The study of rejuvenated-stage volcanism provides insight into spatiotemporal changes to the geochemical structure of the Hawaiian mantle plume and the varying interaction with non-plume sources over an extended period of melting beneath volcanic centres. We present new geochemical and Hf-Pb-Sr-Nd isotope data from 6 samples of rejuvenated-stage volcanism on West Maui, the southernmost and youngest island within the Hawaiian chain to exhibit rejuvenation. Major and trace element geochemistry reveal four discrete silica undersaturated eruptions produced by 3–11% partial melting of a garnet peridotite mantle source of metasomatized upper asthenosphere. High Ba/Th ratios (>200) overlap with rejuvenated-stage lavas from Niʻihau, indicating that a minor carbonatite presence persists within the source of rejuvenated-stage lavas along the Hawaiian chain. Puʻu Laina lavas on West Maui have εHf = +15 and εNd = +8.9, which are among the most depleted values of rejuvenated lavas and plot on or below the terrestrial mantle array. These values are close to that of the most depleted lavas from the North Arch and along with rejuvenated lavas from Kauaʻi and East Molokaʻi trend towards the Pacific MORB. Pyroxenite xenoliths and lavas from Kaʻula and Oʻahu, and lavas from Niʻihau extend to higher εHf values at a given εNd indicating a long-lived depleted source independent of the MORB mantle. West Maui rejuvenated lavas form a steep 208Pb/204Pb-206Pb/204Pb trendline and together with North Arch and East Molokaʻi lavas are shifted towards lower 208Pb/206Pb values typical of Pacific MORB. We propose that the across-plume heterogeneity seen in rejuvenated lavas on Kauaʻi and Niʻihau persists at the southern end of the Hawaiian chain where West Maui and East Molokaʻi rejuvenated lavas, like Kauaʻi and North Arch, preferentially source upper asthenosphere as opposed to an ancient depleted source. This across-plume heterogeneity within rejuvenated-stage lavas closely resembles the Kea and Loa-trend differences in shield stage geochemistry and indicates that similar geodynamic processes are responsible for both.