Study Of Trajectories Research Articles

French Psychiatry and Alcoholism in the 1950s and 1960s: The Paradoxes of Outpatient Care

Summary This article examines the place of alcoholic patients in French psychiatry in the 1950s and 1960s, an era of incipient psychiatric reform. Relying on medical literature, national and department archives, as well as hitherto unexploited patient files from one of the first anti-alcoholic consultations opened in the early 1950s in Paris, it shows how new therapies and drugs, such as disulfiram, revived the interest of psychiatrists for alcoholism and enabled the outpatient treatment of alcoholics. However, the study of patient trajectories reveals that ambulatory care did not substitute itself for hospitalisation. The article then analyses how the psychiatrist–patient relation was transformed in the framework of the consultation, and included new stakeholders such as social workers and family members. It finally explains why therapeutic enthusiasm gave way, at the end of the 1960s, to increasing doubts concerning the role of the psychiatrist in the cure of alcoholism.

Commissioning of Upgrades to T6 to Study Giant Planet Entry

The scientific potential of a mission to the ice giants is well recognized and has been identified by NASA and ESA as a high priority on several occasions, most recently in the 2023–2032 Decadal Survey. The payload capacity of such a spacecraft is limited by the heat shield thickness, which must be sized conservatively due to a lack of reliable data for convective and radiative heat flux along the proposed entry trajectories. Major upgrades to the Oxford T6 Stalker Tunnel have been commissioned that allow study of giant planet entry trajectories, including a flammable gas handling system, a Mach 10 expansion nozzle, and a steel shock tube with optical access. Initial testing has been completed in shock tube and expansion tunnel modes, with peak shock speeds of 18.9 km/s achieved. Convective heat flux and surface pressure were measured at several locations on a 45° sphere cone model in expansion tunnel mode. Measurements of the radiating shock layer were made in shock tube mode to assess the effect of CH4 concentration. This work establishes the first high-enthalpy giant planet entry test bed in Europe.

Identification of an algorithm for the analysis and study of urban road network trajectories

The object of this study is a clustering algorithm using various technologies. This paper compares clustering algorithms that are more commonly used to analyze urban road network trajectories, the growth curve model, with the elbow method and the x-means algorithm. Experiments were conducted with various volumes of big data to determine calculation time, accuracy, and ways to increase calculation time. These results can be used to manage traffic jams in congested areas and city streets. Considering the widespread use of clustering algorithms for solving various problems, this study proposes to introduce GCM, SPGK methods for monitoring and analyzing the state of congestion on city roads. The work was carried out in the following steps: research and selection of methods based on efficiency and time, implementation of parallel computing technologies to improve computation speed, demonstration of the selected method based on collected data from a real city with visualization of the results. The growth curve model algorithm has been proven to be almost 5 times more effective than the elbow method and the x-means algorithm. The time allocated for data processing has been calculated. An increase in the volume of processed data showed an almost stable execution time t = 3 s for the GCM algorithm for data with a volume of up to almost 2,000 units. The effectiveness of SPGK-means was shown for different values of the number of points. Models of the Chengdu transport network obtained using a clustering algorithm with maximum grid density of neighborhoods are presented. There are some deviations between the grid and the road network due to the large grid size. This error is explained by an error of up to one between the points and the real grid. The results obtained clearly show how optimization of congested roads can be influenced. They provide information to obtain data on available routes, which allows you to analyze the road network individually and as a whole

Data-Driven 4D Trajectory Prediction Model Using Attention-TCN-GRU

With reference to the trajectory-based operation (TBO) requirements proposed by the International Civil Aviation Organization (ICAO), this paper concentrates on the study of four-dimensional trajectory (4D Trajectory) prediction technology in busy terminal airspace, proposing a data-driven 4D trajectory prediction model. Initially, we propose a Spatial Gap Fill (Spat Fill) method to reconstruct each aircraft’s trajectory, resulting in a consistent time interval, noise-free, high-quality trajectory dataset. Subsequently, we design a hybrid neural network based on the seq2seq model, named Attention-TCN-GRU. This consists of an encoding section for extracting features from the data of historical trajectories, an attention module for obtaining the multilevel periodicity in the flight history trajectories, and a decoding section for recursively generating the predicted trajectory sequences, using the output of the coding part as the initial input. The proposed model can effectively capture long-term and short-term dependencies and repetitiveness between trajectories, enhancing the accuracy of 4D trajectory predictions. We utilize a real ADS-B trajectory dataset from the airspace of a busy terminal for validation. The experimental results indicate that the data-driven 4D trajectory prediction model introduced in this study achieves higher predictive accuracy, outperforming some of the current data-driven trajectory prediction methods.

Population-based study of disease trajectory after radical treatment for high-risk prostate cancer.

To investigate long-term disease trajectories among men with high-risk localized or locally advanced prostate cancer (HRLPC) treated with radical radiotherapy (RT) or radical prostatectomy (RP). Men diagnosed with HRLPC in 2006-2020, who received primary RT or RP, were identified from the Prostate Cancer data Base Sweden (PCBaSe) 5.0. Follow-up ended on 30 June 2021. Treatment trajectories and risk of death from prostate cancer (PCa) or other causes were assessed by competing risk analyses using cumulative incidence for each event. In total, 8317 men received RT and 4923 men underwent RP. The median (interquartile range) follow-up was 6.2 (3.6-9.5) years. After RT, the 10-year risk of PCa-related death was 0.13 (95% confidence interval [CI] 0.12-0.14) and the risk of death from all causes was 0.32 (95% CI 0.31-0.34). After RP, the 10-year risk of PCa-related death was 0.09 (95% CI 0.08-0.10) and the risk of death from all causes was 0.19 (95% CI 0.18-0.21). The 10-year risks of androgen deprivation therapy (ADT) as secondary treatment were 0.42 (95% CI 0.41-0.44) and 0.21 (95% CI 0.20-0.23) after RT and RP, respectively. Among men who received ADT as secondary treatment, the risk of PCa-related death at 10 years after initiation of ADT was 0.33 (95% CI 030-0.36) after RT and 0.27 (95% CI 0.24-0.30) after RP. Approximately one in 10 men with HRLPC who received primary RT or RP had died from PCa 10 years after diagnosis. Approximately one in three men who received secondary ADT, an indication of PCa progression, died from PCa 10 years after the start of ADT. Early identification and aggressive treatment of men with high risk of progression after radical treatment are warranted.

Understanding family dynamics of obesity: Do parents and children lose and gain weight together?

Obesity is prevalent among children and adults. Yet, understanding the relationship between parent and child weight trajectories is limited. (1) Examine the association between parent/child undesirable body mass index (BMI) category change. (2) Assess whether parental BMI category predicts child modified BMI z-score (mBMIz) annual change. We conducted a cross-sectional study of weight trajectories of 3821 parent-child dyads between March 2020 and December 2021 within the NYC Health + Hospitals system. Undesirability of child and parental BMI category change and the magnitude of mBMIz change by parental BMI are analysed. Of 3821 children (mean [SD] baseline age, 9.84 [3.51]), 1889 were female. Of the 3220 parents (mean [SD] baseline age, 39.9 [8.51]), 2988 were female. Most children (53.52%) and parents (81.94%) presented with overweight and obesity. Undesirable BMI change in children was associated with concordant change in parents (adjusted OR: 1.7, 95% CI [1.45, 2.01], adjusted p < 0.001). Children of parents with obesity (adjusted coef: 0.076, 95% CI [0.004, 0.147], p < 0.038) and severe obesity (adjusted coef: 0.1317, 95% CI [0.024, 0.239], adjusted p < 0.016) demonstrated greater change in mBMIz than those of parents with normal weight or underweight. Parents and children have concordant weight trajectories, and public health interventions targeting both populations are essential.

Особенности развития и психическое здоровье близнецов раннего возраста: обзор отечественных и зарубежных исследований

&lt;p style="text-align: justify;"&gt;&lt;strong&gt;Objectives. &lt;/strong&gt;Due to the increasing birth rate of twins and the high risk of delayed physical, cognitive, and psychosocial development in twins at an early age, there is a need to identify factors that contribute to the mental health and developmental trajectory of children.&lt;/p&gt; &lt;p style="text-align: justify;"&gt;&lt;strong&gt;Methods.&amp;nbsp;&lt;/strong&gt;We conducted a review and analysis of recent domestic and international research from 183 articles published between 2009 and 2024, and available in the Scopus, Semantic Scholar, PubMed, Bielefeld Academic Search Engine, Russian Science Citation Index (RSCI) and Crossref databases. The search used the keywords &amp;ldquo;infant twins&amp;rdquo;, &amp;ldquo;twins at early age&amp;rdquo;, &amp;ldquo;twins early development&amp;rdquo;, &amp;ldquo;twins interaction&amp;rdquo;.&lt;/p&gt; &lt;p style="text-align: justify;"&gt;&lt;strong&gt;Results.&amp;nbsp;&lt;/strong&gt;The interest of researchers in different aspects of the mental health and development of children born from monozygotic and dizygotic twin pregnancies is shown. The main factors affecting the health and development of twins are genetic factors, congenital defects, gestational age and birth weight, the presence of trauma during birth, as well as the somatic health of children in the first months of life. The early development of twins is closely related to the features of the care organization and parenting, interaction with the mother, as with a caring adult, a set of environmental factors and conditions for the education. At an early age, twins are at high risk of lagging in general physical, cognitive and speech impairment development compared with singleton, which should be taken into account in monitoring the need for early help for children.&lt;/p&gt; &lt;p style="text-align: justify;"&gt;&lt;strong&gt;Conclusions.&amp;nbsp;&lt;/strong&gt;There is a need for relevant domestic research on the features of the development of twins at an early age. The study of the individual trajectory of early development of each child from twins should be carried out taking into account the factor of discordance in a twin pair.&lt;/p&gt;

Life course studies – conceptual and methodological approaches and solution

Studies of the life course address the fundamental issue of social sciences – understanding the social change, its directions, reasons and perspectives, the interaction of micro- and macro levels of social reality. Studies of life course developed independently in different social sciences and scientific traditions cover a broad range of topics, issues and methodological approaches. These variety of studies were grouped into few major research frameworks: psychological within the studies of personality development; longitudinal sociological focused on life course of different cohorts and comparative studies of generations, social groups, countries and regions; domain-based – studies of trajectories in different life domains; demographic studying the timing of life events; studies of stability and transformation of values and biographical research. The multiple methodological approaches to study the life course are suggested to group in two main categories – concurrent and retrospective which differ by the time distance between the occurrence of an event and the reporting about the event. Concurrent approach is characterized by relatively high reliability of the measurement, but low flexibility in selecting research indicators, long time for the organization of data collection and large financial investments. Retrospective approach provides high flexibility in organization and design of the survey, allows free selection of indicators to test research hypotheses, but the reliability of the data is hampered by the memory errors and context effect. None of these approaches alone can satisfy the needs and requirements of studying the life course and collecting dynamic multi-level data. The possible solution is to design and test the multimodal approach combining the advantages of different research methods and mitigating their drawbacks. The new long-term longitudinal project “Life course, values and expectations of the generation of 1990s” (G90) included the test of an autobiographical method of data collection for random samples of the general population in quantitative design. The testing revealed high sensitivity of the method to the format (handwritten, printed or oral), high differentiation between respondents in completeness of information and the selection of events included in the autobiography. Supplementing autobiographies by in-depth interviews increased the data standardization, completeness and comparability. The drawbacks of this method found during the survey are high demand for resources for data analysis, individual approach to each autobiography, low respondents’ cooperation in highly demanding tasks, and ethical issues. The future of the life course studies can be found in the convergence of different research frameworks, multidisciplinary research projects, and the application of mixed-model integrated methodology.

Abstract P406: Screen Time and Behavioral Cardiovascular Health in Youth by Age: The Young Hearts Study

Background: Research suggests that screen time is associated with negative health outcomes, including cardiovascular health (CVH) factors (BP, lipids, glucose, BMI) but seldom include CVH behaviors (diet, physical activity, nicotine exposure, and sleep). Methods: Young Hearts is an observational study of CVH trajectories in youth aged 0-20. This analysis includes 1749 participants aged 6-18 with complete baseline surveys. Parents (for 6-17 year olds) and adolescents aged 12+ (for themselves) completed surveys on CVH behaviors, medical history, and social context. Participants (stratified by age groups: 6-9, 10-14, and 15-18) reported hours spent on screens during a typical weekday and weekend day, excluding schoolwork and video calls. For 12-17-year-olds, we calculated the average reported screen time. We calculated CVH using the 4 health behaviors in the AHA’s Life’s Essential 8. Each behavior was assigned a score of 0 to 100 and averaged to create the behavioral CVH score. Linear regression assessed the association between screen time (continuous) and CVH score, adjusting for age, sex, race, ethnicity, income, parental education, chronic disease, insurance type, and depressive symptoms. Results: The mean age of 1749 participants was 12, 47% were female, 46% non-Hispanic White, 26% Hispanic, 20% non-Hispanic Black, and 9% identified as other. For participants aged 10-14, a 1-hour screen time increase was associated with a -0.9 CVH score (95% CI -1.4, -0.4). Inverse associations between screen time and sleep score were observed among youth aged 10-14 and 15-18 (-1.4; 95% CI -2.6, -0.2). Screen time was inversely related to diet across age groups. Among children aged 6-9, screen time was positively associated with physical activity (1.2; 95% CI 0.2 - 2.1). The findings were consistent by race/ethnicity. Conclusion: Higher screen time was associated with less favorable CVH scores due to sleep and diet scores. Future research is needed to better understand the relationship between screen time and physical activity among youth.

Study on dynamic characteristics of acceleration process of spherical hybrid sliding bearings rotor system

Purpose The transient loads on the spherical hybrid sliding bearings (SHSBs) rotor system during the process of accelerating to stable speed are related to time, which exhibits a complex transient response of the rotor dynamics. The current study of the shaft center trajectory of the SHSBs rotor system is based on the assumption that the rotational speed is constant, which cannot truly reflect the trajectory of the rotor during operation. The purpose of this paper truly reflects the trajectory of the rotor and further investigates the stability of the rotor system during acceleration of SHSBs. Design/methodology/approach The model for accelerated rotor dynamics of SHSBs is established. The model is efficiently solved based on the fourth-order Runge–Kutta method and then to obtain the shaft center trajectory of the rotor during acceleration. Findings Results show that the bearing should choose larger angular acceleration in the acceleration process from startup to the working speed; rotor system is more stable. With the target rotational speed increasing, the changes in the shaft trajectory of the acceleration process are becoming more complex, resulting in more time required for the bearing stability. When considering the stability of the rotor system during acceleration, the rotor equations of motion provide a feasible solution for the simulation of bearing rotor system. Originality/value The study can simulate the running stability of the shaft system from startup to the working speed in this process, which provides theoretical guidance for the stability of the rotor system of the SHSBs in the acceleration process.

Longitudinal Quantiles of Frailty Trajectories Considering Death: New Insights into Sex and Cohort Differences in the Reference Curves for Frailty Progression of Older European.

Most previous studies of frailty trajectories in older adults focus on the average trajectory and ignore death. Longitudinal quantile analysis of frailty trajectories permits the definition of reference curves, and the application of mortal cohort inference provides more realistic estimates than models that ignore death. Using data from individuals aged 65 or older (n = 25446) from the Survey of Health, Ageing, and Retirement in Europe (SHARE) from 2004 to 2020, we derived repeated values of the Frailty Index (FI) based on the accumulation of health deficits. We applied weighted Generalized Estimating Equations to estimate the quantiles of the FI trajectory, adjusting for sample attrition due to death, sex, education, and cohort. The FI quantiles increased with age and progressed faster for those with the highest level of frailty (β^a0.9 = 0.0229, p < .001; β^a0.5 = 0.0067, p < .001; H0: βa0.5=βa0.9, p < .001). Education was consistently associated with a slower progression of the FI in all quantiles (β^ae0.1 = -0.0001, p < .001; β^ae0.5 =-0.0004, p < .001; β^ae0.9 = -0.0003, p < .001) but sex differences varied across the quantiles. Women with the highest level of frailty showed a slower progression of the FI than men when considering death. Finally, no cohort effects were observed for the FI progression. Quantile FI trajectories varied by age, sex, education, and cohort. These differences could inform the practice of interventions aimed at older adults with the highest level of frailty.

The interdependence of substance use, satisfaction with life, and psychological distress: a dynamic structural equation model analysis.

Longitudinal studies with annual follow-up including psychological and social variables in substance use disorder recovery are scarce. We investigated whether levels of substance use, satisfaction with life, and psychological distress fluctuate across five years in relation to having drug-free friends. A prospective naturalistic cohort study of change trajectories in a cohort of people diagnosed with substance use disorder and using multiple substances with quarterly and annual follow-up over five years. Two-hundred-and-eight patients were recruited from substance use disorder treatment in Rogaland, Norway. Out of these, 164 participants fulfilled the inclusion criteria. We used Bayesian two-level dynamic structural equation modelling. The variable 'drug-free friends' was assessed by a self-reporting questionnaire, while psychological distress was assessed using the Symptoms Checklist 90 Revised. Satisfaction with life was assessed using the Satisfaction With Life Scale while drug use was assessed using the Drug Use Disorders Identification Test. The main findings are that higher-than-average psychological distress at a three-month lag credibly predicts higher-than-normal substance use at the concurrent time point t. Substance use and satisfaction with life seem to have synchronous trajectories over time, i.e. as the first decreases the latter increases and vice versa. During the five years after treatment, the participants mainly experienced a decrease in substance use and increase in satisfaction with life. Since the participants experienced positive and negative fluctuations for several years after treatment, it seems crucial to establish a dialogue with treatment professionals in order to create functional solutions for maintaining motivation and aiding recovery.

From anonymity to protagonism: the trajectory of industrialists Gustavo Paiva and Delmiro Gouveia in Alagoas

This article investigated the contribution of industrialists Gustavo Paiva and Delmiro Gouveia to the implementation of workers' residential centers at the “Cachoeira” and “Progresso” factories in Rio Largo-AL and “Pedra”, in the former Água Branca-AL. This analysis was carried out through the study of the professional trajectory of the industrialists, understanding the inspirations and models followed, analyzing the labor relations existing in the factories during the period of the industrialists' management, and finally, understanding the importance of the industrialists' figures for the current cities of Rio Largo-AL and Delmiro Gouveia-AL. The research was based on bibliographic, iconographic and audiovisual sources with surveys and systematization of information obtained through research in local archives and virtual portals of journals from scientific institutions; in addition to visiting the cities of Rio Largo-AL and Delmiro Gouveia-AL. In this way, we sought, in addition to enriching the bibliography of Alagoas through the recovery of the history of the implementation of the old manufacturing centers, to establish a relationship between the two industrialists that actually consists of their notable trajectories, following their own way of acting, as pioneers, businessmen and benefactors of the Brazilian northeast, who devoted themselves to the region's socioeconomic progress and important legacies for the history of Brazil.

Non-linear dynamics of a test particle near the Lagrange points L4 and L5 (Earth-Moon and Sun-Earth case)

The two-bodies problem can be fully solved, and was solved by Kepler (1609) and Newton (1687). The general three-body problem is often given as an example of a mathematical problem that ‘can’t be solved’. So, there is no general analytical solution. This problem can be significant and a special case of this problem is the Circular Restricted Three-Body Problem (CRTBP), which can be applied to the Earth-Moon system with a spacecraft, the Sun-Earth system with an asteroid, etc. In this paper, let’s focus on the motion of a test particle near the triangular Lagrange points L4 and L5 in the Earth-Moon and the Sun-Earth systems. Studying the movement of an object around these points is especially important for space mission design. To generate a trajectory around these points, the non-linear equations of motion for the circular restricted three-body problem were numerically integrated into MATLAB® 2023 software and the results are presented in the plane (x, y) and the phase plane (x, vx) and (y, vy). By numerical orbit integration, it is possible to investigate what happens when the displacement is relatively large or short from the Lagrange points. Then the small astronomical body may vibrate around these points. The results in this paper are shown in the rotating and inertia axes. Various initial positions near the Lagrange points and velocities are used to produce various paths the test particle can take. The same examples of numerical studies of trajectories associated with Lagrange points are shown in the inertial and the rotating coordinates system and are discussed. From the results of the numerical tests performed in MATLAB® 2023, it is possible to saw that there are different types of periodic, quasi-periodic, and chaotic orbits

Investigation of genetic determinants of cognitive change in later life

Cognitive decline is a major health concern and identification of genes that may serve as drug targets to slow decline is important to adequately support an aging population. Whilst genetic studies of cross-sectional cognition have been carried out, cognitive change is less well-understood. Here, using data from the TOMMORROW trial, we investigate genetic associations with cognitive change in a cognitively normal older cohort. We conducted a genome-wide association study of trajectories of repeated cognitive measures (using generalised estimating equation (GEE) modelling) and tested associations with polygenic risk scores (PRS) of potential risk factors. We identified two genetic variants associated with change in attention domain scores, rs534221751 (p = 1 × 10−8 with slope 1) and rs34743896 (p = 5 × 10−10 with slope 2), implicating NCAM2 and CRIPT/ATP6V1E2 genes, respectively. We also found evidence for the association between an education PRS and baseline cognition (at >65 years of age), particularly in the language domain. We demonstrate the feasibility of conducting GWAS of cognitive change using GEE modelling and our results suggest that there may be novel genetic associations for cognitive change that have not previously been associated with cross-sectional cognition. We also show the importance of the education PRS on cognition much later in life. These findings warrant further investigation and demonstrate the potential value of using trial data and trajectory modelling to identify genetic variants associated with cognitive change.

An exploratory study of longitudinal trajectory of language, swallowing and cognition post endovascular clot retrieval.

Endovascular clot retrieval (ECR) is known to reduce global disability at 3 months post stroke however limited research exists regarding the trajectory of specific clinical impairments including language, swallowing and cognitive deficits between onset and 3 months. To assess language, swallowing, and cognitive performance following ECR and explore whether impairment severity is correlated with modified Thrombolysis in Cerebral Infarction score (mTICI), stroke severity or quality of life (QoL). Assessment was completed within 7 days (T1), 1 month (T2) and 3 months (T3) post-stroke. Performance was measured with the Functional Oral Intake Scale (FOIS), Repeatable Battery for Assessment of Neuropsychological Status (RBANS), Trail Making Test (TMT A and B) and Brixton Spatial Awareness Test. The Western Aphasia Battery (WAB) was used for left hemisphere stroke. QoL was measured with the Stroke and Aphasia Quality of Life Scale. Twenty-five participants (median 72 years; 64% male) were prospectively recruited following ECR. High reperfusion success (68% mTICI 3) and low stroke severity post ECR (median 24h NIHSS = 3, IQR 7-18) were noted. At T1, 10 participants presented with aphasia, eight required a modified diet and 20 had impaired cognition. At T3 all had recovered to a normal oral diet, 39% had persistent cognitive impairment and 45% of patients with left hemisphere stroke remained aphasic. Performance on the WAB, FOIS, RBANS and TMT changed significantly over time (all p<0.05). The severity score at T1 for all measures, excluding TMT B and Brixton, was significantly correlated with 24h NIHSS. WAB scores at T3 were correlated with QoL (r = 0.618; p = 0.043). This exploratory study found the longitudinal performance of language, swallowing and cognition significantly improved over time and severity in the first-week post-ECR was correlated with 24h NIHSS rather than the degree of reperfusion. What is already known on the subject Randomised control trials have demonstrated the benefit of ECR in patients with ischemic stroke using global measures of disability and function. Limited research exists regarding the trajectory of specific clinical impairments including language, swallowing and cognitive deficits. There is also a reliance on screening assessments and a lack of consideration of the influence of co-occurring impairments. What this paper adds to existing knowledge This prospective study is amongst the first to explore the longitudinal trajectory of language, swallowing and cognitive impairment using a standardised assessment battery. Twenty-four-hour NIHSS was significantly correlated with language, swallowing, global cognition and some measures of executive function. Language performance post ECR was correlated with domain-specific cognitive assessment of attention, immediate memory and delayed memory, which differed from swallowing performance post ECR that correlated with measures of executive function. What are the potential or actual clinical implications of this work? It is important for speech-language pathologists and the wider medical team to monitor language, swallowing and cognitive performance post ECR regardless of treatment success. Stroke severity at 24h post-ECR influences the severity of language, swallowing and cognitive impairments.

A Longitudinal Study of AFP Trajectories and Clinical Outcomes in Intermediate-Stage Hepatocellular Carcinoma After Hepatectomy.

Previous studies have shown that the alpha-fetoprotein (AFP) response has been a key tumour marker in hepatocellular carcinoma (HCC), but its definition remains controversial. Recently, a new study has explored and defined the AFP serological response and used it to explain the subclass of intermediate-stage hepatocellular carcinoma (IM-HCC) with "sharp-falling" AFP change after transarterial chemoembolization (TACE). Itmay be a new and simple tool for assessing the prognosis of patients. This study aims to explore a simplified AFP trajectory and its impact on overall survival (OS) and disease-free survival (DFS) for IM-HCC after hepatectomy. Between January 2007 and May 2012, data from the Sun Yat-sen University Cancer Center was examined in this longitudinal, retrospective cohort study. A generalized additive model was applied to distinguish potential AFP dynamic trajectories. The Kaplan-Meier method was applied to analyze OS and DFS, and multivariate Cox models were used to calculate adjusted hazard ratios (aHRs) and 95% CIs for overall survival. 144 patients who had IM-HCC with at least three AFP repeat measurements were included in the study. Three similar trajectories are displayed using the generalized additive model: low-stable (35.4%; n = 51), high-rising (36.1%; n = 52), and sharp-falling (28.5%; n = 41). Compared with the low-stable class, the aHRs for death were 2.84 (1.50, 5.41) and 0.59 (0.25, 1.40) for the high-rising and sharp-falling classes, adjusted by age and log AFP. Simplified AFP trajectory had higher relative importance than sex, intrahepatic tumor number, Child-Pugh class, and baseline AFP. The simplified AFP trajectory is a promising biomarker for IM-HCC patients undergoing hepatectomy. In the future, it should be verified by a larger population containing various stages of HCC.

Blastomere size in the human 2-cell embryo predicts the division order that leads to imbalanced lineage contribution to the future body.

Retrospective tracing of somatic mutations predicted that most cells in the human body could be traced back to a single cell of the 2-cell stage embryo. Accordingly, a recent prospective study of the developmental trajectory of blastomeres in human embryos confirmed that progeny of the first 2-cell stage blastomere to divide generates more epiblast cells (future body). How the 2-cell blastomeres differ is unknown. Here, we show that 2-cell stage blastomeres in human embryos are asymmetric; they differ in size and the bigger blastomere divides first to 4-cell stage. We propose that this asymmetry might originate differences in cell fate.

Перспективы углеродной нейтральности в сельском хозяйстве России по сценариям SSP: анализ на уровне страны и региона

Sustainable development and reduction of the carbon footprint is an important issue on the development agenda of the Russian national economy and, in particular, the agricultural sector. The study of long-term trajectories of development of the agricultural economy and the conditions for achieving carbon neutrality should take into account the expected climatic and socio-economic changes in the world, which are enshrined in a number of widely used scenarios – ‘Shared Socioeconomic Pathways’ (SSPs) and, as a rule, are based on the use of integral multi-sector models land use dynamics. The study is focused on obtaining projections of climate change and scenarios SSP1, SSP2 and SSP3 on the dynamics of crop production in Russia until 2050, with an emphasis on the development of a large agricultural region of Siberia – Altai Krai, in the context of analyzing the timing and conditions for achieving carbon neutrality. The GLOBIOM model, adapted for modeling at the level of Russian regions, was used as a toolkit. The results of scenario modeling made it possible to assess changes in the scale of production and cropland structure, greenhouse gas emissions in carbon units and the overall dynamics of the carbon footprint as well as expected consequences for Russian economy and harnessing the export potential of crops. It has been revealed that achieving carbon neutrality on the regional level (Altai Krai) is a challenge that requires a significant change in the structure of sown areas, the introduction of environmentally-oriented technologies and a significant increase in the productivity of agricultural land. The results contribute to deepening the understanding of regional economic management processes using the example of the Altai Kray and ways to achieve sustainable development goals, in particular achieving carbon neutrality in crop production. The practice of such research can be transferred to other regions of Russia

Longitudinal study of childhood sleep trajectories and adolescent mental health problems.

To investigate whether childhood sleep trajectories are associated with mental health symptoms such as social phobia, generalized anxiety, depression, attention deficit hyperactivity disorder (ADHD), conduct problems, and opposition at age 15. A total of 2120 children took part in the Quebec Longitudinal Study of Child Development. Childhood sleep trajectories were computed from maternal reports at 2.5, 3.5, 4, 6, 8, 10, and/or 12 years. At age 15, 1446 adolescents filled out mental health and sleep questions. A path analysis model was assessed in the full sample. Four childhood nocturnal sleep duration trajectories were identified: (1) a short pattern (7.5%), (2) a short-increasing pattern (5.8%), (3) a 10 hours pattern (50.7%), and (4) an 11 hours pattern (36.0%). Three childhood sleep latency trajectories were found: (1) a short pattern (31.7%), (2) an intermediate pattern (59.9%), and (3) a long pattern (8.4%). Finally, two childhood wakefulness after sleep-onset trajectories were found: (1) a normative pattern (73.0%) and (2) a long pattern (27.0%). The path analysis model indicated that children following a long childhood sleep latency trajectory were more likely to experience symptoms of depression (β = 0.06, 95% CI: 0.01 to 0.12), ADHD (β = 0.07, 95% CI: 0.02 to 0.13), conduct problems (β = 0.05, 95% CI: 0.00 to 0.10) and opposition (β = 0.08, 95% CI: 0.02 to 0.13) at age 15. This longitudinal study revealed that children presenting a long sleep latency throughout childhood are at greater risk of symptoms of depression, ADHD, conduct problems, and opposition in adolescence.