Strategic Disruption Research Articles

Multi‐Pathway Upconversion Emission in Symmetry‐Broken Nanocavities: Broadband Multiresonant Enhancement and Anti‐Correlated Interfacial Sensitivity

AbstractThe development of efficient, biocompatible, and broadband solid‐state nanocavity platforms with enhanced upconversion emission remains a critical challenge in nanophotonics, particularly for biosensing and bioimaging applications. Here, it is introduced symmetry‐broken nanolaminated plasmonic nanoantenna arrays (NLPNAs) that overcome the limitations of current approaches by achieving the desired balance of multiresonant enhancement, interfacial sensitivity, and scalable fabrication. The strategic disruption of axial symmetry within metal‐insulator‐metal nanocavities enables broadband multiresonant enhancement across multiple upconversion emission pathways, including second harmonic generation, third harmonic generation, and upconversion photoluminescence, under femtosecond laser excitation across a broad near‐infrared (NIR) wavelength range (1000–1600 nm). The fabricated asymmetric NLPNAs demonstrate substantial enhancements compared to their symmetric counterparts, displaying up to 30‐fold increase in upconversion emission. The unique, anti‐correlated interfacial sensitivities exhibited by these distinct emission pathways offer a new avenue for improving the reliability and specificity of multiphoton nanoplasmonic biosensing and bioimaging techniques.

Fragmented frontiers: three approaches to understanding irregular warfare

ABSTRACT This article surveys current thinking, both academic and doctrinal, on the subject of irregular warfare. It argues that from a western perspective the debate has essentially resulted in three competing forms of understanding, what this paper terms the maximal, traditional, and competition-disruption models. Conceptually, all have certain strengths but also a number of highly significant weaknesses. It nevertheless proposes that the last of these, particularly when articulated as a form of ‘strategic disruption’, offers the most coherent vision of irregular warfare. Even then, significant gaps in reasoning still exist. Ultimately, the ability of western thinkers and doctrine writers to agree a common understanding of irregular warfare remains an inherently fragile endeavor.

Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications.

Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications.

D-RAIL: DIRECTING RESPONSES AGAINST ILLICIT INFLUENCE OPERATIONS

On November 19, 2024, Mr. Carl Miller presented D-RAIL: Directing Responses Against Illicit Influence Operations for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed included the strategic disruption of influence operations, as well as the importance of asymmetrical responses and coordination and contextual approaches. Received: 12-30-2024 Revised: 01-28-2025

Evaluating Partitions in Packet Classification with the Asymmetric Metric of Disassortative Modularity

At present, the method of using rule set partitioning technology to assist in constructing multiple decision trees for packet classification has been widely recognized. Rule set partitioning demonstrates a unique symmetry-breaking mechanism, systematically transforming the initial overlapping rule space into a more structured and balanced configuration. By separating overlapping rules in the initial stage, this method significantly reduces rule replication within trees, thereby improving the algorithm’s classification performance. The asymmetric characteristics of this partitioning process are particularly noteworthy: through the strategic disruption of the initial rule set’s symmetric distribution, it creates asymmetric subspaces with enhanced computational efficiency. However, existing research lacks standardized metrics for evaluating the effectiveness of rule set partitioning schemes. The purpose of this paper is to investigate the impact of partitioning on algorithm performance. Based on community structure theory, we construct a weighted graph model for rule sets and propose a disassortative modularity metric to evaluate the effectiveness of rule set partitioning. This metric not only examines intra-community connections but also emphasizes the asymmetric connections between communities. By quantifying these structural features, it provides a novel perspective on rule set partitioning strategies. The experimental results demonstrate a significant positive correlation between disassortative modularity and classification throughput. This metric offers valuable guidance for packet classification partitioning techniques, highlighting the practical significance of symmetry and asymmetry in algorithm design.

An Exploration of Technological Innovations in the Audit Industry: Disruption Theory Applied to a Regulated Industry*

ABSTRACTTechnological innovation is increasing throughout the audit industry. Although prior research has explored how specific technological innovations have influenced the audit product and the profitability of the audit, the strategic implications of technological innovation for the audit industry have yet to be examined. To address this issue, we adopt Christensen's seminal theory of technological innovation (introduced in his 1997 book The Innovator's Dilemma) to gain insight into the results of 27 semistructured interviews with auditors and audit technical specialists. Consistent with Christensen's sustaining and efficiency strategic responses, our findings suggest that, at this time, technology is primarily being used by the audit industry to strengthen the audit industry's ability to serve mainstream clients by providing a “higher‐quality” and lower‐cost audit to replace menial tasks that historically have been done by junior auditors. We find that industry‐disruptive new market entry is currently prevented by regulatory and professional barriers; however, strategic disruption to the audit industry appears inevitable as technology is already being used in audits of nonregulated markets by new entrants. Strategically, the audit industry will survive in its current recognizable form only if self‐disruption occurs before the regulatory barriers are dropped, which requires significant upskilling in the industry to ensure that firms have the skills to be first movers whenever technological innovations are introduced.

Strategic Disruption of Management Competencies in Micro and Small Enterprises: A Literature Review

This article reports on the evolution of scientific production in indexed journals regarding managerial skills from a strategic perspective of micro and small enterprises (MSEs). The methodology employed was a bibliometric analysis with document analysis techniques of articles published in the Scopus, Web of Science, and Taylor & Francis databases. Search filters with the keywords “Management competencies” and the target population (micro and small enterprises) were applied for the selection of research. For this purpose, bibliometric measures were evaluated that assess authors' productivity based on the number of documents consulted and included, as well as by years, countries, and keywords. Furthermore, multiple multidimensional indicators of collaboration among authors were examined, and this information was supplemented with the analysis of bibliographic platforms. In this regard, it's crucial for managers of micro and small enterprises to combine their management skills, creativity, and entrepreneurial spirit to make accurate short and long-term decisions, thereby ensuring the future success of the company. These obtained results can be used for new inquiries and studies, while also posing a challenge for the evolution of managerial competencies in the coming years. Received: 5 January 2024 / Accepted: 15 June 2024 / Published: 02 July 2024

Strategic Disruption: An Operational Framework for Irregular Warfare

Strategic Disruption: An Operational Framework for Irregular Warfare

EIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model.

Cells employ several adaptive mechanisms under conditions of accelerated cell division, such as the unfolded protein response (UPR). The UPR is composed of a tripartite signaling system that involves ATF6, PERK, and IRE1, which maintain protein homeostasis (proteostasis). However, deregulation of protein translation initiation could be associated with breast cancer (BC) chemoresistance. Specifically, eukaryotic initiation factor-4A (eIF4A) is involved in the unfolding of the secondary structures of several mRNAs at the 5' untranslated region (5'-UTR), as well as in the regulation of targets involved in chemoresistance. Importantly, the tumor suppressor gene PDCD4 could modulate this process. This regulation might be disrupted in chemoresistant triple negative-BC (TNBC) cells. Therefore, we characterized the effect of doxorubicin (Dox), a commonly used anthracycline medication, on human breast carcinoma MDA-MB-231 cells. Here, we generated and characterized models of Dox chemoresistance, and chemoresistant cells exhibited lower Dox internalization levels followed by alteration of the IRE1 and PERK arms of the UPR and triggering of the antioxidant Nrf2 axis. Critically, chemoresistant cells exhibited PDCD4 downregulation, which coincided with a reduction in eIF4A interaction, suggesting a sophisticated regulation of protein translation. Likewise, Dox-induced chemoresistance was associated with alterations in cellular migration and invasion, which are key cancer hallmarks, coupled with changes in focal adhesion kinase (FAK) activation and secretion of matrix metalloproteinase-9 (MMP-9). Moreover, eIF4A knockdown via siRNA and its overexpression in chemoresistant cells suggested that eIF4A regulates FAK. Pro-atherogenic low-density lipoproteins (LDL) promoted cellular invasion in parental and chemoresistant cells in an MMP-9-dependent manner. Moreover, Dox only inhibited parental cell invasion. Significantly, chemoresistance was modulated by cryptotanshinone (Cry), a natural terpene purified from the roots of Salvia brandegeei. Cry and Dox co-exposure induced chemosensitization, connected with the Cry effect on eIF4A interaction. We further demonstrated the Cry binding capability on eIF4A and in silico assays suggest Cry inhibition on the RNA-processing domain. Therefore, strategic disruption of protein translation initiation is a druggable pathway by natural compounds during chemoresistance in TNBC. However, plasmatic LDL levels should be closely monitored throughout treatment.

Born to be sustainable: How to combine strategic disruption, open innovation, and process digitization to create a sustainable business

Born to be sustainable: How to combine strategic disruption, open innovation, and process digitization to create a sustainable business

Benzoate Synthesis from Glucose or Glycerol Using Engineered Pseudomonas taiwanensis.

Benzoic acid is one of the most commonly used food preservatives, but currently exclusively produced in petrochemical processes. In this study, a bio-based production pathway using an engineered strain of Pseudomonas taiwanensis is described. In a phenylalanine-overproducing strain, bacterial and plant genes are heterologously expressed to achieve production of benzoate via a β-oxidation pathway. Strategic disruption of the native Pseudomonas benzoate degradation pathway further allows the production of catechol and cis,cis-muconate. Taken together, this work demonstrates new routes for the microbial production of these industrially relevant chemicals from renewable resources.

The End of Resettlement? U.S. Refugee Policy in the Age of Trump

In the past three years, the Trump administration has taken unprecedented actions to slow the flow of refugees to the United States and undermine the foundations of the world’s largest refugee resettlement system. This article considers both the empirical substance of the White House’s anti-refugee policies, as well as their broader theoretical significance as a critical example of the Trump administration’s so-called “administrative deconstruction” agenda. Analyzing refugee policy as a theory-building case study, this article advances a novel argument reframing the administration’s actions through the lens of strategic disruption. Short of systemically deconstructing targeted programs, I contend that the Trump administration is engaged in an improvisational and deliberately antagonistic campaign to upend existing policies for the sake of disruption itself. Ultimately, Trump’s open disregard for established laws and conventions is a distinguishing feature of the administration’s approach, which limits its ability to implement lasting and legally binding change. In the case of refugee resettlement, this approach has produced a series of temporary and highly controversial policies, which have done measurable harm to refugees and humanitarian aid organizations. However, the legal and institutional foundations of the resettlement system remain firmly intact.

Becoming Muslims with a “Queer Voice”: Indexical Disjuncture in the Talk of LGBT Members of the Progressive Muslim Community

This article examines LGBT Muslim erasure by hegemonic Islamic and homonormative ideologies and how those involved in nonconformist Muslim groups queer those ideologies in order to forge narratives of belonging. I analyze the work of ‘queering’ Muslim voices among LGBT Muslims and allies involved in a multisited community of nonconformist Muslim face‐to‐face and online groups, and what such queering explains about the relationship among erasure, voice, ideological disjuncture, and resistance. Through analysis of individual and group conversations alongside ethnographic observations, I argue that LGBT Muslims and allies strategically index queerness and Muslimness as a challenge to marginalizing discourses and to create ‘safe’ spaces that also benefit other Muslims on the margins. Narratives of both LGBT Muslim marginalization and its strategic disruption as well as nonconformist group interactions are used to illustrate how the queering of Muslim discourse creates “indexical disjuncture” to make space for both LGBT Muslims and other nonconformist Muslims. I conclude by considering how providing evidence of language’s role in the process of ‘queering’ contributes to ongoing conversations in queer theory.

Artificial Intelligence: A Strategic Disruption in Public Relations

This article discusses the concept, benefits, application, impact and role of artificial intelligence (AI) in public relations (PR) industry. It examines the application of AI-based systems and their role as strategic disruption in the PR industry. This article is based on qualitative semi-structured interviews of 31 PR professionals and is grounded in the insights from the review of relevant research papers, articles, and case studies. It highlights the developments in research and practice related to AI application in the PR industry. AI-powered systems can scan social media and are smart, intelligent and experts in handling queries. These AI-enabled systems can post responses on social media in real time for the client and manage the crisis. With AI, PR professionals can save time spent on mundane activities like creating media lists, scheduling meetings and sending follow-up emails. Mass personalization and customization using AI are improving the effectiveness of PR activities. It is too early to say whether AI will act as strategic disruption in the PR industry. Based on the insights and discussion in this article, the PR professionals and researchers can make decisions on whether to invest in AI tools and solutions.

Developing Marketing and Advertising Strategies Through Disruption Philosophy

Disruption is about finding the strategic idea, which breaks and overturns a convention in the marketplace, and then makes it possible to reach a new vision or to give new substance to an existing vision. A business strategy revolves around three basic constructs, namely, vision, core values and a business typology. When an organization must drastically change two of the three basic constructs in order to survive, it has been strategically disrupted. These basic constructs represent how the upper management of a business envision the future, how they are guided by their core values to benefit from that vision, and how they would organize the business to maintain these benefits. When the magnitude of change that causes strategic disruption is significant, it is literally a make or break experience for that business or organization. A proactive strategy can help a company to overcome significant disruption. Therefore, this paper explores how disruption philosophy affects strategic marketing and advertising decision-making process. Keywords: Marketing Strategy, Advertising, Business Strategy, Disruption Philosophy, Branding DOI : 10.7176/JMCR/54-05 Publication date :March 31 st 2019

Integrated Enterprise Resilience Architecture Framework for Surviving Strategic Disruptions

Resilient business enterprises are able to survive strategic disruptions like technology disruptions and come back more successful. They succeed because they develop and effectively implement the resilience strategies of mitigation, adaption, and transformation. This paper proposes an integrated resilience framework that is based on a combination of enterprise architecture and business architecture frameworks. At the core of the proposed framework is a meta-model and a method. The framework guides the development of a unified vision of how a business enterprise can address a specific strategic disruption and transform itself in a successful way. The framework articulates the vision through the lens of business blueprint views that guide the formation of transformation initiatives. Through the mapping capabilities of the framework, the transformation initiatives cross over the boundaries between organization structures and domains. In the last section we demonstrate our proposed method and meta-model with the help of a case study.

Integrated Enterprise Resilience Architecture Framework for Surviving Strategic Disruptions

Resilient business enterprises are able to survive strategic disruptions like technology disruptions and come back more successful. They succeed because they develop and effectively implement the resilience strategies of mitigation, adaption, and transformation. This paper proposes an integrated resilience framework that is based on a combination of enterprise architecture and business architecture frameworks. At the core of the proposed framework is a meta-model and a method. The framework guides the development of a unified vision of how a business enterprise can address a specific strategic disruption and transform itself in a successful way. The framework articulates the vision through the lens of business blueprint views that guide the formation of transformation initiatives. Through the mapping capabilities of the framework, the transformation initiatives cross over the boundaries between organization structures and domains. In the last section we demonstrate our proposed method and meta-model with the help of a case study.

Supply Chain Monitoring: LLPs and 4PL Providers as Orchestrators

Supply Chain Monitoring: LLPs and 4PL Providers as Orchestrators

The sharing economy and the future of the hotel industry: Transaction cost theory and platform economics

The sharing economy and the future of the hotel industry: Transaction cost theory and platform economics

The Vulnerable Harvest

This essay explores contemporary literary and artistic strategies to reframe discourses of immigration in the United States, which have frequently represented immigrants as terrifying and disruptive threats or, alternatively, as defenseless and abject victims. The essay analyzes two artistic representations of undocumented Mexican laborers in the US dairy industry, the art exhibition The Golden Cage: Mexican Migrant Workers and Vermont Dairy Farmers (2008), by Caleb Kenna and Chris Urban, and the young adult novel Return to Sender (2009), by Julia Alvarez. Both the exhibition and the novel draw on the same poetics of vulnerability that the United Farm Workers’ Take Our Jobs campaign employs and that Judith Butler theorizes, serving as artistic representations of the ways in which immigrant farm laborers, farmers, and the national food supply are all exposed to risks as a result of unsustainable immigration policies. The essay posits that this artistic focus on the shared vulnerabilities of all residents functions as a strategic disruption of other portrayals of immigration, offering a counternarrative of interconnectedness and mutual responsibility to define the boundaries of our national and international communities.