Structural Foundation Research Articles

An Equity Evaluation of Healthcare Accessibility across Age Strata Using the G2SFCA Method: A Case Study in Karamay District, China

Equitable access to healthcare services is essential for residents’ well-being and social equity, requiring the rational spatial distribution of healthcare facilities in urban planning. Compared with major studies on the spatial accessibility and equity of healthcare services in first-tier cities, second-tier cities, which form the foundational structure of the global urban system, have not be given sufficient attention. Therefore, this study takes Karamay District in Karamay as a case study to analyze the spatial equity of healthcare services using place-based accessibility measures. For accessibility calculations, we employ the Gaussian two-step floating catchment area method to separately analyze the accessibility to hospitals and primary healthcare (PHC) institutions, considering factors such as the number of facilities, population, distance, and transportation modes. Second, we utilize global and local Moran’s I for spatial analysis to identify areas with varying levels of accessibility. Furthermore, considering the spatial equity for different social groups, this study innovatively proposes an analytical framework for assessing healthcare accessibility and equity across age groups using residential-level data and an adjusted search radius in second-tier cities, typically those with small-scale urban areas. The results reveal significant spatial clustering in healthcare accessibility, similar to that observed in most first-tier cities, as well as notable differences in the spatial distribution between hospital accessibility and PHC accessibility. Regarding age strata, results show that the elderly have lower access to hospitals but higher access to PHC institutions, which is opposite to the situation observed for children. Overall, second-tier cities demonstrate better equity in healthcare accessibility compared to first-tier cities, particularly regarding hospital accessibility. However, there are minor inequities in PHC accessibility for children aged 0–12 years. Our findings may provide valuable insights and essential data support for healthcare resource allocation and land use planning in second-tier cities.

Structural basis of TRPV1 inhibition by SAF312 and cholesterol

Transient Receptor Potential Vanilloid 1 (TRPV1) plays a central role in pain sensation and is thus an attractive pharmacological drug target. SAF312 is a potent, selective, and non-competitive antagonist of TRPV1 and shows promising potential in treating ocular surface pain. However, the precise mechanism by which SAF312 inhibits TRPV1 remains poorly understood. Here, we present the cryo-EM structure of human TRPV1 in complex with SAF312, elucidating the structural foundation of its antagonistic effects on TRPV1. SAF312 binds to the vanilloid binding pocket, preventing conformational changes in S4 and S5 helices, which are essential for channel gating. Unexpectedly, a putative cholesterol was found to contribute to SAF312’s inhibition. Complemented by mutagenesis experiments and molecular dynamics simulations, our research offers substantial mechanistic insights into the regulation of TRPV1 by SAF312, highlighting the interplay between the antagonist and cholesterol in modulating TRPV1 function. This work not only expands our understanding of TRPV1 inhibition by SAF312 but also lays the groundwork for further developments in the design and optimization of TRPV1-related therapies.

Interactive Mesh Sculpting with Arbitrary Topologies in Head-Mounted VR Environments

Shape modeling is a dynamic area in computer graphics with significant applications in computer-aided design, animation, architecture, and entertainment. Virtual sculpting, a key paradigm in free-form modeling, has traditionally been performed on desktop computers where users manipulate meshes with controllers and view the models on two-dimensional displays. However, the advent of Extended Reality (XR) technology has ushered in immersive interactive experiences, expanding the possibilities for virtual sculpting across various environments. A real-time virtual sculpting system implemented in a Virtual Reality (VR) setting is introduced in this paper, utilizing quasi-uniform meshes as the foundational structure. In our innovative sculpting system, we design an integrated framework encompassing a surface selection algorithm, mesh optimization technique, mesh deformation strategy, and topology fusion methodology, which are all tailored to meet the needs of the sculpting process. The universal, user-friendly sculpting tools designed to support free-form topology are offered in this system, ensuring that the meshes remain watertight, manifold, and free from self-intersections throughout the sculpting process. The models produced are versatile and suitable for use in diverse fields such as gaming, art, and education. Experimental results confirm the system’s real-time performance and universality, highlighting its user-centric design.

Rational Design of Fluorophores Using MO Theory: Our Journey from BODIPYs to BOIMPYs

This short review demonstrates how MO-theoretical considerations can support the tailor-made design of new dye scaffolds, specifically the recently introduced BOIMPY class of fluorophores. Starting with historical and structural foundations, the influence of canonical streptocyanines on the electronic features of diarylmethenes and rhodamines is examined and the BODIPY scaffold is introduced as the primary structural inspiration for our work. The attachment of five-membered ring heterocycles at the meso position of the BODIPY core enables a relaxation into a co-planar and twofold chelating triarylmethene system. After introduction of two electron-withdrawing BF2 units, efficient rigidity is achieved since hindered rotation prevents non-radiative dissipation of energy via excited state relaxation. Hence, a lowered LUMO level allows the combination of a large red shift with high quantum efficiencies. The synthetic approach to BOIMPYs is straightforward and analogous to BODIPY syntheses starting from benzimidazole or tetrazole carbaldehydes. Cyclic voltammetric measurements prove that BOIMPYs are able to easily accept two electrons and might act as efficient photoredox catalysts.

Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae

The protein import motor in chloroplasts plays a pivotal role in their biogenesis and homeostasis by driving the translocation of preproteins into chloroplasts. While the Ycf2-FtsHi complex serves as the import motor in land plants, its evolutionary conservation, specialization, and mechanisms across photosynthetic organisms are largely unexplored. Here, we isolated and determined the cryogenic electron microscopy (cryo-EM) structures of the native Ycf2-FtsHi complex from Chlamydomonas reinhardtii, uncovering a complex composed of up to 19 subunits, including multiple green-algae-specific components. The heterohexameric AAA+ ATPase motor module is tilted, potentially facilitating preprotein handover from the translocon at the inner chloroplast membrane (TIC) complex. Preprotein interacts with Ycf2-FtsHi and enhances its ATPase activity invitro. Integrating Ycf2-FtsHi and translocon at the outer chloroplast membrane (TOC)-TIC supercomplex structures reveals insights into their physical and functional interplay during preprotein translocation. By comparing these findings with those from land plants, our study establishes a structural foundation for understanding the assembly, function, evolutionary conservation, and diversity of chloroplast protein import motors.

Pengaruh Perbandingan Nilai Termal Terhadap Deformasi Fondasi Tiang Energi Menggunakan Metode Numerik

A thermal energy foundation is an innovative combination of a foundation structure with thermal pipes that can absorb geothermal heat. This allows it to serve as an alternative source of electricity for the building above it. The goal of this technology is to help achieve sustainable infrastructure targets by minimizing the use of fossil fuels from a geotechnical perspective. This study aims to analyze the thermal effect on foundation deformation using the Finite Element Method approach. The modelling is done using PLAXIS software with element meshes to provide comprehensive deformation results. Additionally, the model is used to vary the thermal parameters of the soil and the quality of the foundation concrete. The analysis results indicate that variations in thermal conductivity values lead to a 34.112% decrease in deformation due to reduced thermal conductivity, while variations in the quality of concrete used in the foundation show a relatively small or insignificant effect on the deformation.

Conceptual design and experimental investigation of regolith bag structures for lunar in situ construction

Lunar habitat construction is a critical engineering requirement in lunar exploration missions, characterized by unique structural and material challenges distinct from Earth. To meet the demands of in situ large-scale construction in extreme lunar environments, a general mode of “Prefabricated core module & Inflatable structure &In situ materials structure” is adopted. This work analyzed the structural internal forces and foundation bearing capacity for lunar habitats, highlighting the significance of structural tensile performance and the foundation's allowable bearing capacity. A construction scheme based on regolith bags is proposed, encompassing architectural and structural design, and long-term planning. Multiscale experimental investigations conducted on “material, component, structure, and construction” levels confirm the excellent properties of regolith bag. Aramid fabric and CUG lunar regolith simulant were chosen for material and component testing, focusing on evaluating the regolith bag's performance under tension and compression. Successful construction demonstrations of a regolith bag arch structure and a regolith bag – airbag structural unit validate the feasibility of this construction scheme. Conclusively, the proposed lunar habitat construction scheme based on regolith bag technology provides a viable and efficient method for in situ lunar construction.

Conf-GEM: A geometric information-assisted direct conformation generation model

Molecular conformations generation (MCG) aims to efficiently obtain reasonable and stable three-dimensional (3D) atomic coordinates of the atoms in the molecule from scratch, providing a structural foundation for molecular representation learning models and advanced downstream molecular design tasks such as molecular property prediction, molecular generation, and molecular docking. Existing MCG methods mostly rely on indirect distance-based strategies, which which can result in geometrically unrealistic conformations, or direct coordinate-based methods, which have larger search spaces and are prone to overfitting. Therefore, this study introduces Conf-GEM, a novel geometric information-assisted direct conformation generation model based on E-GeoGNN, a geometrically augmented 3D graph neural network with multiple scales. Pre-training and divide-and-conquer strategies, are integrated into the proposed model. Conf-GEM outperforms RDKit and nine deep-learning-based MCG models on the GEOM-QM9 and GEOM-Drugs datasets, achieving conformational coverage of 96.69% and 96.07%, respectively, without force field optimization. It also excels on the X-ray diffraction crystal structure dataset with up to 97.04% conformational coverage. In conclusion, Conf-GEM provides a novel solution for stabilizing 3D conformations generation. We provide an online prediction service (https://confgem.cmdrg.com) with a user-friendly interface for researchers.

Association among internalizing problems, white matter integrity, and social difficulties in children with autism spectrum disorder

Autism spectrum disorder (ASD) is characterized by social difficulties and often accompanied by internalizing and externalizing problems, which are frequently overlooked. Here, we examined and compared fractional anisotropy (FA) between 79 children with ASD (aged 4–7.8 years) and 70 age-, gender-, and handedness- matched typically developing controls (TDCs, aged 3–7.2 years). We aimed to explore the relationship among social difficulties, internalizing and externalizing problems, and brain structural foundation (characterized by white matter integrity). Compared with the TDCs, the children with ASD exhibited more severe internalizing and externalizing problems, which were positively correlated with social difficulties. Reduced FA values were observed in specific white matter tracts that integrate a fronto–temporal–occipital circuit. In particular, the FA values within this circuit were negatively correlated with internalizing problems and SRS-TOTAL scores. Mediation analysis revealed that internalizing problems mediated the relationship between the FA values in the left middle longitudinal fasciculus (L-MdLF) and corpus callosum forceps major (CCM) and social difficulties in children with ASD. These findings contribute to our understanding of social difficulties, internalizing and externalizing problems, and white matter integrity in children with ASD and highlight internalizing problems as a mediator between social difficulties and white matter integrity.

Substantiation of the Monitoring Network of Talik Zones in Urbanized Permafrost Areas Based on GPR Profiling Data (Anadyr, Chukotka)

Modern climatic changes have an impact on the bearing capacity of permafrost soils at the base of the foundations of buildings and structures in the urbanized territories of the Arctic and Subarctic. The activation of cryogenic processes leads to the destruction of infrastructure and to social, economic, and environmental consequences for the population. Based on the results for the geothermy of frozen and thawing soil, and on the georadar profiling of the city of Anadyr, it was concluded that the main risks of permafrost degradation are associated with the spread of hydrogenic melting zones. Maps of the soil temperature in imaginary cross-sections with depths of 3, 5, and 10 m were compiled, along with maps of the capacity of thawing soils, the permafrost aquifer, and the dangerous spread zones for exogenous cryogenic processes. The total area of talik zones with a depth of 6 m or more in the urban area was 2.34 km2, or 67% of the built-up area. The system of permafrost monitoring in the territory of Anadyr was substantiated, and is based on monitoring the boundaries of talik zones. It consists of an automated network of observations of the ground temperature in 35 wells at the boundary and in the center of 20 zones of the dangerous development of exogenous cryogenic processes, as well as 12 control GPR profiles at the intersection of linear hydrogenic taliks.

L’importanza dei masi come luoghi del paesaggio culturale ladino della Val Gardena

Rural architecture, as an integral part of any cultural landscape, reflects the connection between humans and their habitat. The “masi” (farmsteads) of Val Gardena embody this harmony with nature through the use of wood and stone, blending functionality with the surrounding environmental context. These buildings not only symbiotically relate to the terrain, but they also respond to agricultural needs and natural conditions. The construction of “masi” adheres to philosophical principles of order, expressing the “genius loci” of the location. In Val Gardena, two predominant typologies emerge: the “Einhof” and the “Paarhof”, both characterised by the skilful use of natural materials and integration into the landscape. The evolution of “masi” over time reveals functional and organic transformations, showcasing craftsmanship and adaptability to the environment. Wood, a durable and versatile material, is used to form the structural foundation, reflecting a pragmatic approach to design. The interior spaces, such as the kitchen and “stube” (traditional living room), are configured according to functional needs while still maintaining the essence of traditional dwellings. These buildings exhibit an architectural identity oriented towards modernity, offering insights for contemporary architectural language. This essay, accompanied by selected photographs, delves into the peculiarities of Val Gardena’s “masi”, providing a comprehensive analysis of buildings through construction principles, relationships with the landscape, typologies, spatial characteristics, and potential new uses.

Approximate settlement influence factors for bucket foundations

ABSTRACT The response of bucket foundations for offshore structures has received significant attention from researchers but most of the reported studies focused on ultimate capacity. In this study, a comprehensive series of finite element analyses have been performed to investigate directly how the skirt geometry affects the elastic settlement of bucket foundations of arbitrary rigidity embedded in either a homogeneous or heterogeneous soil medium with finite layer thickness. The effect of soil drainage conditions is also explored. The results are graphically presented in the familiar form of settlement influence factors which can be used in hand calculations to predict the settlement of bucket foundations for a wide range of practical cases. Approximating expressions that capture the settlement influence factors well are developed. A worked example is given to illustrate the use of the graphical and approximating solutions.

Probing the interaction between the metallo-β-lactamase SMB-1 and ampicillin by multispectral approaches combined with molecular dynamics.

Metallo-β-lactamases (MβLs) hydrolyze and inactivate β-lactam antibiotics, are a pivotal mechanism conferring resistance against bacterial infections. SMB-1, a novel B3 subclass of MβLs from Serratia marcescens could deactivate almost all β-lactam antibiotics including ampicillin (AMP), which has posed a serious threat to public health. To illuminate the mechanism of recognition and interaction between SMB-1 and AMP, various fluorescence spectroscopy techniques and molecular dynamics simulation were employed. The results of quenching spectroscopy unraveled that AMP could make SMB-1 fluorescence quenching that mechanism was the static quenching; the synchronous and three-dimensional fluorescence spectra validated that the microenvironment and conformation of SMB-1 were altered after interaction with AMP. The molecular dynamics results demonstrated that the whole AMP enters the binding pocket of SMB-1, even though with a relatively bulky R1 side chain. Loop1 and loop2 in SMB-1 undergo significant fluctuations, and α2 (71-73) and local α5 (186-188) were turned into random coils, promoting zinc ion exposure consistent with circular dichroism spectroscopy results. The binding between them was driven by a combination of enthalpy and entropy changes, which was dominated by electrostatic force in agreement with the fluorescence observations. The present study brings structural insights and solid foundations for the design of new substrates for β-lactamases and the development of effective antibiotics that are resistant to superbugs.

An alternative approach for the sediment control of in-channel stony debris flows with an application to the case study of Ru Secco Creek (Venetian Dolomites, Northeast Italy)

Controlling sediment to reduce debris-flow hazard is generally approached using retention basins that can be closed or have an outlet structure, generally an open check dam. They are usually placed in mild slope zones that allow minimal works for the excavation and the foundation of the outlet structure if present. Recently, it has been shown that the detention of sediments can also be achieved in the high-sloping reaches of debris-flow channels using deposition areas, basins that are open on the downstream side. In this work, we propose an approach for controlling the sediment volume transported by debris flows consisting of a cascade of deposition areas and retention basins. We also include a framework for planning, sizing, and checking the works. Two scenarios are considered, corresponding to the maximum values of the debris-flow peak discharge and volume, respectively. Moreover, the presence or absence of boulders is also considered. For this purpose, a method that evaluates the clogging of a single open check dam as a function of the coarse fraction of the sediment volume is simply extended to the case of multiple dams and implemented in a routing model. The proposed approach is applied along Ru Secco Creek in northeast Italy to defend a resort area and a village hit by a high-magnitude debris flow in 2015. After a careful survey and study, a solution with a combination of deposition areas and retention basins is planned and sized. The validity and performance of the proposed solution are analyzed using debris-flow modeling for two scenarios, considering both the absence and presence of boulders. Most of the sediment volume transported by debris flows is trapped, and a small solid discharge flows downstream of the works.

The roles of tertiary lymphoid structures in genitourinary cancers: molecular mechanisms, therapeutic strategies, and clinical applications.

The presence of tertiary lymphoid structures (TLSs) associated with distinct treatment efficacy and clinical prognosis has been identified in various cancer types. However, the mechanistic roles and clinical implications of TLSs in genitourinary (GU) cancers remain incompletely explored. Despite their potential role as predictive markers described in numerous studies, it is essential to comprehensively evaluate the characteristics of TLSs, including drivers of formation, structural foundation, cellular compositions, maturation stages, molecular features, and specific functionality to maximize their positive impacts on tumor-specific immunity. The unique contributions of these structures to cancer progression and biology have fueled interest in these structures as mediators of antitumor immunity. Emerging data are trying to explore the effects of therapeutic interventions targeting TLSs. Therefore, a better understanding of the molecular and phenotypic heterogeneity of TLSs may facilitate the development of TLSs-targeting therapeutic strategies to obtain optimal clinical benefits for GU cancers in the setting of immunotherapy. In this review, the authors focus on the phenotypic and functional heterogeneity of TLSs in cancer progression, current therapeutic interventions targeting TLSs and the clinical implications and therapeutic potential of TLSs in GU cancers.

Seismic mitigation performance of a periodic foundation for nuclear power structures considering soil-structure interactions

Periodic structures may be designed as periodic foundations to reduce the seismic response of engineering structures. The periodic foundation is more suitable for the seismic mitigation of nuclear power structures because of its wide attenuation domain. Based on the dispersion relationship of infinite periodic structures, this research constructs a one-dimensional layered periodic foundation using rubber and concrete materials, determines the attenuation domain frequency band gap that meets the seismic design requirements of nuclear power structures, and optimizes the raft design of nuclear power structures. At the same time, with the scarcity of bedrock sites, the site selection of nuclear power structures is inevitably shifted to soft rock sites. Therefore, this paper also considers the influence of the soil-structure interaction (SSI) on the seismic response of nuclear power structures. A three-dimensional finite element model of the nuclear power structure-periodic foundation-site system was established, and a detailed parameter analysis of the seismic performance of the periodic foundation of nuclear power structures considering the SSI effect was carried out. The results show that the seismic response of nuclear power structures can be significantly reduced by designing the attenuation domain of the periodic foundation.

Effects of Graphene Reinforcement on Static Bending, Free Vibration, and Torsion of Wind Turbine Blades.

Renewable energy markets, particularly wind energy, have experienced remarkable growth, predominantly driven by the urgent need for decarbonization in the face of accelerating global warming. As the wind energy sector expands and turbines increase in size, there is a growing demand for advanced composite materials that offer both high strength and low density. Among these materials, graphene stands out for its excellent mechanical properties and low density. Incorporating graphene reinforcement into wind turbine blades has the potential to enhance generation efficiency and reduce the construction costs of foundation structures. As a pilot study of graphene reinforcement on wind turbine blades, this study aims to investigate the variations of mechanical characteristics and weights between traditional fiberglass-based blades and those reinforced with graphene platelets (GPLs). A finite element model of the SNL 61.5 m horizontal wind turbine blade is used and validated by comparing the analysis results with those presented in the existing literature. Case studies are conducted to explore the effects of graphene reinforcement on wind turbine blades in terms of mechanical characteristics, such as free vibration, bending, and torsional deformation. Furthermore, the masses and fabrication costs are compared among fiberglass, CNTRC, and GPLRC-based wind turbine blades. Finally, the results obtained from this study demonstrate the effectiveness of graphene reinforcement on wind turbine blades in terms of both their mechanical performance and weight reduction.

The Disulfide Bond-Mediated Cyclization of Oral Peptides.

'Structure determines function' is a consensus in the current biological community, but the structural characteristics corresponding to a certain function have always been a hot field of scientific exploration. A peptide is a bio-active molecule that is between the size of an antibody and a small molecule. Still, the gastrointestinal barrier and the physicochemical properties of peptides have always limited the oral administration of peptides. Therefore, we analyze the main ways oral peptide conversion strategies of peptide modification and permeation enhancers. Based on our analysis of the structure of natural oral peptides, which can be absorbed through the gastrointestinal tract, we believe that the design strategy of natural stapled peptides based on disulfide bonds is good for oral peptide design. This cannot only be used to identify anti-gastrointestinal digestive structural proteins in nature but also provide a solid structural foundation for the construction of new oral peptide drugs.

The involvement of keratinocytes in pruritus of chronic inflammatory dermatosis.

Frequent itching and incessant scratching are commonly observed in various chronic inflammatory skin conditions, including atopic dermatitis and psoriasis. The persistent and prolonged nature of pruritus can worsen one's quality of life. Keratinocytes (KCs), the predominant cells of the epidermis, have been confirmed to interact with sensory neurons and immune cells and be involved in chronic skin inflammatory diseases associated with pruritus. Initially, KCs and sensory neurons form a unique synapse-like connection within the epidermis, serving as the structural foundation for their interaction. Additionally, several receptors, including toll-like receptors and protease-activated receptor 2, expressed on KCs, become activated in an inflammatory milieu. On the one hand, activated KCs are sources of pro-inflammatory cytokines and neurotrophic factors, such as adenosine triphosphate, thymic stromal lymphopoietin, and nerve growth factor, which directly or indirectly participate in stimulating sensory neurons, thereby contributing to the itch sensations. On the other hand, KCs also function as primary transducers alongside intraepidermal nerve endings, directly initiating pruritic responses. This review summarizes the current literature and highlights the critical role of KCs in the development and persistence of chronic itch in inflammatory skin disorders.

Integrated Geophysical and Geotechnical Methods for Pre-Foundation Investigations at Lagos State University of Science and Technology, Ikorodu, Southwestern Nigeria

The recurrence of building collapses and resulting casualties is overwhelming in Lagos State as the state records the highest cases in recent times. This work used geophysical (Ground magnetic (GM) and Electrical resistivity imaging (ERI)) and geotechnical (Dynamic cone penetration test (DCPT)) methods in delineating the subsurface conditions for its competence in foundation structures. Ten profiles of 200 m ground magnetic data were collected at 2 m spacing likewise for Wenner arrays on each profile. DCPT data were collected at points 0 m, 50 m, 100 m,150 m, and 200m to the depth of 3 m on each of the profiles occupied by GM and ERI. The data obtained were processed and interpreted using RES2DINV software for ERI, Excel package for both Magnetic and DCPT. The ground magnetic results gives the minimum relative magnetic intensity as -1689.78 nT representing possible fault/fractured zone and maximum value of 2943 nTindicating area of competence for foundation structure. ERI results gives a resistivity value ranging from 2 Ωm – 7602 Ωm depicting four zones of incompetent/sub-competent clay/sandy clay, moderately competent clayey sand, competent sand and highly competent lateritic sand. DCPT results is in the average range 11.20% to 39.87% representing Clay materials fairly competent for foundation structures, sand and well graded gravel that is competent for construction purposes. To prevent building collapsed in the study area, areas of incompetent materials should be excavated, refill and compact with lateritic sand before foundation is put in place.