Synthesis Of Diethyl Research Articles

ChemInform Abstract: Chloro(trimethyl)silane‐Catalyzed Three‐Component Condensation of Diethyl 3,3′‐(1,3‐Phenylene)bis(3‐oxopropanoate) with Aromatic Aldehyde and Urea. New Synthesis of Diethyl 4,4′‐(1,3‐Phenylene)bis (2‐oxo‐1,2,3,6‐tetrahydropyrimidine‐5‐carboxylates) (IV).

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract: Synthesis of Diethyl 2‐Thioxo‐1,2,3,4‐tetrahydro‐ and Hexahydropyrimidine‐5‐phosphonates.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis of diethyl 2-thioxo-1,2,3,4-tetrahydroand hexahydropyrimidine-5-phosphonates

The reaction of sodium enolate of diethyl (2-oxoprop-1-yl)phosphonate with N-(1-tosylprop-1-yl)thiourea results in the stereoselective formation of diethyl (4R*,5R*,6R*)-6-ethyl-4-hydroxy-4-methyl-2-thioxohexahydropyrimidine-5-phosphonate, which is transformed into diethyl 4-ethyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-phosphonate and diethyl (4R*,5S*,6R*)-4-ethyl-6-methyl-2-thioxohexahydropyrimidine-5-phosphonate by acid-catalysed dehydration and stereoselective reduction with NaBH4–CF3COOH, respectively.

Reaction of diethyl thiocyanatomethylphosphonate with aldehydes as a route to diethyl Z‐1‐alkenylphosphonates

AbstractDiastereoselective synthesis of diethyl Z‐1‐alkenylphosphonates from easily available diethyl thiocyanatomethylphosphonate and aromatic aldehydes has been developed. Olefination of the aldehydes occurs under mild conditions and affords the title compounds with moderate yields. A plausible mechanism of the above‐mentioned reaction is also discussed. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:732–739, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20371

1-Trifluoromethyl-1-diethoxyphosphoryl Carbene: A New Synthon for the Preparation of CF3-Containing α-Hydroxy and α-Amino Phosphonic Acid Derivatives

The first synthesis of diethyl 1-diazo-2,2,2-trifluoroethylphosphonate has been developed starting from readily available compounds. The synthetic utility of this compound is demonstrated via its Rh-catalyzed insertion into O-H and N-H bonds to produce CF3-substituted α-hydroxy phosphonic and α-amino phosphonic acid derivatives

Synthesis and Conformation of Diethyl 2,3‐Diaryltetrahydro‐4,5‐isoxazoledicarboxylates.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Synthesis of diethyl [carbonyl-11C]malonate from [11C]carbon monoxide by rhodium-promoted carbonylation and its application as a reaction intermediate

Rhodium-mediated carbonylation reaction was applied to synthesize diethyl [carbonyl-11C]malonate using [11C]carbon monoxide at low concentration. The synthesis was performed starting with ethyl diazoacetate, ethanol and the rhodium complex being made in situ by chloro(1,5-cyclooctadiene)rhodium(I) dimer ([Rh(cod)Cl]2) and 1,2-bis(diphenylphosphino)ethane (dppe), and the reaction is assumed to proceed via a ketene intermediate. The isolated radiochemical yield was 20% (75% analytical radiochemical yield) and the trapping efficiency of [11C]carbon monoxide in the order of 85%. The specific radioactivity of this compound was measured at 127 GBq/µmol (7.28 nmol total mass) after 8 µAh bombardment and 35 min synthesis. The corresponding 13C-labelled compound was synthesized using (13C)carbon monoxide to confirm the position of the carbonyl-labelled atom by 13C-NMR. Diethyl [carbonyl-11C]malonate was further used in subsequent alkylation step using ethyl iodide and tetrabutylammonium fluoride to obtain diethyl diethyl [carbonyl-11C]malonate in 50% analytical radiochemical yield. Copyright © 2006 John Wiley & Sons, Ltd.

Synthesis and conformation of diethyl 2,3-diaryltetrahydro-4,5-isoxazoledicarboxylates

The microwave assisted synthesis of diethyl 2,3-diaryltetrahydro-4,5-isoxazoledicarboxylates by the cycloaddition of diethyl maleate with appropriate nitrones was carried out. The conformational aspects of the title compounds were investigated by NMR and X-ray studies and the features are compared with a set of related tetrahydroisoxazoles highlighting the effect of substituents on the conformation of central five mem-bered ring.

Synthesis and spectroscopy of diethyl (pyridinylmethyl)phosphates and their palladium (II) complexes: X-ray crystal structures of Pd(II) complexes

The synthesis of diethyl (pyridin-2-, -3-, -4-ylmethyl)phosphate (2-pmOpe, 3-pmOpe, 4-pmOpe) ligands and their palladium (II) complexes of general formula trans-[PdCl 2L 2] (L = 2-pmOpe, 3-pmOpe,4-pmOpe) has been described. Pyridine phosphate derivatives were synthesized via the condensation of phosphorochloridic acid diethyl ester with an appropriate pyridinylmethanol in the presence of triethylamine. The compounds have been identified and characterized by IR, far-IR, 1H NMR, 31P NMR, 31P CP-MAS NMR and elemental analyses. The crystal and molecular structures of palladium (II) complexes, i.e., [PdCl 2(2-pmOpe) 2] and [PdCl 2(4-pmOpe) 2] determined by the X-ray diffraction method, are presented. In both structures, Pd(II) ions are four-coordinated by two chlorine atoms and two pyridine nitrogen atoms. The geometry of complexes is square-planar and adopt a trans configuration, which is consistent with preparation method.

Synthesis of diethyl 2H‐naphtho[2,1,b]pyran‐2,3‐dicarboxylate and some related compounds as UV absorbers

PurposeSynthesis and evaluation of new naphthopyran and related compounds as ultraviolet absorbers.Design/methodology/approachThe new naphthopyran and related compounds were prepared using new synthesis methodology which gave new derivatives via positions not accessible by traditional methods.FindingsA new method for the preparations of naphthopyran was developed. The naphthopyran compounds prepared had promising UV absorption/protection capabilities.Practical implicationsThe new compounds synthesised had unique character enabling them to be used in applications such as UV absorber and sunscreen.Originality/valueNew method of synthesis and the possibility of using the naphthopyran derivatives as UV absorber in many applications.

A novel synthesis of diethyl ( R)-3-( N-benzyloxyamino)-2-hydroxypropylphosphonate, a precursor to hydroxylamine antibiotics FR-33289 and FR-33699

Regioselective opening of the oxirane ring at C(3) of diethyl 2,3-epoxypropylphosphonate 6 with N- or O-benzylhydroxylamine led to 3-( N-benzyl- N-hydroxyamino)- or 3-( N-benzyloxyamino)-2-hydroxypropylphosphonates, 10 or 8. From ( S)- 6 (ee 94%), the phosphonate ( S)- 10 (ee 98%) was prepared in 80% yield. Highly enantiomerically enriched ( R)- and ( S)- 8 (ee 97%) were obtained from ( R)- and ( S)- 6 (ee 88% and 94%), respectively.

ChemInform Abstract: Synthesis of Diethyl 3,4‐Dicyano‐5‐hydroxy‐2‐oxo‐7‐phenyl‐1,2,4a,7‐tetrahydroquinoline‐6,8‐di carboxylate and Its Reaction with Piperidine.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis of diethyl (1 R,2 R)- and (1 S,2 R)-3-acetamido-1,2-dihydroxypropylphosphonates

Diastereomeric diethyl (1 R,2 R)- and (1 S,2 R)-2,3-epoxy-1-benzyloxypropylphosphonates were obtained from the respective 2,3- O-cyclohexylidene-1-hydroxypropylphosphonates via the following sequence of reactions: benzylation, acetal hydrolysis and transformation of the terminal diol into the epoxide using the Sharpless protocol. These epoxides were regioselectively opened with dibenzylamine to afford the title compounds after acetylation and hydrogenolysis.

Synthesis of Diethyl (2-acetyl-5-methyl-3-oxo-1,2,3λ5-Δ5-diazaphospholin-3-yl)methylphosphonate

Synthesis of Diethyl (2-acetyl-5-methyl-3-oxo-1,2,3λ5-Δ5-diazaphospholin-3-yl)methylphosphonate

Synthesis of Diethyl 3,4-Dicyano-5-hydroxy- 2-oxo-7-phenyl-1,2,4a,7-tetrahydroquinoline-6,8-dicarboxylate and Its Reaction with Piperidine

Synthesis of Diethyl 3,4-Dicyano-5-hydroxy- 2-oxo-7-phenyl-1,2,4a,7-tetrahydroquinoline-6,8-dicarboxylate and Its Reaction with Piperidine

A FACILE SYNTHESIS OF DIETHYL 1- ISOTHIOCYANO)ALKYLPHOSPHONATES[1

Novel, diethyl 1-(isothiocyano)alkylphosphonates 3 have been efficiently synthesized via a one-pot reaction of diethyl 1-azidoalkylphosphonates 1 with triphenylphosphine, followed by in situ transformation of thus formed phosphazenes 2 with carbon disulfide. Application of the title compounds in the synthesis of diethyl (N-phenylthioureido)- and (benzothiazol-2-ylamino)methylphosphonates was also described.

Stereoselective addition of sodium organyl chalcogenolates to alkynylphosphonates: synthesis of diethyl 2-(organyl)-2-(organochalcogenyl)vinylphosphonates

Organyl thiolate, selenolate or tellurolate anions reacted with alkynylphosphonates 1 to give diethyl 2-(organyl)-2-(organochalcogenyl)vinylphosphonates [β-organochalcogenyl vinylphosphonates] 2 in satisfactory yields. The reaction was stereoselective, giving predominantly or exclusively the ( Z) -stereoisomer.

Application of 1-Azidoalkylphosphonates in the Synthesis of Phosphonodipeptides and Other N-Substituted Aminophosphonates

Efficient synthesis of diethyl 1-(isothiocyano)alkylphosphonates, and N-derivatives of diethyl 1-aminoalkylphosphonates as well as phosphonodipeptides were developed using diethyl 1-azidoalkylphosphonates as starting materials.

ChemInform Abstract: A Novel Synthesis of Diethyl 1‐Aminoarylmethylphosphonates on the Surface of Alumina.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract: Synthesis of Diethyl 3‐(Trifluoromethyl)glutamate.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.