This paper seeks to analyze the core effects of entropy generation on the peristaltic flow of an incompressible fluid with nonlinear convective heat transfer. The analysis is carried out inside an asymmetric channel with flow subjected to the second order velocity slip conditions. The flow is firstly modeled by the system of partial differential equations (PDEs) and then is simplified using the assumptions of long wavelength and low Reynolds number, in wave frame of reference. Entropy production, its contributing factors and performance of heat and fluid against various parameters is described, discussed, and displayed graphically by assigning an increasing list of numerical values to them. Trapping of the fluid is also portrayed by streamline graphs. Entropy generation is witnessed to be minimized when first order velocity slip and thermal slip parameters are held in check account.