The SBUV and SBUV-2 satellite observations and ground-based measurements of the total NO2 at the NDACC network are used to estimate the effects of the eruption of the Pinatubo volcano and variations in the level of solar activity on the stratospheric O3 and NO2. The NO2 decrease due to the Pinatubo eruption had been from 19 to 34% at different stations, with the NO2 content, on the whole, found to decrease somewhat more strongly in the Southern Hemisphere (SH) than in the Northern Hemisphere (NH). On the contrary, the O3 concentration decreased much more strongly in the lower stratosphere at HN extratropical latitudes (∼10%) than in the SH. The maximal percentage decrease in ozone concentration (by ∼22%) is found around the 10-hPa (32-km) level at 10–15° S. In general traits, the effect of the 11-year solar cycle on the stratospheric ozone is symmetrical about the equator. The altitudinal maxima of the O3 response to the solar cycle are identified at heights of 50–55, 35–40, and below 25 km. Changes in O3 concentration in these layers are usually within a few percent. Substantial interhemispheric differences are found in the NO2 response to the 11-year solar cycle. At most of the SH stations, the NO2 content in the phase of maximum of solar activity is usually smaller than in the phase of minimum. The NO2 content at NH low and middle latitudes is, more often, larger during the maximum than the minimum of solar activity. The NO2 variations during the solar activity cycle are usually within 5%.