In this themed issue of Molecular Omics, in partnership with the U.S. Human Proteome Organization, we are proud to present the latest research featured at the 17th Annual US HUPO conference: Proteomics from Single Cell to Systems Biology in Health an... Read More
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A bright future for proteomics of health and disease. Introduction to the US HUPO 2021 themed issue - proteomics from single cell to systems biology in health and disease.
- Molecular omics
on Sep 28, 2022
Evolution of precision oncology-guided treatment paradigms.
- WIREs mechanisms of disease
on Sep 27, 2022
Cancer treatment is gradually evolving from the classical use of nonspecific cytotoxic drugs targeting generic mechanisms of cell growth and proliferation. Instead, new "patient-specific treatment paradigms" that are based on an individual patient's ... Read More
Identification of the effects of COVID-19 on patients with pulmonary fibrosis and lung cancer: a bioinformatics analysis and literature review
- Scientific Reports
- VOL. 12
on Sep 26, 2022
AbstractCoronavirus disease 2019 (COVID-19) poses a serious threat to human health and life. The effective prevention and treatment of COVID-19 complications have become crucial to saving patients’ lives. During the phase of mass spread of the epidem... Read More
Integrative analysis in Pinus revealed long‐term heat stress splicing memory
- The Plant Journal
on Sep 24, 2022
Current scenario of climate change has led to increase number of studies describing main drivers in abiotic stress. Recent findings suggest that alternative splicing (AS) has a critical role in controlling plant response to high temperature. AS is a ... Read More
Research-driven education: An introductory course to systems and synthetic biology
- Frontiers in Systems Biology
- VOL. 2
on Sep 23, 2022
Systems and Synthetic Biology are complementary fields emerging side-by-side into mainstream scientific research. Whilst systems biologists focus on understanding natural systems, synthetic biologists wish to modify, adapt and re-purpose biological s... Read More
Network Physiology of Exercise: Beyond Molecular and Omics Perspectives
- Sports Medicine - Open
- VOL. 8
on Sep 23, 2022
Molecular Exercise Physiology and Omics approaches represent an important step toward synthesis and integration, the original essence of Physiology. Despite the significant progress they have introduced in Exercise Physiology (EP), some of their theo... Read More
Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma
- Frontiers in Immunology
- VOL. 13
on Sep 23, 2022
BackgroundThe coronavirus disease (COVID-19) pandemic has posed a significant challenge for global health systems. Increasing evidence shows that asthma phenotypes and comorbidities are major risk factors for COVID-19 symptom severity. However, the m... Read More
Network pharmacology and computer-aided drug design to explored potential targets of Lianhua Qingwen and Qingfei Paidu decoction for COVID-19
- Frontiers in Pharmacology
- VOL. 13
on Sep 23, 2022
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, has spread globally, affecting people’s lives worldwide and hindering global development. Traditional Chinese Medicine (TCM) plays a unique role in preventing and treating COVID-19. Representa... Read More
Viral Agents as Potential Drivers of Diffuse Large B-Cell Lymphoma Tumorigenesis
- Viruses
- VOL. 14
on Sep 22, 2022
Among numerous causative agents recognized as oncogenic drivers, 13% of total cancer cases occur as a result of viral infections. The intricacy and diversity of carcinogenic processes, however, raise significant concerns about the mechanistic functio... Read More
DRNASb: a systems biology approach to decipher dynamics of host-pathogen interactions using temporal dual RNA-seq data
- Microbial Genomics
- VOL. 8
on Sep 22, 2022
Infection triggers a dynamic cascade of reciprocal events between host and pathogen wherein the host activates complex mechanisms to recognise and kill pathogens while the pathogen often adjusts its virulence and fitness to avoid eradication by the h... Read More
In silico modeling for the hepatic circulation and transport: From the liver organ to lobules
- WIREs Mechanisms of Disease
on Sep 21, 2022
The function of the liver depends critically on its blood supply. Numerous in silico models have been developed to study various aspects of the hepatic circulation, including not only the macro-hemodynamics at the organ level, but also the microcircu... Read More
Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity
- Acta Physiologica
on Sep 20, 2022
The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a protein interaction hub and dynamic regulator of intra-cellular si... Read More
Pep27 Mutant Immunization Inhibits Caspase-14 Expression to Alleviate Inflammatory Bowel Disease via Treg Upregulation
- Microorganisms
- VOL. 10
on Sep 19, 2022
Inflammatory bowel disease (IBD) is a highly prevalent gut inflammatory disorder. Complicated clinical outcomes prolong the use of conventional therapy and often lead to compromised immunity followed by adverse events and high relapse rates. Thus, a ... Read More
Signatures of Co-Deregulated Genes and Their Transcriptional Regulators in Lung Cancer
- International Journal of Molecular Sciences
- VOL. 23
on Sep 18, 2022
Despite the significant progress made towards comprehending the deregulated signatures in lung cancer, these vary from study to study. We reanalyzed 25 studies from the Gene Expression Omnibus (GEO) to detect and annotate co-deregulated signatures in... Read More
Dissecting genetic links between Alzheimer’s disease and type 2 diabetes mellitus in a systems biology way
- Frontiers in Genetics
- VOL. 13
on Sep 16, 2022
Background: Alzheimer’s disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most common diseases for older adults. Accumulating epidemiological studies suggest that T2DM is a risk factor for cognitive dysfunction in the elderly. In this s... Read More
Decrypting the complexity of the human malaria parasite biology through systems biology approaches
- Frontiers in Systems Biology
- VOL. 2
on Sep 16, 2022
The human malaria parasite, Plasmodium falciparum, is a unicellular protozoan responsible for over half a million deaths annually. With a complex life cycle alternating between human and invertebrate hosts, this apicomplexan is notoriously adept at e... Read More
Potential Biomarkers and Signaling Pathways Associated with the Pathogenesis of Primary Ameloblastoma: A Systems Biology Approach
- International Journal of Dentistry
- VOL. 2022
on Sep 16, 2022
Objective. Ameloblastoma is a benign odontogenic tumor that may lead to ameloblastic carcinoma. This study aimed to determine potential signaling pathways and biological processes, critical genes and their regulating transcription factors (TFs), and ... Read More
Transcriptomics and systems biology identify non-antibiotic drugs for the treatment of ocular bacterial infection.
- iScience
- VOL. 25
on Sep 16, 2022
Increasing antibiotic resistance among ocular pathogens often results in treatment failure for blinding infections such as endophthalmitis. Hence, newer therapeutics is needed to combat multidrug-resistant infections. Here, we show a drug repurposing... Read More
A whole-genome assay identifies four principal gene functions that confer tolerance of meropenem stress upon Escherichia coli
- Frontiers in Antibiotics
- VOL. 1
on Sep 16, 2022
We report here the identification of four gene functions of principal importance for the tolerance of meropenem stress in Escherichia coli: cell division, cell envelope synthesis and maintenance, ATP metabolism, and transcription regulation. The prim... Read More
Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
- Frontiers in Immunology
- VOL. 13
on Sep 16, 2022
BackgroundThe COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global crisis. Although many people recover from COVID-19 infection, they are likely to develop persistent symptoms similar to those of myal... Read More