The inflammatory biomarker, soluble urokinase plasminogen activator receptor (suPAR), has emerged as a promising prognostic biomarker in cardiovascular diseases. However, little is known about suPAR levels in patients admitted with acute heart failure (AHF). This study investigates the prevalence and prognostic value of elevated suPAR in patients hospitalized with AHF. This cohort study included patients presenting with cardiopulmonary symptoms at the Medical Emergency Department of University Hospital Amager-Hvidovre, Denmark, between March 10, 2020, and March 31, 2022. SuPAR was measured upon admission, with the median time from admission to measurement of two hours (IQR 3.9 - 6.9). A cardiologist adjudicated whether the patients had AHF. Patients were stratified according to validated cut-off values of suPAR <6ng/ml and≥6ng/ml. Kaplan-Meier survival analysis and Cox regression were used to assess the association between suPAR levels and one-year mortality. A total of 386 (3.8%) AHF patients, from a total population of 10,027, were included. The mean suPAR value was significantly higher among AHF patients compared to non-AHF patients: 6.2ng/ml (standard deviation [SD]=4.8ng/ml) vs 4.4ng/ml (SD=2.9ng/ml), p<0.001. A suPAR level≥6ng/ml was significantly associated with mortality, log-rank-p-value <0.0001. Furthermore, Cox regression analysis demonstrated that elevated suPAR levels were independently associated with increased risk of mortality with a hazard ratio (HR): 1.06 (95% CI: 1.03-1.1, p<0.001) after adjusting for potential confounders. SuPAR levels measured at hospital admission in AHF patients correlate significantly with one-year mortality and outperform C-reactive protein, supporting their potential role in early prognostication to identify high-risk patients.

Comparative clinical utility of the 2024 Fleischner Society updated glossary versus traditional classifications for pulmonary subsolid nodules.

Diosgenin targets ITGA11-driven angiogenesis in hepatocellular carcinoma: Prognostic and mechanistic insights.

Integrative transcriptomic and machine learning analysis identifies CDH17 and HOXC13 as robust candidate prognostic biomarkers in uveal melanoma.

Deep burn index as a significant prognostic factor of patients with burns≥ 70 % TBSA: A retrospective study.

Adoption and dis-adoption of push-pull technology in East Africa: Evidence from survival analysis and machine learning

The purpose of our study was to describe the time to full oral enteral feeding for extremely low birth weight (ELBW) infants in the neonatal intensive care unit (NICU). We conducted a retrospective chart review of ELBW infants born at a regional medical center between July 1, 2021, and December 31, 2022. Infants who died or were transferred before discharge from the NICU were excluded from the study. Fifty four ELBW infants met the inclusion criteria for the study. Survival analysis was conducted using Kaplan-Meier curves to estimate the time to full oral feeds over an observation period of up to 153 days. A total of 25% of all ELBW infants achieved full oral feeding by 94 days of life, and 33.3% achieved full oral feeding before discharge from the NICU. The median time to full oral feeding for ELBW infants born at 27 to 30 weeks gestational age was 82 days. After adjusting for gestational age and birthweight, infants who did not achieve full oral feeds were discharged 12 days later (95% confidence interval: 2-23 days; P = 0.02) than infants who achieved full oral feeds. The majority of ELBW infants did not achieve full oral feeding before NICU discharge. Early discussion of an alternate home feeding plan may shorten the duration of NICU stay.

Network centrality-driven TOPSIS approach for prioritizing cancer therapeutic targets.

Feasibility and oncologic outcome of en resection with intentional tumor transgression in primary spinal sarcoma: The Korean Society of Spinal Tumors multicenter study (KSST 2024-02).

Tracking photoinhibition and failure dynamics in algae under combined exposure to UVB and water-accommodated oil fractions.

Survival analysis and prognostic factors in advanced NSCLC harboring EGFR PACC mutations: A multicenter retrospective study.

Single-cell analysis of TIGD genes in hepatocellular carcinoma: Prognostic value and functional characterization.

Multi-omics profiling of ACOX3 unveils pan-cancer clinical biomarker potential.

Clinical value of the tissue Doppler derived index of myocardial performance (Tei index) in cats with hypertrophic cardiomyopathy.

Fish oil supplementation and clinical outcomes in patients with sepsis-associated acute kidney injury: A retrospective cohort study from the MIMIC-IV database.

Comparison of Total Leukocyte Chimerism and Lymphocyte Subset Chimerism for Early Detection of Post-Transplant Complications.

Machine learning survival analysis for predicting kidney disease progression in patients with acute kidney injury undergoing continuous kidney replacement therapy: An analysis of the LINKA database.

REST-driven upregulation of SFXN3 promotes AML progression via Wnt/β-catenin activation and confers decitabine resistance.

The association between cancer history and long-term body composition based on a 10-year follow-up.

Therapeutic effects of fingolimod through sphingosine-1-phosphate signaling in pulmonary arterial hypertension.