Generation of engineered human spinal cord organoid in channel-patterned collagen and transplantation for spinal cord regeneration.

Mesaconine alleviates hyperalgesia in CFA-induced mice by modulating YAP1 to suppress cell ferroptosis within the spinal cord.

Chaihu-Shugan-San alleviates functional dyspepsia by inhibiting central sensitization and regulating glutamate metabolism via NMDAR/CaMKII signaling pathway.

Identification of repopulated microglia-associated genes in microglia depleted/repopulated mice after spinal cord injury.

A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regeneration and neural circuit reconstruction via FGF13/Ca2+/CaMK2A/CREB pathway.

Pain and the immune system.

There is increasing interest in uncovering working mechanisms of physiotherapy interventions. Advanced medical imaging enables in-vivo visualisation and quantification of neuroinflammation. This case report reveals for the first time how neuroinflammation in the nervous system may change following neural tissue management. A 56-year-old man presented with a 9-month history of left C7 painful radiculopathy. He reported arm and neck pain, and numbness in the C7 dermatome. Elbow extension strength was reduced. The neurodynamic test (median nerve) was positive. MRI confirmed nerve root compression due to disc herniation C6/C7. Dynamic [11C]DPA713 PET/CT imaging revealed neuroinflammation at the neuroforamen and spinal cord. While being on the surgical waitlist, he received six weeks of neural tissue management, which included 12 sessions of nerve and joint mobilisation, and a home program of neurodynamic exercises. At 6-weeks follow-up, arm and neck pain intensity had markedly reduced, which was maintained at 6 months. These improvements coincided with a substantial decrease in neuroinflammation at the affected neuroforamen (PET/CT: VT: from 12.96 to 6.21). No meaningful decrease was observed in the spinal cord (VT: from 6.43 to 5.38). Following six weeks of neural tissue management, in vivo measures of neuroinflammation reduced substantially at the affected nerve roots and dorsal root ganglion, which coincided with decreased neck and arm pain. Changes in neuroinflammation exceeding the smallest detectable difference can be measured following neural tissue management in a patient with painful cervical radiculopathy. A randomised trial to validate these findings is warranted.

Effects of immediate sacral neuromodulation on bladder in rats with spinal cord hemisection-induced neurogenic bladder.

Bilateral optic neuritis preceding a Baló concentric sclerosis lesion: A case report and literature review.

Dual-responsive PDA-HP hydrogel enables mitochondria-targeted mild photothermal therapy for spinal cord repair.

A multifunctional and ROS response CO-gas delivery platform for spinal cord regeneration.

Patients with peripheral nerve injury (PNI) often experience neuropathic pain (NP), which is difficult to treat effectively due to ongoing inflammation and oxidative stress that impede nerve repair. Traditional anti-inflammatory antioxidants are limited by short half-lives and significant side effects. This study introduces a supramolecular hydrogel formed by combining anti-inflammatory betamethasone phosphate (Betp) with calcium chloride to create betamethasone phosphate hydrogel (Betp@Gel). The antioxidant curcumin (Cur) was incorporated into this gel to form Cur/Betp@Gel, which can be injected directly at the injury site for sustained Cur release. Cur/Betp@Gel demonstrates superior sustained-release capabilities and therapeutic effectiveness compared to Betp@Gel or Cur alone. It enhances pain relief, supports functional recovery after nerve damage, and promotes nerve repair and regeneration. This is achieved by Betp@Gel's anti-inflammatory effects, which inhibit TNF-α, IL-1β, and IL-6, combined with Cur's continuous slow release, which scavenges reactive oxygen species (ROS). Additionally, Cur/Betp@Gel mitigates PNI-induced spinal inflammation by reducing GFAP and Iba-1 expression in the spinal cord. Overall, in-situ injection of Cur/Betp@Gel is a promising strategy for aiding nerve repair and alleviating neuropathic pain.

Brain-enriched guanylate kinase-associated protein in the spinal dorsal horn regulates mechanical allodynia in male mouse neuropathic and inflammatory pain model.

Intraneural delivery of CBD3A6K-RhB via PEG-PLGA nanoparticles for neuropathic pain therapy.

NLRP10 ablation alleviates neuropathic pain by inhibiting excessive NIX/LC3-dependent mitophagy in the spinal cord.

Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosis in EAE mice.

Explainable and evidence-linked recommendations for spine surgery via a retrieval-augmented LLM agent.

Insights into the role of the mechanosensitive Piezo1 channel and signaling mechanisms in CNS functions and diseases.

Reprogramming of astrocytes into motoneuron-like cells by a Ascl1-Myt1l-Pou3f2-Isl1 cocktail.

Synergistic redox and metabolic reprogramming by functionalized Prussian blue nanozymes for spinal cord injury repair