Synthesis Of Dithioacetals Research Articles

Synthesis of dithioacetals via nucleophilic substitution and their antifungal activity evaluation.

A novel dual nucleophilic substitution reaction of dichloromethane with thiols has been developed, which affords dithioacetals in up to 96% yields. This dual substitution reaction with two different nucleophiles is also successfully developed with α-acyloxy sulfides as the product. In addition, in vitro antifungal activity tests against L. theobromae disclose that these α-acyloxy sulfides exhibit excellent antifungal activity with an inhibition rate up to 100 ± 0%. This reaction provides efficient access to potential bioactive dithioacetals from readily available starting materials.

Synthesis of Dithioacetals through Iodine-Promoted Insertion Reactions of Vinylsilane to Disulfides and its Application to Diselenoacetalization

AbstractDescribed herein is an iodide-promoted insertion reaction of vinyltrimethylsilane into diaryl or dialkyl disulfides in the presence of iodine/KF leading to the production of a 1,1′-adduct, a dithioacetal derivative. This method also accomplishes insertion into a diaryl diselenide to afford the corresponding diselenoacetal derivative.

One‐Pot Synthesis of Dithioacetals and Diselenoacetals: An Indium‐Catalyzed Reductive Insertion into Disulfides and Diselenides with Orthoesters as a Methylene Source

One‐Pot Synthesis of Dithioacetals and Diselenoacetals: An Indium‐Catalyzed Reductive Insertion into Disulfides and Diselenides with Orthoesters as a Methylene Source

One‐Pot Synthesis of Dithioacetals and Diselenoacetals: An Indium‐Catalyzed Reductive Insertion into Disulfides and Diselenides with Orthoesters as a Methylene Source

AbstractHerein it is described that an indium(III) compound effectively catalyzes a reductive insertion into either diaryl or dialkyl disulfides with orthoesters to produce a variety of dithioacetal derivatives. This method could also be adapted to the diselenoacetalization of diselenides. During a series of reductive insertions using this method, it is noteworthy that an orthoester functions as a masked methylene moiety.

Synthesis of Open-Chain Dithioacetals from Thiophene-2-carbaldehyde and Its Analogs

A procedure for the synthesis of dithioacetals containing various thiophene fragments was developed on the basis of the reaction of thiophene-2-carbaldehyde and its analogs with thiols in chlorotrimethylsilane.

Synthesis of Dithioacetals and Oxathioacetals with Chiral Auxiliaries.

AbstractFor Abstract see ChemInform Abstract in Full Text.

Synthesis of Dithioacetals and Oxathioacetals with Chiral Auxiliaries

One‐pot synthesis of dithioacetals as well as an efficient method for oxathioacetal is reported. Additionally, some chiral auxiliaries were used to synthesize enantiomerically pure dithioacetals and oxathioacetals.

Efficient synthesis of dithioacetals of ?-oxoketene and dithiofulvenes under phase transfer catalysis conditions

Efficient synthesis of dithioacetals of ?-oxoketene and dithiofulvenes under phase transfer catalysis conditions

ChemInform Abstract: Synthesis of Dithioacetals (IV) from Carbonyl Compounds (I) and Thiols (II) in the Presence of Polyphosphoric Acid Trimethylsilyl Ester (PPSE) (III).

ChemInform Abstract: Synthesis of Dithioacetals (IV) from Carbonyl Compounds (I) and Thiols (II) in the Presence of Polyphosphoric Acid Trimethylsilyl Ester (PPSE) (III).

Synthesis of Dithioacetals from Carbonyl Compounds and Thiols in the Presence of Polyphosphoric Acid Trimethylsilyl Ester (PPSE)

Dithioacetals were synthesized from carbonyl compounds and thiols in the presence of polyphosphoric acid trimethylsilyl ester (PPSE) Aldehydes, Ketones, and trioxane could be used as carbonyl compounds, and aromatic, primary, secondary, and tertiary thiols were applicable in the present reaction. The reaction between cyclohexanone and t-butyl thiol afforded a mixture of corresponding dithioacetal and t-butylcyclohexenylsulfide.

Stepwise reduction of carbon disulfide in the coordination sphere of tungsten. A transition-metal-mediated synthesis of dithioacetals

Reduction de mer-W(CO) 3 (dppe) (η 2 −CS 2 ), avec LiHBEt 3 donnant le complexe dithioformiate fac−Et 4 N [W(CO) 3 (dppe) (η 1 −SCHS)] qui reagit avec les halogenures d'alkyle en 2 etapes jusqu'a mer-[W(CO) 3 (dppe) (η 2 −R'SCHSR)]X reduit en complexes de dithioacetal