid with non-uniform heat source/sink. Effects of radiation, reaction, thermo-diffusion, and viscous dissipation are considerednanoparticles are suspended in water base fluid. The governing non-linear system of PDEs is transformed into a system of ODEs using the similarity transformation and HAM is employed for obtaining solutions. Effects of different physical parameter on momentum, microrotation, energy, and concentration profiles are discussed through graphs. From graphical results, it is concluded that the unsteady parameter and magnetic parameter tend to improve the motion of the fluid. It is also seen that microrotation is raised in the shrinking sheet and reduced in the stretching sheet with the increase in the unsteady parameter. The mass transfer process improved with thermal diffusion parameter while delayed with chemical reaction.