Body Of Stomach Research Articles

The frequency of Helicobacter pylori infection in patients with rheumatoid arthritis and adult residents of the city of Tula

Currently, the list of microorganisms that have a possible connection with the development of rheumatoid arthritis continues to be updated. The role of not only traditional pathogens, but also representatives of conditionally pathogenic microflora is being actively studied. A number of domestic and foreign works demonstrate a high degree of Helicobacter pylori infection in patients with rheumatic diseases, including rheumatoid arthritis.The aim of the present study is to identify the frequency of detection of Helicobacter pylori infection in patients with rheumatoid arthritis and in adult residents of the city of Tula.Material and methods. The study included 3288 residents of Tula who do not have rheumatic diseases, and 119 patients with rheumatoid arthritis. To detect the infection, FEGDS was performed according to the generally accepted method with the taking of biopsies of the mucous membrane of the antrum and the stomach body, followed by verification of Helicobacter pylori using the Helpil-test test system.Results. According to the results of the data on the infection rate of residents of Tula without rheumatic diseases (n=3288), the largest percentage of infected (78.8%) was detected by an invasive method – express diagnosis of urease activity of the biopsy. The detection rate using a respiratory ammonia test and serological method was lower and amounted to 51.1 and 49.3%, respectively. In total, H. pylori was detected in 1692 people, which was 51.46%. Among patients with rheumatoid arthritis, Helicobacter pylori infection was 81.5%. Signs of damage to the mucous membrane of the upper gastrointestinal tract were often detected: superficial and subatrophic gastritis, single erosions.Conclusions. 1. Based on the study, it was found that the infection rate of Helicobacter pylori in patients with rheumatoid arthritis is at a fairly high level, not significantly different from that in residents without rheumatic diseases, when examined by an invasive method – express diagnosis of urease activity of the biopsy (81.5% and 78.8%, respectively). 2. Among patients with rheumatoid arthritis, there was a tendency to increase the frequency of infection with age and peak values in older age groups (r=0.37; p<0.05). 3. The frequency of detection of erosive and ulcerative lesions of the gastrointestinal tract in infected and uninfected Helicobacter pylori patients with rheumatoid arthritis significantly differed (42.2 and 13.6%) (p=0.03). Key words: Tula population, rheumatoid arthritis, Helicobacter pylori infection>˂ 0.05). 3. The frequency of detection of erosive and ulcerative lesions of the gastrointestinal tract in infected and uninfected Helicobacter pylori patients with rheumatoid arthritis significantly differed (42.2 and 13.6%) (p=0.03).

Effect of visceral adipose tissue on the accuracy of preoperative T-staging of gastric cancer

BackgroundDue to the anatomical characteristics of the tumor and the specific variables of the patients, the accuracy of preoperative T-staging of gastric cancer needs to be further improved. This study investigated the effect of visceral adipose tissue (VAT) on the accuracy of clinical T-staging of gastric cancer. MethodsThe clinical data of 455 patients who underwent gastrectomy from January 2013 to December 2018 were analyzed retrospectively. Taking the postoperative pathological results as the reference standard, the patients were divided into accurate staging group and mistaken staging group according to the comparison of clinical T stage (cT) and pathological T stage (pT). The individual characteristics of the two groups were compared, including visceral fat content at L2/L3 level calculated on computed tomography, age, sex, tumor size, tumor location (cardia, stomach body, stomach antrum), and degree of differentiation. Multivariate logistic regression was used to determine the independent factors affecting the accuracy of cT staging. ResultsAmong the 455 patients, 355 patients (78.0 %) had accurate preoperative cT staging and 100 patients (22.0 %) had inaccurate preoperative cT staging. The average area of VAT in the accurate staging group was (129.8 ± 72.6) cm2 and that in the mistaken staging group was (74.6 ± 61.6) cm2 (P < 0.001). The optimal cut-off value of VAT was 97.8 cm2 calculated according to the Yoden index. Multivariate logistic regression analysis showed that VAT, tumor location and tumor size were independent predictors of cT accuracy. ConclusionsPatients with lower visceral fat content (<97.8 cm2) based on L2/L3 level had a higher risk of false staging in preoperative clinical T staging.

Dwarf vipers on a small island: body size, diet and fecundity correlates

Abstract Insular populations offer excellent opportunities to study the factors that influence phenotypes. We observed island dwarfism in a widespread snake, the nose-horned viper (Vipera ammodytes). Island vipers were ~20% smaller than mainland individuals. They also produced fewer and smaller offspring. In snakes, food availability has a positive influence on body size, fecundity and offspring size. Consequently, low energy intake is a plausible explanation for insular dwarfism. The diet of island vipers was principally represented by lizards and centipedes, whereas the most profitable prey items (e.g. rodents) were regularly found in the stomach of mainland vipers. Furthermore, the proportion of individuals captured with a full stomach and good body condition were lower on the island compared with the mainland. Thus, island vipers were likely to be experiencing permanent energy restriction, with cascading effects on adult body size and reproductive output. Large prey promotes high relative jaw length in snakes. Island vipers displayed smaller relative jaw length compared with mainland populations, suggesting that plasticity played a role in insular dwarfism. But the difference in relative tail length between island and mainland populations, a trait not subjected to food-induced plasticity, indicates local adaptation. Both plasticity and adaptation might influence the phenotype of island vipers.

Assessment of Nurses’ Practices toward Enteral Feeding Tube for Premature Neonates

Background: To ensure safe and successful enteral feeding, precise tube insertion in the stomach's body is critical. In fact, feeding tube malposition has been linked to gastric bleeding, aspiration, and gastro-oesophageal reflux problems. Mechanical complications such as tube obstruction, displacement, or dislodgement, as well as infection-related complications, occur infrequently as a result of formula handling, storage, and administration. Objective: This study aims to assess nurses’ practices toward enteral feeding tube for premature neonates. Methodology: This study is a complementary section of a larger study, where a quasi-experimental design using test-retest approach for study group and control group participants employed in Kirkuk City Hospitals being, evaluated in several periods, in this pare the focus is only upon the pre-test period. Data collection is done by self-administrated questionnaire form, and it was given for nurses to answer after taking their agreement. A non - probability purposive sample selected from nurses who were working at the neonatal intensive critical care units. The sample was forty nurses, (20) nurses enrolled as a control group and (20) nurses enrolled as a study group. The study group participants were exposed to an interventional program. The selection criteria included Only pediatric' nurses who have from (1-15) years of experience at critical care units. Results: The finding of this study revealed that nurses have low level of practice regarding the insertion and initiating continuous enteral feeding at the pretest. Conclusion: This study concluded that nurses at the NICU have middle to low level of practice concerning the standard procedures of insertion enteral feeding tube, and initiating enteral feeding.

COMPARATIVE CASE REPORT OF 2 MORPHOLOGICALLY DISTINCT TYPE OF GIST STOMACH.

We present a comparative analysis of 2 cases one of mixed GIST and other of a case of de-differentiated GIST. GIST being the most common mesenchymal tumor of alimentary canal is commonly reported. Here, we compare the morphological features of two types of GIST. One patient is a 49 years old male with abdominal discomfort and pain and mass in body of stomach. Other patient a 57 years old female who presented with generalized weakness and anemia. Both of them were histologically GIST one mixed type and other de- differentiated type.

Spatial-temporal mapping of the intra-gastric pepsin concentration and proteolysis in pigs fed egg white gels

While there is a consensus that food structure affects food digestion, the underlying mechanisms remain poorly understood. A previous experiment in pigs fed egg white gels of same composition but different structures evidenced such effect on food gastric disintegration. In this study, we detailed the consequences on intra-gastric pH, pepsin concentration and proteolysis by sampling throughout the stomach over 6 h digestion. Subsequent amino acid absorption was investigated as well by blood sampling. While acidification was almost homogeneous after 6 h digestion regardless of the gel, pepsin distribution never became uniform. Pepsin started to accumulate in the pylorus/antrum region before concentrating in the body stomach beyond 4 h, time from which proteolysis really started. Interestingly, the more acidic and soft gel resulted in a soon (60 min) increase in proteolysis, an earlier and more intense peak of plasmatic amino acids, and a final pepsin concentration three times higher than with the other gels.

Improving the quality of gastric cancer surgery: factors associated with positive resection margins for gastrectomy

PurposePositive margins after gastrectomy have been associated with poor patient prognosis. This study aimed to identify risk factors associated with margin-positive resections.MethodsThe National Cancer Database was queried from 2004 to 2014 for all patients with gastric adenocarcinoma who underwent resection with curative intent and had known margin status. Univariable and multivariable logistic regression analysis was performed to identify variables associated with positive margins.ResultsA total of 32,193 patients were identified who met study inclusion criteria, of which 11.8% (3786 patients) had a margin-positive resection. Tumor size > 6 cm, T3 or T4 tumors, tumor location in the body of stomach or in multiple regions, signet ring cell histology, presence of lymphovascular invasion, positive lymph node involvement, and lack of neoadjuvant therapy were independently associated with an increased risk of positive margins.ConclusionsAdvanced disease characteristics, aggressive tumor pathology, and absence of neoadjuvant therapy were associated with margin-positive resections.

102 Reduced Caloric Intake Increases the Incidence Rate of Gastric Ulcers in Growing Pigs

Abstract Our objective was to evaluate effects of a disease feed intake pattern on gastric ulcerations. Eighty mixed sex pigs (27.9 ± 1.45 kg BW) were allotted to individual pens and 2 treatments using a complete randomized design. All pigs were fed a 450 µm ground corn-soybean meal diet. Period 1 (d 0-28), all pigs were fed ad libitum. In period 2 (d 29-42), 40 pigs were fed daily based on their individual body weight (averaging 1.45x maintenance) to mimic a disease feed intake (RF) profile. The remaining pigs stayed on ad libitum feed (Ad). Pigs were weighed at d 0, 28 and 42, and feed disappearance measured to calculate ADG, ADFI and G:F within period. At d 42, all pigs were euthanized, stomach pH recorded, and stomach ulcerations scored (0-3 scale, with 0 being normal). Performance, pH and ulceration frequency data were analyzed with pig as the experimental unit and the fixed effect of feeding level. Performance was not different in period 1 (P &amp;lt; 0.05). Compared with the Ad, RF pigs had lower ADG (1.10 vs 0.24 kg/d, P &amp;lt; 0.0001), ADFI (2.15 vs 0.85 kg/d, P &amp;lt; 0.0001) and G:F (0.51 vs 0.28, P &amp;lt; 0.0001) in period 2. Stomach pH was greater in the RF compared with the Ad pigs (P &amp;lt; 0.001). A greater percentage of Ad pig stomachs scored normal to mild on pars oesophagea ulcerations (85 vs 62%), while a greater percentage of RF pigs had a maximum score compared with the Ad (38 vs 15%, respectively). RF pigs had a higher frequency of severe stomach body ulcerations (score 3) compared with the Ad (20.5 vs 15.0%, respectively). These data suggest that a disease feed intake pattern exacerbates the incidence of gastric ulcerations in grower pigs fed a fine micron ground corn.

In-vitro release study of Pt(II) and Fe(III) metallocefotaxime drug candidates in pH dependent releasing mediums mimicking human biological fluids

Cefotaxime (CFT), a third-generation broad-spectrum cephalosporin antibiotic against gram-positive and gram-negative bacterial infections, inhibits bacteria's cell wall synthesis by binding to the targets of cephalosporin. Pharmacological properties and biological activity of cephalosporins are quite higher when they are in the form of metal complexes. Inspired by the superior pharmacokinetics and biological activities of metallocefotaxime drug candidates, the present study is the first attempt to investigate the in-vitro releasing profiles of Pt-CFT and Fe-CFT drug complexes. To that aim, a crosslinked free-radical polymerized poly(acrylic acid) (PAA) based hydrogel system was prepared, then release of CFT, Pt-CFT, and Fe-CFT were examined at 37°C in pH dependent releasing mediums mimicking enzyme-free human stomach (pH 1.2), intestine (pH 7.4), and physiological body fluid (pH 7.4). Degree of swelling and release profiles of metal-CFT complexes from the PAA hydrogel was compared to CFT. In-vitro antimicrobial activity of CFT, Pt-CFT, and Fe-CFT was tested by agar disc-diffusion method. It has been observed that all hydrogel systems except for that of high weight percentages of N,N-methylenebisacrylamide:Acrylic Acid loaded with low quantity of Fe-CFT responded to all studied releasing medium. Scanning Electron Microscopy images of drug loaded hydrogels have shown that the distribution of the loading material in the hydrogel matrix is quite uniform. All the studied hydrogel systems show the highest SR% in SPF (pH 7.4) medium. As a result, PAA-based hydrogel matrixes prepared in this work have the potential to act as a suitable drug carrier for the delivery of CFT, Pt-CFT, and Fe-CFT drug candidates.

Trace element and lipidomic analysis of bottlenose dolphin blubber from the Yucatan coast: Lipid composition relationships

Bottlenose dolphins (Tursiops truncatus) are found in coastal and estuarine ecosystems where they are in continuous contact with multiple abiotic and biotic stressors in the environment. Due to their role as predators, they can bioaccumulate contaminants and are considered sentinel organisms for monitoring the health of coastal marine ecosystems. The northern zonal coast of the Yucatan peninsula of Mexico has a high incidence of anthropogenic activities. The principal objectives of this study were two-fold: 1) to determine the presence of trace metals and their correlation with lipids in bottlenose dolphin blubber, and 2) to use a lipidomics approach to characterize their biological responses. Levels of trace elements (Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, Pb) were analyzed using ICP-MS and lipids were measured using a targeted lipidomics approach with LC-MS/MS. Spearman correlation analysis was used to identify associations between lipids and trace elements. The influences of gender, stranding codes, presence of stomach content, growth stages and body length were also analyzed. Blubber lipid composition was dominated by triacylglycerols (TAG). Our results demonstrated the presence of heavy-metal elements such as Cd and As, which were correlated with different lipid species, mainly the ceramides and glycerophospholipids, respectively. Organisms with Cd showed lower concentrations of ceramides (CER, HCER and DCER), TAG and cholesteryl esters (CE). Trace elements Cr, Co, As and Cd increased proportionately with body length. This study provides a novel insight of lipidomic characterization and correlations with trace elements in the bottlenose dolphin which might contribute to having a better understanding of the physiological functions and the risks that anthropogenic activities can bring to sentinel organisms from coastal regions.

Dietary fatty acid profiles shape crayfish biosynthesis and performance: Implications for riverine food webs

Abstract Alteration of riverine flows can modify the structure and function of ecosystems, changing energy pathways and patterns of micronutrient transfer between trophic levels. Fatty acids (FAs) commonly are used to evaluate food quality, since some FAs required for somatic growth and physiological functions in animals must be obtained from their diet. FAs also are used in food‐web studies as biotracers as a consequence of their constrained metabolic biosynthesis by animals. However, their utility may be confounded by selective retention or modification of dietary FAs by consumers. We conducted a 70‐day feeding trial to compare growth and survival of an abundant and widespread mesoconsumer (Cherax destructor, the common yabby or crayfish) fed three contrasting diets: a poor‐quality detritus‐based diet; a high protein invertebrate diet; and a high‐quality commercial aquaculture pellet. Fatty acid profiles were obtained for each dietary treatment and contrasted with crayfish FA profiles at the end of the experiment to examine patterns of FA retention and integration. We also collected wild crayfish from floodplain wetland and river habitats, and obtained FA profiles from their stomach contents and body tissue to compare with experimental crayfish. Experimental crayfish fed high‐quality commercial pellets doubled in mass during the 70‐day assay, invertebrate fed crayfish growth was intermediate, and growth of crayfish fed detritus was negligible. Fatty acid profiles of crayfish fed our three contrasting diets differed significantly at the end of the experiment. Proportions of the polyunsaturated omega‐6 FA linoleic acid (LIN, 18:2ω6) in crayfish followed the same inequality observed in growth and diets: pellets &gt; invertebrates &gt; detritus. Pellet‐fed crayfish preferentially assimilated greater proportions of FAs 20:4ω6 (ARA), 20:5ω3 (EPA) 18:1ω9 (OA) and 16:1ω7 (POA) into their tissue. Fatty acid profiles of floodplain crayfish differed to profiles of riverine crayfish, and floodplain crayfish had higher proportions of essential FAs ARA and LIN in their tissues. Fatty acid biosynthesis by crayfish was best described by a hypothesis of FA allostasis rather than homeostasis; in this, FA profiles of crayfish were shaped by their diet, and selective integration and modification of high‐quality FAs from basal resources rich in these micronutrients led to higher proportions in crayfish tissues. Here we present evidence for the conversion of shorter‐chain essential FAs by freshwater crayfish to compensate for a lack of long‐chain FAs in their diet. We provide a necessary step for improving our understanding of micronutrient dynamics and the transfer of essential molecules between trophic levels in lowland river food webs. Floodplain habitats are known to provide higher‐quality basal food resources for mesoconsumers than riverine habitats, and here we identify one mechanism by which that may be extended to subsequent trophic levels.

Cholangiocarcinoma presenting as dysphagia and misdiagnosed as gastritis: a case report

BackgroundHeterotopic tumor is a rare disease. Thus far, no cases of heterotopic cholangiocarcinoma have been reported in the world. Cholangiocarcinoma mainly metastasizes by direct invasion, and it can lead to liver metastasis in its advanced stage. There were few clinical cases of gastric metastasis in advanced tumors, mainly seen in breast cancer, lung cancer, liver cancer, malignant melanoma, choriocarcinoma, and hematological tumors. Metastases of cholangiocarcinoma to the stomach also are exceptionally rare.Case presentationA 58-year-old man was admitted to the hospital because of difficulty swallowing for one year. Upon gastroscopy, we found the tumor at the region of the cardia and gastric fundus. Macroscopical appearance of the tumor suggested its malignant nature. Computed tomography (CT) findings showed that the wall of the cardia, fundus, and stomach body were thickened, suggesting a tumor. Because the patient had obvious difficulty swallowing, we invited cardiothoracic surgeons for consultation. They considered that the patient had definite mechanical obstruction in the lower esophagus; hence, they performed an operation. Immunohistochemical staining revealed low-to-medium differentiated adenocarcinoma (containing mucinous adenocarcinoma components) of biliary origin.ConclusionsWe highlight the importance of the endoscopic biopsy of gastric tumor. However, when its results are inconsistent with the clinician’s judgment, further examination is required. Endoscopic ultrasonography and enhanced CT may be a good choice. If necessary, on the premise of patient acceptance, the diagnosis could be confirmed after surgical excision. Here we report a case of a patient with heterotopic cholangiocarcinoma in the gastric fundus. The most common tissue ectopias in the digestive tract include esophagogastric gastric mucosal ectopia, duodenal gastric mucosal ectopia, and gastric mucosal small intestinal ectopia. Thus far, there have been no reports of ectopic cholangiocarcinoma and associated cancer in the stomach. In addition, metastases of cholangiocarcinoma to the stomach are also exceptionally rare, and most of them are due to a direct invasion. The discovery of the primary lesion is an important clue for the reliable diagnosis in such cases.

Isolated dextrogastria with eventration of right hemidiaphragm and hiatal hernia in an adult male

BackgroundType 2 isolated dextrogastria in conjunction with protrusion of the right hemidiaphragm and hiatal hernia is an uncommon anomaly among all transpositions of the viscera. Clear diagnosis is not straightforward in such cases both clinically and with various imaging techniques leaving often only laparotomy for diagnosis.Case presentationHere, we discuss the case of a so far asymptomatic 19-year-old male, who had a 3-month history of abdominal pain and 2 days of vomiting with absolute constipation, and reduced air entry in the base of the right lung. A large air fluid level was found in the right lower hemithorax, furthermore, a loss of the normal diaphragmatic outline, and paucity of the bowel gases in the rest of the abdomen. Computer tomography with contrast was suggestive of loss of right lung volume, with stomach and bowel loops herniating into the right hemithorax and compressive atelactatic changes in the adjacent lung alongside an enlarged liver. A barium test showed the stomach fundus and body posteriorly positioned, while both duodenal bulb loops and the duodeno-jejunal junction alongside the small and large bowels were detected in their normal positions.ConclusionIn case of visceral transpositions, routine diagnostic blood and radiological tests may lead the health care provider to misdiagnosis. It is necessary, in particular when surgery is required, to carefully elucidate the organ anomaly. The use of additional imaging and radiological methods may be called for; CT scan and a barium test were critical here. This is the first case of isolated dextrogastria with eventration of right hemidiaphragm and hiatal hernia reported from Pakistan providing insights for diagnostic procedures.

A RARE CASE OF SPONTANEOUS CYSTOGASTROSTOMY IN A PSEUDOCYST OF PANCREAS

BACKGROUND: Pancreatic pseudocysts (PPs), common sequelae of acute or chronic pancreatitis and trauma, are uid collections arising in or adjacent to the pancreas enclosed by a wall of brous granulation tissue, but lacking a true epithelial lining. It is the most common complication of pancreatitis. Hence, accurate diagnosis and timely management is important. Spontaneous resolution occurs in more than 80% cases. In case of persistence or specic indications, endoscopic intervention and surgical management is considered. Spontaneous rupture is a very rare and serious complication of pseudocyst of pancreas and should be managed carefully whenever encountered as it can cause severe peritonitis and requires emergent surgical exploration. We describe a case of a 42-year-old, alcoholic male patient who came to casualty with complaints of pain over abdomen since 4 days and was diagnosed with acute on chronic pancreatitis with pseudocyst of pancreas who developed spontaneous rupture of pseudocyst into body of stomach and was managed conservatively. Spontaneous resolution of pancreatic pseudocyst have been reported with acute gastrointestinal bleed, extension into the biliary tree and pelvicalceal system. Spontaneous rupture of pseudocyst into the body of stomach is very rare that can be managed conservatively, which avoids surgical intervention and hence decrease in mortality rate among these patients.

Expression of let-7a, miR-106b and miR-29b is changed in human gastric cancer.

MicroRNA (miRNA) are small, noncoding RNA sequences that post-transcriptionally regulate the proliferation, activity and apoptosis of human gastric cancer cells by controlling various signaling cascades. Processes that involve miRNA molecules can create a specific network of interactions in a cell, and disruption of its functioning may contribute to the transformation of normal cells into cancerous cells. Aims of our survey were: 1) study the relationship between the expression of selected miRNA types (let-7a, miR-106b, miR-29b, miR-21, miR-155, miR-222) in the gastric mucosa and pathomorphological changes determined by classical histopathological methods, 2) perform in silico analysis to select target genes for selected miRNAs and to perform functional analysis of these genes. Eighty-three subjects (45 women, 38 men; mean age 39±14 years, range: 21-80 years, were examined). Among them were 18 (21.5%) patients with chronic active gastritis, 42 (50.6%) people with chronic inactive gastritis, 9 (10.8%) patients with gastric cancer and 14 (16.9%) patients without histopathological changes. The study demonstrated that mainly the expression of 3 (miR-29b, let-7a miR-106b) out of 6 selected miRNAs are significantly different depending on the site of biopsy (body of the stomach or antrum) and the group of patients. Expression of miR-106b in the antrum and body was the highest in the group of cancer patients and the lowest in patients with chronic active gastritis. The expression of let-7a differed depending on group of patients and location. The highest expression was in the body in the group with inactive gastritis and the lowest in gastric cancer. Patients with cancer had the lowest expression of miR-29b in stomach body and it was the highest in the patients with inactive gastritis in this location. Expression of miR-21 and miR-155 determinations were not statistically significant in comparison to groups or locations, and of miR-222 was not different between the groups, but only in the control group was higher in the antrum than in the body. We conclude that identification of miRNAs may represent a promising modern complementary method in the diagnosis of gastric diseases, especially cancer.

Indocyanine green fluorescence angiography-guided simultaneous laparoscopic distal gastrectomy and spleen-preserving distal pancreatectomy for conserving the gastrosplenic ligament: A case report.

Introduction and importanceIndocyanine green (ICG) fluorescence angiography is being increasingly performed intraoperatively to detect restricted blood flow intraoperatively for the prevention of postoperative organ ischemia and anastomotic leakage. This is the first case report of simultaneous laparoscopic distal gastrectomy (LDG) and spleen-preserving distal pancreatectomy (LSPDP) involving ICG angiography use to avoid the remnant stomach ischemia.Case presentationA 55-year-old man was diagnosed with early cancer of the stomach body and intraductal papillary mucinous neoplasms of the pancreatic tail. We performed simultaneous LDG with D2 dissection and LSPDP to conserve the gastrosplenic ligament and preserve blood supply to the remnant stomach. Intraoperatively, blood flow to the remnant stomach was visualized using ICG fluorescence angiography, after which Roux-en-Y reconstruction was performed. There was no perioperative remnant stomach ischemia.Clinical discussionDespite the preserved splenic artery and vein, complete splenic infarction occurs after LSPDP possibly due to thrombus formation during surgical procedures. In this patient, we conserved the gastrosplenic ligament for the short gastric artery, which supplied blood to the remnant stomach; however, remnant stomach ischemia may occur. Therefore, we performed ICG fluorescence angiography during this operation to ensure that sufficient blood supply to the remnant stomach was maintained.ConclusionOur experience demonstrates that ICG angiography may be useful for the prevention of remnant stomach ischemia.

Useful traction technique for laparoscopic fundoplication without removing proceeding gastrostomy in a neurologically impaired patient with a body deformity.

Severely neurologically impaired patients often require the creation of a gastrostomy when they develop difficulty with oral intake followed by antireflux surgery. We use a traction technique for laparoscopic fundoplication without removing the gastrostomy in such cases. Right lateral traction of the round ligament of the liver and left lateral traction of the stomach body are performed using a needle device. The left liver lobe is elevated with a liver retractor inserted via the epigastrium. This traction technique allows a sufficient surgical field for manipulating forceps to be created in cases with a gastrostomy, enabling fundoplication to be performed safely without removing the gastrostomy.

Effectiveness of rebamipide in treatment of erosions in stomach mucosa

The aim. To evaluate the effectiveness of the drug Rebamipide-SZ when used in combination with proton pump inhibitors in the treatment of erosive changes in the gastric mucosa.Materials and methods. 40 patients were monitored who had erosive lesions of the stomach: 20 patients (group 1) with erosive gastritis not associated with Helicobacter pylori, 20 patients (group 2) with erosive changes in the gastric mucosa while taking nonsteroidal anti-inflammatory drugs (NSAIDs). Before the start of therapy and after the end of treatment, patients underwent a comprehensive examination: assessment of complaints according to the survey data, assessment of the severity of dyspepsia on the GIS scale, assessment of gastroenterological complaints on the GSRS scale, assessment of the effectiveness of treatment on the visual-analog scales of abdominal pain and general well-being, assessment of quality of life (questionnaire SF-36), upper gastro-intestinal endoscopy with biopsy (one biopsy from the stomach body, one biopsy from the antrum of the stomach) for verification of Helicobacter pylori infection (rapid urease test) and histological examination, assessment of side effects. All patients were prescribed therapy: Rebamipide-SZ one tablet three times a day after meals for a month and a proton pump inhibitor (rabeprazole) 20 mg two times a day for 15–30 minutes before meals for a month. Results. There was a complete relief of epigastric pain and a significant decrease or complete relief of dyspeptic complaints. When assessing the dynamics of endoscopic changes after usage of Rebamipide-SZ therapy, there was a regression of hyperemia of the gastric mucosa and complete epithelization of erosions in the stomach in almost all patients. Histological analysis of the gastric mucosa before and after treatment showed a decrease in the severity of acute and chronic inflammatory changes. There were no adverse events, no new complaints, no negative changes in clinical and biochemical blood tests during treatment. No allergic reactions were observed.Conclusion. The intake of Rebamipide-SZ is highly effective and safe for patients with various etiology erosive lesions of the gastric mucosa, including those caused by taking NSAIDs. Rebamipide-SZ can be recommended for course use in the complex therapy of patients with various pathologies of the upper gastrointestinal tract as a gastroprotective agent that helps restore the permeability of the gastric mucosa.

Successful retrieval of an accidentally ingested endodontic file from the body of stomach using endoscopy: A case report

Successful retrieval of an accidentally ingested endodontic file from the body of stomach using endoscopy: A case report

Biomarkers CDX2, CK20, CK7 in Schoolchildren with Gastritis in the Realization of Familial Predisposition of Stomach Cancer.

We studied the association of expression of CDX2, CK20, CK7 proteins with familial predisposition to stomach cancer in schoolchildren with gastritis and its activity. Gastroscopy with biopsy of the gastric mucosa was performed in 89 schoolchildren aged 7-17 years with gastrointestinal complaints. The morphological study included the diagnosis of gastritis (Sydney classification) and the presence of Helicobacter pylori. The expression of CDX2, CK20, and CK7 was evaluated immunohistochemically. In children with familial predisposition to stomach cancer, the expression of CK20 in the stomach body was significantly increased (p=0.0225). In addition, the expression of CK20 (p=0.0979) and CDX2 (p=0.0849) tended to insrease in the antral compartment. No significant differences in the expression of CK7 in the gastric antrum and body were found. Some features of the expression of CDX2, CK20, and CK7 proteins in children with family predisposition to stomach cancer were revealed.