Boer (n = 132), Kiko (n = 92), and Spanish (n = 79) straightbred does were studied across 6 yr to assess doe fitness on southeastern US pastures. Does were exposed to Boer, Kiko, and Spanish bucks in a complete 3-breed diallel mating scheme each fall for spring kidding in March or May. A total of 1,041 doe-yr units were observed with does (ranging from 2 to 8 yr of age) managed together in a semi-intensive manner. The proportion of buck-exposed does delivering at least 1 live kid was less (P < 0.01) for Boer does (80%) than for Kiko (96%) and Spanish does (94%). Litter size and litter weight at birth were not affected (P > 0.15) by breed of dam. By weaning at 3 mo, the proportion of available does weaning at least 1 kid was less (P < 0.01) for Boer does (53%) than for Kiko (84%) and Spanish does (82%). For does weaning kids, litter size at weaning was greater (P = 0.01) for Spanish does (1.74 kids) than for Kiko (1.59 kids) and Boer does (1.47 kids). Litter weaning weight was lighter (P < 0.01) for Boer dams (23.0 kg) than for Kiko (27.2 kg) and Spanish dams (26.5 kg). The efficiency ratio of litter weight to dam weight at weaning differed (P < 0.05) among all 3 dam breeds: Boer = 51%; Kiko = 62%; Spanish = 68%. Annual rates of lameness, endoparasitism, and attrition, respectively, were greater (P < 0.01) for Boer does (69, 53, and 28%) than for Kiko (32, 24, and 10%) and Spanish does (42, 22, and 11%). Postpartum fecal egg counts for endoparasite loads were less (P < 0.05) for Spanish dams (346 eggs/g) than for Kiko (524 eggs/g) and Boer does (675 eggs/g). Whole-herd annual doe productivity based on all available does was less (P < 0.01) for Boer does (11.7 kg weaned/doe) compared with Kiko (22.0 kg weaned/doe) and Spanish does (21.1 kg weaned/doe). Boer does expressed substantially decreased levels of fitness compared with Kiko and Spanish does when semi-intensively managed on humid, subtropical pasture. Kiko and Spanish should be preferred as maternal breeds in meat goat production systems under conditions reflective of this study.