Theory Of Mind Task Performance Research Articles

Affective theory of mind in people with mild and moderate Alzheimer's disease.

This study compared the affective theory of mind (ToM) of people with mild and moderate Alzheimer's disease (AD) and healthy older adults and also investigated the relationship between affective ToM and cognitive and clinical functioning in AD people. This cross-sectional study included 156 older adults with AD and 40 healthy older adults. We used an experimental task involving reasoning processes in different contextual situations. The affective ToM was impaired in AD groups compared with healthy group, with moderate AD group showing lower performance than mild AD group. The affective ToM task of mild AD group was significantly correlated with the Mini-Mental State Examination (MMSE) and education years. Linear regression showed only education years as a predictor of ToM task performance. The neuropsychiatric symptoms and functionality were not correlated with the affective ToM. Our findings demonstrated that people with mild and moderate AD presented impairments in affective ToM that can be explained by the difficulties to infer emotion from reasoning processes. In addition, the education years variable proved to be an affective ToM performance's predictor for the mild AD group, but not for the moderate AD group, indicating that ToM abilities are affected differently in different stages of AD. Neuropsychiatric symptoms and functionality seem to have no influence on affective ToM impairments in people with AD.

Childhood trauma, IL-6 and weaker suppression of the default mode network (DMN) during theory of mind (ToM) performance in schizophrenia

BackgroundBoth low-grade systemic inflammation and functional connectivity of the default mode network (DMN) during rest have recently been observed to mediate the association between childhood trauma (CT) and behavioural performance on an emotion recognition task. Whether inflammation also mediates the association between CT and functional connectivity of the DMN during social cognitive task performance is unknown. Methods51 patients with schizophrenia (SZ) or schizoaffective disorder (SZA) and 176 healthy participants completed a theory of mind (ToM) task during fMRI. IL-6 was measured in plasma using ELISA. DMN connectivity was measured during performance of the fMRI ToM task. To examine DMN connectivity, we selected 4 a priori seeds of the DMN, i.e., the medial prefrontal cortex (PFC), right lateral parietal (LP), left LP, and posterior cingulate cortex (PCC) according to the Harvard-Oxford Cortical and Subcortical Atlas (http://www.cma.mgh.harvard.edu/fsl_atlas.html) as implemented in CONN. ResultsPatients showed significantly increased DMN connectivity compared to healthy participants between each of the four seeds of the DMN and with other clusters in the brain. Across the entire sample, higher levels of IL-6 predicted increased connectivity between the mPFC and regions encompassing the cerebellum (<0.001 FWE). IL-6 mediated the association between physical neglect and weaker suppression of the posterior cingulate cortex (PCC) DMN seed -left precentral and postcentral gyrus (βINDIRECT = .0170, CI: 0.0008 to.0506) connectivity during ToM performance. DiscussionThis is the first study to our knowledge that provides evidence that higher plasma IL-6 mediates the association between higher childhood neglect and increased DMN connectivity during ToM task performance. Consistent with our previous study that IL-6 mediated the association between early life stress exposure and reduced connectivity of the DMN during rest, here IL-6 mediated the association between early life stress and increased connectivity of the DMN during ToM based cognitive processing. These findings suggest a biological mechanism for how chronic stress impacts social cognitive processing.

Theory of mind and its relationship with alexithymia and quality of life in patients with psychogenic nonepileptic seizures: Comparisons with generalised epilepsy and healthy controls

ObjectivePsychogenic nonepileptic seizures (PNES) are associated with high alexithymia, social cognition problems and low quality of life (QoL). Theory of Mind (ToM) has been studied in several conditions as a significant predictor of QoL. We aimed to assess the relationship between ToM abilities, alexithymia and subjective QoL in PNES patients and compare with generalised epilepsy (ES) patients and healthy controls. MethodPatients with PNES (n = 28), ES (n = 28) and healthy volunteers (n = 28) were evaluated for alexithymia and quality of life (QoL) with Toronto Alexithymia Scale-20 (TAS-20) and Short Form-36 (SF-36). Reading the Mind in the Eyes test was used for assessment of affective ToM and Hinting Task and Strange Stories tests for cognitive ToM abilities. ResultsAnalyses revealed lower SF-36 scores and poorer ToM performance in the PNES group compared to healthy group and poorer cognitive ToM performance than ES group. Cognitive ToM performance was inversely correlated with TAS-20 “difficulty identifying feelings” subscale and “physical functioning” subscale of SF-36 in the PNES group. ConclusionThese results are consistent with previous research on PNES and other somatoform disorders and suggest that PNES is associated with impaired ToM task performance. ToM task performance might be related to specific aspects of alexithymia and QoL.

Executive function and Theory of Mind in explaining young children’s moral reasoning: A Test of the Hierarchical Competing Systems Model

Children’s moral reasoning in early childhood is dynamic, and requires coordination of multiple social domains. Hierarchical Competing Systems Model (HCSM; Marcovitch & Zelazo, 2009) posits that underlying cognitive mechanisms, namely executive functions (EF), might allow for greater reflection and integration of multiple domains. In the current study, 121 preschool-age children (Mage = 53.24 months) completed an age-appropriate Stroop task, a theory of mind (ToM) battery, and open-ended story-interviews pertaining to intentional and accidental harm. Findings largely support the HCSM in explaining children’s moral reasoning. Stroop performance explained morally-embedded ToM task performance, such that stronger EF corresponded with better ToM performance. ToM performance explained attributions of intentions for events of intentional harm and accidental harm, but did not explain children’s own evaluations of either transgression. Stroop performance also explained discrepant justificatory strategies across harmful events, for instance with faster Stroop performance corresponding with reasoning strategies related to fairness, but only for the accidental event. Implications, limitations, and future directions are discussed.

No links between genetic variation and developing theory of mind: A preregistered replication attempt of candidate gene studies.

Genetic variability is being discussed as a source of inter-individual differences in Theory of Mind development. Previous studies documented an association between variations in DRD4 VNTR 48bp, OXTR rs53576, COMT rs4680, and Theory of Mind task performance. As empirical evidence on these associations is sparse, we conducted a preregistered replication attempt of a study reporting a link between DRD4 VNTR 48bp and false belief understanding in 50-month-old children [Lackner, C., Sabbagh, M. A., Hallinan, E., Liu, X., & Holden, J. J. (2012). Developmental Science, 15(2), 272-280.]. Additionally, we attempted a replication of studies on the role of OXTR rs53576 and COMT rs4680 in Theory of Mind. In both replication attempts, we did not find any evidence for associations between the sampled genetic markers and Theory of Mind ability in a series of analyses. Extending the replication attempt of Lackner et al., we employed longitudinal data from several tasks and measurement points, which allowed us to run follow-up robustness checks with more reliable scores. These extensive analyses corroborated our null finding. This comprehensive non-replication is important to balance current research on genetic markers of Theory of Mind. In a combined evaluation of our own and previous studies, we point to substantial methodological issues that research on the genetic basis of Theory of Mind development faces. We conclude that these limitations currently prevent firm conclusions on genetic influences on Theory of Mind development.

Relations between theory of mind and family environment among Brazilian preschool children

Given the importance of the environment for the development of the theory of mind (ToM) in childhood, as well as the scarcity of studies in low-income Latin American countries, we aimed to investigate the relation between family environment characteristics and performance in ToM tasks in a group of Brazilian children. A total of 49 children participated, whose ages ranged between 3 and 5 years (M = 4.43; SD = 0.71), all of whom attended a public kindergarten school located in the metropolitan region of São Paulo, Brazil, and took the Theory of mind test for children (TMTC). The observation of the characteristics of the family environment was conducted by using the Home Observation for Measurement of the Environment (HOME) instrument in the very home setting of each participating child. By controlling the effects of children’s age, intelligence, vocabulary, and mother’s and father’s educational level, a consistent positive, significant, and low-magnitude correlation was found between HOME’s Responsiveness subscale with the total score in TMTC. A robust regression analysis also showed that individual and contextual variables (above cited, plus sex) and Responsiveness accounted for 28.4% of ToM variance. This study corroborates previous findings on the relation between family aspects and ToM, specifically highlighting parents’ responsiveness.

Neural Correlates of Theory of Mind in Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder, and the Comorbid Condition.

Theory of mind (ToM) or mentalizing difficulties is reported in attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), but the mechanism underpinning these apparently shared deficits is relatively unknown. Eighty-three young adult males, 19 with ASD alone, 21 with ADHD alone, 18 with dual diagnosis of ASD and ADHD, and 25 typically developing (TD) controls completed the functional magnetic resonance imaging version of the Frith-Happé animated-triangle ToM task. We compared neural function during ToM with two non-ToM conditions, random and goal directed motions, using whole-brain and region-of-interest analysis of brain activation and functional connectivity analyses. The groups showed comparable ToM task performance. All three clinical groups lacked local connectivity increase shown by TD controls during ToM in the right temporoparietal cortex, a key mentalizing region, with a differentially increased activation pattern in both ASD and comorbid groups relative to ADHD. Both ASD groups also showed reduced connectivity between right inferior lateral prefrontal and posterior cingulate cortices that could reflect an atypical information transmission to the mentalizing network. In contrast, with mentalizing both ADHD groups showed decreasing connectivity between the medial prefrontal and left temporoparietal cortices when compared to TD controls. Therefore, despite the complex pattern of atypical brain function underpinning ToM across the three disorders, some neurofunctional abnormalities during ToM are associated with ASD and appeared differentiable from those associated with ADHD, with the comorbid group displaying combined abnormalities found in each condition.

Mentalizing: What’s language got to do with it?

ABSTRACT Understanding that people’s ideas may be false is a challenging step in Theory of Mind (ToM) development, which is accomplished around the age of 4–5 years old by typically developing (TD) children. False-belief attribution remains difficult beyond this age for certain clinical populations, such as Autism Spectrum Disorder (ASD), where delays in this realm are significant, and Developmental Language Disorder (DLD), where delays tend to be subtler. Research has identified links between ToM success and language skills, in particular complement clauses such as John thought/said that aliens landed in his garden, in TD, as well as in ASD and DLD. It has been hypothesized that these structures serve as tools for representing subjective truths. This article reports results from our experimental work further examining the link between complementation and ToM. Study 1 investigates if complements have a more privileged influence on ToM in ASD and TD children than abilities such as Executive Functions, which arguably also play a role. Study 2 determines if complementation skills in ASD support ToM reasoning or are merely implied in ToM task performance. Study 3 extends the evaluation of complementation in ToM reasoning to DLD and explores whether clinical groups of different etiologies—ASD and DLD—perform comparably for ToM once they have similar complementation skills, as expected by a linguistic determinism approach. Study 4 addresses speculation that complementation training may not be efficient to trigger improved ToM in instances of ToM impairments by empirically testing whether training on complements via a newly created iPad application can be useful for ToM remediation in both ASD and DLD. Taken together, this body of work both enhances our theoretical understanding of the language-cognition interface as well as widens our repertoire of clinical tools addressing difficulties in this domain.

Pediatric Stroke Impairs Theory of Mind Performance.

This pilot study explored whether childhood stroke impairs performance on theory of mind (ToM) tasks and whether ToM task performance correlates with resting state connectivity in brain regions linked with social cognition. We performed a case-control study of 10 children with stroke and 10 age- and gender-matched controls. They completed 2 ToM tasks, and resting state connectivity was measured with functional magnetic resonance imaging (MRI). Children with stroke performed worse than controls on conative ToM tasks. Resting state connectivity in the central executive network was significantly higher and connectivity between right and left inferior parietal lobules was significantly decreased in children with stroke. Resting state activity and ToM performance were not significantly correlated. Childhood stroke results in poorer performance on specific ToM tasks. Stroke is associated with changes in resting state connectivity in networks linked with social cognition including ToM. Although the basis for these changes in connectivity is not well understood, these results may provide preliminary insights into potential mechanisms affecting social cognition after stroke. The findings suggest that further study of the effect of childhood stroke on network connectivity may yield insights as to how stroke affects cognitive functions in children.

The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis

Psychotic disorders are characterized by theory of mind (ToM) impairment. Although ToM undergoes maturational changes throughout adolescence, there is a lack of studies examining ToM performance and its brain functional correlates in individuals with an early onset of psychosis (EOP; onset prior to age 18), and its relationship with age. Twenty-seven individuals with EOP were compared with 41 healthy volunteers using the “Reading-the-Mind-in-the-Eyes” Test, as a measure of ToM performance. A resting-state functional MRI scan was also acquired, in which the default mode network was used to identify areas relevant to ToM processing employing independent component analysis. Group effects revealed worse ToM performance and less intrinsic functional connectivity in the medial prefrontal cortex in EOP relative to healthy volunteers. Group by age interaction revealed age-positive associations in ToM task performance and in intrinsic connectivity in the medial prefrontal cortex in healthy volunteers, which were not present in EOP. Differences in ToM performance were partially mediated by intrinsic functional connectivity in the medial prefrontal cortex. Poorer ToM performance in EOP, coupled with less medial prefrontal cortex connectivity, could be associated with the impact of psychosis during a critical period of development of the social brain, limiting normative age-related maturation.

Theory of Mind Skills Are Related to Resting-State Frontolimbic Connectivity in Schizophrenia.

Patients with schizophrenia (SCH) often demonstrate impairment in social-cognitive functions as well as disturbances in large-scale network connectivity. The ventromedial prefrontal cortex (vmPFC) is a core region of the default mode network, with projections to limbic structures. It plays an important role in social and emotional decision-making. We investigated whether resting-state functional connectivity (FC) relates to the cognitive and affective domains of theory of mind (ToM). Twenty-three SCH patients and 19 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scanning. vmPFC seed connectivity was correlated with behavioral measures assessing ToM domains. SCH performed less well than HCs in both ToM task domains. An analysis of the resting-state FC revealed that SCH had reduced connectivity from the vmPFC to the subcallosal cortex, right amygdala, and right hippocampus as a function of behavioral scores in both ToM domains. Within-group analyses indicated that in HCs, the performance in ToM was positively associated with frontoamygdalar resting-state connectivity, whereas in SCH, the performance in ToM was negatively associated with the frontosubcallosal connectivity. Differences in the pattern of the resting-state frontolimbic connectivity and its associations with performance in ToM tasks between the two study groups might represent a different setup for processing social information in patients with SCH.

Aberrant within- and between-network connectivity of the mirror neuron system network and the mentalizing network in first episode psychosis

IntroductionIt has been suggested that the mentalizing network and the mirror neuron system network support important social cognitive processes that are impaired in schizophrenia. However, the integrity and interaction of these two networks have not been sufficiently studied, and their effects on social cognition in schizophrenia remain unclear. MethodsOur study included 26 first-episode psychosis (FEP) patients and 26 healthy controls. We utilized resting-state functional connectivity to examine the a priori-defined mirror neuron system network and the mentalizing network and to assess the within- and between-network connectivities of the networks in FEP patients. We also assessed the correlation between resting-state functional connectivity measures and theory of mind performance. ResultsFEP patients showed altered within-network connectivity of the mirror neuron system network, and aberrant between-network connectivity between the mirror neuron system network and the mentalizing network. The within-network connectivity of the mirror neuron system network was noticeably correlated with theory of mind task performance in FEP patients. ConclusionThe integrity and interaction of the mirror neuron system network and the mentalizing network may be altered during the early stages of psychosis. Additionally, this study suggests that alterations in the integrity of the mirror neuron system network are highly related to deficient theory of mind in schizophrenia, and this problem would be present from the early stage of psychosis.

Impaired theory of mind in adults with traumatic brain injury: A replication and extension of findings

ObjectiveTo replicate a previous study of Theory of Mind (ToM) task performance in adults with traumatic brain injury (TBI) under different working memory (WM) demands, and determine if there are sex-based differences in effects of WM load on ToM task performance. Method58 adults with moderate-severe TBI (24 females) and 66 uninjured adults (34 females) matched group-wise for age, sex, and education viewed a series of video vignettes from the Video Social Inference Task (VSIT) (Turkstra, 2008) and answered ToM questions. Vignette presentation format required updating and maintenance of information, and WM load was manipulated by varying presence of distracters. ResultsThere were main effects of group and WM load, no significant effect of sex, and a marginal interaction of group by WM load, with larger between-group differences in conditions with higher WM load. VSIT scores for the condition with the highest WM load were significantly correlated with scores on the first trial of the California Verbal Learning Test. ConclusionsWe replicated findings of lower scores in adults with TBI on a video-based ToM task, and provided additional evidence of the effect of WM load on social cognition task performance. There were no significant accuracy differences between men and women, inconsistent with prior evidence – including our own data using the same test. There is strong evidence of a female advantage on other social cognition tasks, and the parameters of this advantage remain to be discovered.

Plasticity in older adults’ theory of mind performance: the impact of motivation

ABSTRACTObjective: Recently, motivation has been found to attenuate the age-related decline in Theory of Mind (ToM) performance (i.e. faux pas recognition). However, whether or not this effect could be generalized to other ToM tasks is still unknown. In the present study, we investigated whether and how motivation could enhance older adults’ performance and reduce age differences in ToM tasks (Faux Pas vs. Animation task) that differ in familiarity. Method: Following a previous paradigm, 171 Chinese adults (87 younger adults and 84 older adults) were recruited, and we experimentally manipulated the level of perceived closeness between participants and the experimenter before administering the ToM tasks in order to enhance participants’ motivation. Results: Results showed that, for the Faux Pas task, we replicated previous findings such that older adults under the enhanced motivation conditions performed equally well as younger adults. Conversely, for the Animation task, younger adults outperformed older adults, regardless of motivation. Discussion: These results indicate that motivation can enhance older adults’ performance in ToM tasks, however, this beneficial effect cannot be generalized across ToM tasks.

Relations between theory of mind and executive function in middle childhood: A short-term longitudinal study

Studies with preschool children have shown significant links between children’s executive function (EF) and theory of mind (ToM), but few studies have examined these associations in primary school children. To address this gap, we designed a three-wave cross-lagged longitudinal study in which we followed a group of 113 children (61 boys) across three time points from age 9.5–10.5years (mean age at Time 1=112.3months, SD=4.18; mean age at Time 2=118.3months, SD=4.15; mean age at Time 3=124.7months, SD=4.06). At each time point, we measured EF (working memory and inhibitory control), ToM, and language. Our analyses showed (a) moderate rank-order stability of individual differences in both EF and ToM and (b) growth in ToM task performance across time. Cross-lagged longitudinal analyses revealed an asymmetric developmental relation between ToM and working memory. Early working memory predicted later ToM but not vice versa. Our results suggest a specific role for working memory in the ongoing development of ToM in middle childhood.

Indirect task instructions better reveal theory-of-mind impairment, independent of executive dysfunction, in schizophrenia

Theory of mind (TOM) impairments associate significantly with executive deficits in schizophrenia, consistent with the proposal that executive abilities can limit TOM task performance, and confounding identification of those patients who would benefit most from targeted mentalising interventions. 50 schizophrenia patients and 30 healthy controls completed an executive battery and four TOM tasks that were alike with regards generating overt measures of causal false-belief reasoning, but differed with regards using indirect (vs. more direct) instructions. Only the TOM tasks that used indirect instructions to elicit spontaneous false-belief inferences revealed impairment, independent of executive dysfunction, in the schizophrenia patients.

Theory of mind in non-suicidal self-injury (NSSI) adolescents.

The aim of the present study is to investigate different facets of the theory of mind (ToM), i.e. first vs. third-person, first vs. second-order ToM, egocentric vs. allocentric perspective, in a clinical sample of 20 non-suicidal self-injury (NSSI) adolescent inpatients and 20 healthy controls. We investigated whether performance in ToM tasks was related to both the type and frequency of self-injuring behavior and attitude toward life and death, using a semi-structured interview and different self-report questionnaires. NSSI participants performed less well than the control group in all the ToM dimensions investigated. Furthermore, ToM performance was negatively related to Attraction to Death, in terms of both the type and frequency of self-injuring behavior, and it was positively related to Attraction to Life. These preliminary findings have interesting implications for future clinical investigations, in that they provide previously unavailable information regarding the association between ToM and NSSI behavior.

Alterations in functional connectivity of the amygdala in unilateral mesial temporal lobe epilepsy

The aim of this work was to evaluate the relationship between ipsilateral amygdala dysfunction in unilateral mesial temporal lobe epilepsy (MTLE) and remote temporal, frontal, and parietal brain structures and to identify their association with theory of mind (ToM) abilities. Functional magnetic resonance imaging (fMRI) data were acquired from MTLE patients with unilateral hippocampal sclerosis (n = 28; 16 left-sided) and healthy controls (HC, n = 18) watching an animated fearful face paradigm. To explore functional connectivity, we used independent component analysis (ICA) of fMRI data to characterize possible amygdala network alterations that may be caused by lateralized amygdala dysfunction. We furthermore investigated the relationship between activation within the amygdala network and ToM task performance. The pattern of amygdalar BOLD activation observed in response to an animated fearful face paradigm was bilateral amygdalar activation in HC and amygdala activation lateralized to the contralateral side in MTLE patients. In HC, a hemispheric asymmetry of the amygdala network was present with amygdala co-activation in predominantly left temporolateral and frontal brain structures. In MTLE patients, the observed asymmetry of amygdala connectivity was modulated by the side of pathology and the extent of amygdalar connectivity to the parahippocampal gyrus and insula was related to ToM test performance. These findings suggest that ipsilateral amygdalar dysfunction in MTLE is associated with alterations in remote temporal and frontal brain areas. The study of psychiatric and neurological disorders via network analysis allows for a shift of focus away from viewing dysfunctions of individual structures to a pathological network that possibly gives rise to a variety of symptoms.

Play and theory of mind: associations with social competence in young children

This study aimed to investigate whether: (1) the development of theory of mind (ToM) is associated with social competence; and (2) social peer play is also associated with social competence in young children. Associations between ToM task performance, frequencies of observed social and solitary free‐play and parent‐rated social competence were investigated in three‐ to five‐year‐old Australian preschool children [N = 85 (46 F/39 M); M = 4 years 6 months, SD = 8 months]. Children’s verbal ability was controlled. Children’s overall performance on combined ToM tasks improved with age, but was not associated with their parent‐rated level of social competence. High frequency of social‐interactive play (i.e. interacting with others in a playful context) was associated with social competence. High frequency of solitary play was inversely associated with social competence and positively associated with overall problem behaviour. Results suggest the importance of social interaction during play for the development of young children’s social competence. More research is needed to determine what role, if any, ToM ability has in young children’s social development.

Implications of Social Competence among Thirty-Month-Old Toddlers: A Theory of Mind Perspective

BackgroundThe purpose of this study was to examine the relations between children’s social competence and initial index of theory of mind at 30 months of age.MethodsThe participants of the study were 322 toddlers and parents/caregivers who were registered with the Japan Science and Technology Agency (JST) project. They completed a five-minute interaction session, which was coded using the Interaction Rating Scale (IRS) as an evidence-based practical index of children’s social competence. In addition, the children were asked to complete a diverse-desire task as a ToM (theory of mind) index.ResultsThe results showed that the ToM index was related to the total score and subscales of the IRS, such as Empathy and Emotional regulation.ConclusionsThese findings show that the IRS score was related to ToM task performance at 30 months of age.