The human tendency to slow down immediately following an error is commonly reported in cognitive psychology. This is referred to as post-error slowing (PES), which appears to reflect an engagement of mental resources that impact subsequent behavior. Is PES evident in a reactive balance task where cancellation of a highly-prepotent balance recovery step is emphasized? Data were pooled from two studies (N = 41) to investigate PES in a reactive balance context. Participants were released from a supported forward lean, which triggered a rapid balance recovery step. A STOP signal (tone) was occasionally delivered shortly after release of the support cable (i.e., postural perturbation). On these trials, participants were instructed to suppress a step and relax into a secondary, failsafe cable. Force plates detected step responses to measure reaction time post-perturbation (GO cue). The main outcome was step reaction time to determine if reactions slowed immediately following a STOP signal, particularly if a step error occurred. Participants had significantly slower step reactions following a STOP signal. This was evident both on GO trials after an error and following successful suppression trials. Follow-up analysis revealed that stopping accuracy was inversely correlated with PES. However, this relationship was not present following successful stopping trials. PES offers a novel way to assess the cognitive contribution to reactive balance, including quantification of how we learn from recent experience and adapt to future events. This may offer an important metric of cognitive control in gait and posture research.

Laryngopharyngeal Reflux and Chronic Cough.

ABSTRACT Active forgetting through retrieval suppression can impair memory for information encountered nearby in time (“amnesic shadow”). Whether this collateral effect extends to spatial memory is unclear. Across three experiments, we examined how suppression influences the encoding of new spatial memories. Experiment 1 used a modified hippocampal-modulation paradigm that paired the Think/No-Think task with a spatial location task. Spatial locations encoded between suppression trials were recalled less accurately than those encoded between retrieval trials or a baseline, evidencing an amnesic shadow for spatial memory. Experiment 2 introduced a 24-hour delay and showed that the deficit persisted, indicating durability beyond initial encoding. Experiment 3 manipulated control strategies: direct suppression produced the shadow, whereas thought substitution did not impair nearby spatial learning. Together, the results support systemic-suppression accounts in which prefrontal control transiently down-regulates hippocampal function, broadly weakening hippocampus-dependent processes. By extending the amnesic shadow to spatial memory and isolating it to direct suppression, this work provides a strategy-specific behavioural marker of memory control and clarifies how attempts to contain unwanted thoughts can unintentionally degrade concurrent spatial learning.

ABSTRACT Traditional hydrogels face limitations in suppressing coal spontaneous combustion due to their reliance on physical mechanisms (heat absorption and oxygen isolation) and lack of chemical inhibition, compounded by intricate preparation procedures. To address these limitations, this study developed a CAA-TA composite hydrogel with synergistic physical-chemical inhibition properties. The hydrogel was synthesized using carboxymethyl cellulose (CMC) as the matrix, acrylamide (AM) and 2-acrylamido-2-methylpropanesulfonic acid (AMPS) as copolymerization monomers, and tannic acid (TA) as an antioxidant. The optimal formulation was determined by optimizing gelation time, water retention, and permeability to meet mine fire prevention requirements. Fourier transform infrared spectroscopy (FTIR) confirmed the successful grafting of AM-AMPS onto the CMC backbone, while hydrogen bonding interactions between the hydroxyl groups of CMC, phenolic hydroxyl groups of TA, and N-H groups of AM contributed to a stable three-dimensional network structure. Scanning electron microscopy (SEM) revealed a dense wrinkled surface and honeycomb-like porous morphology, which enhanced water confinement through physical entrapment and capillary effects, endowing the hydrogel with high water retention and stability. Programmed heating tests highlighted superior low-temperature inhibition, with CAA-TA treated coal exhibiting 52.2% and 56.7% reductions in CO emissions at 100°C and 180°C, respectively, outperforming TA-free counterparts. Fire suppression trials demonstrated rapid temperature reduction from 800°C to 88.9°C within 30 min without re-ignition, surpassing conventional CAA hydrogels. The CAA-TA composite hydrogel achieves efficient coal spontaneous combustion inhibition through a synergistic mechanism combining heat absorption/oxygen isolation and radical scavenging/antioxidant effects. This study advances the design of multifunctional fire-retardant materials through rational integration of physicochemical strategies.

Considerable evidence attests to a relationship between executive function and falls. Notable among cognitive elements related to fall risk is the ability to suppress a highly automatic but unwanted action-that is, response inhibition. Although the ability to stop may seem like an unlikely foundation for maintaining balance, there are many situations in daily life where the ability to adapt planned action is critical to reducing instability. Most of what we know about the role of inhibition in balance control is based on correlations between cognitive test performance and self-reported falls, leaving a sizable gap in understanding mechanisms linking inhibition and balance control. Here, we expand from traditional balance assessments that accentuate reflexive action and instead impose a need to suppress a prepotent balance recovery step. We leveraged techniques developed in cognitive neuroscience to expose neuromuscular events leading to successful inhibition. Specifically, we used high-density electroencephalography to measure neural markers previously shown to predict successful inhibition in seated voluntary reaction tasks using hand responses (ß-bursts) and applied this to a balance recovery step task. Contrary to our hypothesis, higher ß-burst volume after a stop cue was associated with failed step suppression. Other ß oscillation characteristics revealed slightly earlier ß-burst onsets in successful suppression trials and higher average ß power prior to the stop signal for successful versus failed stop trials. The current study offers insight into potential key markers underlying suppression of a recovery step, and we highlight unique challenges associated with studying cognitive processes during rapid, whole-body balance recovery.

Gastroesophageal reflux disease (GERD) is characterized by significant clinical heterogeneity. Conventional diagnostic approaches, including symptom-based questionnaires, empirical acid suppression trials, and single-modality objective tests, demonstrate limited sensitivity and specificity, often resulting in diagnostic inaccuracies and inefficient resource utilization. To overcome these diagnostic challenges, this article provides a systematic review of recent advancements and ongoing debates in GERD diagnostics, with a focus on the diagnostic value of multimodal parameters as outlined in the Lyon Consensus 2.0. It also explores the clinical relevance of emerging auxiliary diagnostic metrics. We emphasize that integrating clinical symptomatology, endoscopic findings, esophageal physiological measurements, and psychosocial factors (augmented by composite scoring systems and artificial intelligence), offers a promising strategy for accurate diagnosis and personalized treatment of GERD.

This study investigates the potential of hydrate-based fire extinguishers for Class B fire suppression, presenting the first comparative analysis of different hydrate extinguishers. The gas uptake kinetics and suppression efficiency of fire extinguisher hydrates were examined, revealing a strong dependence on the guest gas type and its selective occupancy within the hydrate cavities. A novel hydrate pelletization technique was developed, enabling the continuous production of hydrate-based fire suppression materials. Fire suppression trials using hydrates of HFC-125a, HFC-23, and CO2 in both cube (1–10 mm) and powder (0.5 mm) forms demonstrated that hydrate powders exhibited superior suppression performance due to their larger surface area and faster dissociation. The study also highlights the critical role of dispersion within the fire zone, which significantly influences the suppression efficiency. Comparative evaluations showed that hydrate powders outperformed conventional agents such as ammonium dihydrogen phosphate and ice powders, particularly in preventing flame reignition. Among the tested hydrates, HFC-125a and HFC-23 effectively inhibited reignition, whereas CO2 hydrates demonstrated lower efficiency. Additionally, results emphasized the necessity of maintaining a minimum extinguishing concentration for optimal fire suppression with the hydrate yield playing a key role in determining total gas release. HFC-23 required the highest heat of dissociation of HFC-125a and CO2. The suppression efficiency followed the order: HFC-125a > HFC-23 > CO2. These findings establish gas hydrates as promising fire suppression agents, offering both enhanced suppression performance and improved resistance to flame reignition. This study provides valuable insights for further optimization and large-scale application of hydrate-based fire extinguishing technologies.

Chronic laryngopharyngeal symptoms (LPS) are increasingly prevalent presentations to gastroenterologists' offices, and clinicians often make a presumptive diagnosis of laryngopharyngeal reflux disease (LPRD) based on LPS symptoms or laryngoscopic findings alone. Such presumptive diagnoses of LPRD often are incorrect, and establishing the correct diagnosis poses significant challenges for clinicians. This review addresses the timely need for advances in evaluating and managing LPS/LPRD, given their diagnostic complexity and the healthcare burden of ineffective empiric treatments. Recent evidence emphasizes the diverse etiologies of LPS including LPRD, oropharyngeal or other airway pathologies, allergic conditions, and cognitive-affective processes or altered brain-larynx interaction. The diagnostic approach should be individualized and multimodal, including upfront reflux testing over empiric acid suppression trials for possible LPRD, given the poor correlation between LPS and objective evidence of reflux. Predictive models and risk stratification tools such as the COuGH RefluX score show promise to help guide testing and therapeutic strategies. Reflux testing modalities include wireless pH monitoring and impedance-based testing (traditional impedance-pH or combined hypopharyngeal-esophageal reflux monitoring). Biochemical testing for salivary pepsin may also offer adjunctive value. Management should include antireflux strategies for those with objectively-proven LPRD, alongside treatments targeting nonreflux mechanisms of LPS, such as voice therapy, neuromodulation, and behavioral therapy. An individualized, multidisciplinary approach is essential in managing LPS/LPRD. Objective reflux testing improves diagnostic accuracy, avoids unnecessary therapies, and enables tailored treatment. Future research should further refine diagnostic thresholds, validate risk stratification tools, and explore novel therapeutic targets to optimize outcomes.

Functional electrical stimulation (FES) and sensory electrical stimulation (SES) are widely used in tremor suppression for Parkinson's disease (PD), however, their therapeutic efficacy varies significantly across individuals. This study investigated the differential cortical effects of FES and SES during closed-loop tremor suppression in PD patient, aiming to identify neurophysiological biomarkers for guiding personalized neuro modulation strategies. We developed an inertial based closed-loop tremor suppression system that delivers out-of-phase FES and continuous SES based on real-time tremor detection. Fifteen PD patients were recruited in tremor suppression trials while surface electroencephalography (EEG) and inertial-based movements of hand and forearm were measured. Both FES and SES significantly reduced tremor amplitude, with FES showing overall greater suppression (hand suppression rate: 60.72% vs. 48.31%, p >0.05; forearm suppression rate: 62.25% vs. 54.41%, p >0.05) where substantial inter-individual variability was observed. EEG analysis revealed that FES induced contralateral beta-band event-related desynchronization ( $\beta $ -ERD), whereas SES elicited beta-band event-related synchronization ( $\beta $ -ERS). These distinct cortical response patterns were significantly correlated with tremor suppression performance (FES $\beta $ -ERD: r = -0.629, p = 0.012; SES $\beta $ -ERS: r = 0.679, p = 0.005). Resting-state spectral analysis further revealed modality-specific changes in alpha power across sensorimotor regions. These findings revealed functional neurodynamic signatures associated with individual responsiveness to stimulation. The observed $\beta $ -band oscillatory responses may serve as candidate biomarkers for predicting individual treatment outcomes, offering a potentially biomarker-guided approach for personalized neuromodulation for PD tremor.

Experimental study on how the settings of plasma affect its effectiveness of suppression of thermoacoustic oscillations in a Rijke tube

Symptoms/complications related to extraesophageal reflux (EER) are increasingly prevalent presentations and pose significant challenges for clinicians. We summarize and discuss clinical advances and developments in pathophysiology, testing and treatment algorithms of upper/lower airway manifestations of EER. Growing evidence supports likely multifactorial causes of laryngeal symptoms, including EER, oropharyngeal pathologies, allergic conditions, and cognitive-affective processes (brain-larynx interaction). Diagnostic paradigm for laryngopharyngeal reflux (LPR) is shifting towards a personalized approach with noninvasive strategies/prediction tools to risk-stratify patients for upfront reflux testing over empiric acid suppression trials. Management should be multipronged to include antireflux therapies and treatments targeting other causes. Lower airway complications of EER may result in lung dysfunction and poor transplant outcomes. Esophageal symptoms are often absent and routine esophageal/reflux testing to guide timely antireflux therapies may lead to improved outcomes. Modalities that leverage impedance technology may be important, given the potential role of nonacidic reflux. Novel impedance-based metrics such as mean nocturnal baseline impedance and postreflux swallow-induced peristaltic wave index may provide adjunctive diagnostic values. Standardized approach to diagnosis/management of EER should include multidisciplinary care teams and consider different phenotypes, nonreflux contributors, and the complex gut-airway relationships. Prompt antireflux therapies after careful candidate selection may improve outcomes of these airway complications.

Abstract The article presents data on the most commonly used antiarrhythmic drugs of subclass IC: propafenone, flecainide, and a drug manufactured in Latvia — ethacizine. The features and priority areas of each drug use were identified. The author conducted a critical analysis of the results of Cardiac Arrhythmia Suppression Trials (CAST)-I and CAST-II and suggested ways to further study of subclass IC antiarrhythmic drugs in the context of current treatment strategies. The results of CAST-I and CAST-II should be interpreted in view of the heterogeneity of the subclass IC antiarrhythmic drugs and the fact that among the drugs of this subclass that are currently registered and approved for use in Ukraine, only flecainide was studied in CAST-I, and none of these drugs — in CAST-II. Ethacizine has a special position as a promising drug, especially effective in the treatment of vagus-induced heart rhythm disorders, with a small number of contraindications and drug interactions compared with propafenone and flecainide. Despite many years of use in several countries, this drug remains “invisible” to researchers around the world due to a limited number of international studies. The author draws attention to the need to re-evaluate antiarrhythmic drugs with an outdated evidence, in some cases quite limited, and to plan new experimental studies to clarify the possibility of subclass IC drugs to influence new pharmacological targets in arrhythmology, as well as large-scale well-planned studies of the safety and efficacy of subclass IC antiarrhythmic drugs in real present-day clinical practice.

Cognitively suppressing the retrieval of an unwanted memory causes its forgetting and, in the meantime, disrupts hippocampal functions. The present study investigated whether retrieval suppression induces virtual amnesia, which disturbs any existing memories that are reactivated in the temporal vicinity but are otherwise unrelated to the targets of suppression. Participants performed retrieval suppression on a set of memories while cues of an unrelated set of memories were briefly presented near in time to the suppression trials. Results showed that retrieval suppression impaired the retrieval of both the directly suppressed content and the reactivated unrelated memory. This amnesic shadow functioned in both the forward and backward temporal directions, and its forgetting effect was revealed by independent cues that were not presented in the shadow. Remarkably, a negative memory could be impaired simply by presenting it between the suppression episodes of an unrelated neutral memory. These findings provide support for systemic influence of retrieval suppression on hippocampal functions and offer a way to disrupt existing episodic memory strategically. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Synthesis and combustion inhibition efficiency of iron short-chain perfluorocarboxylates

Eosinophilic esophagitis (EoE) is an esophageal allergic inflammatory disorder often presenting with infant/toddler gastroesophageal reflux symptoms refractory to treatment, including acid suppression trials with histamine H2 antagonists and proton pump inhibitors. We propose to evaluate the impact of infant acid suppressant exposure in EoE. Geisinger's pediatric EoE cases were matched to controls (1:5 EoE case control ratio) using age, race, sex, and ages at other diagnoses of asthma, eczema, and environmental allergies, totaling 526 EoE cases and 2,630 controls. Comparisons between EoE cases and matched controls were tested with regard to rates of acid suppression use with H2 antagonists and PPIs during infancy. Our analyses found the use of acid suppression in infancy was positively associated with EoE: PPI (5.7% EoE cases vs. 1.6% controls; P < 0.0001), H2 antagonists (8.8% EoE cases vs. 4.5% controls; P < 0.0001). Additionally, analysis of EoE cases using acid suppression during infancy indicated a likelihood for the diagnosis with EoE at an earlier age. Early acid suppression use in infants is significantly associated with the diagnosis of EoE in childhood in this well-matched retrospective cohort study. The potential link warrants additional investigation. Our study further reinforces the evidence-based stewardship of acid suppressant use, especially in our most vulnerable populations.

Fire suppression efficiency of water mists containing organic solvents

Functional neuroimaging studies have attempted to explore brain activity that occurs with tic occurrence in subjects with Tourette syndrome (TS). However, they are limited by the difficulty of disambiguating brain activity required to perform a tic, or activity caused by the tic, from brain activity that generates a tic. Inhibiting ticcing following the urge to tic is important to patients' experience of tics and we hypothesize that inhibition of a compelling motor response to a natural urge will differ in TS subjects compared to controls. This study examines the urge to blink, which shares many similarities to premonitory urges to tic. Previous neuroimaging studies with the same hypothesis have used a one-size-fits-all approach to extract brain signal putatively linked to the urge to blink. We aimed to create a subject-specific and blink-timing-specific pathophysiological model, derived from out-of-scanner blink suppression trials, to eventually better interpret blink suppression fMRI data. Eye closure and continuously self-reported discomfort were reported during five blink suppression trials in 30 adult volunteers, 15 with a chronic tic disorder. For each subject, data from four of the trials were used with an empirical mathematical model to predict discomfort from eye closure observed during the remaining trial. The blink timing model of discomfort during blink suppression predicted observed discomfort much better than previously applied models. Combining this approach with observed eye closure during fMRI blink suppression trials should therefore extract brain signal more tightly linked to the urge to blink. The simple mean of time-discomfort curves from each subject's other trials also outperformed older models. The TS group blinked more than twice as often during the blink suppression block, and reported higher baseline discomfort, smaller excursion from baseline to peak discomfort during the blink suppression block, and slower return of discomfort to baseline during the recovery block.

Oil-in-water microemulsion containing ferrocene: A new fire suppressant

Recent guidelines defined and differentiated the management of gastroesophageal reflux (GER) and gastroesophageal reflux disease (GERD). The guidelines recommend against using empiric acid suppression therapy for infantile GER. The primary objective of this study was to assess inpatient guideline adherence regarding management of infantile GER through the perspective of pharmacists. Secondary objectives included assessing pharmacist comfort level with differentiation between GER and GERD, observing current trends in practice relating to the primary objective, and determining the availability of institution-specific guidelines that address the management of infantile GER. An institutional review board-approved, national, online survey of pharmacists with inpatient pediatric experience was conducted. Pediatric pharmacy membership directories were used to create the listserv of eligible pharmacists. The 2009 NASPGHAN/ESPGHAN (North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Gastroenterology, Hepatology, and Nutrition) Pediatric Gastroesophageal Reflux Clinical Practice Guideline was used to develop the survey and to define both GER and GERD. Demographic data was also collected regarding the institutional setting and pharmacists responding. The overall response rate was 14.8% (n = 149). Although 29.7% of pharmacists stated empiric acid suppression trials were not used for infantile GER at their institution, 44.6% responded that these trials are initiated 1 to 2 times per week in their hospitals. In addition, 19.6% responded that these empiric trials were initiated 3 to 5 times per week. A smaller percentage of responders reported even higher frequencies per week at their institutions. From the results of the survey, infants continue to receive empiric acid suppression trials for GER in the inpatient setting, which is not adherent to the current guideline recommendation.

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