Acteoside (ACT) and icariin (ICA) were used as dual reference peaks to calibrate the fingerprint system, and 15 batches of Rong’e Yishen oral liquid (REYS) HPLC digital fingerprints were established and evaluated. The external standard method was used to quantify the samples with dual markers. The super-information characteristics digital parameters of REYS fingerprints have been deeply mined and a total of 77 parameters have been analyzed in detail. Systematically quantified fingerprint method (SQFM) and quantified ratio fingerprint method (QRFM) were used to simultaneously analyze the macro (ratio) qualitative similarity [Sm (Sr)] and macro (ratio) quantitative similarity [Pm (Pr)] of samples. The content of ACT and ICA in different batches fluctuated in the range of 318.0–522.7 μg/mL and 420.8–606.8 μg/mL, respectively. According to the ± 15% range standard of RFP characteristic technical parameters, S3, S6-S9, S14, and S15 were out of bounds. The evaluation results showed that all the samples were within the acceptable range [Sm (Sr) ≥ 0.90, 70%≤Pm (Pr) ≤ 130%]. The different evaluation and analysis results of SQFM and QFRM proposed a new strategy for quality evaluation of traditional Chinese medicine (TCM). Therefore, the method established in this paper can clearly identify and sensitively reflect the small variation of REYS, not only can supply quality control method and digital technology guarantee for REYS, but also provide support for the development of digital TCM that is conducive to quality control technology.