Temporal Course Research Articles

Gas dynamics features of physico-chemical processes in the SRM large-sized charges at open firing

The problem of utilization of solid rocket motors (SRM) with large-sized charges is a relevant objective. This is due to the decommissioning of SRM that failed or were rejected during production and operation, as well as with the implementation of strategic arms reduction treaties. Comparative analysis of SRM with large-sized charge utilization methods showed that the simplest, most productive, and relatively safe technique is open firing. At the same time, the information on the dynamics of harmful substances emission into the environment is needed to conduct quantitative assessment of the concentrations of environmentally hazardous combustion products formed during open firing. The calculation of intraballistic parameters in SRM makes it possible to estimate the consumption parameters of harmful gaseous and condensed combustion products entering the atmosphere. Also, it allows analyze the spatial and temporal course of the concentrations of these substances and optimize ways to reduce environmental hazards. The mathematical model and results of gas dynamics parameters calculation at the open firing of large-sized SRM with the demounted nozzle unit and forward bottom are submitted. The key features of realized flow modes are marked: significant pressure differentials along the length of the SRM in the initial stage of its activity; transonic velocities of intrachannel flow; erosion effects on the initial stages of burning rate.

A case of breast implant illness presenting as chronic headaches: A case report

AbstractWe describe a middle‐aged patient with breast implants presenting with chronic headaches. We obtained a detailed clinical history from the patient about the temporal course of her headaches to her breast implant placement. We tried to rule out another potential differential diagnosis. Chronic headaches started 6 months after the patient underwent bilateral breast augmentation with saline breast implants, and they resolved soon after the implant was removed. We were able to rule out other possible causes of headaches clinically. Several well‐powered studies have shown a strong association between breast implant illness and neurological conditions. However, this may be easily overlooked if we do not have a solid clinical suspicion based on history. In an appropriate clinical setting, breast implant illness should be considered in patients presenting with new‐onset persistent headaches.

Hemidystonia secondary to pediatric thalamic glioblastoma: a case report

IntroductionThalamic tumors are rare and uncommonly manifest as movement disorders, including hemidystonia. Despite this association, little is known about the evolution of hemidystonia.Case descriptionWe report on a 11-year-old boy who complained of hypaesthesia and fine motor problems in the left hand. A magnetic resonance imaging showed a large mass in the right thalamus. Stereotactic biopsy revealed a WHO grade 4 astrocytoma, and the patient underwent normofractioned radiochemotherapy with proton-beam radiation and temozolomide. Three months later, a spastic hemiparesis developed on the left side, which progressed over months. Over the following months, the hemiparesis slowly improved, but hemidystonia in the same side developed. This was accompanied with radiological evidence of tumor regression, showing a persistent lesion in the ventral posterolateral and the intralaminar thalamus.ConclusionThis case illustrates the unusual and complex temporal course of appearance and disappearance of hemidystonia along with the regression and growth in glioblastoma involving the thalamus.

Structural and functional changes in rat uterus induced by neonatal androgenization.

Fetal or neonatal androgen exposure has a programming effect on ovarian function inducing a polycystic ovarian syndrome-like condition. Its effects on uterine structure and function are poorly studied. The aim of this work was to characterize the temporal course of changes in the rat uterine structure induced by neonatal exposure to aromatizable or not aromatizable androgens. Rats were daily treated with testosterone, dihydrotestosterone or vehicle during follicle assembly period (postnatal days 1 to 5). Uterine histoarchitecture, hormonal milieu, endometrial stromal collagen and capillary density were analyzed at prepubertal, pubertal and adult ages. Our data shows that neonatal androgen exposure induces early and long-lasting deleterious effects on uterine development, including altered adenogenesis and superficial epithelial alterations and suggest a role for altered serum estradiol levels in the maintenance and worsening of the situation. Our results suggest that alterations of the neonatal androgenic environment on the uterus could be responsible for alterations in the processes of implantation and maintenance of the embryo in women with polycystic ovary syndrome.

Persistent brain damage in reversible cerebral vasoconstriction syndrome on 99mTc-ethyl cysteinate dimer single-photon emission computed tomography: A long-term observational study

BackgroundBlood-brain barrier (BBB) breakdown is considered a key step in the pathophysiology of reversible cerebral vasoconstriction syndrome (RCVS); however, its temporal course remains unclear. Based on the characteristics and dynamics of 99mTc-ethyl cysteinate dimer (99mTc-ECD) as a tracer, 99mTc-ECD single-photon emission computed tomography (SPECT) can detect not only hypoperfusion but also BBB breakdown and/or brain tissue damage. Therefore, this study aimed to investigate this course using 99mTc-ECD SPECT. MethodsBetween 2011 and 2019, we enrolled seven patients (one male and six female patients) with RCVS without ischemic or hemorrhagic stroke or posterior reversible encephalopathy syndrome. 99mTc-ECD SPECT was performed repeatedly in each patient. SPECT data were statistically analyzed using an easy Z-score imaging system. ResultsThunderclap headache was the initial symptom in all the patients and was most commonly triggered by bathing (three patients). All the patients exhibited vasoconstriction and reduced cerebral uptake of 99mTc-ECD during the acute stage. Follow-up assessment from 3 to 16 months showed that reduced cerebral uptake persisted in all the patients, even after the vasoconstriction had resolved. ConclusionReduced cerebral uptake of 99mTc-ECD persisted in the late stage of RCVS, even after vasoconstriction and headache subsided. BBB breakdown and/or brain tissue damage may underlie this phenomenon. 99mTc-ECD SPECT is an effective neuroimaging method to detect brain functional abnormalities, reflecting BBB breakdown or tissue damages, throughout the treatment course of RCVS.

The feasibility of virtual reality for anatomic training during temporal bone dissection course

Introduction: In recent decades, the lack of educational resources for cadaveric dissections has complicated the hands-on otological surgical training of otorhinolaryngology residents due to the poor availability of cadaver temporal bones, facilities, and limited hours for practice. Since students must gain adequate and patient-safe surgical skills, novel training methods need to be considered. In this proof-of-concept study, a new virtual reality (VR) software is described; this was used during a national temporal bone dissection course where we investigated its feasibility for otological surgical training.Methods: A total of 11 otorhinolaryngology residents attended the annual 2-day hands-on temporal bone dissection course; they were divided into two groups with similar experience levels. Both groups received a lecture on temporal bone anatomy. A total of 22 cadaver temporal bones were harvested for the course; 11 of these bones were imaged by computed tomography. VR software designed for preoperative planning was then used to create 3D models of the imaged temporal bones. Prior to dissection training, the first group underwent a 30-min VR session, where they identified 24 surgically relevant anatomical landmarks on their individual temporal bone. The second group proceeded directly to dissection training. On the second day, the groups were switched. The feasibility of VR training was assessed with three different metrics: surgical performance evaluation using a modified Hopkins objective structured assessment of technical skill (OSATS), time for the surgical exposure of anatomical landmarks, and the user experience collected with a Likert scale questionnaire.Results: No differences were noted in the overall performance between the groups. However, participants with prior VR training had a lower mean time for surgical exposure of anatomical landmarks (antrum 22.09 vs. 27.64 min, p = 0.33; incus 60.00 vs. 76.00, p = 0.03; PSCC 71.83 vs. 88.50, p = 0.17) during dissection training. The participants considered VR beneficial for anatomy teaching, surgery planning, and training.Conclusion: This study demonstrated the feasibility of implementing VR training in a temporal bone dissection course. The VR training demonstrated that even short expert-guided VR sessions are beneficial, and VR training prior to the dissections has a positive effect on the time needed to perform surgical tasks while maintaining comparable performance scores.

A two-case study on CSL learners’ agency in classroom settings from the perspective of language socialization

Abstract Examining the learner agency expressed by two learners of Chinese as a second language (CSL), the current two-case study was conducted from the perspective of language socialization. Qualitative data have been collected through classroom observations and semi-structured interviews. Data analysis reveals that the two cases in the current study exhibited eight forms of learner agency in their CSL learning, including self-determination, self-motivation, self-regulation, participation, cooperation, negotiation, hesitancy and resistance. In addition, learner agency observed in the two cases is constantly mediated by multiple sociocultural factors in specific contexts of CSL socialization. The results of the current study imply the socioculturally mediated essence of learner agency and suggest that learner agency develops through a temporal course and is constrained by social structures.

Aggregate dissolution kinetics

The alkali–silica reaction (ASR) starts with the dissolution of silica in alkali-reactive aggregates. Besides the thermodynamic basics of silica dissolution, kinetic data are needed to model ASR in order to describe the temporal course of the reaction. Although the dissolution kinetics of silica has been investigated frequently, data for concrete-like environments (pH > 12) and under special influences, such as de-icer impact by sodium chloride (NaCl) or the release of aluminium (Al) from feldspars, are rare or missing. In the present study, long-term (2.5 years) dissolution tests were performed to obtain kinetic data for two types of aggregate (granodiorite, rhyolite) under concrete-like conditions (pH 13.8, with/without calcium hydroxide (Ca(OH)2) and sodium chloride) at temperatures of 25, 45 and 60°C. The findings show that silica dissolution rates effective for ASR differ up to four orders of magnitude, ranging from (log r1) −13.13 to −9.96 mol/m2s as a function of aggregate type, temperature, sodium chloride concentration and calcium hydroxide. Besides a predominant influence of temperature and calcium hydroxide, sodium chloride promotes the dissolution of silica and lowers the aluminium concentration, especially at higher temperatures. The activation energy for silica dissolution (84 ± 4 kJ/mol) did not change significantly in the presence of sodium chloride.

Variability in Opioid-Related Drug Overdoses, Social Distancing, and Area-Level Deprivation during the COVID-19 Pandemic: a Bayesian Spatiotemporal Analysis.

Monitoring the spatial and temporal course of opioid-related drug overdose mortality is a key public health determinant. Despite previous studies exploring the evolution of drug-related fatalities following the stay-at-home mandates during the COVID-19 pandemic, little is known about the spatiotemporal dynamics that mitigation efforts had on overdose deaths. The purpose of this study was to describe the spatial and temporal dynamics of overdose death relative risk using a 4-week interval over a span of 5 months following the implementation of the COVID-19 lockdown in the city of Chicago, IL. A Bayesian space–time model was used to produce posterior risk estimates and exceedance probabilities of opioid-related overdose deaths controlling for measures of area-level deprivation and stay-at-home mandates. We found that area-level temporal risk and inequalities in drug overdose mortality increased significantly in the initial months of the pandemic. We further found that a change in the area-level deprivation from the first to the fourth quintile increased the relative risk of a drug overdose risk by 44.5%. The social distancing index measuring the proportion of persons who stayed at home in each census block group was not associated with drug overdose mortality. We conclude by highlighting the importance of contextualizing the spatial and temporal risk in overdose mortality for implementing effective and safe harm reduction strategies during a global pandemic.Supplementary InformationThe online version contains supplementary material available at 10.1007/s11524-022-00675-x.

Gratitude endures while indebtedness persuades: investigating the unique influences of gratitude and indebtedness in helping

ABSTRACT What is the temporal course of gratitude and indebtedness and how do these feelings influence helping in the context of reciprocity? In an online-game tapping real-life behaviour, Study 1 (N = 106) finds that while gratitude towards a benefactor remains elevated after an opportunity to reciprocate, indebtedness declines along with helping. Yet, indebtedness rather than gratitude better predicts real-life helping of a benefactor. Using a vignette-based experiment, Study 2 (N = 217) finds that after reciprocation indebtedness and likelihood of helping a benefactor reset to a baseline level while gratitude endures. Furthermore, the decrease in helping after reciprocation is better explained by indebtedness than by gratitude. Study 3 (N = 217) assessed the unique influences of gratitude and indebtedness on helping by comparing contexts in which gratitude is at a baseline level but indebtedness is elevated (e.g. before a monetary payment for a service received) to contexts in which indebtedness is at a baseline level but gratitude is elevated (e.g. after reciprocation of benefits freely given by a friend). People are more likely to help in the former compared to latter context, and this difference is better explained by indebtedness rather than by gratitude. We discuss the interrelated and understudied relationships between gratitude, indebtedness, and reciprocity.

Quantification of temporal and spatial changes in soil suspension density, specific surface area and parameters of the distribution of the texture of the dispersed soil phase

Number of engineering tasks concerning water management as well as hydrological research require sound knowledge of temporal and spatial changes of soil suspension density, specific surface area and distribution parameters of soil texture in dispersed soil phase. This contribution is based on the hypothesis that there is a dependence between density of soil suspension, specific surface area of soil particles and distribution parameters of soil texture d(10), d(50) and d(90). The contribution analyses the results of an experiment investigating the temporal and spatial course of soil suspension density, specific surface area of soil particles and the distribution parameters of soil texture d(10), d(50) and d(90) in soil suspension. For the research purposes, the methods of laser diffraction, sedimentation analysis and statistical correlation analysis were used. The results of the experiment are displayed graphically. To enhance the visual representation of the course of the investigated parameters, the measured values are approximated by empirical polynomials of various degrees. Close correlations between the investigated parameters are identified.

How does negative evidence impact argument strength during semantic category-based induction? An event-related potential study.

Negative evidence may influence category-based inductive reasoning, but the underlying time course of cognitive brain processing is unclear. This study adopted event-related potentials (ERPs) to investigate this effect by manipulating the category type (related vs. unrelated) and argument type (positive vs. negative) in a semantic category-based induction task. The behavioral results showed that, under unrelated conditions, a negative argument produced greater argument strength and shorter reaction time than a positive argument did. Meanwhile, the ERP results found a negative argument elicited larger P300, N400, and slow negative component amplitudes than a positive argument, which could possibly embody the expectation-related processing produced by memory updating, semantic integration, and the more complex inference-driven information integration and interpretation processes and cognitive load in hypothesis generation. This study provides novel evidence on the temporal course of how negative evidence influences argument strength during semantic category-based induction.

Patient-centered weaning from venoarterial extracorporeal membrane oxygenation: "A practice-oriented narrative review of literature".

Venoarterial extracorporeal membrane oxygenation (V-A ECMO) is increasingly used in cardiogenic shock for rapid stabilization and bridging towards recovery, long-term mechanical circulatory support or transplant. Although technological advances have instigated its widespread use, the complex, long-lasting ECMO care creates a significant strain on hospital staff and resources. Therefore, optimal clinical management including timely decisions on ECMO removal and further therapy are pivotal, yet require a well-structured weaning approach. Although dedicated guidelines are lacking, a variety of weaning protocols have distillated echocardiographic and hemodynamic predictors for successful weaning. Nevertheless, a strikingly high mortality up to 70% after initial successful weaning raises concerns about the validity of current weaning strategies. Here, we plead for a patient-tailored approach including a bailout strategy when weaning fails. This should account not only for left- but also right ventricular function and interdependence, as well as the temporal course of cardiac recovery in function of extracorporeal support. Patients with a high risk of weaning failure should be identified early, enabling timely transportation to an advanced heart failure center. This review summarizes predictors of successful weaning and discusses all relevant elements for a structured weaning approach with a central role for patient-specific clinical considerations and echocardiography.

The brain dynamics of trust decisions and outcome evaluation in narcissists.

Individuals with narcissism are, by definition, self-centered, focus on self-benefit, and demonstrate less prosocial behaviors. Trusting strangers is risky, as it can result in exploitation and non-reciprocation. Thus, the trust may be antagonistic to narcissism. However, how narcissists make the choice to trust remains to be elucidated. The current study examined 44 participants (22 rated high in narcissism) playing as trustors in one-shot trust games, and their electroencephalograms were recorded. Individuals high in narcissism exhibited less trust toward strangers, especially following gaining feedback for their trust. In addition, narcissists exhibited a larger N2 following distrust and a stronger negatively-valanced difference in feedback-related negativity (dFRN) after trustee feedback. Our findings provide insights into how individuals with narcissism trust strangers. The results also shed light on the temporal course of brain activity involved in trust decision-making and outcome evaluation in individuals with narcissism.

Thermal Characterization of a Gas Foil Bearing-A Novel Method of Experimental Identification of the Temperature Field Based on Integrated Thermocouples Measurements.

Maintenance of adequate thermal properties is critical for correct operation of a gas foil bearing. In this work, the authors present the results of the experimentally conducted thermal characterization of a prototype installation of the bearing. A novel method of temperature identification, based on integrated thermocouples readings, has been employed to determine the thermal properties of the specialized sensing top foil mounted in the tested bearing. Two measurement campaigns have been subsequently completed, applying freely-suspended and two-node support configurations, to gather complementary knowledge regarding the bearing’s operation. Apart from the rotational speed and temperature field measurements, the authors have also studied the friction torque and the shaft’s journal trajectories based on its radial displacements. The temporal courses for the above-mentioned quantities have enabled inference on the effects present during run-up, run-out and stable state operation at a constant speed. As confirmed, the applied distribution of the integrated sensors allows for temperature readings on the entire outer surface of the foil, and therefore, provides useful data for the bearing characterization. The work is concluded with presentation of the recommended directions regarding future improvements of the proposed measurement technique and more comprehensive study of the bearing’s characteristics.

N-terminal and mid-region tau fragments as fluid biomarkers in neurological diseases

Brain-derived tau secreted into CSF and blood consists of different N-terminal and mid-domain fragments, which may have a differential temporal course and thus, biomarker potential across the Alzheimer’s disease continuum or in other neurological diseases. While current clinically validated total tau assays target mid-domain epitopes, comparison of these assays with new biomarkers targeting N-terminal epitopes using the same analytical platform may be important to increase the understanding of tau pathophysiology.We developed three total tau immunoassays targeting specific N-terminal (NTA and NTB total tau) or mid-region (MR total tau) epitopes, using single molecule array technology. After analytical validation, the diagnostic performance of these biomarkers was evaluated in CSF and compared with the Innotest total tau (and as proof of concept, with N-p-tau181 and N-p-tau217) in three clinical cohorts (n = 342 total). The cohorts included participants across the Alzheimer’s disease continuum (n = 276), other dementias (n = 22), Creutzfeldt–Jakob disease (n = 24), acute neurological disorders (n = 18) and progressive supranuclear palsy (n = 22). Furthermore, we evaluated all three new total tau biomarkers in plasma (n = 44) and replicated promising findings with NTA total tau in another clinical cohort (n = 50).In CSF, all total tau biomarkers were increased in Alzheimer’s disease compared with controls (P < 0.0001) and correlated with each other (rs = 0.53−0.95). NTA and NTB total tau, but not other total tau assays, distinguished amyloid-positive and amyloid-negative mild cognitive impairment with high accuracies (AUCs 84% and 82%, P < 0.001) matching N-p-tau217 (AUC 83%; DeLong test P = 0.93 and 0.88). All total tau assays were excellent in differentiating Alzheimer’s disease from other dementias (P < 0.001, AUCs 89–100%). In Creutzfeldt–Jakob disease and acute neurological disorders, N-terminal total tau biomarkers had significantly higher fold changes versus controls in CSF (45–133-fold increase) than Innotest or MR total tau (11–42-fold increase, P < 0.0001 for all). In progressive supranuclear palsy, CSF concentrations of all total tau biomarkers were similar to those in controls. Plasma NTA total tau concentrations were increased in Alzheimer’s disease compared with controls in two independent cohorts (P = 0.0056 and 0.0033), while Quanterix total tau performed poorly (P = 0.55 and 0.44).Taken together, N-terminal-directed CSF total tau biomarkers increase ahead of standard total tau alternatives in the Alzheimer’s disease continuum, increase to higher degrees in Creutzfeldt–Jakob disease and acute neurological diseases and show better potential than Quanterix total tau as Alzheimer’s disease blood biomarkers. For progressive supranuclear palsy, other tau biomarkers should continue to be investigated.

Support Pressure Acting on the Epicardial Surface of a Rat Left Ventricle-A Computational Study.

The present computational study investigates the effects of an epicardial support pressure mimicking a heart support system without direct blood contact. We chose restrictive cardiomyopathy as a model for a diseased heart. By changing one parameter representing the amount of fibrosis, this model allows us to investigate the impairment in a diseased left ventricle, both during diastole and systole. The aim of the study is to determine the temporal course and value of the support pressure that leads to a normalization of the cardiac parameters in diseased hearts. These are quantified via the end-diastolic pressure, end-diastolic volume, end-systolic volume, and ejection fraction. First, the amount of fibrosis is increased to model diseased hearts at different stages. Second, we determine the difference in the left ventricular pressure between a healthy and diseased heart during a cardiac cycle and apply for the epicardial support as the respective pressure difference. Third, an epicardial support pressure is applied in form of a piecewise constant step function. The support is provided only during diastole, only during systole, or during both phases. Finally, the support pressure is adjusted to reach the corresponding parameters in a healthy rat. Parameter normalization is not possible to achieve with solely diastolic or solely systolic support; for the modeled case with 50% fibrosis, the ejection fraction can be increased by 5% with purely diastolic support and 14% with purely systolic support. However, the ejection fraction reaches the value of the modeled healthy left ventricle (65.6%) using a combination of diastolic and systolic support. The end-diastolic pressure of 13.5 mmHg cannot be decreased with purely systolic support. However, the end-diastolic pressure reaches the value of the modeled healthy left ventricle (7.5 mmHg) with diastolic support as well as with the combination of the diastolic and systolic support. The resulting negative diastolic support pressure is −4.5 mmHg, and the positive systolic support pressure is 90 mmHg. We, thereby, conclude that ventricular support during both diastole and systole is beneficial for normalizing the left ventricular ejection fraction and the end-diastolic pressure, and thus it is a potentially interesting therapy for cardiac insufficiency.

64-Year-Old Woman With Aphasia and Troponin Elevation

64-Year-Old Woman With Aphasia and Troponin Elevation

ЦИРКУЛЯЦИОННЫЕ ОСОБЕННОСТИ ФОРМИРОВАНИЯ МНОГОСНЕЖНЫХ И МАЛОСНЕЖНЫХ ЗИМ НА ЮГЕ КАЗАХСТАНА

The article considers the climatic parameters (precipitation and air temperature) that determine snowy and little snowy winters for the period from December to February of 1971 to 2020 years in the south of Kazakhstan. Graphs of the temporal course of atmospheric precipitation and air temperature for the study area were constructed and analyzed. The main statistical characteristics of atmospheric precipitation are calculated. A catalog of major precipitation anomalies (excess, deficit and norm) for the territory of South Kazakhstan has been compiled. A catalog of snowy warm and little snowy cold winters is presented based on the use of the complex criterion W for the study area. The circulation conditions for the formation of snowy and little snowy winters in the south of Kazakhstan are revealed by analyzing the Wangenheim-Girs circulation forms, the North Atlantic Oscillation and Blinova indices.

High temporal resolution RNA-seq time course data reveals widespread synchronous activation between mammalian lncRNAs and neighboring protein-coding genes.

The advent of massively parallel sequencing revealed extensive transcription beyond protein-coding genes, identifying tens of thousands of long noncoding RNAs (lncRNAs). Selected functional examples raised the possibility that lncRNAs, as a class, may maintain broad regulatory roles. Expression of lncRNAs is strongly linked with adjacent protein-coding gene expression, suggesting potential cis-regulatory functions. A more detailed understanding of these regulatory roles may be obtained through careful examination of the precise timing of lncRNA expression relative to adjacent protein-coding genes. Despite the diversity of reported lncRNA regulatory mechanisms, where causal cis-regulatory relationships exist, lncRNA transcription is expected to precede changes in target gene expression. Using a high temporal resolution RNA-seq time course, we profiled the expression dynamics of several thousand lncRNAs and protein-coding genes in synchronized, transitioning human cells. Our findings reveal that lncRNAs are expressed synchronously with adjacent protein-coding genes. Analysis of lipopolysaccharide-activated mouse dendritic cells revealed the same temporal relationship observed in transitioning human cells. Our findings suggest broad-scale cis-regulatory roles for lncRNAs are not common. The strong association between lncRNAs and adjacent genes may instead indicate an origin as transcriptional by-products from active protein-coding gene promoters and enhancers.