Surface roughness is one of the most important factors that play an important role in increasing the connection between the surface of the tooth and the applied restoration. Due to the increased interest in zirconia and the improvement of its mechanical and aesthetic properties, studies have increased that work to improve and increase its surface roughness so that it can be used as a veneer in the future. This study aims to compare the effect of two types of lasers on the surface of highly transparent zirconia to evaluate the surface roughness resulting from the two techniques. The study sample consisted of 20 ceramic cubes made of translucent zirconia (DD cubeX2, Dental Direct, Germany). It was made using a CAD-CAM Zircodenta device (Imes-Icore, Germany) and a zirconia sintering furnace (Imes-Icore, Germany). The study sample was divided into two groups; the first group consisted of 10 cubes exposed to Nd:YAG laser and the second group consisted of 10 discs exposed to continuous wave CO2 laser. The surface roughness test was conducted for the study samplesin each of the groups using a surface roughness tester. Data were collected and analyzed using SPSS v25 software. The surface roughness was measured and its mean was 1.208±0.22in the Nd:YAG laser group and 0.809±0.21in the CO2laser group. There was a significant difference between the study groups according to the independent sample T-test. This study concluded that the Nd:YAG laser surface roughensof zirconia isgreaterthan the continuous wave CO2 laser, with a substantially significant difference.
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