Porphyromonas gingivalis (PG), a key periodontal pathogen, has been implicated in various systemic diseases, including colorectal cancer and cardiovascular diseases. However, its potential role in promoting gut inflammation and the underlying mechanisms remain unclear. Furthermore, multiple studies have reported an association between tea polyphenols and a reduced risk of periodontal disease and colitis, but it remains unclear whether they play a role in mitigating gut inflammation exacerbated by PG. In this study, we demonstrated that Tea polyphenols (TP) reduced the activity of PG and lowered the expression levels of virulence factors. Intervention with TP can prevent the worsening of gut inflammation exacerbated by PG, including body weight loss and shortened colon length. TP not only alleviated the differentiation of Th17 cells and the secretion of related cytokines but also promoted the enrichment of potentially beneficial bacteria like Ruminococcus and Lactobacillus. Metabolomics revealed that TP enriched potential beneficial microbial metabolites, such as secondary bile acids, and showed certain correlations with immune-related markers.