Sore Eyes Research Articles

Persistent symptoms following SARS-CoV-2 infection amongst children and young people: A meta-analysis of controlled and uncontrolled studies

BackgroundData on the long-term impact of SARS-CoV-2 infection in children and young people (CYP) are conflicting. We assessed evidence on long-term post-COVID symptoms in CYP examining prevalence, risk factors, type and duration. Methods: Systematic search of published and unpublished literature using 13 online databases between 01/12/2019 and 31/07/2021. Eligible studies reported CYP ≤19 years with confirmed or probable SARS-CoV-2 with any symptoms persisting beyond acute illness. Random effects meta-analyses estimated pooled risk difference in symptom prevalence (controlled studies only) and pooled prevalence (uncontrolled studies also included). Meta-regression examined study characteristics hypothesised to be associated with symptom prevalence. Prospectively registered: CRD42021233153.FindingsTwenty two of 3357 unique studies were eligible, including 23,141 CYP. Median duration of follow-up was 125 days (IQR 99–231). Pooled risk difference in post-COVID cases compared to controls (5 studies) were significantly higher for cognitive difficulties (3% (95% CI 1, 4)), headache (5% (1, 8)), loss of smell (8%, (2, 15)), sore throat (2% (1, 2)) and sore eyes (2% (1, 3)) but not abdominal pain, cough, fatigue, myalgia, insomnia, diarrhoea, fever, dizziness or dyspnoea. Pooled prevalence of symptoms in post-COVID participants in 17 studies ranged from 15% (diarrhoea) to 47% (fatigue). Age was associated with higher prevalence of all symptoms except cough. Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms.InterpretationThe frequency of the majority of reported persistent symptoms was similar in SARS-CoV-2 positive cases and controls. This systematic review and meta-analysis highlights the critical importance of a control group in studies on CYP post SARS-CoV-2 infection.

Tulsi (Ocimum sanctum): A Potent Adaptogen

Tulsi or holy basil is a dedicated plant of India. It is a pungent plant in the family Lamiaceae which is mother to the Indian subcontinent and widespread as a cultivated plant throughout the Southeast Asian tropics. Tulsi is considered to be an adaptogen, balancing different processes in the body, and helpful for adapting to stress. Tulsi, one with a purple‑colored leaf or dark variety, commonly known as the Shyama or Krishna Tulsi and the second type with a green‑colored leaf or light variety known as Rama Tulsi or Sri Tulsi. The chemical composition of Tulsi is highly complex, containing many nutrients and other biologically active compounds. Tulsi also helps to check cancers caused by toxic compounds by reducing DNA damage. Tulsi has also been shown to boost defenses against infective threats by intensify immune responses in non-stressed and stressed animals and healthy humans. The O. sanctum fixed oil elongate clotting time, response being similar to aspirin. Basil juice is an effective medicament for sore eyes and night-blindness, which is generally caused by deficiency of vitamin A

Can Patient-Reported Ocular Symptoms Guide Dose Modifications in Patients with Relapsed/Refractory Multiple Myeloma Receiving Belantamab Mafodotin?

Can Patient-Reported Ocular Symptoms Guide Dose Modifications in Patients with Relapsed/Refractory Multiple Myeloma Receiving Belantamab Mafodotin?

Guidelines on how to manage rosacea

British Journal of DermatologyVolume 185, Issue 4 p. e162-e162 Plain Language Summary Guidelines on how to manage rosacea First published: 04 October 2021 https://doi.org/10.1111/bjd.20672AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Linked Article: Hampton et al. Br J Dermatol 2021; 185:725–735. Rosacea is a common skin condition that mostly affects the central face (nose, forehead, cheeks and chin). Although rosacea mainly affects young to middle-aged adults, it can occur at any time of life. How individuals are affected can vary; patients may experience any combination of symptoms including flushing, changes to skin colour, prominent surface blood vessels, soreness, dryness, inflamed skin bumps (which may contain pus), sore eyes or facial swellings known as ‘phymas’. As a skin condition that is highly visible it has a negative impact on patients’ quality of life. Although the causes of rosacea remain in question, many treatments that reduce symptoms have been described. The British Association of Dermatologists put together a group of dermatologists, an ophthalmologist, patient representatives and a technical team from the UK, to review published evidence (up to February 2020) on treating rosacea. Following strict criteria, the group has developed an up-to-date, evidence-based guideline that provides 23 recommendations for managing rosacea. Establishing which signs and symptoms are affecting the patient is the first step to guiding treatment choice, and this also depends on the severity of the symptoms. Patients may benefit from avoiding known triggers (e.g. alcohol, sun exposure, hot drinks or spicy foods), using moisturizers (including soap substitutes) and applying sun protection. After that, topical therapies would be considered the first treatment option (e.g. lotions, gels, creams), followed by oral therapies (i.e. tablets). Within each of these categories, various options exist and can be decided upon following consultation. Therapies directed at the symptoms of rosacea involving the eyes may also be needed, and procedural therapies are also helpful, such as laser for excess facial blood vessels and surgery for phymas. In conclusion, these guidelines provide an up-to-date and patient-centred approach to the clinical management of rosacea. Volume185, Issue4October 2021Pages e162-e162 RelatedInformation

Impact of Visual Discomfort Symptoms On SDMT Performance Among Persons With Multiple Sclerosis

<h3>Research Objectives</h3> To examine how visual discomfort symptoms affect performance on the symbol digit modalities test (SDMT), a visually mediated information processing speed task which is considered a gold standard measure for cognition in multiple sclerosis (MS) research. <h3>Design</h3> Observational, cross-sectional study. <h3>Setting</h3> General community. <h3>Participants</h3> Eighty-seven persons with MS and 30 healthy controls (HCs). <h3>Interventions</h3> Not applicable. <h3>Main Outcome Measures</h3> Visual discomfort questionnaire (VDQ) and SDMT. <h3>Results</h3> Persons with MS reported significantly more severe visual discomfort symptoms on the VDQ than HCs (W = 424, p < 0.001). More severe visual discomfort symptoms was significantly associated with worse SDMT performance (ρ = -0.24, p = 0.011). Specifically, reports of symptoms such as text moving or fading while reading (p = 0.038), blurriness and diplopia (p = 0.055), having to re-read texts (p = 0.076), and slow reading (p = 0.008) were significantly related to SDMT performance, while symptoms related to headache and eye soreness (p = 0.824) and glare (p = 0.961) were not linked to SDMT performance. <h3>Conclusions</h3> Visual discomfort symptoms may impact/interfere with SDMT performance in persons with MS. When determining information processing speed deficits using the SDMT, visual discomfort symptoms need to be considered. <h3>Author(s) Disclosures</h3> Authors declare no conflicts of interest.

The Artificial Lighting Analysis of Study Rooms in Dormitories and Classrooms Islamic Boarding School Of Lil Banat Parepare

This study aims to find out the intensity of light in the study room of Islamic boarding school of DDI Lil Banat Parepare. Measurements are taken in rooms that are often used by students to learn, namely classes and dormitories. The type of research used is quantitative by simulation method. Variables are tied to exposure measurement i.e. light intensity. While the variables are free, namely the arrangement of light points and the layout of the study room. Measurements were carried out over three days using a digital lux meter tool. The measurement results showed that the intensity of light in the dormitory did not meet the Indonesian National Standard for study space both night and day. During the day classrooms meet Indonesian National Standards but not at night. Although students as a space user is comfortable with the condition of light intensity in the study room and can learn according to these conditions, students still feel some complaints in the form of sore eyes, tense eyes and difficulty focusing. Thus, researchers made recommendations on the design of study rooms that can make students more comfortable learning in dormitories and classrooms so as to reduce complaints while studying. Lighting design recommendations are made in several alternatives by adding the number of lamps and changing the type of lamp using Dialux simulation. The simulation results of the study room lighting design recommendations have met the standards for use so that it can be applied to dormitories and classes at the Islamic boarding school of DDI Lil Banat Parepare.&#x0D; &#x0D; Keywords: Artificial lighting design; study room; light intensity

Association between screen time and dry eye symptoms

Background: Electronic media has become a necessity in everyday life because of its function to access information, communication, etc. These functions cause an increase in average screen time and risk of developing dry eye symptoms such as photophobia, grittiness, sore eyes, and blurred vision.Objective: This study aims to determine whether there is a relationship between screen time and dry eye symptoms.Methods: An observational-analytic study with a cross-sectional approach was conducted on 66 medical students. All students would download a screen time application on each electronic media they have for one week before data collection. Furthermore, data were collected using a questionnaire consisted of screen time and Ocular Surface Disease Index (OSDI) and were statistically analyzed.Results: A total of 90.91% of the students use electronic media =8 hours/day. The proportion of students who experience dry eye symptoms is 46.97%. There was no statistically significant between screen time and dry eye symptoms (p = 0.676).Conclusion: More than ninety percent of students spend more than 8 hours/day using electronic media but no statistically significant between screen time and dry eye (p&gt;0.05).

Factors Influencing Patient Satisfaction with Upper Blepharoplasty in Elderly Patients.

Background:Upper blepharoplasty in elderly patients has characteristics that differ from those of younger patients. Blepharoptosis in elderly patients causes not only aesthetic problems but also functional problems such as entropion, visual disturbance, and sore eyes. We hypothesized that factors influencing patient satisfaction with upper blepharoplasty in elderly patients include aesthetic outcomes, functional outcomes, and personal factors.Methods:This study included 57 patients aged >65 years who underwent upper blepharoplasty between April 2018 and March 2019. All surgeries were performed through the “Upper Blepharoplasty Service Project” of the public health center in Geoje City. To evaluate the individual characteristics of the patients, a preoperative questionnaire (including sociodemographic characteristics, main symptoms of discomfort in the upper eyelid, and degree of expectation of surgical results) was administered to the patients. After 6 months, a satisfaction survey was conducted accordingly.Results:The main symptoms of discomfort were sagging of the skin of the upper eyelid. The mean score for patient satisfaction was 3.84 ± 0.40, and satisfaction with the results of surgery relative to the cost was 4.53 ± 0.63, which was the highest score. Significant verification of the regression coefficients showed that functional improvement and cognitive degree of postsurgery precautions had a significant effect on patient satisfaction, whereas aesthetic outcomes and expectations of surgical results were not correlated with patient satisfaction.Conclusion:The findings indicated that elderly patients tended to be satisfied with functional improvement that resolved their symptoms of discomfort and personal factors such as cost and cognitive degree of precautions after upper blepharoplasty.

Old strabismus surgery is not a sight for sore eyes: new approaches are necessary

Old strabismus surgery is not a sight for sore eyes: new approaches are necessary

A sight for sore eyes: the relationship between Diplostomum von Nordmann, 1832 and Tylodelphys Diesing, 1850 in perch (Perca fluviatilis L.) in the Erne Catchment (Ireland).

A sight for sore eyes: the relationship between Diplostomum von Nordmann, 1832 and Tylodelphys Diesing, 1850 in perch (Perca fluviatilis L.) in the Erne Catchment (Ireland).

Bilateral external ophthalmoplegia due to uremia in Goodpasture syndrome

Several ophthalmic manifestations have been reported in patients with uremia due to chronic kidney disease (CKD). These include chronic sore eyes, ischemic optic neuropathy, and retinal detachment. In this case report, we discuss a patient of Goodpasture syndrome undergoing hemodialysis for CKD who presented with a complaint of diplopia. The patient had bilateral near-total external ophthalmoplegia, which initially progressed and remained constant at the last follow-up. The patient was neurologically stable with normal neuroimaging; however, his serum creatinine and blood urea levels remained persistently elevated despite regular hemodialysis. After considering several differential diagnoses, we finally arrived at a diagnosis of bilateral external ophthalmoplegia secondary to uremia and propose potential mechanisms for its pathogenesis.

Underlying neurological mechanisms associated with symptomatic convergence insufficiency

Convergence insufficiency (CI) is the most common binocular vision problem, associated with blurred/double vision, headaches, and sore eyes that are exacerbated when doing prolonged near work, such as reading. The Convergence Insufficiency Neuro-mechanism Adult Population Study (NCT03593031) investigates the mechanistic neural differences between 50 binocularly normal controls (BNC) and 50 symptomatic CI participants by examining the fast and slow fusional disparity vergence systems. The fast fusional system is preprogrammed and is assessed with convergence peak velocity. The slow fusional system optimizes vergence effort and is assessed by measuring the phoria adaptation magnitude and rate. For the fast fusional system, significant differences are observed between the BNC and CI groups for convergence peak velocity, final position amplitude, and functional imaging activity within the secondary visual cortex, right cuneus, and oculomotor vermis. For the slow fusional system, the phoria adaptation magnitude and rate, and the medial cuneus functional activity, are significantly different between the groups. Significant correlations are observed between vergence peak velocity and right cuneus functional activity (p = 0.002) and the rate of phoria adaptation and medial cuneus functional activity (p = 0.02). These results map the brain-behavior of vergence. Future therapeutic interventions may consider implementing procedures that increase cuneus activity for this debilitating disorder.

Exposure to Secondhand Heated-Tobacco-Product Aerosol May Cause Similar Incidence of Asthma Attack and Chest Pain to Secondhand Cigarette Exposure: The JASTIS 2019 Study.

Although secondhand cigarette smoke is known to cause various health consequences, even the short-term effects of exposure to secondhand heated-tobacco-product (HTP) aerosol are unknown. The purpose of this study was to examine short-term symptoms related to secondhand HTP aerosol exposure. An internet-based self-reported questionnaire survey was conducted in 2019 as a part of the Japan Society and New Tobacco Internet Survey (JASTIS) study. In total, 8784 eligible respondents aged 15–73 years were analyzed. We examined the frequency (%) of secondhand combustible cigarette smoke and HTP aerosol exposure, and the exposure-related subjective symptoms (sore throat, cough, asthma attack, chest pain, eye pain, nausea, headache, and other symptoms). Overall, 56.8% of those exposed to secondhand cigarette smoke had any subjective symptoms, compared to 39.5% of those exposed to HTP aerosol. Asthma attack and chest pain were reported more frequently when associated with secondhand HTP exposure (10.9 and 11.8%, respectively) than with secondhand cigarette smoke exposure (8.4 and 9.9%, respectively). Sore throat, cough, eye pain, nausea, and headache were also more frequently reported when associated with secondhand cigarette smoke than with secondhand HTP exposure. This is the first study to examine severe subjective symptoms such as asthma attacks and chest pains, and to suggest that respiratory and cardiovascular abnormalities could be related to secondhand heated-tobacco-product aerosol exposure. Further careful investigations are necessary.

Evaluation of ocular symptoms in COVID-19 subjects in inpatient and outpatient settings.

PurposeEvaluation of subtle ocular involvement and clinically significant conjunctivitis symptoms in a group of patients with COVID-19 in outpatient and inpatient settings.MethodOverall, 1083 patients infected with SARS-CoV-2 were recruited as subjects. Patients were divided into inpatients (group 1, n = 371) and outpatients (group 2, n = 712). Demographical and general medical data included age, sex, and comorbidities. Patients whose diagnosis was confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR) were called by phone, and their chronic ocular disease, previous ocular surgery, ocular medication, contact lens wear and ocular irritation symptoms were queried during the active disease period.ResultsThe mean age of the patients was 44.2 ± 16.5 (19–97) years; 635 (58.6%) were male, and 448 (41.4%) were female. Comorbidity, chronic ocular disease, ophthalmic medication and previous ocular surgery rates were significantly higher in group 1 (p < 0.05), while contact lens wear was not significantly different between groups. The main complaints received from patients were sore eye or burning sensation, foreign body sensation, itching and red eye and were significantly higher in group 1. Clinically significant conjunctivitis symptoms, such as red eye, ocular discharge and eyelid edema, were observed in 28 patients (2.6%), with 14 (3.8%) patients in group 1 and 14 (2%) patients in group 2.ConclusionClinically significant conjunctivitis symptoms were detected in 28 subjects in the inpatient and outpatient groups. As systemic findings of COVID-19 intensify,

Applications of Massage in Children from the Perspective of Persian Medicine

In Persian medicine (PM), massage is one of the principles for maintaining health. This study presents the viewpoint of PM about massage in pediatrics and the scientific evidence for its efficacy. The PM textbooks including Canon of Medicine, Mufarrah al-qulub, Kholase-alHekmah, Kholase-al-Tajareb, Tadbir al-hobali val atfal va-sebyan, Exir-e-Azam, Ehya-al-Atfal, Risalat-al-Dallakieh were reviewed for applications of massage in children. The keywords were Dalk, Ghamz, rubbing, and massage. The effectiveness of PM recommendations for massage in modern medicine was searched in Google Scholar, PubMed, Scopus and science direct, SID, and Magiran with the keywords massage, pediatrics, and children. The selection criteria were clinical trials or reviews on pediatric massage in English or Persian language without time limitation. Applications of pediatric massage in PM which scientific articles approve their efficacy include facilitating the growth, development, and weight gain, reducing muscle and joint pain, relieving colic and bloating, helping to treat skin dryness, and convulsion. Other applications including sore throats, colds, vomiting, and eye aberrations are needed to be evaluated in clinical studies.

Evaluation of Acacia auriculiformis Benth. leaves for wound healing activity in type 2 diabetic rats

Background: Acacia auriculiformis Benth. is a perennial shrub which has been traditionally known to treat various medical complications such as sore eyes, allergy, rheumatism, sore eyes, and rashes. Objectives: The current study is designed to decipher a shred of clinical confirmation and biochemical support for wound-healing efficacy of methanolic leaves extract of A. auriculiformis. Materials and Methods: We prepared the leaves extract in different solvents, i.e., petroleum ether, chloroform, ethyl acetate, acetone, butanol, and methanol. The in vitro studies were carried out on the above leaf's extracts using α-glucosidase and α-amylase inhibition in vitro antidiabetic assays. Animal model of streptozotocin-induced diabetes was used in the 0-, 7-, and 15-day studies, respectively. The comparison study was carried out in diabetic wound control in respect of the period of epithelialization, %wound contraction, and hydroxyproline content in the excision wound model. However, the breaking strength parameter was used to calculate healing potential in the incision wound model. The bioactive methanol extract was subjected to LC-MS/MS analysis to characterize the phytoconstituents responsible for pharmacological activity. Results: The methanolic leaves extract showed the highest percentage inhibition of 94.259% and 95.259% in α-glucosidase and α-amylase in vitro antidiabetic assays, respectively. The high content of collagen fibers and stronger epithelial cells growth were observed in histopathological studies of hydrogel containing methanolic leaves extract as compared to the diabetic wound control and standard. Subsequently, for investigating the biological impact upon live cells, cytotoxicity study was tested in different cell lines (A549, HEK-293, and MCF-7). Cytotoxic results showed that greater than 75% of cells were visible in all the cell lines, which gives the confirmation of biocapability of the extract. The LC-MS/MS results revealed the presence of compounds such as β-sitosterol, lupeol, stigmasterol, and quercetin. Conclusion: A. auriculiformis is a potent medicinal plant that can be further utilized as a complementary and alternative therapy for the treatment of diabetes-induced wounds and the management of oxidative stress and diabetes.

Analysis of relationship between asthenopia and terminal screen exposure in college students during COVID-19 epidemic period.

Objective To understand the relationship between the visual fatigue of college students and the exposure of terminal screens during the novel coronavirus pneumonia (New Coronary Pneumonia) epidemic. Methods The cluster sampling method of the current situation survey was adopted. From March 1 to July 1, 2020, a questionnaire survey of 2671 college students in Hefei City, Anhui Province was conducted to analyze the eye discomfort, daily eye use and eye care of college students during the new coronary pneumonia epidemic. Situation and so on. Results Among the 2 671 college students, 1 860 cases were positive for asthenopia, with a total positive rate of 69.64%. Eye fatigue [5646% (1508/2671)], dry eyes [46.01% (1 229/2 671)], eye swelling [ The incidence of 38.26% (1022/2671)], eye itching and pain [28.15% (752/2 671)] ranked the top 4. Lunch break habits and the number of drinking glasses per day are common protective factors for eye fatigue, dry eyes, sore eyes, and itchy eyes;closing doors and windows during online classes and staying up late each week are common risks for eye fatigue, dry eyes, and sore eyes Factors;daytime terminal screen exposure time is a common risk factor for dry eyes, sore eyes, and itchy eyes. Conclusion During the new crown pneumonia epidemic, the incidence of visual fatigue among college students is relatively high. Terminal screen exposure is one of the risk factors for visual fatigue. Reducing the exposure time of college students to terminal screens is an effective measure to prevent visual fatigue. (English) [ABSTRACT FROM AUTHOR] 目的了解新型冠状病毒肺炎(简称新冠肺炎)疫情期间大学生视疲劳与终端屏幕暴露的关 联。方法采用现况调查整群抽样方法,2020 年3月1日至7月1日通过问卷调查安徽省合肥市高校的2671 名大学生,分析新冠肺炎疫情期间大学生眼部不适､日常用眼及护眼情况等。结果 2 671 名大学生中视疲劳 阳性 1 860 例,总阳性率为69.64%,眼疲劳感[5646%(1508/2671)]､眼干涩[46.01%(1 229/2 671)]､眼酸 胀[38.26%(1022/2671)]、眼痒痛[28.15%(752/2 671)]发生率排前4位。午休习惯和每天饮水杯数是眼疲 劳感､眼干涩､眼酸胀､眼痒痛的共同保护因素;上网课时关闭门窗和每周熬夜次数是眼疲劳感､眼干涩､眼酸胀 的共同危险因素;白天终端屏幕暴露时间是眼干涩､眼酸胀､眼痒痛的共同危险因素。结论 新冠肺炎疫情期 间大学生视疲劳发生率较高,终端屏幕暴露是视疲劳的危险因素之一,降低大学生对终端屏幕暴露时间是预防 視疲劳的有效措施. (Chinese) [ABSTRACT FROM AUTHOR] Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

All Sore Eyes and Beasts: Spiritual Care Providers' Role in End-of-Life Existential Distress

All Sore Eyes and Beasts: Spiritual Care Providers' Role in End-of-Life Existential Distress

Ocular symptoms and clinical profile associated with COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly contagious pathogen, led to the coronavirus disease 2019 (COVID-19) pandemic. Ocular secretions can be one of the possible causes of SARS-CoV-2 transmission, and it should not be ignored. In the group of severe COVID-19 complications, ocular manifestations are underreported, and elucidation of ocular signs among COVID-19 patients is necessary. According to many research studies, conjunctivitis and sore eyes were the most reported ocular symptoms. Many studies have limitations such as low sample size or lack of proper findings, and much more studies need to be performed for a better inference.

Persistent Symptoms Following SARS-CoV-2 Infection Among Children and Young People: A Meta-Analysis of Controlled and Uncontrolled Studies

Background: Data on the long-term impact of SARS-CoV-2 infection in children and young people (CYP) is conflicting. We assessed evidence on long-term post-COVID symptoms in CYP examining prevalence, risk factors, type and duration.Methods: Systematic search of published and unpublished literature using 13 online databases between 01/12/2019 – 31/07/2021. Eligible studies reported CYP ≤19 years with confirmed or probable SARS-CoV-2 with any symptoms persisting beyond acute illness. Random effects meta-analyses examined pooled risk difference in symptom prevalence (controlled studies only) and pooled prevalence (uncontrolled studies also included). Meta-regression examined study characteristics hypothesised to be associated with symptom prevalence. Prospectively registered: CRD42021233153. Findings: Twenty two of 3357 unique studies were eligible, including 23,141 CYP. Median duration of follow-up was 125 days (IQR 99-231).Pooled risk difference in post-COVID cases compared to controls (5 studies) were significantly higher for cognitive difficulties (3% (95% CI 1, 4)), headache (5% (1, 8)), loss of smell (8%, (2, 15)), sore throat (2% (1, 2)) and sore eyes (2% (1, 3)) but not abdominal pain, cough, fatigue, myalgia, insomnia, diarrhoea, fever, dizziness or dyspnoea.Pooled prevalence of symptoms in post-COVID participants in 17 studies ranged from 15% (diarrhoea) to 47% (fatigue). Age was associated with higher prevalence of all symptoms except cough. Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms.Interpretation: The frequency of the majority of reported persistent symptoms was similar in SARS-CoV-2 positive cases and controls. This systematic review and meta-analysis highlights the critical importance of a control group in studies on CYP post SARS-CoV-2 infection.Funding: None to declare. Declaration of Interest: SAB, RS, SDB, AXDZ, LLO, SNL, BLDS, RMV and OVS have no conflicts of interest. TJS is the Chair of the Health Research Authority for England who reimburse his university for his time. He is not paid personally. He has recused himself from research studies in which he is personally involved and which require ethical approval from the HRA.