Alkanes Research Articles

Rapid synthesis and post-polymerization modification of poly(vinylene sulfide) via sequential nucleophilic thiol-yne/ene click reactions

Click chemistry has emerged as a versatile and robust polymerization technique for the construction of functional polymers. In this work, organocatalyst-mediated consecutive thiol-yne and thiol-ene click reactions were performed for the synthesis and modification of the electron-deficient poly(vinylene sulfide) (PVS) structure. PVS was prepared within an hour in the presence of 1,4-diazabicyclo[2.2.2] octane (DABCO) and in an anti-Markovnikov fashion, with a high molecular weight (M n = 12.9 kDa) and high stereoregularity (88% E-isomer). Following various optimization studies using 1-propanethiol as the model thiol, the obtained PVS was modified with various thiols in chloroform for 10 min using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as the catalyst, resulting in thioacetal main chain polymers. The scope of thiols used in the modification studies spans from alkyl and cycloalkyl to aromatic and allylic, and the polymers were obtained with varying efficiencies. Primary alkyl and aromatic thiols exhibited high efficiencies ranging from 87% to 100%. Similar high efficiencies were found for secondary mercaptans (70% and 92%); however, a very low efficiency (5%) was found for a tertiary mercaptan due to steric hindrance. It is believed the proposed indirect polythioacetal synthesis method holds the potential to be utilized in bio-related applications and material science.

Sedimentary environment shift and organic matter enrichment mechanism in response to volcanic ash influence: A case study of the Permian Lucaogou Formation, Santanghu Basin, NW China

The second member of the Lucaogou Formation (P2l2) in the Tiaohu and Malang Sags of the Santanghu Basin (study area) underwent periodic volcanic activity and frequent lithological changes. This study comprehensively analyzed the organic geochemistry, mineral composition, organic matter (OM) types, volcanic cycle, and palaeoenvironment of shale in the study area. Techniques such as total organic carbon (TOC), rock pyrolysis (Rock-Eval), organic petrology, scanning electron microscopy (SEM) with energy-dispersive spectrum (EDS) analysis, X-ray diffraction (XRD), trace elements, and saturated hydrocarbon gas chromatography and mass spectrometry (GC–MS) were employed. The findings suggest that limited terrigenous input during the sedimentary period of the P2l2 led to the deposition of a distinctive mixture of volcanic ash (felsic) and carbonate (dolomite and calcite), with a low average clay mineral content of 6%. The P2l2 shale emerged as a high-quality source rock, predominantly composed of type I and II kerogens, with moderate OM maturity. The deposition environment was characterized by hot and arid conditions, high salinity, and intensive reducibility, which was favorable for algae development and conducive to OM preservation. Notably, two lamalginite types, labeled as lamalginite “A” and lamalginite “B,” were identified. Lamalginite “B”-rich shales were deposited in a hotter and drier climate compared to lamalginite “A”-rich shales. Lamalginite “B”- rich shale inexhibited high levels of C28 regular sterane and β-carotenes, distinguishing it from lamalginite “A”-rich shale. A comprehensive analysis involving organic petrology, SEM, sedimentary environment, and biomarker characteristics suggests that lamalginite “B” may be a salt-tolerant green alga, while lamalginite “A” may be a cyanobacterium. Finally, an OM enrichment model for the P2l2 shale was established.

Regio- and Diastereoselective Synthesis of Trisubstituted Alkenes Through Hydroalkylation of Alkynyl Boronamides.

Hydroalkylation of alkynes is a powerful method for alkene synthesis. However, regioselectivity has been difficult to achieve in transformations of internal alkynes hindering applications in the synthesis of trisubstituted alkenes. To overcome these limitations, we explored using boryl groups as versatile directing groups that can control the regioselectivity of the hydroalkylation and subsequently be replaced in a cross-coupling reaction. The result of our exploration is a nickel-catalyzed hydroalkylation of alkynyl boronamides that provides access to a wide range of trisubstituted alkenes with high regio- and diastereoselectivity. The reaction can be accomplished with a variety of coupling partners, including primary and secondary alkyl iodides, α-bromo esters, α-chloro phthalimides, and α-chloro boronic esters. Preliminary studies of the reaction mechanism provide evidence for the hydrometalation mechanism and the formation of alkyl radical intermediates.

Regio‐ and Diastereoselective Synthesis of Trisubstituted Alkenes Through Hydroalkylation of Alkynyl Boronamides

Hydroalkylation of alkynes is a powerful method for alkene synthesis. However, regioselectivity has been difficult to achieve in transformations of internal alkynes hindering applications in the synthesis of trisubstituted alkenes. To overcome these limitations, we explored using boryl groups as versatile directing groups that can control the regioselectivity of the hydroalkylation and subsequently be replaced in a cross‐coupling reaction. The result of our exploration is a nickel‐catalyzed hydroalkylation of alkynyl boronamides that provides access to a wide range of trisubstituted alkenes with high regio‐ and diastereoselectivity. The reaction can be accomplished with a variety of coupling partners, including primary and secondary alkyl iodides, α‐bromo esters, α‐chloro phthalimides, and α‐chloro boronic esters. Preliminary studies of the reaction mechanism provide evidence for the hydrometalation mechanism and the formation of alkyl radical intermediates.

Merging Ring-Opening 1,2-Metallate Shift with Asymmetric C(sp3)-H Borylation of Aziridines.

Chiral secondary alkyl amines with a vicinal quaternary stereocenter are undoubtedly important and ubiquitous subunits in natural products and pharmaceuticals. However, their asymmetric synthesis remains a formidable challenge. Herein, we merge the ring-opening 1,2-metallate shift with iridium-catalyzed enantioselective C(sp3)-H borylation of aziridines to deliver these frameworks with high enantioselectivities. We also demonstrated the synthetic application by downstream transformations, including the total synthesis of two Amaryllidaceae alkaloids, (-)-crinane and (+)-mesmebrane.

Zinc Promoted Cross-Electrophile Sulfonylation to Access Alkyl-Alkyl Sulfones.

The transition metal-catalyzed multi-component cross-electrophile sulfonylation, which incorporates SO2 as a linker within organic frameworks, has proven to be a powerful, efficient, and cost-effective means of synthesizing challenging alkyl-alkyl sulfones. Transition metal catalysts play a crucial role in this method by transferring electrons from reductants to electrophilic organohalides, thereby causing undesirable side reactions such as homocoupling, protodehalogenation, β-hydride elimination, etc. It is worth noting that tertiary alkyl halides have rarely been demonstrated to be compatible with current methods owing to various undesired side reactions. In this work, a zinc-promoted cross-electrophile sulfonylation is developed through a radical-polar crossover pathway. This approach enables the synthesis of various alkyl-alkyl sulfones, including 1°-1°, 2°-1°, 3°-1°, 2°-2°, and 3°-2° types, from inexpensive and readily available alkyl halides. Various functional groups are well tolerated in the work, resulting in yields of up to 93%. Additionally, this protocol has been successfully applied to intramolecular sulfonylation and homo-sulfonylation reactions. The insights gained from this work shall be useful for the further development of cross-electrophile sulfonylation to access alkyl-alkyl sulfones.

Electrophotochemical metal-catalyzed synthesis of alkylnitriles from simple aliphatic carboxylic acids.

We report a practical and sustainable electrophotochemical metal-catalyzed protocol for decarboxylative cyanation of simple aliphatic carboxylic acids. This environmentally friendly method features easy availability of substrates, broad functional group compatibility, and directly converts a diverse range of aliphatic carboxylic acids including primary and tertiary alkyl acids into synthetically versatile alkylnitriles without using chemical oxidants or costly cyanating reagents under mild reaction conditions.

Recent Advances in Halogen-Metal Exchange Reactions.

ConspectusThe halogen-metal exchange reaction is a very powerful method for preparing functionalized organometallic reagents in the fields of organic and organometallic chemistry. Since its inception, significant interest has been directed toward the on-demand development of new halogen-metal exchange reactions, primarily through the upgrading of exchange reagents. The enduring quest for optimal reactivity, superior functional group compatibility, and innovative synthetic applications of exchange reagents remains a fundamental objective. In the past several years, the emergence of some significant discoveries in halogen-metal exchange reactions has proclaimed a renaissance to this field. This Account outlines the latest advances within the domain contributed by the Knochel group, including the main points as follows.The stereoretentive I/Li exchange on stereodefined secondary alkyl iodides was developed for the synthesis of nonstabilized chiral secondary alkyllithium reagents. This provided a straightforward method to access chiral organolithium reagents, which can be trapped by various electrophiles or transmetalated with other metals such as copper, zinc, and magnesium, thus enabling the stereoselective synthesis of a series of functionalized compounds and natural products.Faster halogen-magnesium and halogen-zinc exchanges in toluene were realized using a novel kind of exchange reagent complexed with lithium alkoxide. These highly efficient exchange reactions are much faster than traditional ones and performed in an industrially friendly solvent. These advantages are of great value in practical synthesis, paving the way for new developments in this evolving area.Halogen-lanthanide exchanges and their novel applications in organic synthesis were established. These new exchanges introduced the lanthanide metals into halogen-metal exchange reactions for the first time, thereby opening new avenues in synthetic chemistry. Building on these achievements, a comparative analysis of the exchange reaction rates by kinetic study has quantified the relationship between the electronegativity of metals and the rates of halogen-metal exchanges.Br/Na exchange in continuous flow was achieved using a hexane-soluble exchange reagent, 2-ethylhexylsodium. This approach effectively circumvented the poor solubility of the organosodium reagent, which has proven to be of significant practical value and greatly enhanced the synthetic utility of the organosodium reagent in organic synthesis.These remarkable breakthroughs as mentioned above are fueled mainly by upgrading the exchange reagents, resulting in the development of new halogen-metal exchange reactions and innovative applications in organic synthesis. Given the importance of halogen-metal exchanges in synthetic chemistry, the pursuit of other types of exchange reactions, particularly those involving new metals, will be in continuous demand. This Account provides a timely summary of recent progress and will undoubtedly inspire further advances to drive this research field forward.

Biomedical Applications of Green Synthesized Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Using Aqueous Extract of Ziziphus Oxyphylla Leaves.

Zinc oxide (ZnO) and magnesium-doped zinc oxide (Mg-doped ZnO) nanoparticles (NPs) were synthesized using Ziziphus oxyphylla 's aqueous leaf extract as reducing agent. UV-Vis absorption peaks at 324 nm and 335 nm were indicative of ZnO and Mg-doped ZnO, respectively. FTIR absorption bands observed at 3238, 1043, 1400, 1401, 2186 and 2320 cm -1 suggested the presence of phenols, alcohols, saturated hydrocarbons, and possibly alkynes. X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) spectroscopy revealed pure, spherical and agglomerated NPs with average size of 35.9 nm (ZnO) and 56.8 nm (Mg-doped ZnO). Both NPs remained active against all bacterial strains with the highest inhibition zones observed against Proteus vulgaris (21.16±1.25 mm for ZnO and 24.1±0.76 mm for Mg-doped ZnO. EtBr fluorescence (cartwheel assay) indicated efflux pump blockage, suggesting its facilitation in the bacterial growth inhibition. Antioxidant potential, determined via DPPH radical scavenging assay, revealed stronger antioxidant potential for Mg-doped ZnO (IC [Formula: see text]/mL) than pure ZnO (IC [Formula: see text]/mL). Furthermore, both NPs showed antileishmanial activity against Leishmania tropica promastigotes (IC [Formula: see text]/mL for Mg-doped ZnO and 64.34±6.56 for ZnO), while neither NP exhibited significant hemolysis, indicating biocompatibility and further assessment for their drugability.

Degradation of Waste Tetra Pak Packaging with Hydrothermal Treatment in Sub-/Supercritical Water.

Tetra pak packaging is one of the most frequently used types of packaging in the food industry. The recycling of the tetra pak packaging waste presents a difficult task because of its multi-layered, multi-component structure. In this study, the degradation of tetra pak packaging in subcritical (SubCW) and supercritical (SCW) water was investigated. The experiments were carried out in one (SCW) or two stages (SubCW and SCW), whereby the influence of the reaction temperature and time on the yield and composition of the products obtained was investigated. The maximum oil phase yield achieved in a one-stage and a two-stage degradation process was 60.7% and 65.5%, respectively. The oil and gas phases were composed of different types of hydrocarbons. Higher temperature and longer time led to higher amounts of saturated aliphatic hydrocarbons in both the oil and gas phases. The aqueous phase contained sugars (glucose, fructose) and sugar derivatives (levulinic acid, glyceraldehyde, furfurals). Based on these results, the degradation pathway of waste tetra pak packaging in SubCW and SCW was proposed. The results of the study show that the degradation of waste tetra pak packaging with SubCW and SCW is a promising recycling process.

Desymmetrization of Inert meso-Diethers through Copper-Catalyzed Asymmetric Allylic Alkylation with Grignard Reagents.

We have developed a highly regio-, diastereo-, and enantioselective Cu-catalyzed desymmetrization of inert meso-diethers using Grignard reagents. Moreover, previous inaccessible sterically hindered organometallic reagents are realized in the reaction with broad secondary alkyl Grignard reagents. Finally, detailed control experiments and density functional theory calculations revealed the desymmetrization of meso-diethers exploits a direct anti-SN2' pathway, in the absence of an in situ-generated allyl bromine intermediate. The following oxidative addition is the crucial rate-determining and enantioselectivity-determining step.

A Rationally Designed Iron(II) Catalyst for C(sp3)−C(sp2) and C(sp3)−C(sp3) Suzuki–Miyaura Cross‐Coupling

AbstractDespite the paramount importance of the Suzuki–Miyaura coupling (SMC) in academia and industry, and the great promise of iron to offer sustainable catalysis, iron‐catalyzed SMC involving sp3‐hybridized partners is still in its infancy. We herein report the development of a versatile, well‐defined electron‐deficient anilido‐aldimine iron(II) catalyst. This catalyst effectively performed C(sp3)−C(sp2) and C(sp3)−C(sp3) SMC of alkyl halide electrophiles and (hetero)aryl boronic ester and alkyl borane nucleophiles respectively, in the presence of a lithium amide base. These couplings operated under mild reaction conditions and displayed wide functional group compatibility including various medicinally relevant N‐, O‐ and S‐based heterocycles. They also tolerated primary, secondary and tertiary alkyl halides (Br, Cl, I), electron‐neutral, ‐rich and ‐poor boronic esters and primary and secondary alkyl boranes. Our methodology could be directly and efficiently applied to synthesize key intermediates relevant to pharmaceuticals and a potential drug candidate. For C(sp3)−C(sp2) couplings, radical probe experiments militated in favor of a carbon‐centered radical derived from the electrophile. At the same time, reactions run with a pre‐formed activated boron nucleophile coupled to competition experiments supported the involvement of neutral, rather than an anionic, (hetero)aryl boronic ester in the key transmetalation step.

A Rationally Designed Iron(II) Catalyst for C(sp3)-C(sp2) and C(sp3)-C(sp3) Suzuki-Miyaura Cross-Coupling.

Despite the paramount importance of the Suzuki-Miyaura coupling (SMC) in academia and industry, and the great promise of iron to offer sustainable catalysis, iron-catalyzed SMC involving sp3-hybridized partners is still in its infancy. We herein report the development of a versatile, well-defined electron-deficient anilido-aldimine iron(II) catalyst. This catalyst effectively performed C(sp3)-C(sp2) and C(sp3)-C(sp3) SMC of alkyl halide electrophiles and (hetero)aryl boronic ester and alkyl borane nucleophiles respectively, in the presence of a lithium amide base. These couplings operated under mild reaction conditions and displayed wide functional group compatibility including various medicinally relevant N-, O- and S-based heterocycles. They also tolerated primary, secondary and tertiary alkyl halides (Br, Cl, I), electron-neutral, -rich and -poor boronic esters and primary and secondary alkyl boranes. Our methodology could be directly and efficiently applied to synthesize key intermediates relevant to pharmaceuticals and a potential drug candidate. For C(sp3)-C(sp2) couplings, radical probe experiments militated in favor of a carbon-centered radical derived from the electrophile. At the same time, reactions run with a pre-formed activated boron nucleophile coupled to competition experiments supported the involvement of neutral, rather than an anionic, (hetero)aryl boronic ester in the key transmetalation step.

Development of a new reagent for the prevention of asphaltene-resin-paraffin deposits

Asphaltene-Resin-Paraffin deposits (ARPD) form a certain proportion of the crude oil mass, separating as temperature and pressure decrease and adsorbing to the surfaces of the reservoir wellbore zone, downhole equipment and tubulars. These deposits precipitate in the wellbore zone, oilfield equipment and pipes,resulting in reduced system productivity, reduced pumping efficiency of the pumping equipment and other negative consequences. Asphalt-resin and paraffin deposits (ARPD) are a complex mixture of solid paraffin hydrocarbons, asphalt-resin substances (ARS), water and mechanical impurities. The strength and composition of ARPD depend on the composition and properties of oil, geological, physical and technological conditions of field development. Chemical methods for removing deposits are currently the most widely used, as they are highly effective and technologically advanced. To this end, new reagents have been developed and their physico-chemical properties have been studied. Subsequently, the selected reagents were tested on oil samples from Oil and Gas Production Department (OGPD) with a paraffin content of more than 6 %. It was also shown that paraffin inhibitors have individual effects; a reagent that is effective on oil from one field may not have the same effect on oil from other fields. The research includes studies of selected reagents for paraffinic oils from different fields. Using the «cold finger» method, the efficacy of the selected reagents against paraffin deposition was investigated and their optimum doses were determined. Keywords: reagent; sendiment; paraffin; asphaltene; resin; well bottom zone; viscosity; depressor.

Merging Quinoxalin-2(1H)-ones Excitation with Cobaloxime Catalysis: C3 Alkylation of Quinoxalin-2(1H)-ones with Unactivated Alkyl Iodides and Carboxylic Acids under Light.

Reported herein is a practical, economical, and efficient construction of 3-alkylated quinoxalin-2(1H)-ones with alkyl carboxylic acids and alkyl iodides by quinoxalin-2(1H)-one excitation and cobaloxime catalysis. Primary, secondary, and tertiary alkyl iodides and carboxylic acids all could be efficiently transferred into target products with excellent functional group tolerance. Mechanism studies reveal that the quinoxalin-2(1H)-one derivatives could be directly excited and yield alkyl carbon radicals from alkyl carboxylic acids and alkyl iodides with the aid of the cobaloxime complex.

In Situ Combustion Characteristics of Heavy Oil in the Liaohe Oilfield at Different Temperatures

This study conducted in situ combustion oxidation experiments on crude oil from Block D within the Liaohe Oilfield, utilizing a kettle furnace low-pressure oxidation reaction method at various temperatures. The molecular composition of oxidation products was analyzed using gas chromatography–mass spectrometry (GC–MS) and high-resolution mass spectrometry. The results reveal that the molecular composition of the products remains relatively stable up to 300 °C, exhibiting a slight increase in C13-C30 alkanes. The ratio of the peak area for C21 to bisnorhopane is 0.082. From 300 °C to 450 °C, compounds with long alkyl chains gradually undergo thermal cracking, resulting in a significant increase in the production of alkanes within the C10–C30 range. The concentration of saturated hydrocarbons produced through thermal cracking reaches its maximum at a temperature of 400 °C. The most abundant peak of n-alkane is observed at C21, with a quantified ratio of peak area for C21 to bisnorhopane at 6.5, indicating a two-order magnitude increase compared to crude oil. From 500 °C to 600 °C, compounds undergo more profound thermal cracking and condensation processes. The predominant hydrocarbons consist of aromatic molecules containing two to six rings substituted with short side chains. The double bond equivalent (DBE) values of carbazoles and carboxylic acids are determined as 30 and 25, respectively. At 600 °C, the peak area ratio of naphthalene to biodecane is 300, indicating a remarkable increase of five orders of magnitude compared to the crude oil. The present study elucidates the correlation between the characteristics of combustion components in crude oil and the corresponding combustion temperature. Primary cracking reactions within crude oil are promoted effectively when keeping the combustion zone at 350 °C and 450 °C. This process significantly reduces the viscosity of heavy oil and enhances its fluidity.

PH-switchable hydrophobic deep eutectic solvents for sustainable recycling extraction of high oily waste

The accumulation of oily waste increases annually with the growth in crude oil demand. Its toxicity and high heating value present both opportunities and challenges for treatment technologies. In recent years, the emergence of hydrophobic deep eutectic solvents (HDES) has promoted advancements in low-toxicity extraction processes. Leveraging the advantages of HDES and addressing the challenges posed by real oily sawdust (with a 67.9 % oil content), this study presents a novel green HDES solvent composed of ethyl maltol and fatty acids, accompanied by a corresponding extraction process. At a low temperature of 60 °C, the process achieved impressive results: an oil extraction efficiency close to 86.3 %, a dehydration rate exceeding 92.2 %, and a heavy metal removal rate ranging from 15 % to 75 %. In the exploration of solvents recycling, pH-switching facilitated the deprotonation and protonation of phenol-fatty acid HDES, promoting effective recovery of the oil phase. Even after 5 cycles, the oil extraction rate could still be maintained above 75 %. It is worth noting that the regenerated HDES exhibited greater selectivity for extracting light oil after multiple uses. The total ratio of saturated and aromatic hydrocarbons reached approximately 81.7 %, significantly enhancing the value of the recovered oil. Integrating systematic characterization with the extraction performance, as well as the variation in recovered oil phase components, highlighted the multifaceted effects of introducing ethyl maltol. Specifically, this effect is demonstrated in its ability to enhance the oil phase’s solubility by regulating the intermolecular spacing of HDES, and to impede the dissolution of heavy oil into its gaps by optimizing the local zone through the formation of complexes with HDES and heavy metals.

Insights into organic matter source and depositional environments of shales from the Ponta Grossa Formation in Parana basin, Brazil

Marine transgression events and plant species' evolution to terrestrial environments increased the amount of organic matter in sediments during the Devonian Period. Subsequently, a bituminous material known as shale was formed, containing organic compounds that enable the reconstruction of environmental conditions from previous eras. These rock formation events are recorded worldwide, however, in the Ponta Grossa Formation, southern Brazil, a deeper understanding of samples from the Devonian Period is necessary. The goal of this study was to understand the regional environmental conditions, the origin of the organic matter, and the degree of maturation of the bituminous material. Shale samples were collected from an outcrop on the eastern border of the Paraná Basin and processed in the laboratory to obtain the saturated hydrocarbons fraction posteriorly analyzed. The results indicate a poorly oxygenated environment, with various salinity levels, mixed organic sources, and a high thermal maturity of the samples. The analysis of compound hydrocarbons elucidates the environmental conditions during the Devonian Period in the Ponta Grossa Formation, providing inferences applicable to the stratigraphic interval represented by this record and within the domain of the sampled area.

Thermal steam treatment effect of metallic sodium nanoparticles for high-carbon, low permeability Domanic rocks

In a study aimed at exploring novel methods for enhancing hydrocarbon extraction from shale reservoirs, we conducted an experimental study to model the effects of thermal steam treatment on high-carbon, low-permeability Domanic shale in the presence of sodium metal nanoparticles. We characterized the mineral composition of the rock samples and evaluated the yield and quality of extracted hydrocarbons before and after treatment. Our results demonstrated an increase in extract yield with increasing treatment temperature. Notably, we observed a significantly augmented effect when we introduced sodium nanoparticles into the reaction system, enabling a 100 °C reduction in treatment temperature while maintaining comparable capabilities for extracting organic matter. It was found that the experimental products exhibited enrichment in saturated hydrocarbons, coupled with a decrease in resinous-asphaltenic substances. Within the saturated fraction, we observed a shift towards lighter alkanes and cycloalkanes (C12–C14). Moreover, it has been found that the highest yield of low molecular weight liquid hydrocarbons is acheived in the experiment involving sodium nanoparticles at 250 °C. Upon further increasing the temperature to 300 °C, we noted a decline in liquid hydrocarbon content, accompanied by an increase in gaseous hydrocarbons (C1–C4). Besides, thermal steam treatment substantially reduced the proportion of sulfur-containing aromatic compounds, such as alkylbenzothiophenes, dibenzo- and naphthothiophenes, in the aromatic fraction. The addition of sodium nanoparticles facilitated near-complete desulfurization of this fraction. Moreover, we observed a significant reduction in the total sulfur content of the extracted organic matter. Hydrothermal treatment in the presence of nanoparticles induced transformations in the kerogen structure and structural and phase changes in the mineral components of the shale.

Adsorption and barrier properties of bio-based coating on paper against MOSH for improving food packaging safety

Mineral oil saturated hydrocarbons (MOSHs) are commonly found in food packaging printing inks. They can migrate into packaged food, posing risks to human health.In this study, a bio-based coating using sugarcane fibre (SF), anionic starch (AS), nanofibrated cellulose (NFC), and chitosan (CTS) is developed and applied to the internal surface of a food packaging white cardboard. The coating is investigated for its efficiency in reducing MOSH migration into dry food simulants (Porapak). The MOSH adsorption capacity of coated white cardboard is 4.6 and 14 times greater than those of uncoated and polythene (PE)-coated versions, respectively. Hence, the surface of SF-AS-NFC-CTS coating functions as a sponge and protective screen, adsorbing and hindering significant amounts of MOSH and subsequently slowing and reducing the migration of MOSH to food.Meanwhile, the basic properties, such as mechanical properties, air permeability (barrier property to MOSH), oil resistance, thermal stability, and antibacterial efficacy, of the coated cardboard for food packaging are all improved. Therefore, this study can offer a promising solution to food contamination concerns for food packaging.