Squamous Odontogenic Tumor-like Proliferations Research Articles

SQUAMOUS ODONTOGENIC TUMOR-LIKE PROLIFERATIONS IN RADICULAR CYST: CASE REPORT

Squamous odontogenic tumor-like proliferations (SOT-LPs) are an uncommon histopathological finding occurring in the fibrous capsule of odontogenic cysts, which share certain microscopic features with squamous odontogenic tumor (SOT). A 36-year-old woman presented with an 18-month history of a painless, slow-growing swelling in the maxilla. Her medical history was unremarkable. Computed tomography revealed a well-defined, unilocular hypodense lesion extending from nonvital tooth #21 to tooth #11, with expansion and rupture of vestibular cortical bone, measuring approximately 1.5 cm. Under the diagnostic hypothesis of radicular cyst, an excisional biopsy was performed. Histopathological analysis disclosed a cystic cavity lined by nonkeratinized stratified squamous epithelium exhibiting hyperplasia, exocytosis, and spongiosis. The fibrous capsule revealed conspicuous islands of well-differentiated squamous epithelium, some of them exhibiting foci of microcystic degeneration. The final diagnosis was radicular cyst with SOT-LPs. The patient remains under close follow-up. Squamous odontogenic tumor-like proliferations (SOT-LPs) are an uncommon histopathological finding occurring in the fibrous capsule of odontogenic cysts, which share certain microscopic features with squamous odontogenic tumor (SOT). A 36-year-old woman presented with an 18-month history of a painless, slow-growing swelling in the maxilla. Her medical history was unremarkable. Computed tomography revealed a well-defined, unilocular hypodense lesion extending from nonvital tooth #21 to tooth #11, with expansion and rupture of vestibular cortical bone, measuring approximately 1.5 cm. Under the diagnostic hypothesis of radicular cyst, an excisional biopsy was performed. Histopathological analysis disclosed a cystic cavity lined by nonkeratinized stratified squamous epithelium exhibiting hyperplasia, exocytosis, and spongiosis. The fibrous capsule revealed conspicuous islands of well-differentiated squamous epithelium, some of them exhibiting foci of microcystic degeneration. The final diagnosis was radicular cyst with SOT-LPs. The patient remains under close follow-up.

Squamous Odontogenic Tumor-Like Proliferation in Odontogenic Cysts: Report of Two Cases

Squamous Odontogenic Tumor-Like Proliferation in Odontogenic Cysts: Report of Two Cases

Radicular Cyst with Squamous Odontogenic Tumor-like Proliferation: An Unusual Entity

Squamous odontogenic tumor-like proliferation (SOT-LP) is a nonneoplastic lesion with a histological pattern similar to that of the SOT. This entity is characterized by SOT proliferations isolated in the cyst wall of an odontogenic cyst. This pattern is rarely seen in radicular cysts. The nature of these proliferations is not clear, and there is a varied opinion on the origin. Although it has a benign behavior, it should be differentiated from other aggressive lesions such as intraosseous carcinoma, ameloblastoma, odontogenic keratocyst, and SOT. Knowledge about this unusual lesion can help in the accurate diagnosis and treatment of the patients. Here, we are discussing a rare case of an SOT-LP emerging in a radicular cyst of the maxilla.

Squamous odontogenic tumor-like proliferation in a radicular cyst: A case report

The squamous odontogenic tumour is a rare benign neoplasm whose aetiology remains unknown. It usually appears in the jaw and its origin could be related to the ephitelial remnants of Malassez. Histologically comprises numerous islets of squamous, non-keratinized, well-differentiated and rounded epithelial cells a fibrous stroma without signs of atypical cells. There is a non-neoplastic lesion with the same histological pattern than the squamous odontogenic tumour. This entity is characterized by squamous odontogenic tumour proliferations isolated into the cyst wall of an odontogenic cyst. It is rare and has a benign behavior. It has been suggested that these epithelial proliferations could be the former expression of the neoplastic form. It is very important to carry out clinical and radiological controls periodically. So far it has not been documented any change towards a squamous odontogenic tumour nor toward malignancy in a squamous odontogenic tumour like proliferation. Key words:Radicular cyst, squamous odontogenic tumour.

Squamous Odontogenic Tumor-like Proliferations in Radicular Cysts: A Clinicopathologic Study of Forty-two Cases

Introduction Squamous odontogenic tumor-like epithelial islands occurring in the walls of odontogenic cysts are histologically identical to the squamous odontogenic tumor (SOT). Microscopically, the squamous odontogenic tumor-like proliferations (SOTLPs) share certain histologic features with SOT, acanthomatous and desmoplastic ameloblastoma, and well-dif-ferentiated squamous cell carcinoma. Little is known about the rarely reported SOTLPs occurring in radicular cysts. The purpose of this study was to define the clinical and histopathologic spectrum of SOTLP in radicular cysts and to investigate its histogenesis, prevalence, and biologic behavior. Methods A retrospective clinicopathologic study was conducted at the Louisiana State University School of Dentistry, and a total of 42 radicular cysts with SOTLPs were accepted. Clinical findings and detailed histopathologic features were documented, and follow-up information was solicited for the 42 cases. Results Forty-two cases of radicular cysts with SOTLPs were found among 1241 radicular cysts. Two thirds of the cases revealed the SOTLPs were arising from budlike extensions of the epithelial lining of the cyst. The SOT-like epithelial islands were in areas free of inflammatory cells in 73.8% of the cases. No evidence of recurrence or unexpected clinical behavior was reported in 11 cases with adequate follow-up. Conclusions The prevalence of SOTLPs in radicular cysts at Louisiana State University School of Dentistry is 3.4%. The SOTLPs appear to originate from the epithelial lining of the cyst and do not appear to be directly associated with inflammation. The biologic behavior of the radicular cyst with SOTLP is innocuous, with no apparent potential for neoplastic transformation or recurrence.

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Squamous odontogenic tumor-like proliferation (SOTP) is considered a benign legion associated with odontogenic cysts. Histologically, SOTP associated with hyperplasia of odontogenic squamous epithelial cells must be differentiated from squamous odontogenic tumor, which is a true odontogenic neoplasm. Here we report a case of SOTP associated with radicular cyst occurring in the upper incisor region of a 49-year-old man. The legions were removed by conventional enucleation, and the postoperative course was uneventful.

Glandular odontogenic cyst: Clinicopathologic analysis of three cases

The glandular odontogenic cyst is a rare cyst of odontogenic origin, first described in 1988 by Gardner et al. Three previously unreported glandular odontogenic cysts are presented; none recurred after the initial surgical treatment, and one example was associated with a squamous odontogenic tumor-like proliferation in the wall. Ten similar cases were found in the literature, and their clinical and roentgenographic features, and follow-up, have been compared with the present cases.

Squamous odontogenic tumor.

The twenty-fifth reported case of squamous odontogenic tumor is presented. The patient was a 39-year-old Chinese Malaysian male. The lesion was asymptomatic and did not recur after excision. It is important to distinguish this type of lesion from squamous odontogenic tumor-like proliferation. The rest of Malassez is thought to be responsible for the histogenesis of the lesion. Better understanding will only be achieved when more cases are reported and studied.

Squamous odontogenic tumor-like proliferations in periapical cysts

Squamous odontogenic tumor-like proliferations were observed in the wall of an apical cyst in a 45-yr-old man. Review of the literature revealed nine similar cases. In spite of the histological similarity of these proliferations to squamous odontogenic tumors they differ clinically, radiographically, and biologically and, therefore, should be separated.

Squamous odontogenic tumor: Report of five cases and review of the literature

Five previously unreported cases of squamous odontogenic tumor are reported and the literature is reviewed. This lesion appears to be a benign odontogenic neoplasm arising from rests of Malassez; it occurs over a wide age range and has a predilection for the anterior maxilla and the posterior mandible. Maxillary lesions are more aggressive than mandibular ones. The most common sign is mobility of teeth in the area. Radiographically, the most characteristic picture is that of a well-circumscribed semicircular radiolucency bounded by a sclerotic border and emanating from the area of the alveolus adjacent to the roots of teeth. The histologic features are sufficiently characteristic to differentiate it from ameloblastoma and epidermoid carcinoma; however, evaluation of the entire clinicopathologic picture is necessary to exclude the diagnosis of squamous odontogenic tumorlike proliferations in an odontogenic cyst.

Squamous odontogenic tumorlike proliferations in odontogenic cysts

Five cases of squamous odontogenic tumorlike proliferations occurring in the walls of odontogenic cysts are presented. These lesions showed no more aggressive potential than the cysts, if taken alone, in which they occurred. The lesions showed no tendency to develop into solid tumors and, on the basis of this limited series of cases, conservative surgery appears to be the treatment of choice.