Strontium Phosphate Research Articles

Dental Composites with Calcium / Strontium Phosphates and Polylysine.

PurposeThis study developed light cured dental composites with added monocalcium phosphate monohydrate (MCPM), tristrontium phosphate (TSrP) and antimicrobial polylysine (PLS). The aim was to produce composites that have enhanced water sorption induced expansion, can promote apatite precipitation and release polylysine.Materials and MethodsExperimental composite formulations consisted of light activated dimethacrylate monomers combined with 80 wt% powder. The powder phase contained a dental glass with and without PLS (2.5 wt%) and/or reactive phosphate fillers (15 wt% TSrP and 10 wt% MCPM). The commercial composite, Z250, was used as a control. Monomer conversion and calculated polymerization shrinkage were assessed using FTIR. Subsequent mass or volume changes in water versus simulated body fluid (SBF) were quantified using gravimetric studies. These were used, along with Raman and SEM, to assess apatite precipitation on the composite surface. PLS release was determined using UV spectroscopy. Furthermore, biaxial flexural strengths after 24 hours of SBF immersion were obtained.ResultsMonomer conversion of the composites decreased upon the addition of phosphate fillers (from 76 to 64%) but was always higher than that of Z250 (54%). Phosphate addition increased water sorption induced expansion from 2 to 4% helping to balance the calculated polymerization shrinkage of ~ 3.4%. Phosphate addition promoted apatite precipitation from SBF. Polylysine increased the apatite layer thickness from ~ 10 to 20 μm after 4 weeks. The novel composites showed a burst release of PLS (3.7%) followed by diffusion-controlled release irrespective of phosphate addition. PLS and phosphates decreased strength from 154 MPa on average by 17% and 18%, respectively. All formulations, however, had greater strength than the ISO 4049 requirement of > 80 MPa.ConclusionThe addition of MCPM with TSrP promoted hygroscopic expansion, and apatite formation. These properties are expected to help compensate polymerization shrinkage and help remineralize demineralized dentin. Polylysine can be released from the composites at early time. This may kill residual bacteria.

Strontium phosphate conversion coating as an economical and environmentally-friendly pretreatment for electroless plating on AM60B magnesium alloy

Abstract Corrosion resistance of the magnesium alloys must be improved before any outdoor applications by an appropriate technology such as electroless plating. In this study, application of Ni-P electroless coating on AM60B magnesium alloy via strontium phosphate (Sr-P) conversion coating as economical and complete environmentally-friendly pretreatment has been investigated. Morphology, composition, microstructure, and corrosion behavior of the coatings were investigated by scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction and electrochemical techniques respectively. After conversion coating process, flake-like crystals were formed on some parts of the substrate while the remaining areas were covered by an amorphous, composite and porous film. After immersion in the Ni-P bath, nickel nuclei were mainly formed through the pores of the conversion coating at initial plating times and then were grown in the horizontal and vertical directions to cover whole substrate. Uniform and pore-free electroless coatings with compact grain boundaries were formed on the 2 and 5 min Sr-P treated samples while the coating on the 15 min treated sample showed granular structure with obvious inter-granular space. All of the coatings showed mixed crystalline-amorphous structure with moderate amounts of the phosphorous. The amount of the phosphorous increased with decreasing the time of the Sr-P treatment led to disappearance of the grain boundaries and formation of more compact structure. The electroless coating obtained by 2 min Sr-P treatment showed the best corrosion protection in 3.5 wt% NaCl due to its compact structure while the coating applied on 15 min treated sample was failed when exposed to the corrosive solution.

Luminescent properties and energy transfer behavior between Tm3+ and Dy3+ ions in co-doped phosphate glasses for white LEDs

In order to obtain white light-emitting materials, the luminescent glasses composed of SrO–ZnO–TiO2–P2O5 co-doped with Tm3+ and Dy3+ ions were synthesized by a conventional melting-quenching method. The luminescent properties of Tm3+ and Dy3+ in zinc strontium phosphate glasses were investigated, where the emission spectra show possible energy transfer mechanism between Tm3+ and Dy3+ ions. The energy transfer carries out via resonant transfer modes, which is easily understood from Tm3+ and Dy3+ energy level diagrams. The decreasing in mean-duration time of Tm3+:1D2 and Dy3+:4F9/2 obtained from the decay curves makes a further evidence of energy transfer from Tm3+ to Dy3+ ions and Dy3+ to Tm3+ ions in the glasses.

Osteoanabolic Implant Materials for Orthopedic Treatment.

Osteoporosis is becoming more prevalent due to the aging demographics of many populations. Osteoporotic bone is more prone to fracture than normal bone, and current orthopedic implant materials are not ideal for the osteoporotic cases. A newly developed strontium phosphate (SrPO4 ) coating is reported herein, and applied to Ti-29Nb-13Ta-4.6Zr (wt%), TNTZ, an implant material with a comparative Young's modulus to that of natural bone. The SrPO4 coating is anticipated to modulate the activity of osteoblast (OB) and osteoclast (OC) cells, in order to promote bone formation. TNTZ, a material with excellent biocompatibility and high bioinertness is pretreated in a concentrated alkaline solution under hydrothermal conditions, followed by a hydrothermal coating growth process to achieve complete SrPO4 surface coverage with high bonding strength. Owing to the release of Sr ions from the SrPO4 coating and its unique surface topography, OB cells demonstrate increased proliferation and differentiation, while the cellular responses of OC are suppressed, compared to the control case, i.e., bare TNTZ. This TNTZ implant with a near physiologic Young's modulus and a functional SrPO4 coating provides a new direction in the design and manufacture of implantable devices used in the management of orthopedic conditions in osteoporotic individuals.

Addressing the challenge in osteoporotic fracture fixation through strontium-releasing surface

Event Abstract Back to Event Addressing the challenge in osteoporotic fracture fixation through strontium-releasing surface Yunfei Ding1, Rachel W. Li2, 3*, Trina Majumdar1*, Nick Birbilis1*, Paul N. Smith2, 3* and Xiaobo Chen1 1 Monash University, Materials Science and Engineering, Australia 2 The Australian National University, The Medical School, Australia 3 The Australian National University, John Curtins School of Medical Research, Australia Osteoporotic fracture is a prevailing symptom in the ageing population, postmenopausal women, and male patient suffering chronic kidney disease. All sophisticated implantable devices for bone fracture treatment, however, lack the design and functionalities that satisfy the particular requirements for osteoporotic cases. We developed a strontium phosphate (SrP) coating on a titanium-29niobium-13tantalum-4.6zirconium (TNTZ, wt.%) implant candidate with comparative Young’s modulus value to that of natural bone, to address this challenge through modulating the growth of osteoblast and osteoclast cells in opposite ways. TNTZ with excellent biocompatibility and extreme bio-inertness was pre-treated in a concentrated alkaline solution under hydrothermal conditions, i.e. 2.5 M NaOH, at 200 oC over 24 h, followed by a coating growth process conducted at 200 oC over 24 h, to achieve a full surface coverage with SrP deposits. With aid of controllable release of Sr ions from the resulting coating into physiological environments, osteoblast cells performed remarkably upgraded proliferation and differentiation, whilst the cellular responses of osteoclasts were dramatically suppressed. This TNTZ implant with SrP coating provides a new pathway to design and manufacture implantable devices that are desperately required for the clinical treatment of osteoporotic fracture. Keywords: Surface modification, Crystal growth, Bone repair, bioactive interface Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Biomimetic materials Citation: Ding Y, Li RW, Majumdar T, Birbilis N, Smith PN and Chen X (2016). Addressing the challenge in osteoporotic fracture fixation through strontium-releasing surface. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01954 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. * Correspondence: Dr. Rachel W Li, The Australian National University, The Medical School, Acton, Australia, rachel.li@anu.edu.au Dr. Trina Majumdar, Monash University, Materials Science and Engineering, Clayton, Australia, trina.majumdar@monash.edu Dr. Nick Birbilis, Monash University, Materials Science and Engineering, Clayton, Australia, nick.birbilis@monash.edu Dr. Paul N Smith, The Australian National University, The Medical School, Acton, Australia, psmith@orthoact.com.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Yunfei Ding Rachel W Li Trina Majumdar Nick Birbilis Paul N Smith Xiaobo Chen Google Yunfei Ding Rachel W Li Trina Majumdar Nick Birbilis Paul N Smith Xiaobo Chen Google Scholar Yunfei Ding Rachel W Li Trina Majumdar Nick Birbilis Paul N Smith Xiaobo Chen PubMed Yunfei Ding Rachel W Li Trina Majumdar Nick Birbilis Paul N Smith Xiaobo Chen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Sensitization of Sn2+ on Tb3+ luminescence for deep UV excitation in phosphate glasses

Tb3+ and Sn2+ co-doped strontium phosphate glasses are prepared and their unique photoluminescence (PL) properties for deep UV excitation are investigated. With the co-doped Sn2+ ions, Tb3+ keeps the original PL behaviors under near UV excitation while its PL action for deep UV excitation is enhanced tremendously. PL emission and excitation spectra demonstrate the sensitization role of Sn2+ on the Tb3+ emissions for deep UV excitation that is associated with the strong deep UV absorption of Sn2+ for greatly enhancing the resonance of the Tb3+ excitation with the deep UV light source. The decay curves of Sn2+ and Tb3+ emissions for both singly doped and co-doped samples are single exponentially well fitted with almost the same emission lifetime (τ) values in the microsecond and millisecond time regimes, respectively, confirming that Sn2+ and Tb3+ act as an independent activator in the present phosphate glass matrix while an involved energy transfer from Sn2+ to Tb3+ is radiative. Moreover, Sn2+ and Tb3+ can be co-excited with deep UV light to emit tunable light from blue to green with the definite CIE chromaticity coordinate for different applications.

Gel-derived SiO2–CaO–P2O5 bioactive glasses and glass-ceramics modified by SrO addition

The effect of SrO substitution for CaO in two sol–gel glasses with different chemical compositions (mol%) A2Sr: (54−x)CaO–xSrO–6P2O5–40SiO2 and S2Sr: (16−x)CaO–xSrO–4P2O5–80SiO2 (x=0, 1, 3 and 5) stabilized at 700°C on their structure (XRD, FTIR) and bioactive properties (SBF test) was investigated. Preliminary in vitro tests using human articular chondrocytes of selected A2Sr glass were also conducted. Moreover, the subject of this study was to detect the changes on material properties after heat treatment at 1300°C. The results show that the effect of strontium substitution on structure, bioactivity and crystallization after treatment at both the above temperatures strongly depends on CaO/SiO2 molar ratio. The presence of 3–5mol% of strontium ions creates more expanded glass structure but does not markedly affect crystallization ability after low temperature treatment. Sintering at 1300°C of A2 type glasses results in crystallization of pseudowollastonite, hydroxyapatite and also Sr-substituted hydroxyapatite for 3–5mol% of SrO substitution. The increase of strontium concentration in silica-rich materials after sintering leads to appearance of calcium strontium phosphate instead of calcium phosphate. Bioactivity evaluation indicates that substitution of Sr for Ca delays calcium phosphate formation on the materials surface only in the case of silica-rich glasses treated at 700°C. Calcium-rich glasses, after both temperature treatments, reveals high bioactivity, while crystal size of hydroxyapatite decreases with increasing Sr content. High temperature treatment of high-silica glasses inhibits their bioactivity. Preliminary in vitro tests shows Sr addition to have a positive effects on human articular chondrocytes proliferation and to inhibit cell matrix biomineralization.

Microwaves in Catalysis: Methodology and Applications

The hydrolysis/dehydration of glucose and cellulose to 5-hydroxymethylfurfural (HMF) catalyzed by alkaline earth phosphates was investigated under hot compressed water condition. The catalysts were synthesized by reactions of CaCO3 or SrCO3 with ortho-H3PO4 via conventional precipitation method in acetone–water media system. The experimental results revealed that the calcination temperature greatly influenced the crystalline phases of the catalysts and the catalytic activity. The calcium and strontium phosphate catalysts without calcination are Ca(H2PO4)·H2O and Sr(H2PO4)2, respectively. The calcium phosphate catalysts calcined at 600 and 900 °C are β-CaP2O6 while the strontium phosphate catalysts display Sr2(PO3)4, and α-Sr(PO3)2, respectively. The incorporation of Ca and Sr into phosphate network of calcined samples can further improve catalytic performance. Among all synthesized catalysts, the α-Sr(PO3)2 calcined at 900 °C showed the best catalytic activity, providing the HMF yield of 21.0% from glucose dehydration and total yield of glucose and HMF of 34.8% from hydrolysis coupling dehydration of cellulose.

Coatings with calcium and strontium phosphates and tantalum oxide on titanium for biomedical applications

Layered coatings of the composition Ca- and Sr-phosphate/Ta2O5/TiO2 have been obtained by sequential application of plasma electrolytic oxidation (PEO) in an electrolyte with fluoride complexes of tantalum (stage I) and in one with tripolyphosphate complexes of Ca(II) and Sr(II) (stage II). Calcium and strontium phosphates are contained in the coating surface part, whereas tantalum oxides are present in the coating bulk. The fabricated coating/titanium composites are of interest for testing as biocompatible and bioinert implants to be used in medical practice.

Osteoblastic differentiation of stem cells from human exfoliated deciduous teeth induced by thermosensitive hydrogels with strontium phosphate.

Stem cells from human exfoliated deciduous teeth (SHEDs) are a novel source of multi-potential stem cells for tissue engineering because of their potential to differentiate into multiple cell lineages. Strontium exhibits an important function in bone remodeling because it can simulate bone formation and decrease bone resorption. Hydrogels can mimic the natural cellular environment. The association of hydrogels with cell viability is determined using biological tests, including rheological experiments. In this study, osteogenic differentiation was investigated through SHED encapsulation in hydrogels containing strontium phosphate. Results of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and proliferating cell nuclear antigen (PCNA) immunofluorescence staining indicated that the cells grew well and SHEDs proliferated in the hydrogels. Strontium-loaded chitosan-based hydrogels induced the biomineralization and high expression of alkaline phosphatase. Moreover, the expression levels of bone-related genes, including type-I collagen, Runx2, osteopontin (OP), and osteonectin (ON), were up-regulated during the osteogenic differentiation of SHEDs. This study demonstrated that strontium can be an effective inducer of osteogenesis for SHEDs. Elucidating the function of bioceramics (such as strontium) is useful in designing and developing strategies for bone tissue engineering.

Monochromic orange emission of Pr3+ ions in phosphate glass

Zinc strontium phosphate glasses doped with different trivalent praseodymium ion (Pr3+) concentrations are presented and their photoluminescence properties are investigated upon 442 nm excitation. With the Pr3+ concentration decreasing, the orange emission of Pr3+ (D21 HJ3) is enhanced steadily at the cost of its blue emission (P1,03 H43). Monochromic orange emission of Pr3+ ions is obtained when the Pr3+ doping is reduced to 0.05 mol.%. The mechanism controlling the monochromatic characteristic of Pr3+ emissions is supposed to be associated with the phonon-aided nonradiative relaxation process of Pr3+: Pj3→

Effect of calcination temperature on catalytic performance of alkaline earth phosphates in hydrolysis/dehydration of glucose and cellulose

The hydrolysis/dehydration of glucose and cellulose to 5-hydroxymethylfurfural (HMF) catalyzed by alkaline earth phosphates was investigated under hot compressed water condition. The catalysts were synthesized by reactions of CaCO3 or SrCO3 with ortho-H3PO4 via conventional precipitation method in acetone–water media system. The experimental results revealed that the calcination temperature greatly influenced the crystalline phases of the catalysts and the catalytic activity. The calcium and strontium phosphate catalysts without calcination are Ca(H2PO4)·H2O and Sr(H2PO4)2, respectively. The calcium phosphate catalysts calcined at 600 and 900°C are β-CaP2O6 while the strontium phosphate catalysts display Sr2(PO3)4, and α-Sr(PO3)2, respectively. The incorporation of Ca and Sr into phosphate network of calcined samples can further improve catalytic performance. Among all synthesized catalysts, the α-Sr(PO3)2 calcined at 900°C showed the best catalytic activity, providing the HMF yield of 21.0% from glucose dehydration and total yield of glucose and HMF of 34.8% from hydrolysis coupling dehydration of cellulose.

Effective removal of methyl blue by fine-structured strontium and barium phosphate nanorods

In this work, the composite of strontium phosphate and barium phosphate (called SBP) nanorods have been synthesized, characterized and studied for removal of methyl blue (MB). The effects of pH, temperature, contact time, initial dye concentration on removal of MB were studied in detail. Results suggest that pH and temperature were not critical limiting factors for the removal of MB. Reaching equilibrium was very rapid (within 10min) and the high adsorption capacity of MB by SBP nanorods was 1691.8mg/g at initial dye concentration of 2000mg/L. The adsorption process obeyed the pseudo-second-order kinetics model and Langmuir isotherm model. Importantly, the mechanism contributed to the MB removal was proposed to be the ionic interaction and hydrogen bonds for low dye concentration, chemical precipitation for high dye concentration. It is predicted that the SBP nanorods being an effective adsorbent for elimination of MB from colored aqueous solutions.

Osteogenic differentiation of stem cells from human exfoliated deciduous teeth on poly(ε-caprolactone) nanofibers containing strontium phosphate.

Mimicking the architecture of the extracellular matrix is an effective strategy for tissue engineering. Composite nanofibers similar to natural bone structure can be prepared via an electrospinning technique and used in biomedical applications. Stem cells from human exfoliated deciduous teeth (SHEDs) can differentiate into multiple cell lineages, such as cells that are alternative sources of stem cells for tissue engineering. Strontium has important functions in bone remodeling; for example, this element can simulate bone formation and decrease bone resorption. Incorporating strontium phosphate into nanofibers provides a potential material for bone tissue engineering. This study investigated the potential of poly(ε-caprolactone) (PCL) nanofibers coated or blended with strontium phosphate for the osteogenic differentiation of SHEDs. Cellular morphology and MTT assay revealed that nanofibers effectively support cellular attachment, spreading, and proliferation. Strontium-loaded PCL nanofibers exhibited higher expressions of collagen type I, alkaline phosphatase, biomineralization, and bone-related genes than pure PCL nanofibers during the osteogenic differentiation of SHEDs. This study demonstrated that strontium can be an effective inducer of osteogenesis for SHEDs. Understanding the function of bioceramics (such as strontium) is useful in designing and developing strategies for bone tissue engineering.

Synthesis, characterization and electrochemical properties of cation selective ion exchange composite membranes

In this work polystyrene based strontium phosphate membranes (SPMs) were prepared by applying different pressures. The membrane potential is measured with uni-univalent electrolytes (KCl, NaCl, and LiCl) solutions using saturated calomel electrodes (SCEs). The effective fixed charge density of these membranes is determined by the Torell, Meyer and Sievers method and it showed the dependence of membrane potential on the porosity, the charge on the membrane matrix, charge and size of permeating ions. The membranes are characterized by X-ray diffraction, scanning electron microscopy and IR spectroscopy. The order of surface charge density for electrolytes is KCl>NaCl>LiCl. Other parameters such as transport number, distribution coefficient, charge effectiveness and related parameters are calculated. The membrane was found to be mechanically stable, and can be operated over a wide pH range.

Protective strontium phosphate coatings for magnesium biomaterials

A biocompatible strontium phosphate (SrP) conversion coating was used to reduce the degradation rate of pure magnesium (Mg) as tested in vitro in minimum essential medium (MEM). The coating has been specifically developed on the basis of its excellent corrosion resistance, and its potential for biocompatibility and orthopaedic functionality. The surface of Mg was investigated after being coated via several processing conditions in order to elucidate the coating growth process. Scanning electron microscopy equipped with energy dispersive X-ray spectroscopy, potentiodynamic polarisation curves and mass loss measurement were employed to characterise the SrP coatings and their degradation performance. It is revealed that the conversion coating deposition initiates rapidly in the processing stage (<5 s), and the surface of Mg is fully covered by a conversion coating after ∼3 min. The coating system contains a magnesium oxide intermediate layer and an outer film of SrP. The biomimetic coating presents superior protection on Mg, representing as an evolution from the conventionally studied calcium phosphate coatings.

Osteogenic differentiation and mineralization of human exfoliated deciduous teeth stem cells on modified chitosan scaffold

Stem cells from human exfoliated deciduous teeth (SHEDs) have been considered as alternative sources of adult stem cells in tissue engineering because of their potential to differentiate into multiple cell lineages. Strontium has an important function in bone remodeling because it can simulate bone formation and decrease bone resorption. In this study, the effects of strontium phosphate on the osteogenic differentiation of SHEDs were investigated. Strontium phosphate was found to enhance the osteogenic differentiation of SHEDs with up-regulated osteoblast-related gene expression. The proliferation of SHEDs was slightly inhibited by chitosan scaffolds; however, type-I collagen expression, alkaline phosphatase activity, and calcium deposition on chitosan scaffolds containing strontium were significantly enhanced. Furthermore, cells seeded in a 3D scaffold under dynamic culture at an optimal fluid rate might enhance cellular differentiation than static culture in osteoblastic gene expression. This experiment might provide a useful cell resource and dynamic 3D culture for tissue engineering and bone repair.

Effect of Ti and Mg dopants on the mechanical properties, solubility, and bioactivity in vitro of a Sr-containing phosphate based glass

Resorbable materials are desirable components for applications such as temporary implants, as they degrade in a controlled manner until completion of the osseointegration of the bone, eliminating the need of a second surgery to remove them. Phosphate based glasses (PBG) have properties that allow them to be used as hard tissue substitutes with the advantage of being resorbable. Incorporation of strontium into PBG has been widely studied because it is considered a bone formation stimulator. Although strontium phosphate glasses have better cellular response, their degradation rate is higher. Some studies show that the addition of TiO2 and MgO significantly reduces the degradation rate of soluble phosphate glasses. Furthermore, these oxides interfere with the chemical structure of the glass, and consequently improve their mechanical properties. Therefore, our aim was to evaluate the effect of dopants (TiO2 and MgO) on a phosphate based glass and, consequently, on its degradation behavior, hardness, elastic modulus and fracture toughness. Our results showed that the glass structure was modified by the dopants, becoming more rigid, and as a result, decreasing the glass degradation, and increasing the hardness, elastic modulus, and fracture toughness.

Controlling initial biodegradation of magnesium by a biocompatible strontium phosphate conversion coating

A simple strontium phosphate (SrP) conversion coating process was developed to protect magnesium (Mg) from the initial degradation post-implantation. The coating morphology, deposition rate and resultant phases are all dependent on the processing temperature, which determines the protective ability for Mg in minimum essential medium (MEM). Coatings produced at 80°C are primarily made up of strontium apatite (SrAp) with a granular surface, a high degree of crystallinity and the highest protective ability, which arises from retarding anodic dissolution of Mg in MEM. Following 14days’ immersion in MEM, the SrAp coating maintained its integrity with only a small fraction of the surface corroded. The post-degradation effect of uncoated Mg and Mg coated at 40 and 80°C on the proliferation and differentiation of human mesenchymal stem cells was also studied, revealing that the SrP coatings are biocompatible and permit proliferation to a level similar to that of pure Mg. The present study suggests that the SrP conversion coating is a promising option for controlling the early rapid degradation rate, and hence hydrogen gas evolution, of Mg implants without adverse effects on surrounding cells and tissues.

Microwave assisted solution combustion synthesis of strontium phosphate (SrP) whiskers

A rapid microwave assisted solution combustion process is used to synthesize SrCaP and SrP whiskers. It is observed that SrP whiskers composed of Sr2P2O7 and Sr5(PO4)3Cl can be efficiently synthesized. However, co-existence of Ca2+ and Sr2+ ions in the reaction can inhibit one-dimensional crystal growth. The introduction of Cl− ions to the reacting system is the key to induce the crystal formation towards to one-dimensional structure. The as-synthesized SrP whiskers were characterized and evaluated for potential biomedical applications.