Abstract Addressing the common limitations of current six-axis force sensors, including the degradation of strain gauge accuracy due to environmental influences and the necessity for a complete replacement when damaged, this paper proposes an innovative six-axis force sensor that integrates a hybrid serial–parallel structure featuring flexible hinges. The sensor’s bracket is designed using a combination of serial–parallel flexible hinges, which confer load distribution capabilities, are lightweight, have high strength, and facilitate replacement. The static force model and the overall stiffness model of the sensor were developed based on the 3-universal–prismatic–universal parallel mechanism theory, providing a theoretical foundation for evaluating the sensor’s performance. To validate the accuracy of the stiffness model, finite element software is utilized for simulation-based verification. Subsequently, a calibration experiment is performed on the sensor, yielding results that conclusively show an error margin of less than 5% between experimental and theoretical values, satisfying the design criteria for sensor measurement.