The effects of soil-structure interactions on the dynamic response of a series of reinforced concrete wall-frame buildings with regard to failure criteria and its specific substrate were studied. For modeling the concrete, the modified version of Concrete damaged plasticity (CDP) was used with the latest and most effective method to calculate the tensile and compressive damage parameters of the concrete. The proposed model was validated; the seismic responses of the three laboratory models were analyzed by the analytical model, and the comparison of the results suggests the high accuracy of the proposed model. Then, reinforced concrete frames of 3, 7, and 12 floors with shear walls were modeled in Abaqus software. The effects of soil and structural interactions were also considered. The results of numerical modeling show that the plastic behavior of concrete and the effects of soil and structure interaction have a significant effect on the seismic response of the reinforced concrete wall-frames. Also, these responses were incremental or decreasing when compared to the rigid support. Consequently, the effect of soil and structure interaction causes the support of the structure to become softer, and the period of the structure increases. This increase is about 3.57% for the 3-story structure, 4.4% for the 7-story structure, and 10.2% for the 12-story structure. The change of base shear is evident due to considering the effects of soil and structure interaction. In this research, the amount of base shear increased by 2.03 times and 2.63 times in the 3-story and 12-story models, respectively. Finally, the results indicate an increase in the relative displacement considering the effects of soil and structure interaction.