Text Terms Research Articles

Evaluation of Syndromic Surveillance Data for Studying Harmful Algal Bloom-Associated Illnesses - United States, 2017-2019.

Harmful algal and cyanobacterial blooms (harmful algal blooms) are large colonies of algae or cyanobacteria that can harm humans, animals, and the environment (1-3). The number of algal blooms has been increasing in the United States, augmented by increasing water temperatures and nutrients in water from industry and agricultural run-off (4,5). The extent to which harmful algal bloom exposures cause human illness or long-term health effects is unknown. As the number of blooms increases annually, the likelihood of negative health outcomes (e.g., respiratory or gastrointestinal illness) from exposure also increases (4,5). To explore the utility of syndromic surveillance data for studying health effects from harmful algal bloom exposures, CDC queried emergency department (ED) visit data from the National Syndromic Surveillance Program (NSSP) for harmful algal bloom exposure-associated administrative discharge diagnosis codes and chief complaint text terms related to harmful algal bloom exposure (6). A total of 321 harmful algal bloom-associated ED visits were identified during January 1, 2017-December 31, 2019. An increase in harmful algal bloom-associated ED visits occurred during warmer months (June-October), consistent with seasonal fluctuations of blooms and recent publications (6,7). Although syndromic surveillance data are helpful for understanding harmful algal bloom-associated ED visits in the United States, exposures were documented infrequently with discharge diagnosis codes; 67% of harmful algal bloom-associated ED visits were identified through querying chief complaint text. Improving the documentation of harmful algal bloom exposures in medical records would further benefit future health studies.

THE EFFICACY OF PIE (POINT, ILLUSTRATION, EXPLANATION) STRATEGY IN TEACHING WRITING NARRATIVE TEXT

This research aimed at finding out the students writing ability in term of narrative text through using PIE (point, illustration, explanation) strategy. Pre-experimental method was applied in this research. The research had conducted with treatment, where the class consisted of four meetings. The location of this research was done at the second grade students of one of state junior high schools with 20 students and stand by one class using pre-test and post-test design. The instrument was used written test as pre-test and post-test. In pre-test the students made the material about narrative text that they had read or listened without involving PIE (point, illustration, explanation) strategy. While in the post-test students also made the material about narrative text that they had read or listened which was involved PIE (point, illustration, explanation) strategy. The findings indicated that the application of PIE (point, illustration, explanation) strategy was significant to improve the students’ writing ability and it was proved by means score in pre-test was 51.75 and the post-test was 75.25. it means that the means score of post-test is greater then the pre-test, and also there was significant because the result of t-test was 6.94 and t-table was 2.093. It means that was significant because t-table was smaller than t-test. Thus, can be concluded that the use of PIE (Point, Illustration, Explanation) Strategy improved the students’ writing achievement.

A method for translating search strategies efficiently into HMIC and SPP.

Small databases, such as Health Management Information Consortium (HMIC) and Social Policy and Practice (SPP), can add value to systematic searches. Search strategies designed for large databases may not be appropriate in small sources. A different approach to translating strategies could ensure that small databases are searched efficiently. To establish the contribution HMIC and SPP made to public health guidelines (PHGs); and to recommend an efficient method of translating search strategies. Eight PHGs were analysed to establish how many included publications were retrieved from HMIC and SPP. Six options for translating strategies from MEDLINE, using variations of free text and subject terms, were compared. Health Management Information Consortium contributed 15 and SPP eight of the 483 publications cited in the PHGs. The free-text only search was the one option to miss an included publication. The heading word (with truncation) option was more precise than applying subject headings. There is a risk of missing relevant publications in free-text only searches and it is preferable to include subject terms efficiently. The heading word (with truncation) option did not miss the evidence included in the PHGs and was the most efficient method for translating MEDLINE to HMIC and SPP.

Dental Considerations in Pregnancy – A Systematic Review

Background: Good oral health during pregnancy can not only improve the health of the pregnant mother, but also potentially the health of her child. There is inconclusive and contrasting nature of evidence regarding the effect of pregnancy on oral health. So the purpose of this study was to systematically review the dental considerations during Pregnancy for further investigation.
 Methods: For the identification of the studies included in this review, we devised the search strategy for each database. The search strategy used a union of controlled vocabulary and free text terms. The main electronic database used to access the studies were PubMed, PubMed Central, Cochrane Review, Embase and Google Scholar.
 Results: A total of 28 articles fulfilled the criteria and were selected for the review. Some prenatal oral health conditions have adverse effects on the child. Periodontitis is associated with preterm birth, low birth weight infants and high level of cariogenic bacteria in pregnant mother can lead to increased risk of dental caries in the infant. Oral lesions such as gingivitis and pregnancy tumours are benign in nature and require only reassurance and monitoring.
 Conclusion: It has been suggested that some oral conditions may have adverse consequences on their children awareness related to oral health during pregnancy. Oral health care services should be routinely integrated with prenatal care services for all the pregnant women and specific preventive oral health care program should be made an integral part of antenatal care.

Clinical Information Systems Research in the Pandemic Year 2020

SummaryObjective: In this synopsis, we give an overview of recent research and propose a selection of best papers published in 2020 in the field of Clinical Information Systems (CIS). Method: As CIS section editors, we annually apply a systematic process to retrieve articles for the International Medical Informatics Association Yearbook of Medical Informatics. For seven years now, we use the same query to find relevant publications in the CIS field. Each year we retrieve more than 2,400 papers which we categorize in a multi-pass review to distill a preselection of 15 candidate papers. External reviewers and yearbook editors then assess the selected candidate papers. Based on the review results, the IMIA Yearbook editorial board chooses up to four best publications for the section at a selection meeting. To get an overview of the content of the retrieved articles, we use text mining and term co-occurrence mapping techniques. Results: We carried out the query in mid-January 2021 and retrieved a deduplicated result set of 2,787 articles from 1,135 different journals. We nominated 15 papers as candidates and finally selected four of them as the best papers in the CIS section. As in the previous years, the content analysis of the articles revealed the broad spectrum of topics covered by CIS research. Thus, this year we could observe a significant impact of COVID-19 on CIS research. Conclusions: The trends in CIS research, as seen in recent years, continue to be observable. What was very visible was the impact of the Corona Virus Disease 2019 (COVID-19) pandemic, which has affected not only our lives but also CIS.

Enriching and Clustering Short Text Using KNN

Semantic Hashing technique wraps the meaning of short texts into compressed binary codes. So, to find out that whether two short texts are alike or not in their meaning, their binary codes need to be matched. A deep neural network is used for encoding. Bag-of-words representation of texts is used to train the neural network. Unfortunately, the fundamental semantics are not sufficiently captured by the above mentioned form of representation for short texts such as titles, tweets, or queries. We propose adding additional semantic signals to better group short texts using their meaning. More specifically, we procure the co-occurring terms and concepts of every term in the short text via a knowledge database to further enhance the short text. Additionally, we use a k-Nearest Neighbor based approach id for hashing. Multiple experiments provide evidence that by increasing the number of semantic signals, our neural network is better capable to capture the meaning of short texts, which enables various uses like retrieving information, classifying data, and processing of short texts.

A Pattern and POS Auto-Learning Method for Terminology Extraction from Scientific Text

A lot of new scientific documents are being published on various platforms every day. It is more and more imperative to quickly and efficiently discover new words and meanings from these documents. However, most of the related works rely on labeled data, and it is quite difficult to deal with unlabeled new documents efficiently. For this, we have introduced an unsupervised method based on sentence patterns and part of speech (POS) sequences. Our method just needs a few initial learnable patterns to obtain the initial terminology tokens and their POS sequences. In this process, new patterns are constructed and can match more sentences to find more POS sequences of terminology. Finally, we use obtained POS sequences and sentence patterns to extract terminology terms in new scientific text. Experiments on paper abstracts from Web of Knowledge show that this method is practical and can achieve a good performance on our test data.

AMFormulaS: an intelligent retrieval system for traditional Chinese medicine formulas

BackgroundFormula is an important means of traditional Chinese medicine (TCM) to treat diseases and has great research significance. There are many formula databases, but accessing rich information efficiently is difficult due to the small-scale data and lack of intelligent search engine.MethodsWe selected 38,000 formulas from a semi-structured database, and then segmented text, extracted information, and standardized terms. After that, we constructed a structured formula database based on ontology and an intelligent retrieval engine by calculating the weight of decoction pieces of formulas.ResultsThe intelligent retrieval system named AMFormulaS (means Ancient and Modern Formula system) was constructed based on the structured database, ontology, and intelligent retrieval engine, so the retrieval and statistical analysis of formulas and decoction pieces were realized.ConclusionsAMFormulaS is a large-scale intelligent retrieval system which includes a mass of formula data, efficient information extraction system and search engine. AMFormulaS could provide users with efficient retrieval and comprehensive data support. At the same time, the statistical analysis of the system can enlighten scientific research ideas and support patent review as well as new drug research and development.

Impact of Tai Chi on CRP, TNF-alpha and IL-6 in inflammation: a systematic review and meta-analysis

Previous studies have reported that C reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in Coronavirus disease 2019 (COVID-19) patients are significantly increased, and their progressive increases are clinical warning indicators of severe and critical severity. The purpose of this meta-analysis is to evaluate the efficacy of Tai Chi on CRP, TNF-alpha and IL-6, and provide a basis for complementary treatment of COVID-19. Five English databases (PubMed, Web of Science, Physiotherapy Evidence Database, Cochrane Library and Embase) and four Chinese electronic databases (CNKI, Wanfang, China Science and Technology Journal Database and SinoMed) were searched from inception to April 1st, 2020. Combination MeSH and free text terms were used to make up search strategy. Interventions in RCTs were Tai Chi with or without comparison (usual care, health education, drug therapy, psychosocial therapy). Revman version 5.3 was used to analyze the extracted data. Continuous outcomes were described by SMD, and the I2 test was used to assess heterogeneity. Revised Physiotherapy Evidence Database scale was used to assess methodological quality. Nine RCTs involving 571 participants met the inclusion criteria, and the sample size ranged from 19 to 100 per study. Tai Chi can significantly reduce TNF-alpha (Tai Chi intervention: SMD =-0.92, 95% CI: -1.32 to -0.53; Tai Chi plus drug treatment intervention: SMD =-0.63, 95% CI: -1.15 to -0.11), moreover, it could reduce the amount of IL-6 (Tai Chi intervention: SMD =-0.62, 95% CI: -1.00 to -0.23; Tai Chi plus drug treatment intervention: SMD =-2.17, 95% CI: -3.69 to -0.64) and CRP (Tai Chi plus drug treatment intervention: SMD =-1.98, 95% CI: -2.47 to -1.50) while with a high exercise amount. A low exercise amount of Tai Chi showed poor efficacy on CRP (Tai Chi intervention: SMD =-0.18, 95% CI: -0.61 to 0.25; Tai Chi plus drug treatment intervention: SMD =-0.15, 95% CI: -0.47 to 0.16) and IL-6 (Tai Chi intervention: SMD =0.15, 95% CI: -0.24 to 0.55). The strength of evidence might be limited due to relatively low methodological quality, heterogeneity and indirectness. The overall results elucidate that Tai Chi could significantly reduce TNF-alpha while it did not show the same effects in IL-6 and CRP. After subgroup analysis, Tai Chi with a high exercise amount can reduce IL-6 and CRP. Tai Chi with a high exercise amount could be suggested as a complementary intervention for people with COVID-19. PROSPERO CRD42020177655.

How helpful is the halo-gravity traction in severe spinal deformity patients?: A systematic review and meta-analysis.

This study sought to evaluate the complications and clinic outcome in radiographic parameters, pulmonary function, and nutritional status of halo-gravity traction (HGT) in treating severe spinal deformity. Embase, PubMed, Cochrane, Web of Science databases were searched comprehensively for relevant studies from inception to February 2021, by using combined text and MeSH terms and English language restriction was used. The data, including radiographic parameters, pulmonary function (FVC %), and nutritional status (BMI) was extracted from included studies. All meta-analyses were conducted using random or fixed-effects models according the between-study heterogeneity, estimated with I2. Four hundred and forty-six studies were identified and twelve studies with a total of 372 patients were included in this review. Compared with pre-traction values, there were reduction in cobb angle of 28.12° [95% CI (22.18, 34.18)], decrease in thoracic kyphosis of 26.76°[95% CI (20.73, 32.78)], improvements in spine height[SMD = -0.89, 95% CI (- 1.56, - 0.21)] and in coronal balance[WMD = - 0.03, 95% CI (- 1.56, - 0.21), P = 0.84] with preoperative halo-gravity traction for severe spinal deformity patients. Besides, our pooled analysis showed the improvement in pulmonary function (FVC %) [WMD = - 9.56, 95% CI (- 1.56, - 0.21)] and increase in nutritional status (BMI) [WMD = - 0.50, 95% CI (- 1.56, - 0.21)]. Partial correction can be achieved by preoperative HGT, thereby reducing the difficulty of the operation and the risk of neurologic injury caused by excessive correction. Moreover, preoperative HGT can improve pulmonary function and nutritional status and, thus, increase patients' tolerance to surgery.

Cultural Linguistics and Religion: Human Anatomical Terms in the Holy Bible

This study investigates, within the scope of Cultural Linguistics, underlying cultural conceptualisations of human anatomical (body part) terms in the Holy Bible linked to the Christian worldview. It comes as a response to the call for further research on the reciprocal relationship between language and religion from other sub-disciplines. In recent years, the analytical framework of Cultural Linguistics has shown how religious language can embody the specific worldview that lies at the core of the religion through analysis of the language and conceptualisations associated with the religion and its belief systems. This study applies corpus-linguistics and the analytical framework of Cultural Linguistics to unpack cultural metaphors, cultural categories and cultural schemas associated with body part terms in the Bible. This approach, referred to as Corpus-Cultural analysis, was used to collect data and analyse conceptualisations drawn from the original Hebrew and Greek manuscripts, Bible concordance, Bible encyclopedia and dictionary, as well as scripture commentaries. The findings reveal that body part terms in biblical texts play an important role in providing a significant conceptual base for representing the Christian worldview of the specified body parts. For example, the term ‘heart’ is conceptualised as the seat of, emotions, determination or courage, intellect, understanding and conscience in the Bible. In addition, it was found that various conceptualisations derive from several sources, including ancient Hebrew and Greek worldviews, Jewish religion and customs, translation of original text into English, biblical commentaries, and religious literature. Overall, the study concludes that the Corpus-Cultural approach contributes to the in-depth understanding of Holy texts.

Peran Bahasa dalam Teks – Teks Perkembangan Pemikiran Ekonomi Islam

The aim of this article was to analyze the relationship between the role of language in development of Islamic economic thought. The article used library research method. Furthermore, it was analyzed based on the relationship between two foundations in terms of the role of language development contained in the Tafsir Al-Mishbah and terms of historical chronological texts of the development of Islamic economic thought from the era of Rasulullah to Contemporary Islam in Janwari literature. The results of the analysis of the role of language in a series of long histories are relevant to support the texts of Islamic economic thought gave birth to economic term system that continue to develop following the conditions of contemporary development and human basic needs until now.

The development of linguistic and cultural meanings of English colour lexis: dynamics and modern state

The article is devoted to the study of the dynamics of development and the current state of linguacultural meanings in colour terms that are used in English-language women’s prose. In the course of the analysis of the theoretical and methodological material, it has been revealed that the colour terms in the literary text contribute to the fact that the descriptions and pictures drawn by its author are perceived as correctly as possible by the reader, and the latter more accurately perceives the sensations and emotions experienced by the characters at different moments of the story. During the analysis of the corpus of selected contexts (more than 700 fragments) with colour terms (500 units) from the works of fiction of modern women’s prose – criminal literature of the British writer Elizabeth Haynes – a number of features have been established. All the analyzed works are rich in the use of various colours, generally the main ones, and their shades, but there are also other colours. Thematic groups of colour terms include descriptions of the appearance of the main and secondary characters, everyday realia of the surrounding world, phenomena and objects of the natural world, and other abstract notions. Frequently occurring primary colour terms that do not have a transfer of meaning have been distinguished, and less frequent secondary colour terms with a transfer of meaning, and the secondary ones usually had a more complex morphological and syntactic structure. The selected colour terms that describe the appearance of the characters and have a transfer of meaning are divided into two groups, one of which includes colour terms with a metaphorical component, and the other contains colour terms that form transferred epithets. Within the framework of the description of natural phenomena and objects, the authors distinguish fully metaphorized colour terms, partially metaphorized colour terms that include a metaphorized component that does not extend its influence to the other structural elements of the colour term, as well as colour terms represented by an explicit comparison. In general, colour terms fill the work with a deep content, an additional meaning that the author lays down when writing a literary work.

A Critical Discourse Analysis of Intertextuality and Interdiscursivity in Burnt Shadows by Kamila Shamsie

ABSTRACT Dialectical relationship between language and other elements of social life constitute the bases of Fairclough’s (2003) Model of Critical Discourse Analysis. He combines the textual analysis with the contextual analysis, taking discourse as a form of social practice—linked to other discourses and social practices in more than one way. This paper explores how Shamsie’s discourse in Burnt Shadows is interdiscursive in these specific ways. Fairclough’s model of CDA has been used as a research method. His conceptual framework of interdiscursivity is used to explore the relationships between the text and the context in terms of other texts and actual events of human history and their reflection in different literary discourses. Shamsie links War on Terror with World War II to expose the ideology behind the world power structures and power politics in the world where might is the only right. Life moved full circle from Nagasaki on the fatal day of dropping of the second atomic bomb in World War II to taking mere suspects to Guantanamo Bay with the sole objective to ‘save the Americans’ lives.’ This study shows Shamsie’s insightful knowledge of the world history of colonialism, postcolonialism and neocolonialism and how these apparently different movements are intertwined in more than one way. Her fictional discourse bears many examples of Interdiscursivity. Keywords: Interdiscursivity, intertextuality, dialogism, ideology and socio-political practices

'Z-trip'? A Comprehensive Overview and a Case-series of Zolpidem Misuse.

Although believed safer compared to short-acting benzodiazepines (BZD), in the past few years a growing concern has developed relating to the abuse of Z-drugs, and specifically of zolpidem. Here we aim to review the evidence for the misuse of zolpidem and describe several related cases collected in Italy. A comprehensive overview is here carried by using several databases, and by combining the search strategy of free text terms and exploding a range of MESH headings relating to the topics of Zolpidem and Abuse and/or Misuse as follows: ((Zolpidem[Title/]) AND (Abuse[Title/]) OR (Misuse[Title/])), without time and/or language restrictions. Furthermore, a case series of 8 cases of zolpidem misuse and/or abuse, collected in different Italian psychiatric settings (psychiatric public hospital, psychiatric private rehabilitation clinic, and private practice), have been here described. According to our findings, zolpidem should be prescribed with the same caution as BZDs, especially in patients with a history of drug abuse or in the elderly. Behavioural modifications, including bizarre behaviours, psychomotor agitation, sleep-related complex behaviours have been reported. Monitoring of zolpidem use in selected populations is warranted. Psychiatrists and physicians should be aware of the misuse potential of zolpidem and adopt measures restricting its use.

The Glossaryfication Web Service – an automated glossary creation tool to support One Health communication

Efficient communication and collaboration across sectors is an important precondition for true One Health Surveillance (OHS) activities. Despite the overall willingness to embrace the One Health paradigm, it is still challenging to accomplish this in day-to-day practice due to the differences in terminology and interpretation of sector-specific terms. In this sense, simple interventions like the inclusion of integrative glossaries in OHS documents (e.g. reports, research papers and guidelines) would help to reduce misunderstandings and could significantly improve the written communication in OHS. Here, we present the Glossaryfication Web Service that generates a document-specific glossary for any text file provided by the user. The web service automatically adds the available definitions with their corresponding references for the words in the document that match with terms in the user-selected glossaries. The Glossaryfication Web Service was developed to provide added value to the OHEJP Glossary that was developed within the OHEJP project ORION. The OHEJP Glossary improves the communication and collaboration among OH sectors by providing an online resource that lists relevant OH terms and sector-specific definitions. The Glossaryfication Web Service supports the practical use of the curated OHEJP Glossary and can also source information from other glossaries relevant for OH professionals (currently supporting the online CDC, WHO and EFSA glossaries). The Glossaryfication Web Service was created using the open-source software KNIME and the KNIME Text Processing extension (https://www.knime.com/knime-text-processing). The Glossaryfication KNIME workflow is deployed on BfR’s KNIME Server infrastructure providing an easy-to-use web interface where the users can upload their documents (any text-type file e.g. PDF, Word, Excel) and select the desired glossary to compare with. The Glossaryfication KNIME workflow reads in the document provided via the web interface and applies natural language processing (e.g. text cleaning, stemming), transforming (bag-of-words generation) and information retrieval methods to identify the matching terms in the selected glossaries. The Glossaryfication Web Service generates as an output a table containing all the terms that match with the selected glossaries. It also provides the available definitions, corresponding references and additional meta-information, e.g. the term frequency, i.e., how often each term appears in the given text, and the sectoral classification (only for the OHEJP Glossary terms). Furthermore, the workflow generates a tag cloud where the terms are categorized as: (i) exact match when the term in the text matches exactly with the entry of this term in the glossary; (ii) inexact match when the term appears in the text slightly modified (e.g. plural forms or suffixes) and (iii) non-matching that corresponds to all the other words appearing in the text that do not match with any glossary term. Through the user interface, the users can then choose if they want to download the whole list of terms, select only the exact/inexact matching terms, or just choose those terms and definitions that match with the meaning intended for this term in the user-provided document. The resulting table of terms can be downloaded as an Excel file and added to the user’s document as a document-specific glossary. The Glossaryfication Web Service provides an easy-to-adopt solution to enrich documents and reports with more comprehensive and unambiguous glossaries. Furthermore, it improves the referentiality of terms and definitions from different OH sectors. An additional feature provided by the Glossaryfication Web Service is the possibility of extending its use to other glossaries from other national or international institutions allowing the user to customize this glossary creation service.

Efficacy and feasibility of deep brain stimulation for patients with depression: A protocol for systematic review and meta-analysis.

Background:Previous meta-analyses have examined the clinical efficacy and acceptability of deep brain stimulation (DBS) compared with sham therapy or paired active therapy. However, the absence of head-to-head clinical trials with some treatment comparisons creates uncertainty for decision makers. Thus, to provide new evidence-based medical evidence for clinical treatment, we undertook a meta-analysis to assess the efficacy and safety of DBS in patients with depression based on high-quality randomized controlled studies.Methods:The protocol was written following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement guidelines. PubMed/Medline and EMBASE will be searched before May 2021 for all studies, using various combinations of the following free text and key terms: deep brain stimulation; depression; random. No language restrictions will be applied. The method of data extraction will follow the approach outlined by the Cochrane Handbook for Systematic Reviews of Interventions. Review Manager software 5.3 is used for the meta-analysis. The quality of randomized trials will be assessed by Cochrane risk of bias tool for randomized controlled trials.Results:The results of our review will be reported strictly following the PRISMA criteria and the review will add to the existing literature by showing compelling evidence and improved guidance in clinic settings.OSF registration number:10.17605/OSF.IO/Q5B3S.

Outcomes of allogeneic hematopoietic cell transplantation in patients with myelofibrosis: A systematic review and meta-analysis.

7045 Background: Allogeneic hematopoietic cell transplant (allo-HCT) remains the only potentially curative therapeutic modality for patients with primary or secondary myelofibrosis (MF). However, many patients (pts) are ineligible for allo-HCT and transplant-related mortality can be substantial. Data on the efficacy and safety of allo-HCT are mixed and largely derived from retrospective studies. Methods: To synthesize the available evidence, we conducted a systematic review and meta-analysis searching Cochrane Library, Google Scholar, Ovid Medline, Ovid Embase, PubMed, Scopus, and Web of Science Core Collection from inception to October 11, 2020 for studies on allo-HCT in MF. Databases were searched using a combination of controlled vocabulary and free text terms for relevant studies on the efficacy and safety of allo-HCT in pts with primary and secondary MF. This study protocol has been registered on PROSPERO (CRD42020188706). Random-effects models were used to pool response rates for the co-primary outcomes of 1-year, 2-year and 5-year overall survival (OS). Results: We identified 4247 studies after duplicate removal. 393 studies were assessed as full-texts for eligibility and 43 studies (38 retrospective, 1 prospective study, 4 phase II clinical trials) with 8739 pts were included in this meta-analysis. Study quality was limited by the absence of randomized clinical trials and retrospective design of most studies. Rates of 1-year, 2-year, and 5-year OS were 66.7% (95% confidence interval: 63.5-69.8%), 64.4% (57.6-70.6%), and 55.0% (51.8-58.3%), respectively. Rates of 1-year, 2-year, and 5-year non-relapse mortality were 25.9% (23.3-28.7%), 29.7% (24.5-35.4%), and 30.5% (25.9-35.5%), respectively. Among evaluable studies, rates of 1-year, 2-year, and 5-year relapse-free survival were 65.3% (56.5-73.1%), 56.2% (41.6-69.8%), and 53.6% (39.9-66.9%), respectively. Adverse events related to all-HCT were manageable with rates of acute and chronic graft-versus-host disease in 44.0% (39.6-48.4%; grade III/IV: 15.2%) and 46.5% of patients (42.2-50.8%; extensive or moderate/severe: 26.1%), respectively. Subgroup analyses did not show any significant difference between conditioning regimen intensity (myeloablative vs reduced-intensity), median patient age, and proportion of DIPSS-intermediate-2/high pts. Conclusions: Given the poor prognosis of patients not receiving transplant and in the absence of curative non-transplant therapies, our results support consideration of allo-HCT for eligible pts with MF. However, additional studies in pre- and post-allo-HCT setting are necessary to enhance patient selection (e.g. by incorporation of molecular markers), to optimize transplant strategies (e.g. peri-transplant ruxolitinib, conditioning regimens, and donor selection), symptom management and decrease non-relapse mortality.

Risk Factors for Accidental Dural Tears in Spinal Surgery.

Accidental dural tears (DTs) are familiar complications of spinal surgery. Their reported incidence varies widely, and several risk factors have been proposed in the literature. The aim of this study was to conduct a systematic review and meta-analysis to determine the rate of DTs and assess their associated risk factors. A systematic literature search was conducted using specific MeSH and Text terms. Only articles with prospective data reporting the incidence and risk factors were selected and reviewed based on specific inclusion and exclusion criteria. Twenty-three studies were included. The reported incidence rate ranged from 0.4% to 15.8%, giving an overall pooled incidence rate of 5.8% (95% confidence interval [CI] 4.4-7.3). The incidence rate varied in relation to the part of the spine and the type of surgery. Three factors were associated with a high rate of DTs: age (overall mean difference of 3.04, 95% CI 2.49-3.60), revision surgery (overall odds ratio of 2.28, 95% CI 1.84-2.83), and lumbar stenosis (overall odds ratio of 2.03, 95% CI 1.50-2.75). Diabetes was weakly associated with DTs, with an odds ratio of 1.40 (95% CI 1.01-1.93). The overall effects of sex and obesity were not statistically significant. Advancing age, revision surgery, and lumbar stenosis were significantly associated with increased risk of DTs. These factors should be taken into consideration during the consenting process for spinal surgery. Risk of dural tear during spine surgery.

Analysis of Chinese Video Website Barrage Language Based On the Influence Of The ACGN Culture

In recent years, with the rapid growth of China’s animation industry, the two-dimensional culture and consumption have been immersed in the daily lives of young people. The two-dimensional culture that mainly exists on young people is gradually entering the public’s field of vision, making the two-dimensional culture not It is only restricted to the fixed fan circle, but is known to more people outside the circle. At the same time, the barrage (screen text) cultures in video websites has become popular with some film and television works, Internet terms, etc., and has attracted the attention on mainstream culture. On the one hand, its cultural products have appeared on traditional mainstream video websites and advertisements on provincial satellite TV. And in the program, on the other hand, a small part of the screen text and cultural terms are also used by some celebrities and other ordinary people who don’t understand the meaning of the terms at all, and have caused widespread dissemination. Sometimes the video website itself is also mentioned, which obviously shows a difference. The tendency towards a kind of screen texts subculture to penetrate the mainstream culture.