Suitability Of Blood Research Articles

Сonsolidation of somatic rights in international regulations

The issue is topical in the context of actively expanding the list of human rights, including within the national dimension, because human rights as a dual category are subject to transformation due to the following factors: European integration processes, creating the need for integration and harmonization of Ukrainian legislation with European Union law; globalization processes, as Ukraine is a member of the world community and modern economic, environmental, legal, etc. phenomena have a direct impact on national state processes, and on the legal reality, and on the rights and freedoms of the individual.
 It is determined that the recognition of new human rights, the expansion of the existing list - one of the trends in the development of the legal status of the individual. And when regulating relations in the field of somatic claims through the category of human rights, it should be borne in mind that somatic human rights should be characterized by what characterizes the category of human rights in general. It is pointed out that in human history no "new right" has really been recognized without a struggle and without overcoming the fierce opposition of some "old rights".
 It is proved that the legal regulation of the possibility of exercising somatic rights in the international arena (primarily within the European Union) has significantly improved. Basically, we are talking about the existing basic (basic) regulations in the field we study. Thus, among the most important of them, we should first focus on such as, the Council of Europe Convention on Human Rights and Biomedicine 1997, the EU Council Recommendation of June 29, 1998 "On the suitability of blood and plasma donors and donor blood screening. in the European Community" (98/463 / EC), Directive 2004/23 / EC of 31 March 2004 on the establishment of quality and safety standards for the donation, purchase, testing, treatment, preservation, storage and distribution of human tissues and cells". That is, we believe that the Council of Europe and the European Union, as regional international organizations, have established common normative criteria for the possibility of implementing and protecting somatic human rights in general and in the field of biomedical research in particular.

Mossbauer study of different factors influence on donated blood quality

Packed red blood cells (RBC) are main blood components used in transfusiology. During storage, preserved blood cells undergo progressive structural and functional changes that may reduce red-cell function and viability after transfusion. As the hemoglobin is the main and active component of erythrocytes, we consider that oxidized hemoglobin derivatives formation cause those changes. With the aim of developing the new criteria for donated blood suitability for transfusion, we studied storage-related changes in red blood cells hemoglobin by means of analytical fitting of Mossbauer spectra. We analyzed Mossbauer spectra of set RBC’s samples from volunteer donors every few days during their storage. Using those data, we built kinetic curves of various hemoglobin derivatives changes during RBC storage for different hemoglobin forms concentration in RBC samples. We found that kinetic curves are specific for each donor. They also depend on the donor’s age and health condition at the time of donation. Based on our spectroscopy results we suggested an objective criteria for duration of storage of regular donors RBC.

Balanced Caloric Macronutrient Composition Downregulates Immunological Gene Expression in Human Blood Cells—Adipose Tissue Diverges

Cardiovascular disease, obesity, and type 2 diabetes are conditions characterized by low-grade systemic inflammation, strongly influenced by lifestyle, but the mechanisms that link these characteristics are poorly understood. Our first objective was to investigate if a normocaloric diet with a calorically balanced macronutrient composition influenced immunological gene expression. Findings regarding the suitability of blood as biological material in nutrigenomics and gene expression profiling have been inconclusive. Our second objective was to compare blood and adipose tissue sample quality in terms of adequacy for DNA-microarray analyses, and to determine tissue-specific gene expression patterns. Blood and adipose tissue samples were collected for gene expression profiling from three obese men before, during, and after a 28-day normocaloric diet intervention where each meal contained an approximately equal caloric load of macronutrients. Time series analyses of blood gene expression revealed a cluster of downregulated genes involved in immunological processes. Blood RNA quality and yield were satisfactory, and DNA-microarray analysis reproducibility was similar in blood and adipose tissue. Gene expression correlation between blood and adipose tissue varied according to gene function, and was especially low for genes involved in immunological and metabolic processes. This suggests that diet composition is of importance in inflammatory processes in blood cells. The findings also suggest that a systems biology approach, in which tissues are studied in parallel, should be employed to fully understand the impact of dietary challenges on the human body.

Blood Donation by Patients With Hemochromatosis

To the Editor. —Dr Grindon 1 has discussed the suitability of blood obtained by phlebotomy from patients with hemochromatosis to be used for transfusions. Hemochromatosis is a hereditary disorder in which iron

Increased risk of a positive test for antibody to hepatitis B core antigen (anti-HBC) in autologous blood donors.

Controversy exists about the suitability of blood from autologous donors for homologous use. We compared the infectious disease test results of 426 autologous donors, designated by donor history as suitable for homologous use, to those of 86,138 volunteer donations collected over the same 5 month period. Although donor characteristics differed, the relative risk of a positive test for anti-HBc in the autologous group was 2.09. When 413 autologous donors were compared to 413 volunteer donors matched for age, sex, and zip code, the relative risk of a positive test for anti-HBc in the autologous group was 3.2. If anti-HBc is a marker for non-A, non-B hepatitis transmissibility, then our autologous group is not as safe as our volunteer donors. We recommend that autologous blood, even when designated by donor history and laboratory screening results as suitable for homologous transfusion, not be used for other than the intended autologous recipient.

Growth of Small Numbers of Acid-fast Bacteria in Blood and in Serum.

The survival or growth of tubercle bacilli in blood is an important question from several points of view: the immunological action of serum and leucocytes, the investigation of tuberculous bacillemia, and the suitability of blood as a culture medium. Some investigators have emphasized the unfavorable action of blood on the growth of tubercle bacilli on solid media, while others have reported the growth of these organisms in blood. These points of view were reconciled when it was learned that the influence of blood in the two situations is quite different. This note indicates that, although blood interferes with the growth of tubercle bacilli on a solid substrate, it is actually an excellent medium.Saline, defibrinated rabbit blood, or serum, .45 cc, were mixed with .05 cc volumes of 4 decimal dilutions of “clump-free” suspensions of human, bovine, avian, and timothy bacilli in 10 × 75 mm Pyrex tubes. Of these mixtures .05 cc was spread evenly on each of two slants of Corper's egg-yolk medium (in screw-cap...