Strong Relationship Research Articles

Keratin-15 high expression links with lymph node metastasis and poor survival prognosis in epithelial ovarian cancer patients

BackgroundKeratin-15 (KRT15) involves in the progression and owns prognostic values in several solid cancers, whose clinical role in epithelial ovarian cancer (EOC) is rarely reported. This study aimed to identify the association of KRT15 expression with tumor features and survival of surgical EOC patients.MethodsFormalin-fixed paraffin-embedded tumor tissues of 140 EOC patients who underwent tumor resection were retrieved for KRT15 determination using immunohistochemistry (IHC) assay.ResultsThe median (interquartile range) KRT15 IHC score was 0.0 (0.0–1.0), ranging from 0.0 to 12.0. Among all, 36.4% of patients had positive KRT15 expression (IHC score > 0) and 15.0% of patients had high KRT15 expression (IHC score > 3). KRT15 was positively related to lymph node metastasis incidence (P = 0.027), and showed a tendency to correlate to FIGO stage but without statistical significance (P = 0.052), while it was not correlated with age, other tumor features, and tumor markers. Positive KRT15 expression was linked with poor disease-free survival (DFS) (P = 0.009) and overall survival (OS) (P = 0.032). Notably, high KRT15 expression showed an even stronger relationship with worse DFS (P = 0.001) and OS (P < 0.001). After adjustment of multivariable Cox’s regression, high KRT15 expression was independently correlated with unfavorable DFS (hazard ratio (HR): 2.241, P = 0.007).ConclusionEven though KRT15 is insufficiently expressed in EOC tissues generally, its positive expression or high expression can predict the lymph node metastasis and poor survival prognosis in EOC patients who undergo tumor resection.

Dua Dekade Kebebasan Akademik di Indonesia: Tantangan di Tengah Menguatnya Otoritarianisme dalam Model Barunya

This research focuses on analyzing the debates and roles of the academic freedom movement in Indonesia’s authoritarian politics. Numbers of scholars argued on the democracy decline and its current situation of authoritarian turn (Mietzner 2016, 2020; Hadiz 2017; Wiratraman 2018; Waburton and Aspinal 2019; and Winters 2021). Authoritarianism governance in recent politics has been worsening situation of free expression, including academic freedom. Recently, one of attacks is connected to cyber-attacks, which has been targeting journalists, academics, activists or students who defend human rights and environment, indigenous leaders, anti-corruption activists, and women's groups. This article discusses first, how has academic freedom at campuses been shaped by Indonesia's the rise of authoritarian politics; and second how academic freedom has been influenced and easily attacked in the rise of digital authoritarianism. By using an interdisciplinary approach, this article argues that there is a strong relation between the threat of academic freedom and the strengthening of authoritarianism in Indonesia, especially by disciplining campuses through a more systematic bureaucratization. While at the same time, academic freedom has been affected by stronger control of authoritarianism regime by deplying cyber troops in digital spheres. Hence, this article also discusses how human rights instruments and its institutions could promote and defend academic freedom in general.

Head-to-head comparison of leading blood tests for Alzheimer's disease pathology.

Blood tests have the potential to improve the accuracy of Alzheimer's disease (AD) clinical diagnosis, which will enable greater access to AD-specific treatments. This study compared leading commercial blood tests for amyloid pathology and other AD-related outcomes. Plasma samples from the Alzheimer's Disease Neuroimaging Initiative were assayed with AD blood tests from C2N Diagnostics, Fujirebio Diagnostics, ALZPath, Janssen, Roche Diagnostics, and Quanterix. Outcomes measures were amyloid positron emission tomography (PET), tau PET, cortical thickness, and dementia severity. Logistic regression models assessed the classification accuracies of individual or combined plasma biomarkers for binarized outcomes, and Spearman correlations evaluated continuous relationships between individual plasma biomarkers and continuous outcomes. Measures of plasma p-tau217, either individually or in combination with other plasma biomarkers, had the strongest relationships with all AD outcomes. This study identified the plasma biomarker analytes and assays that most accurately classified amyloid pathology and other AD-related outcomes. Plasma p-tau217 measures most accurately classified amyloid and tau status. Plasma Aβ42/Aβ40 had relatively low accuracy in classification of amyloid status. Plasma p-tau217 measures had higher correlations with cortical thickness than NfL. Correlations of plasma biomarkers with dementia symptoms were relatively low.

Progression of vertebral fractures in metastatic melanoma and non-small cell lung cancer patients given immune checkpoint inhibitors

IntroductionThe immune system mediates important effects on bone metabolism, but little has been done to understand immunotherapy’s role in this interaction. This study aims to describe and identify risk factors for the occurrence and/or exacerbation of vertebral fractures (vertebral fracture progression) during immune checkpoint inhibitors (ICIs). MethodsWe conducted an observational, retrospective, monocentric study. We collected data on melanoma and NSCLC patients, treated with first-line ICIs at the Medical Oncology Department ASST Spedali Civili of Brescia, between January 2015 and November 2021, and with a median follow-up of 20.1 (6–36) months. We collected data on patients, diseases, immune-related adverse events, and cortico-steroid therapy initiated on concomitant ICIs. ResultsWe identified 135 patients, 65 (48.2 %) with locally advanced/metastatic melanoma and 70 (51.8 %) with locally advanced/metastatic non-small cell lung cancer (NSCLC). Twenty-one (15.6 %) patients already had an asymptomatic vertebral fracture at baseline before starting ICIs in monotherapy. A total of ten patients, or 7.4 %, had a vertebra fracture progression defined as a new vertebral fracture or a worsening of a previous fracture. There was a strong relation between the steroid therapy and irAEs with vertebra fracture progression [OR (95 % CI) 8.1 (3.7–17.8) p-value < 0.001] in univariable analysis. However, only steroid therapy resulted to be an independent risk factor [8.260 (95 % CI 0.909–75.095); p-value 0.061] at the multivariable analysis. ConclusionConcurrent steroid therapy in patients receiving immunotherapy exposes them to a high risk of fractures due to skeletal fragility. The use of bone resorption inhibitors should be considered in these patients to prevent these adverse events.

Governance, institutional quality and economic complexity in selected African countries

AbstractNew economic thinking speculates that the diversification and sophistication of economic capabilities/structures is key in explaining why African countries lag in development behind the rest of the world. We question the extent to which non-traditional growth factors such as governance and institutional quality are related to economic complexity for 35 African countries. We estimate panel GMM regressions using 8 different measures of governance/institutional quality for both linear and kinked regressions using annual data collected between 1996 and 2021. The baseline estimates reveal a positive linear relationship between most measures of governance and institutional quality and economic complexity. Our sensitivity analysis further show that institutions/governance have stronger relationship with economic complexity in the post-global financial crisis era. Moreover, nonlinear or kinked relationships emerge once the data is segregated into different income and resource abundant groups. Altogether, our findings of a nonlinear relationship between institutions/governance and economic complexity are novel to the literature and offer unique insights on how African policymakers can use governance/institutions for improving the complexity of production processes.

WEB DEVELOPMENT REQUEST FOR INFORMATION (RFI)

The design of a Web-Based Online Request for Information (RFI) System aims to analyze issues within the verification procedures in the country of origin or loading country during the Import Technical Verification Program (VPTI) by KSO SCISI. This research also intends to evaluate the potential implementation of a web-based online Request for Information (RFI) system as a solution to enhance the efficiency and effectiveness of the verification process in the country of origin or loading country, while facilitating expedited services within VPTI. The research methodology involves initial stages of problem identification and observation of ongoing processes at KSO SCISI, supplemented by literature review to comprehend aspects of information system design and development through web-based platforms. Additionally, interviews with relevant stakeholders were conducted. The research adopts the Linear Sequential (Waterfall) methodology for system development, which translates analysis into design, coding, and testing. The primary outcome of this study is the design of a web-based online RFI system that eliminates the need for lengthy and intricate steps by enabling direct communication of physical verification location requests from the headquarters to exporters, without the involvement of branch offices in the country of origin or loading country. Implications of this research encompass procedural simplification, service efficiency enhancement, and fostering strong customer relations. An innovative facet of this study lies in the utilization of the online RFI system to streamline and expedite complex verification procedures, while also fostering more efficient connectivity between the headquarters and exporters. In conclusion, the web-based RFI system is poised to facilitate, accelerate, and fortify high-quality VPTI services by KSO SCISI.

Psychological and psychosocial determinants of COVID related distancing behaviours: A systematic review

AbstractBackgroundThe COVID‐19 pandemic, caused by the SARS‐CoV‐2 virus, has resulted in illness, deaths and societal disruption on a global scale. Societies have implemented various control measures to reduce transmission of the virus and mitigate its impact. Individual behavioural changes are crucial to the successful implementation of these measures. One commonly recommended measure to limit risk of infection is distancing. It is important to identify those factors that can predict the uptake and maintenance of distancing.ObjectivesWe aimed to identify and synthesise the evidence on malleable psychological and psychosocial factors that determine uptake and adherence to distancing aimed at reducing the risk of infection or transmission of COVID‐19.Search MethodsWe searched various literature sources including electronic databases (Medline ALL, Child Development &amp; Adolescent Studies, ERIC, PsycInfo, CINAHL &amp; Web of Science), web searches, conference proceedings, government reports, other repositories of literature and grey literature. The search strategy was built around three concepts of interest including (1) context (terms relating to COVID‐19), (2) behaviour of interest and (3) terms related to psychological and psychosocial determinants of COVID‐19 Health‐Related Behaviours and adherence or compliance with distancing, to capture malleable determines. Searches capture studies up until October 2021.Selection CriteriaEligibility criteria included observational studies (both retrospective and prospective) and experimental studies that measure and report malleable psychological and psychosocial determinants and distancing (social and/or physical) at an individual level, amongst the general public. We defined physical distancing as, maintaining the recommended distance from others when physically present. And social distancing being defined as, minimising social contact with those outside of your own household. Screening was supported by the Cochrane Crowd. Studies' titles and abstracts were screened against the eligibility criteria by three independent screeners. Following this, all potentially relevant studies were screened at full‐text level by the research team. All conflicts between screeners were resolved by discussion between the core research team.Data Collection and AnalysisAll data extraction was managed in EPPI‐Reviewer software. All eligible studies, identified through full‐text screening were extracted by one author. We extracted data on study information, population, determinant, behaviour and effects. A second author checked data extraction on 20% of all included papers. All conflicts were discussed by the two authors until consensus was reached. We assessed methodological quality of all included studies using an adapted version of the Joanna Briggs Institute Quality appraisal tool.Main ResultsA total of 91 studies were suitable for inclusion in the review, representing 199,604 participants. The vast majority of studies had samples from the general public, with 15 of the studies focusing on specific samples. The majority of studies included participants over 18 years old, with 5 reporting on specific ages (adolescents and adults over 65). The quality of 29 of the studies was rated as unclear, 48 were rated as low, and 14 rated high risk of bias, predominately due to lack of reporting of recruitment, sample characteristics and methodology. Overall the majority of these relationships were weak. Stronger relationships were observed between attitudes, social norms, perceived behavioural control and both social and physical distancing. And between worry, response effectiveness, self‐efficacy and social distancing. However, there is a high level of heterogeneity in the findings. This heterogeneity might be, partly, due to the differences in measurement of the determinants and distancing across studies.Authors' ConclusionsThe findings from this review indicate that social distancing behaviours are more likely to be undertaken by people who are worried about COVID‐19 and who believe that social distancing is an effective way of avoiding COVID‐19. Physical distancing behaviours are more likely to be undertaken by those who believe that they can control physical distancing from others, who believe that physical distancing is the social norm and who have a positive attitude to engaging in this behaviour. It is important to understand how to strengthen these behavioural determinants to develop effective interventions to promote distancing behaviours in any potential future waves of COVID‐19, and other respiratory infections.

Surface fatigue characterization and its enhancement by the engineered ultrasonic rolling process for 300 M ultrahigh strength steel

The fatigue life of surface layer (FSL) is innovatively characterized to accurately capture the effect of surface integrity on the fatigue behavior of the components. The sensitivity of FSL of 300 M ultrahigh strength steel to the surface integrity indexes induced by representative manufacturing processes was analyzed by analytical modeling and fatigue tests from the perspective of engineering fracture mechanics. The ultrasonic surface rolling process (USRP) was introduced to optimize the fatigue limit of 300 M steel, and the improvement in fatigue life was experimentally quantified. Besides, the fracture analysis was conducted to provide the reason why USRP can enhance the fatigue behavior of 300 M steel. The results show that FSL occupies a majority with percentage of over 95 % in the entire fatigue life and a strong relation with the machined surface defects, especially the surface machining marks. The excellent surface finishing effect and high compressive residual stresses induced by engineered USRP could transfer the crack source from surface machining marks into subsurface inclusions, which greatly prolongs the fatigue crack initiation life and thereby the entire fatigue life. To be specific, the fatigue life was elevated by more than 40 times and the fatigue strength was increased by 34.7 % after USRP for the tested 300 M steel.

Türkiye’s Foreign Relations with Regional Blocs in Sub-Saharan Africa: The Case of AU and ECOWAS

Strong foreign relations among nations are crucial for fostering global stability, economic growth, and cross-cultural understanding. A stable global system that resolves conflicts through dialogue rather than confrontation benefits from positive foreign relations. This paper examines Türkiye’s changing foreign policy approach towards Sub-Saharan African regional blocs, with an emphasis on their political, cultural, and economic facets. Türkiye’s strategic involvement with influential regional bodies such as the African Union (AU) and the Economic Community of West African States (ECOWAS), among others, reflects its broader objective to expand its influence and cultivate multifaceted partnerships across the African continent. The scope of this paper is limited to the AU and ECOWAS. Through a comprehensive analysis, the paper evaluates Türkiye’s economic initiatives, including trade agreements and investment flows, as well as its contributions to infrastructure development. The findings established Türkiye’s peacekeeping roles, cultural diplomacy, diplomatic efforts, and educational exchanges. Through the investigation of these diverse aspects, the conclusion outlines a comprehensive understanding of Türkiye’s place in geopolitical dynamics and regional integration in Sub-Saharan Africa.

Talking in a language that everyone can understand? Clarity of speeches by the ECB Executive Board

We use data on speeches held by members of the European Central Bank's (ECB) Executive Board to analyze whether the clarity of central bank communication has increased over time. Employing readability measures as proxy variables, we find that the clarity of information provision is trending upward since the inception of the ECB. The increase is gradual rather than being induced by changes in the board composition or major macroeconomic events. We also show that clarity is higher for speeches aimed at general audiences and for speeches by female speakers. Moreover, we find that higher clarity of speeches is associated with more optimistic media sentiment about the ECB and a stronger relationship between speech and media sentiment.

Influence of climate on soil viral communities in Australia on a regional scale

AbstractViruses play a crucial role in regulating microbial communities and ecosystem functioning. However, the biogeographic patterns of viruses and their responses to climate factors remain underexplored. In this study, we performed viral size fraction metagenomes on 108 samples collected along a 2600 km transect across Australia, encompassing distinct climate conditions. A total of 14,531 viral operational taxonomic units were identified. Climate factors had a greater influence than edaphic and biotic factors on driving the alpha diversity of viral communities. The strongest relationship was observed between mean annual temperature and the diversity of viral communities. Moreover, climate factors, particularly aridity index, were the primary drivers of viral community structure. Overall, these findings underscore the pivotal role of climate factors in shaping viral communities and have implications for understanding how climate change influences soil viral ecology.

Positive plant diversity effects on soil detritivore feeding activity and stability increase with ecosystem age

Increasing species diversity frequently enhances ecosystem functioning - a pattern strengthened with ecosystem age. It has been suggested that strengthened responses over time may be due to community assembly processes and cumulative effects over the history of interactions between and among plant and soil communities. However, most soil studies are conducted with destructive one-time samplings, and little is known about how phenological patterns of soil activity change with biodiversity and ecosystem age. Here, we investigate phenology metrics related to soil detritivore feeding activity (i.e., duration, total magnitude, variability), measured via the bait-lamina method, in a long-term grassland biodiversity experiment that included an experimental removal of plant and soil history, resulting in older and younger assembled plant and soil communities. Detritivore feeding activity peaked in spring and/or early summer, with another short increase in fall. Increased plant species richness enhanced the total magnitude and variability (i.e., the coefficient of variation) of detritivore feeding activity. Plant and soil history enhanced the buffering effects of plant richness on variability, causing older plant and soil communities to have the strongest relationships between plant richness and stability. However, older plant and soil communities showed the shortest duration of detritivore feeding activity, and species richness was not important in changing activity duration. These findings underscore the importance of considering ecosystem age as a critical component that modifies plant diversity effects on ecosystem functioning, with important implications for promoting ecosystem stability and resilience under environmental change.

Energy‐Water Asynchrony Principally Determines Water Available for Runoff From Snowmelt in Continental Montane Forests

ABSTRACTChanges in the volume, rate, and timing of the snowmelt water pulse have profound implications for seasonal soil moisture, evapotranspiration (ET), groundwater recharge, and downstream water availability, especially in the context of climate change. Here, we present an empirical analysis of water available for runoff using five eddy covariance towers located in continental montane forests across a regional gradient of snow depth, precipitation seasonality, and aridity. We specifically investigated how energy‐water asynchrony (i.e., snowmelt timing relative to atmospheric demand), surface water input intensity (rain and snowmelt), and observed winter ET (winter AET) impact multiple water balance metrics that determine water available for runoff (WAfR). Overall, we found that WAfR had the strongest relationship with energy‐water asynchrony (adjusted r2 = 0.52) and that winter AET was correlated to total water year evapotranspiration but not to other water balance metrics. Stepwise regression analysis demonstrated that none of the tested mechanisms were strongly related to the Budyko‐type runoff anomaly (highest adjusted r2 = 0.21). We, therefore, conclude that WAfR from continental montane forests is most sensitive to the degree of energy‐water asynchrony that occurs. The results of this empirical study identify the physical mechanisms driving variability of WAfR in continental montane forests and are thus broadly relevant to the hydrologic management and modelling communities.

Removal of persistent and mobile organic micropollutants from drinking water utilizing a synthesized waste-derived adsorbent

Persistent and mobile (PM) substances refer to a wide range of organic micropollutants (OMPs) with high persistence and mobility in water. So far, only a few methods have been explored for the removal of PM substances from drinking water. In this work, a new adsorbent based on spent coffee grounds and aluminum waste was synthesized and utilized to remove 25 OMPs, including 22 PM substances, from drinking water. Different characterization methods, including powder X-ray diffraction (XRD), analyses according to Brunauer−Emmett−Teller (BET), field-emission scanning electron microscopy (FE-SEM) and energy dispersive X-ray spectroscopy (EDS), were applied to describe the adsorbent's textural and structural characteristics. The results revealed that the adsorbent is highly effective in removing OMPs. Common OMPs (i.e. carbamazepine, sulfamethoxazole and diclofenac) were completely removed from drinking water. Also, many of the PM substances were removed by more than 80% using an adsorbent dosage of 0.1 g/L. A strong relation between abatement of ultraviolet light absorbance at 254 nm (UV254) and OMP removal was observed. Therefore, UV254 abatement is a useful surrogate for a quick estimation of OMP removals.

Assessing dynamics of urban solar PV power generation using grid divisional method

The assessment of solar energy potential and urban density has become a crucial prerequisite for urban sustainable development. However, two significant challenges persist: the high computational cost associated with assessments across large urban areas and the lack of detailed rooftop information for each building. This study aims to integrate solar photovoltaic (PV) systems in urban environments of varying built density in an Indian city and assesses the solar energy potential (SEP) using grid divisional method and simulations. The methodology involved extracting, filtering and developing a 2.5 D model with GIS using the open buildings dataset, followed by simulations of grid-connected PV systems using PV-Sol. The results demonstrated the dynamics in correlation of SEP and grid morphology indicators, with built density and roof area showing a strong positive relation. The financial analysis resulted in average payback period of 8–10 years. The study also highlighted significant CO2 emission reductions, with thermal power plants generating 26,982 tons/kWh compared to just 1,513 tons/kWh for solar power. The findings demonstrate the financial viability and environmental benefits of PV adoption in urban areas, offering crucial insights for sustainable energy planning and policy development.

Surprisingly good fit of pressure-based cropland condition map and bird census data at the national scale

As the world is struggling to halt the rapid decline of biodiversity, the assessment and mapping of ecosystem condition is getting ever increasing attention. Croplands are artificial ecosystems, but as they occupy a large portion of land, they significantly influence biodiversity. Yet, there is a knowledge gap about their suitability to support and maintain wildlife on a national scale. Large-scale condition mapping is meant to address this gap; the good condition of croplands includes their ability to support biodiversity. However, the lack of suitable databases is often a challenge when creating such maps. As there is a strong causal relation between pressures on the ecosystem and its condition, pressure indicators can be used as proxies to approximate condition when more direct indicators are lacking. The validation of condition maps based on pressure proxies is a key but challenging step. In this study, we tested a previously designed pressure-based cropland condition map for Hungary using bird census data. Besides validating the composite condition indicator, we also tested some key elements of the mapping process, such as the choice of variables and thresholds.Using multiple comparisons of means by Tukey’s contrast and Random Forest modelling, we examined the relationship of (1) the continuous pressure-based cropland condition variables, (2) their rescaled, ordinal version (called sub-indicators), and (3) the composite cropland condition indicator (sum of the sub-indicators) with a biodiversity measure, the standardised relative richness of characteristic farmland bird species (rRRCS). To get a picture of the spatial patterns of the examined relationships across Hungary, individual Random Forest models were constructed for all the spatial units of the bird census database, using focal analysis with a 30 km radius moving window.We found significant differences in the mean rRRCS for nearly all sub-indicator categories, signifying that the literature-derived thresholds were mostly sound. Categories with higher (better) condition scores had higher mean rRRCS; the differences are significant in the mid-range but not in the extreme categories, indicating a need for a meaningful simplification of the categories. The goodness-of-fit (R2) of the Random Forest models was found to be high, but it is spatially heterogeneous (ranged from 0.69 to 0.89, with a median value of 0.81), similarly to the variable importance. The proportion of semi-natural areas proved to be the most important condition variable. The proportion of maize and alfalfa were more important than parcel size. Our results show that condition maps based on pressure proxies can reflect patterns of biodiversity surprisingly well. They also highlight the spatial context dependence of the uncertainty of condition maps.

Black, Low-Income Undergraduates’ Perceptions of Course-Related Factors Associated With Reduced Academic Stress at a Predominantly White Institution

Academic stress is a common struggle for learners of all ages. High levels of academic stress can sometimes relate to lower academic outcomes and higher attrition rates. Black college students at predominantly White institutions (PWIs) face unique stressors such as discrimination and imposter syndrome. Being low-income can carry added stressors associated with a lack of access to resources. Prior literature indicates that support and stronger relationships with faculty are associated with lower stress levels and higher academic success. The purpose of this study was to develop a better understanding of course-related factors that reduce academic stress among Black, low-income undergraduates at a PWI. Interviews with 19 Black undergraduates recruited from a department that servees low-income, first-generation students revealed a set of interrelated factors that produce greater feelings of support, relatedness, and competence, which aligns with a reduction in stressful experiences. A thematic analysis was used to create descriptive categories and produce a visual representation of these factors. Implications for university staff and faculty are discussed.

The Impact of Environmental Knowledge on Food Waste Reduction and Sustainability Practices among Hospitality Students in Malaysia

Environmental sustainability and food waste reduction are among the critical challenges facing the hospitality industry worldwide. This study was conducted to identify the impact of environmental knowledge on food waste reduction and sustainability practices among hospitality students in Malaysia. A quantitative approach was used, and we surveyed 94 hospitality students from various programs at UiTM Penang. The online questionnaire was conducted and analyzed using Pearson correlation and multiple regression analysis. There is a significant positive correlation between environmental knowledge, food waste behaviors and sustainability-related behaviors. The strongest relationship was found between food waste behaviors and sustainability-related behaviors, suggesting that environmental knowledge and food waste practices are closely related to broader sustainability behaviors in hospitality education. The study contributes to the understanding of how environmental education can shape the future of hospitality professional practice, offering valuable insights for the development of industry curricula and training programs aimed at promoting sustainable practices in the hospitality sector.

Meaning salience as a moderator of the relationship between presence of meaning in life and wellness

Meaning salience, or awareness of meaning in the present moment, is an emerging concept with potential implications for health and wellness. The purpose of this study was to understand the relationships between meaning salience and eight dimensions of wellness, and to see whether meaning salience moderated the relationship between presence of meaning and wellness. Participants (N = 1711) were recruited to complete a cross-sectional survey through Amazon’s Mechanical Turk. Meaning salience was related to better wellness in seven of the eight wellness domains (healthy eating and activity, financial stress, occupational wellness, sleep, perceived wellness, social wellness, and stress, excluding avoiding unhealthy foods). Meaning salience significantly moderated the relationships between presence of meaning and four of eight wellness dimensions, such that at high levels of meaning salience, both high and low presence of meaning had stronger relationships with wellness. Those with high meaning salience and high presence of meaning scored best on four wellness dimensions; however, those with high meaning salience and low presence of meaning scored the worst on four wellness dimensions. Future research should explore what factors drive the relationship between meaning salience and wellness.

Different origins of magnetic disturbances during substorm growth and expansion phases and insufficiency of the AL index as their sole measure

The paper examines the relationship between the PC index, characterizing the solar wind energy input into the magnetosphere, and the AL index, characterizing the magnetic substorm intensity for the expansion phase of isolated substorms recorded in 1998–2017. Magnetic disturbances in the course of the expansion phase are produced by the DP11 current system with a powerful westward electrojet disposed in the midnight auroral zone. It is generally accepted that this electrojet is generated by the “substorm current wedge” system of fieldaligned currents (SCW FAC) providing closure of the magnetotail plasma sheet currents through the auroral ionosphere. As this takes place, magnetic disturbances in the course of the substorm growth phase are produced by the DP12 current system with westward and eastward electrojets located, correspondingly, in the morning and evening sectors of the auroral zone, with the electrojets generated by the R1/R2 FAC system operating in the inner (closed) magnetosphere. The intensity of R1 currents is determined by the “coupling function” EKL, which represents the optimal combination of all geoeffective solar wind parameters affecting the magnetosphere. The DP2 magnetic disturbances generated by the R1 FAC system in polar caps forms the basis for estimating the PC index, which strongly follows the EKL field changes and correlates well with the development of magnetic substorms. Analyses performed in AARI revealed the principally distinctive character of the relationships between the PC index and AL index in the course of the substorm growth (DP12 disturbances) and explosive (DP11 disturbances) phases. The DP12 disturbances, generated by FAC systems in the closed magnetosphere, are developed in strong relation to the PC index. The DP11 disturbances, generated by the SCW FAC system, related to the magnetotail plasma sheet, show quite irregular character of relationship between the PC and AL values: the sudden jumps of the substorm intensity (ALpeaks) might occur, time and again, at any value of the PC index and with quite different delay times relative to sudden substorm onset. It means that the processes in the tail plasma sheet, leading to the formation of a “substorm current wedge” are determined by the state of the magnetotail plasma sheet itself. The solar wind influence (evaluated by the PC index) affects but does not control the processes in the magnetotail, unlike those in the inner magnetosphere. It should be noted in this connection that the intensity of magnetic DP12 and DP11 disturbances, observed in the course of the substorm growth and explosive phases, is estimated by a single AL index, in spite of the different origin of these disturbances (R1/R2 and SCW FAC systems). It is necessary to employ two separate indices characterizing DP12 and DP11 disturbances in order to allow for the effects of the solar wind on the processes in the inner magnetosphere and in the magnetotail.