Our recent meta-analysis on the blood pressure (BP) lowering effects of concurrent exercise training (CET) found systolic BP (SBP) and diastolic BP (DBP) were moderately reduced an average of ~3 mmHg overall. However, large SBP/DBP (~9/8 mmHg) reductions were noted among adults with hypertension, indicating the potential clinical utility of CET as antihypertensive lifestyle therapy. PURPOSE: To perform a meta-analysis to determine whether acute concurrent exercise (CE) is also efficacious antihypertensive lifestyle therapy. METHODS: Databases were searched for controlled studies that included: adults (≥19 yr), a single bout of CE, and measured BP pre- and post-CE and control. Analyses followed random-effects assumptions. RESULTS: 8 studies and 13 interventions (k) qualified. Subjects (N=109) were young to middle-aged (35.9±16.4 yr), overweight (26.7±3.1 kg/m2) men (34.6%) and women (65.4%) with a resting SBP/DBP of 122.3±11.9/76.6±7.2 mmHg. Among the total sample, 38.6% (N=42) had hypertension, 12.4% (N=14) prehypertension, and 49.0% (N=53) normal BP. Acute CE was performed at moderate-to-vigorous intensity (aerobic=65.6±17.5% maximum oxygen uptake, resistance=63.9±16.5% one-repetition maximum) for 55.0±6.1 min, with 53.9% of the interventions performing aerobic first. Aerobic exercise interventions included walking (38.5%, k=5), cycling (38.5%, k=4), running (15.4%, k=2), and step aerobics (7.7%, k=1) for 29.1±3.0 min. Dynamic resistance exercise interventions were performed on machines for 26.1±4.9 min, and consisted of 2.8±1.2 sets of 11.5±5.4 repetitions per set for 5.9±1.2 exercises. BP was measured in the laboratory for 89.2±45.4 min post-CE. Overall, acute CE elicited large reductions in SBP (d+ [95% CI]= -0.84 [-1.23, -0.44]; -9.2 mmHg), but not DBP (d+ [95% CI]= -0.08 [-0.27, 0.11]; -0.6 mmHg) compared to control. We observed significant heterogeneity for SBP (I2 [95% CI]= 82.7% [71.6%, 89.4%]) and DBP (I2 [95% CI]= 49.7% [4.9%, 73.43%]), but no significant moderators emerged. CONCLUSION: Similar to CET, acute CE leads to clinically meaningful reductions in SBP (~9 mmHg), but in contrast to CET, not DBP. The BP lowering patterns appear to differ between acute and chronic CE, findings that should be confirmed in future randomized CE trials.