Drawing on Douglas and Stemerding's special issue of Systems and Synthetic Biology that examined synthetic biology in relation to global health, I suggest that synthetic biology (syn bio) work in global health should attend seriously to local contexts and would benefit from historical and anthropological insights. Specifically, I emphasize the importance, in syn bio projects, of: (1) the inclusion of multiple publics from the outset, (2) locating the technological promise of syn bio in broader social projects and contexts, and (3) subjecting syn bio institutions and projects to examination.
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