MRI has limited accuracy in diagnosing complex regional pain syndrome Type 1 - a systematic review of the literature.

Simple mucinous cysts of the pancreas: Clinical and imaging findings - Case series and systematic review of the literature.

Lateral femoral cutaneous neuropathy secondary to prior regional surgery: a systematic review of the literature.

Background: Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that has recognized anti-inflammatory and analgesic actions. Given that inflammation, excitotoxicity, oxidation damage, and microvascular and blood-brain barrier dysfunction are neurodegenerative processes typical of cognitive impairment in diseases such as Alzheimer's and Parkinson's, it is considered possible that treatments with supplemental PEA can alleviate chronic pain and protect against neuronal damage. to the patient. The objective is to analyze neurodegenerative and anti-inflammatory protective actions of Palmitoylethanolamide (PEA) in murine hippocampal neuronal cell line HT-22 subjected to hypoxia and reoxygenation to apply in patients diagnosed with neurodegenerative diseases. Material and methods: The methodology applied was a systematic review of the literature, and the material used was 12 studies according to inclusion criteria. Results:Murine model and in patients focused on Alzheimer's and Parkinson's, being the effective treatment of PEA with antioxidant supplements, frequent protective action at the hippocampal level and modulation of cytokine and proteins in addition to a decrease in acetylcholine (ACh). Other neurodegenerative diseases may benefit from PEA with further specific investigations (in murine model or patients. Conclusion: Intracellular signaling under PEA and investigation into other neurodegenerative diseases should be further explored.

Organisational competences in Services 4.0: a systematic review of the literature

A filum terminale arteriovenous fistula fed by the left L1 artery of adamkiewicz: a case report and updated systematic review of 71 cases.

Delirium is an acute neurocognitive disorder commonly seen in intensive care units (ICUs), associated with increased mortality, prolonged hospital stays, functional impairment, and long-term cognitive sequelae. Its timely identification and the implementation of preventive interventions continue to be a challenge for healthcare teams, especially nurses, given their central role in monitoring critically ill patients. Objective: to identify and analyze evidence-based protocols for the prevention of delirium in critically ill patients in intensive care units, with the aim of synthesizing the most effective strategies and strengthening evidence-based critical care. Method: a systematic review of the literature was conducted following the PRISMA 2020 guidelines. Studies were searched for in PubMed, Scopus, Web of Science, Cochrane Library, and SciELO. Studies published between 2020 and 2025, in English and Spanish, that addressed prevalence, risk factors, diagnostic methods, or interventions for the prevention and management of delirium in adults in the ICU were included. The selection was made through independent evaluation by two reviewers and consensus resolution. The risk of bias was assessed using validated tools (RoB2, ROBINS-I, AMSTAR-2, QUADAS-2). Results: Fifty-three studies were included, including clinical trials, cohorts, observational studies, systematic reviews, and instrument validations. The most common risk factors were advanced age, deep sedation, benzodiazepine use, prolonged mechanical ventilation, metabolic disturbances, and sleep deprivation. Non-pharmacological interventions—especially ABCDE/ABCDEF bundles, early mobilization, cognitive reorientation, sensory environment control, and family involvement—were most effective in preventing delirium. Pharmacological interventions (omega-3, minocycline, dexmedetomidine) showed promising but heterogeneous results. The CAM-ICU, ICDSC, and Nu-DESC tools were the most widely used for diagnosis. Conclusions: Delirium is a preventable syndrome that requires a comprehensive strategy based primarily on non-pharmacological interventions, continuous assessment, and active participation by the nursing team. The available evidence reaffirms the effectiveness of care bundles, early mobilization, and a multicomponent approach. Despite advances, limitations persist regarding the use of specific drugs and the standardization of diagnostic protocols. It is recommended to strengthen evidence-based practices and promote multicenter research evaluating innovative interventions and their long-term effects.

Augmented and Virtual Reality in Open Neurovascular Surgery: A Systematic Review of the Literature.

Diagnostic performance of diffusion-weighted imaging (DWI) in Legg-Calvé-Perthes disease: A systematic review and meta-analysis.

Underrepresentation of Africa in HIV cure research: A systematic review of the literature from 2010 to 2022

Worsening tricuspid regurgitation after mitral valve surgery: a meta-analysis and meta-regression.

Persistent suicidality: A systematic scoping review of the literature

The aim of the present study was to conduct a systematic review of the literature on changes in the trabecular bone of individuals with and without bruxism assessed through fractal analysis of panoramic radiographs. The review followed the PRISMA guidelines and used the PECOS strategy to formulate the research question and eligibility criteria, considering observational studies that analyzed changes in the mandibular trabecular bone of adults with and without bruxism. Two reviewers made the selection and a third reviewer intervened in cases of disagreement. Data were extracted and managed using the Rayyan software. Risk of bias was assessed using the Joanna Briggs tool. After the removal of duplicates and screening, eight studies were included in the review. Individuals with bruxism had lower fractal dimension values in the condylar region and higher values in the mandibular angle as well as the gonial and alveolar regions than those without bruxism. However, the meta-analysis found no statistically significant differences between participants with and without bruxism in the condylar and gonial regions, indicating that bruxism is not associated with evident structural changes in these areas. The present review revealed a relationship between bruxism and mandibular bone remodeling, with variations related to sex and age. However, the meta-analysis found no structural differences in the condyle or gonion between individuals with and without bruxism. These findings broaden the understanding of the impacts of bruxism on bone structure and can assist in the development of more effective clinical and therapeutic strategies. The protocol was registered with the Prospective International Register of Systematic Reviews under number CRD42023464946.

ABSTRACT This systematic literature review centers on diversity and inclusion in museology literature. Specifically, we investigated how museums are approaching inclusivity and diversity and. the extent to which the curb-cut effect discussed in the museum literature. We identified 68 peer-reviewed articles published between 2005 and 2024 and indexed in Google Scholar, ScienceDirect, EBSCO, or ProQuest. The articles were peer-reviewed, available in full text, and published in English. We find that diversity and inclusion efforts in museums is a relatively recent and growing tendency. Nine themes emerged in the literature: Community Connections, Anti-Ableism and Museums, Engaging the Next Generation, Systematic Transformation for Equity and Inclusion, Museums as Spaces of Social Change, Integrated Museum Engagement Frameworks, Digital Technology and Multisensory Environments, Cultivating Visitors’ Meaning-Making, and Becoming an Inclusive Museum. Together, these themes present a comprehensive understanding of the ways in which museums are working towards becoming more relevant, accessible, and impactful in fostering equity, inclusion, and cultural participation.

BackgroundBreast cancer remains one of the most prevalent and lethal malignancies among women worldwide. Axillary lymph node (ALN) metastasis is a critical prognostic factor guiding treatment, yet the current diagnostic approaches such as sentinel lymph node biopsy (SLNB) and axillary lymph node dissection (ALND) are invasive and carry notable risks. Noninvasive imaging modalities including magnetic resonance imaging (MRI) and ultrasound (US) have shown value in ALN evaluation but exhibit limitations in accessibility, operator dependence, and diagnostic accuracy. Meta-analyses on this subject have largely focused on single modalities or included outdated data. This study thus aimed to provide an updated nondirect comparative assessment of conventional ultrasound (CUS), contrast-enhanced ultrasound (CEUS), and MRI in detecting ALN metastasis through a review of the relevant literature published between 2014 and 2025.MethodsRelevant studies on CUS, CEUS, and MRI published from January 2014 to September 2025 in the PubMed, Embase, and Web of Science databases were retrieved before September 5, 2025. Histopathological findings from SLNB or ALND served as the reference standard. Study quality and bias risk were assessed via the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. A bivariate random-effects model was applied to estimate the pooled sensitivity, pooled specificity, diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic curve (AUC) for meta-analysis. This study was registered with the PROSPERO (International Prospective Register of Systematic Reviews) (No. CRD42024589342).ResultsA total of 41 studies comprising 53 datasets examining patients with breast cancer, comprising 17 CUS studies (n=5,603), 20 CEUS studies (n=2,907), and 16 MRI studies (n=2,232), that met the inclusion and exclusion criteria were included. Each study used SLNB or ALND as the histopathological reference standard. Among the 17 studies on CUS, the pooled sensitivity and specificity for detecting ALN metastasis were 0.69 (95% CI: 0.56–0.80) and 0.85 (95% CI: 0.77–0.90), respectively, while the AUC was 0.85 (95% CI: 0.82–0.88). Among the 20 studies on CEUS, the combined sensitivity and specificity for detecting ALN metastasis were 0.86 (95% CI: 0.79–0.91) and 0.88 (95% CI: 0.84–0.91), respectively, while the AUC was 0.93 (95% CI: 0.90–0.95). Among 16 studies on MRI, the pooled sensitivity and specificity for detecting ALN metastasis were 0.62 (95% CI: 0.53–0.71) and 0.85 (95% CI: 0.79–0.89), respectively, while the AUC was 0.82 (95% CI: 0.78–0.85). Additionally, QUADAS-2 assessment indicated a low overall risk of bias. Meta-regression analysis revealed that sample size, study design, publication year, and specific technical characteristics were significant sources of heterogeneity across CUS, CEUS, and MRI modalities, generally influencing specificity, although sample size also significantly affected sensitivity in CEUS, and sensitivity analysis confirmed the robustness of the result. Deeks’ funnel plot showed no substantial publication bias except for in the CEUS studies (P>0.05).ConclusionsCUS, CEUS, and MRI possess distinct advantages in detecting ALN metastasis of breast cancer. However, in the selection of imaging diagnostic methods for clinical decision-making, factors such as cost and technical demand should be carefully considered.

Emergence of therapeutic resistance is a critical clinical challenge in cancer treatment, contributing to treatment failure, disease relapse, and overall poor prognosis. Adaptive therapy (AT), a resistance management strategy, aims to address this issue by selectively applying therapeutic pressure to promote competition between therapy-sensitive and therapy-resistant clones, allowing for long-term control of tumor burden. AT relies upon the assumption that resistance comes at some fitness cost in the absence of therapy. Is that assumption justified? We conducted a systematic review of the literature on experimental tests of the fitness cost of therapeutic resistance. We conducted a search for peer-reviewed papers that fulfilled the following selection criteria: (i) experiments of direct competition, (ii) between therapy-resistant and therapy-sensitive clones, (iii) in a therapy-free environment. We found 47 experiments that matched those criteria. Of those experiments, approximately two-thirds (68%) found a fitness cost to resistance in a competitive environment. Of all pooled features from the studies reviewed, we found that the resistance characteristic was most significantly associated with whether resistant clones exhibited a fitness advantage in competition (p=0.0147). Further, we identify complex ecological interactions that may influence the behavior of the cancer cell population without selection by therapeutic pressure. Predicting which resistance characteristics can be exploited therapeutically with AT and identifying potential methods of modulating the costliness of the resistant phenotype may be critical to future improvements in cancer therapy.

The case study approach has been consolidated in higher education as a pedagogical methodology that promotes deep, active and contextually relevant learning. This research, developed through a systematic review of the literature between 2017 and 2024, analyzes the strengths and weaknesses associated with the use of this methodology. The information was obtained from databases such as Scopus, Web of Science and Google Scholar, using rigorous inclusion criteria based on the PRISMA protocol. Among the most outstanding contributions are the improvement in academic performance, the promotion of metacognitive abilities, autonomy in learning and the transfer of knowledge to practical contexts, especially in areas such as health and education. Despite these benefits, limitations related to resistance to modifying traditional practices, heterogeneity of learning styles, and temporal constraints within academic programs are recognized. It is concluded that the case study represents an effective way for comprehensive training, as long as its implementation is supported by a favorable institutional structure, continuous teacher training and curricular adjustments that facilitate its regular use. It is recommended to develop longitudinal studies and explore student perception of this strategy, particularly in hybrid or virtual environments.

Background/Objectives: Appendiceal collision tumors (ACTs), defined by the coexistence of two or more histologically distinct neoplastic components within the appendix, are rare entities. We aimed to characterize their clinicopathologic features, management strategies, and outcomes by integrating an institutional case series with a systematic review of the literature. Methods: We retrospectively identified ACTs diagnosed at our institution and performed a PRISMA 2020-guided search of PubMed, Scopus, and Web of Science databases through May 2025 for case reports and case series. Two reviewers screened studies and extracted data on presentation, histologic composition, treatment, approaches and outcomes. Results: ACTs accounted for 4% of appendiceal tumors in our institution, all combining a neuroendocrine neoplasm (NEN) with a low-grade appendiceal mucinous neoplasm. The literature search identified 69 ACTs from 33 studies; pooled with our cases, 74 patients were evaluated. The most common pairings were NEN–appendiceal mucinous neoplasm (53%) and NEN–adenocarcinoma (26%), while three-component tumors were rare (n = 2). Early-stage tumors (pTis–pT1) were uniformly managed with appendectomy or limited resection, in line with established stage-based management algorithms for appendiceal neoplasms. Advanced-stage tumors (pT3–pT4) were treated according to the biologically dominant component, frequently with colectomy and, in high-risk mucinous disease, cytoreductive approaches. Across stages, outcomes appeared to be driven by the non-neuroendocrine component; a coexisting low-grade NEN did not independently confer worse prognosis. In ACTs with an adenocarcinoma component, goblet cell morphology was common, and outcomes appeared similar to those reported for non-collision appendiceal adenocarcinoma. Conclusions: ACTs represent a heterogeneous group in which prognosis is dictated by the non-neuroendocrine component and tumor stage. Low-grade NEN components appear biologically indolent, whereas adenocarcinoma and high-risk mucinous components have been observed to exhibit behavior similar to their solitary counterparts.

Over the last decade, the accounting function has evolved from a role focused on recording and compliance to that of a strategic partner to management. This systematic review of the literature from 2020 to 2025 explores how artificial intelligence (AI) is disrupting accounting by automating processes, generating predictive information and supporting decision-making. Five objectives are examined: (1) mapping the evolution of accounting within the company; (2) classifying AI applications according to technologies and processes; (3) assessing the impact of AI on the quality and use of accounting information; (4) analysing the relationship between accounting AI and value creation; and (5) identifying contingent factors and barriers. The results indicate that adopting AI enables accounting to free up time from routine tasks and to collaborate actively in the design of the business model. The technologies used range from machine learning and language processing to intelligent robotics, applied to automation, forecasting, and anomaly detection. AI improves the accuracy and timeliness of information, though it poses challenges in terms of explainability and governance. Value creation depends on the right combination of data, analytical capabilities and good governance. The review reveals barriers such as data quality, implementation costs and cultural resistance, and proposes a configurational framework linking AI, processes, information, management decisions and value creation.

The acronym ESG, which stands for environmental, social and governance initiatives, is gaining increasing importance in the Brazilian agribusiness sector. Brazil is a global agricultural powerhouse, but it faces significant challenges related to sustainability. In the ESG context, there is increasing pressure for agribusiness companies to adopt practices that minimize environmental impacts, promote social well-being and improve their governance structures. Given this context, the objective of this study is to identify the results and trends in scientific research on environmental, social and governance initiatives in Brazilian agribusiness between 1986 and 2024. The research combined a bibliometric analysis with a systematic review of the literature, which resulted in 140 scientific articles. The results demonstrate the growth of scientific research on the subject of the study with a large number of researchers and institutions in Brazil. Environmental initiatives are the most recurrent in current studies and future challenges focus on the development of new production systems, higher levels of communication, regulation and a greater balance between ESG initiatives and the economic dimension.