Hyaluronic Acid In Synovial Fluid Research Articles

Analysis of ‘Boosted Lubrication’ in Human Joints

The load-bearing human joint is a self-acting dynamically loaded bearing which employs a porous and elastic bearing material (articular cartilage) and a highly non-Newtonian lubricant (synovial fluid). The authors' understanding is that the human joint experiences fluid-film (including elastohydrodynamic), mixed and boundary lubrication in its various operating conditions. It has been recognized that squeeze-film action is capable of providing considerable protection to the cartilage surface once a fluid film is generated (6) (8)§. Furthermore, the possibility of an increasing concentration of hyaluronic acid in synovial fluid during the squeeze-film action due to the porous nature of the cartilage and its surface topography and the known relationship between this concentration and the effective viscosity (7) has led to the concept of ‘boosted lubrication’ as an important feature of joint behaviour (10). A mathematical analysis of the concept of boosted lubrication of human joints is presented in this paper. The predictions of the analysis are shown to be in good agreement with experimental findings (12).

Hyaluronic acid in synovial fluid. 3. Effect of maturation and aging on the chemical properties of bovine synovial fluid of different joints.

Hyaluronic acid in synovial fluid. 3. Effect of maturation and aging on the chemical properties of bovine synovial fluid of different joints.

Concentration of Hyaluronic Acid in Synovial Fluid

Abstract 1. The concentration of hyaluronic acid in synovial fluid was determined by a modification of the Dische carbazole method for the determination of uronic acids. 2. The results of this determination in 80 specimens of normal and abnormal synovial fluid confirmed values reported by other methods. 3. An inverse relationship between the hyaluronic acid in the synovial fluid and the degree of synovitis was suggested.

The physiological function of hyaluronic acid in synovial fluid; viscous, elastic and lubricant properties.

The Journal of PhysiologyVolume 119, Issue 2-3 p. 244-252 ArticleFree Access The physiological function of hyaluronic acid in synovial fluid; viscous, elastic and lubricant properties A. G. Ogston, A. G. OgstonSearch for more papers by this authorJ. E. Stanier, J. E. StanierSearch for more papers by this author A. G. Ogston, A. G. OgstonSearch for more papers by this authorJ. E. Stanier, J. E. StanierSearch for more papers by this author First published: 27 February 1953 https://doi.org/10.1113/jphysiol.1953.sp004842Citations: 222AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume119, Issue2-3February 27, 1953Pages 244-252 RelatedInformation

On the state of hyaluronic acid in synovial fluid

On the state of hyaluronic acid in synovial fluid