Solubilization Phenomena Research Articles

Impact of deep eutectic solvent pre-treatment on the extraction of cellulose nanofibers

Deep Eutectic Solvents (DESs) have emerged as promising eco-friendly pre-treatment agents for lignocellulosic biomass, offering considerable advantages for the nanofibrillation process. This study investigates the impact of DESs on cellulose fibers morphology, focusing on solubilization phenomena in the amorphous regions that may facilitate cellulose nanofiber production. The pre-treatment process combining a DES (triethylmethylammonium chloride and imidazole, TEMA:IMD) with microwave (MW) energy was optimized to enhance the solubility of cellulosic fibers. A response surface methodology (RSM) was employed to optimize the DES-MW-assisted pre-treatment. Results show that the reaction time and the temperature significantly influence the solubility of cellulosic fibers. The optimized conditions resulted in cellulose fibers with low content of hemicellulose and lignin, high crystallinity index, and improved thermal stability. The effectiveness of DES-MW pre-treatment in producing cellulose nanofibers (CNFs) from native and pre-treated fibers was investigated. Cellulose fibers pre-treated with a DES yielded CNFs with a narrower diameter distribution. Overall, optimized DES-MW pre-treatment offers a promising strategy for the efficient and sustainable extraction of CNFs.

Synergistic Solvation as the Enhancement of Local Mixing.

Mixing two solvents can sometimes make a much better solvent than expected from their weighted mean. This phenomenon, called synergistic solvation, has commonly been explained via the Hildebrand and Hansen solubility parameters, yet their inability in other solubilization phenomena, most notably hydrotropy, necessitates an alternative route to elucidating solubilization. While, recently, the universal theory of solubilization was founded on the statistical thermodynamic fluctuation theory (as a generalization of the Kirkwood-Buff theory), its demand for experimental data processing has been a hindrance for its wider application. This can be overcome by the solubility isotherm theory, which is founded on the fluctuation theory yet reduces experimental data processing significantly to the level of isotherm analysis in sorption. The isotherm analysis identifies the driving force of synergistic solvation as the enhancement of solvent mixing around the solute, opposite in behavior to hydrotropy (characterized by the enhancement of demixing or self-association around the solute). Thus, the fluctuation theory, including its solubility isotherms, provides a universal language for solubilization across the historic subcategorization of solubilizers, for which different (and often contradictory) mechanistic models have been proposed.

Moment Analysis of Solute Permeation Kinetics at an Interface of Mixed Micelles of Anionic and Nonionic Surfactants

Abstract Solubilization phenomena of neutral solutes into mixed micelles of anionic and nonionic surfactants were studied by means of micellar electrokinetic chromatography (MEKC). MEKC experiments were conducted by using mixed micelles consisting of sodium dodecylsulfate (SDS) and polyoxyethylene sorbitan monolaurate (Tween 20) or monostearate (Tween 60) as pseudo-stationary phases while changing the concentration of SDS-Tween mixed micelles and the molar fraction of Tween 20 or 60 in mixed micelles. Elution peak profiles measured by MEKC were analyzed on the basis of the moment theory to determine the solute partition equilibrium constant (Kp) and the rate constants of solute permeation at the interface of mixed micelles (kin and kout). It seems that the values of Kp, kin, and kout are increased by adding Tween 20 or 60 and that the influence of the addition of Tween 60 on their values is more remarkable than that of Tween 20. It was demonstrated that moment analysis of MEKC data is effective for studying solubilization phenomena of surfactant micelles under the conditions that both immobilization and chemical modification (i.e., fluorescence labeling) of solute and micelles are not required.

Application of Hydrotropic Solubilization Phenomenon for Estimation of Fenticonazole in Bulk and Vaginal capsules using UV-spectrophotometry Methods

The purpose of this study is to establish Novel Zero-order UV-Spectrophotometric - absorbance and Zero Order- Area under curve (AUC) methods for estimation of Fenticonazole Nitrate in bulk and vaginal capsules with the application of hydrotropic solubilization phenomenon. Fenticonazole Nitrate is an antifungal drug and it is completely insoluble in water. Pluronic F127 (10% w/v) solution was used as solvent for solubilization of Fenticonazole Nitrate. Maximum absorption for Fenticonazole Nitrate was found to be at wavelength 253nm when dissolved in Pluronic F127 (10% w/v) solution. The methods are based upon measurement of absorbance at 253nm and integration of area under curve for analysis of Fenticonazole Nitrate in the wavelength range of 242.2-261.6nm. The drug followed linearity in the concentration range of 8 - 40µg/mL with correlation coefficient value r2> 0.99 for both methods. The proposed methods were validated for accuracy (% recovery), precision, repeatability and ruggedness, as per ICH guidelines. The proposed methods were applied for qualitative and quantitative estimation of Fenticonazole Nitrate in vaginal capsules and results were found in good agreement with the label claimed. Developed methods can be used for routine analysis of Fenticonazole Nitrate in bulk and Vaginal Capsules.

Solubilization of azo dyes by cetyltrimethylammonium bromide micelles as structure control factor at synthesis of ordered mesoporous silicas

Solubilization of anionic azo dyes, methyl red and alizarin yellow, in micelles of cationic surfactant, cetyltrimethylammonium bromide, was studied in aqueous solutions with pH ~ 10 by conductometry and UV–Vis spectroscopy. The electro-conductivity measurements were used to evaluate influence of azo dyes on critical micelle concentration of cetyltrimethylammonium bromide and estimate standard thermodynamic parameters of micellization process. It was found that solubilization of azo dyes by micelles of surfactant is spontaneous process which causes lowering of critical micelle concentration of long-chain quaternary ammonium salt. The phenomenon of azo dyes solubilization by surfactant micelles was confirmed by analysis of the effect of different concentrations of cetyltrimethylammonium bromide on the UV-Vis spectra of azo dyes solutions. Differential spectroscopic technique was employed to obtain quantitative characteristics of azo dyes solubilization in micellar media. The values of binding constant, partition coefficient, and free energy change of partition for azo dyes were calculated. Obtained results proved that methyl red and alizarin yellow incorporate into the CTAB micelle in such a way that their carboxylic groups are lying near by positively charged head group of surfactant and the rest of the molecule is oriented towards center of micelle. Micelles of cetyltrimethylammonium bromide with solubilized azo dyes were used as template in base catalysed hydrothermal-assisted sol-gel synthesis of mesoporous aminosilicas of MSM-41 type. The mesoporous structure of synthesized materials was characterized by low-temperature nitrogen adsorption-desorption and x-ray diffraction analysis. It was proved that incorporation of azo dye additives as solubilizates into the surfactant micelles in sol-gel synthesis leads to the formation of silica materials with improved long-range ordered mesoporous structure.

Part 1. Evaluation of Epigallocatechin Gallate or Tannic Acid Formulations of Hydrophobic Drugs for Enhanced Dermal and Bladder Uptake or for Local Anesthesia Effects.

Epigallocatechin gallate (EGCG) and tannic acid (TA) are known to increase the aqueous solubility and cellular uptake of the hydrophobic drugs docetaxel, paclitaxel, amphotericin B, and curcumin. In this study the practical application of gallate-based solubilization phenomena for the uptake of these drugs into dermal and bladder tissue and of lidocaine for wound healing application was studied. The penetration of all these drugs into pig skin or docetaxel into pig bladder using EGCG or TA formulations was measured. Overall, EGCG and TA particulate or propylene glycol paste formulations of drugs allowed for greatly increased levels of drug uptake into skin as compared to control formulations. EGCG/propylene glycol pastes allowed for rapid lidocaine uptake into skin. EGCG and TA formulations of docetaxel allowed for approximately 10 fold increases in bladder tissue uptake of docetaxel over tween based solutions. Morphologically, both EGCG and TA caused a mild, dose dependent exfoliation of the bladder wall. Both EGCG and TA formed injectable viscous pastes with propylene glycol which solidified in water and degraded and released lidocaine over 2-35 days. These data support the use of EGCG and TA based formulations of certain drugs for improved dermal, bladder and wound applications.

Novel and ecofriendly UV-Spectrophotometry methods for estimation of Tolvaptan using hydrotropic agent

The aim of present investigation is to establish simple and economical UV- Spectrophotometric methods for estimation of Tolvaptan using Zero order UV-Spectrophotometric absorbance method and Zero Order- Area under curve (AUC) method with the application of hydrotropic solubilization phenomenon. Tolvaptan is non-peptide vasopressin V2 receptor antagonist. It is completely insoluble in water. Hydrotropic agent, sodium lauryl Sulfate (SLS) 5% w/v was used to enhance the solubility of Tolvaptan. Maximum absorption for Tolvaptan was found to be at 269 nm. The methods are based upon measurement of absorbance at 269 nm and integration of area under curve for analysis of Tolvaptan in the wavelength range of 263.2-282.2 nm. The drug followed linearity in the concentration range of 3 - 18 µg/mL with correlation coefficient value r2> 0.99 for both methods. The proposed methods were validated for accuracy, precision, repeatability and ruggedness, as per ICH guidelines. The proposed methods were applied for qualitative and quantitative estimation of Tolvaptan in pharmaceutical formulation and results were found in good agreement with the label claimed. Developed methods can be used for routine analysis of Tolvaptan in bulk and tablets. Keywords: Sodium Lauryl Sulphate, Tolvaptan, UV- Spectrophotometry - Area under Curve, UV-Spectrophotometry, Hydrotropy .

Effect of nonionic surfactants in release media on accelerated in-vitro release profile of sirolimus eluting stents with biodegradable polymeric coating

It is a well-known fact that sirolimus (SRL) undergoes degradation process via hydrolysis in aqueous media, leading to incorrect assessment of drug amount and thus release characteristics of formulations. The main objective of the present study was to evaluate the effect of nonionic surfactants in media on in-vitro release profiles for sirolimus eluting stents (SES) coated with biodegradable polymeric matrix. Phosphate buffer and acetate buffer incorporating nonionic surfactants with varying concentrations were examined for adequate solubility and stability (by RP-HPLC). Good sink condition was achieved in phosphate buffer (at pH 4.0) with 1.0% Tween 20, 1.0% Brij 35% and 0.5% Brij 58. Hydrodynamic size (by DLS) and the micelle-water partition coefficient (P) with standard free energy of solubilization (∆Gs°) of drug were evaluated to get some understanding about the solubilization phenomena. About 80% of drug release during the period of 48h was achieved in optimized drug release media which was 1.0% Tween 20 in phosphate buffer pH 4.0. The obtained accelerated SRL release profile in optimized medium correlated well with the real time in-vitro release in phosphate buffer (pH 7.4). Surface morphology changes (by SEM), changes in gravimetric weights and molecular weight change (by GPC) were examined before and after drug release to understand the drug release mechanism which explains that the polymer did not undergo degradation during the drug release.

SOLUBLITY ENHANCEMENT OF MICONAZOLE BY FORMULATION OF HYDROTROPIC SOLID DISPERSIONS

In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water-soluble drugs. Bulk drug samples were identified by the observed IR spectra and the melting points determination. Sodium benzoate, niacinamide, and urea are the hydrotropes were selected for the solubility enhancement of drugs Solubility enhancement ratios for selected poorly water-soluble drugs were determined. Results showed that remarkable increase in aqueous solubility of Miconazole in presence of large concentration of hydrotropes. Marketed Miconazole tablets determined by spectrophotometric analysis using hydrotropic solubilization techniques. Validation of the proposed analysis methods is confirmed by satisfactorily low values of statistical parameters viz., standard deviation, percent coefficient of variation and standard error. Keywords : Solubility enhancement, hydrotropes, Solid dispersion, Miconazole.

β-CD assisted aqueous dissolution of cetylpicolinium dichromates (CPDC)—Evolution of a class of green water compatible lipopathic Cr(VI) oxidants

Water-insoluble lipopathic dichromates have been successfully solubilized in aqueous phase by the entrapment of their hydrophobic tails in β-cyclodextrin (β-CD) non-polar cavity. Aqueous solubility of α-, β-, and γ- cetylpicolinium dichromate (CPDC) molecules, synthesized in our lab, has been studied to find their suitability for Cr(VI) oxidation purposes in water medium. The analysis of phase solubility shows the existence of a Bs type curve and its significance has been fully deciphered through dynamic light scattering (DLS) analysis. The limiting concentration of β-CD up to which it can induce 1:1 host-guest complexation with the CPDC entities, has been determined and the stoichiometry has been confirmed from Job’s plot. The binding constant and complexation efficiency of the β-CD-CPDC complexes have been determined and temperature effect on these parameters has been discussed through thermodynamic calculations. Analyses of viscosity variation of the aqueous solutions of the complexes have been done and correlated with the solubilization phenomenon.

Solubilization characteristics of licorice based on supramolecular “imprinted template” theory

To investigate the effect of the ingredient group of traditional Chinese medicine (TCM) with different "imprinted template" on the supramolecular solubilization ability of licorice, in order to lay a theoretical foundation for explaining the solubilization phenomenon of the components of TCM. Based on the independent supramolecular "imprinted template" rules, molecular connectivity index (MCI) and the correlation of n-octanol-water partition coefficient (logP) were used to indicate hydrophilic lipophilic capacity of TCM, and the extractum rate was used to indicate the solubilization effect of licoriceon single TCM herbs or compounds. The solubilization ability of licorice was evaluated based on MCI, logP and the extractum rate. According to the results, the correlation coefficient between MCI and logP for single herbs was 0.942, and that for single herb adding licorice was 0.916. The extractum rate of most herbs was increased after adding licorice. The correlation coefficient among the extractum rate as well as MCI and logP change values before and after adding licorice were respectively 0.837, 0.405. The correlation coefficient between MCI and logP for eight compounds was 0.937. Meanwhile, licorice had a solubilization effect on the remaining 7 compound except for Huangqi decoction. Therefore, licorice shows the solubilization effect through the independent supramolecular "imprinted template", so as to improve the hydrophilic lipophilic ability. There was a high positive correlation between the MCI and logP in ingredients for TCM, which could be used as important parameters to indicate the "imprinted template" feature for components of TCM. The study on the solubilizing effect of TCM with the supramolecular "imprinted template" theory was feasible, and will lay a foundation for the reform of single-herb dosage form.

Aggregation properties of levofloxacin in water and ethanol and its interaction with sodium dodecyl sulphate: A thermodynamic study

This manuscript reports the determination of critical micelle concentration (CMC) of levofloxacin (LF) in two solvents, water and ethanol, by using surface tension, refractive index and absorbance measurements. The data thus obtained were used to calculate different thermodynamic parameters for micellization process like free energy of micellization, free energy of adsorption, entropy and enthalpy of micellization. The interaction of this drug with anionic surfactant (SDS) was also studied using UV/Visible spectroscopy and conductometry. With rise in temperature, CMC of the drug was found to decrease in ethanol and increase in aqueous solution indicating dominance of lipophobic desolvation over lipophilic desolvation in ethanol and reverse, in case of aqueous solution. A strong drug/surfactant interaction was found to exist. The data obtained from drug/surfactant interaction were also used to find different interaction parameters like partition constant, free energy of partition, binding constant and free energy of binding which are very useful to understand the phenomenon of solubilization. Critical micelle concentration of levofloxacin increases with temperature in aqueous solution and decreases in ethanol. Processes of micellization and adsorption of drug molecules at solution-air interface are spontaneous and results in increase in entropy. The drug shows strong interaction with anionic surfactant (SDS) due to solubilization of drug molecules between ionic head groups of micelles of SDS.

Copper-Containing Rod-Shaped Nanosized Silica Particles for Microwave-Assisted Synthesis of Triazoles in Aqueous Solution

Cu-doped rod-shaped mesoporous silica nanoparticles (Cu-RMSN) were synthesized by a new one-step approach based on in situ functionalization procedure referring to the phenomenon of micellar solubilization. SEM and TEM studies revealed the rod-like morphology of uniformly sized particles with longitudinal mesopore channels. The BET specific surface areas were near 500 m2 g–1 and the average pore diameter varied from 3 to 3.6 nm. The composite Cu-RMSN proved to be an efficient heterogeneous catalyst for a microwave-assisted three-component 1,3-dipolar cycloaddition reaction in aqueous solution. The one-pot preparation of 1,4-dibustituted-1,2,3-triazole derivatives was straightforward and high yielding, due to the high copper dispersion at the pore surface resulting in the high accessibility of the active sites. The efficiency of the catalyst was also demonstrated upon recycling, making such synthesis a truly green process with marked step and solvent economy and important waste reduction.

Indirect micellar spectrophotometric determination of lead in various soybean based products using green chemistry

The study was conducted for the purpose of quantifying lead in various samples of soy-products by micellar spectrophotometry using green chemistry approach. The ligandN2P4HB was synthesized for the purpose with the help of weak acid and is found to be soluble in alcohol, acetone and in chlorinated hydrocarbons such as chloroform. It dissolves in alkaline aqueous media but is practically insoluble in water at pH less than 6. In the presence of surfactants its solubility has been found to be increased significantly. On addition of solution of ligand in presence of surfactants to metal ion solution, colored complex were formed. The local nonpolar microenvironment of the micelles incorporates the non-polar colored complex. Secondly a marked increase in absorption intensity has also been observed. This phenomenon of micellar solubilization with increasing absorption intensity has been used to develop a novel, green, simple, inexpensive and sensitive spectrophotometric method for determination of heavy metal ion in various soy products.

Statistically Comparable UV-spectrophotometric Method development for the Estimation of Probenecid in tablet Dosage Form with the Application of Hydrotropic Solubilization Phenomenon.

Statistically comparable method has been developed, validated, for estimating probenecid in tablet dosage form with the application of hydrotropic solubilization phenomenon. This research effort utilizes 2M sodium acetate as hydrotropic solubilizing agent which enhances the aqueous solubility of probenecid by 85 folds. The drug stability in hydrotropic solution was found to be more than 48hrs.The probenecid hydrotrope obeys the Beer’s – Lambert law at maximum wavelength of 244.5nm. The drug response was found to be linear in the range of 2 – 26 µg/ml with correlation coefficient of 0.9987.The non-interference of hydrotropic agent and additives in the course of probenecid estimation ensures the specificity of the proposed method.The mean recovery of 99.43% reflects its accuracy, obtained in good terms. The method precision results were found to be within limit expressed in %RSD (NMT 2%). The results of comparison of proposed method with standard method (IP 2010) were found to be in the similar range. The comparison provides evidence of proposed method to be simple, less time consuming, safe and eco-friendly. The validation (as per ICH 2005) of the proposed method accesses its use in the routinely quality control of probenecid in tablet dosage form.

Total Arsenic in Raw and Boiled Portions of Norway Lobster (Nephrops norvegicus) from the Central Adriatic Sea

The distribution of total arsenic in different portions of Norway lobster (Nephrops norvegicus L., Crustacea) was studied both in fresh samples and after a boiling process. All individuals (n = 80) were selected of medium standard commercial size (13-15 cm). The highest mean concentrations (26.86 ± 1.57 mg/kg wet weight (ww)) were found in the raw brown meat of the crustacean, probably due to its detoxification role, whereas the lowest mean values (15.97 ± 0.85 mg/kg ww) were in the raw exoskeleton. The raw white meat reported mean values of 16.09 ± 0.61 mg/kg ww. The levels of arsenic contamination detected in the boiled portions showed a significant (p < 0.01) decrease compared to the raw portions, as a consequence of solubilization phenomena. In fact, a large amount of arsenic from raw lobsters was transferred to the corresponding boiling broth. In the most commonly consumed portion, the white meat, only slight losses (7.22%) in total arsenic content were observed compared to the raw portion.

Water solubilization, conductivity and structural characteristics of single and mixed surfactant water-in-oil microemulsions in absence and presence of ionic liquids

The present study is focused on the determination of the solubilization capacity and conductance behavior of mixed microemulsions [AOT/Brij-56 or Brij-58 or Brij-76 or TX-100 or Tween-80/Hp or Dc or IPM/water] in presence of ionic liquids (ILs) of different chemical structures and physicochemical properties [viz. bmimCl, hmimCl, bmimBF4 and BzmimCl] at different compositions (Xnonionic=0, 0.1) at fixed surfactant concentration and temperature. Synergism in solubilization capacity has been evidenced in presence of ILs. All these systems exhibit volume-induced percolation of conductance. The maximum solubilization capacity (ω0,max), [IL]max (concentration of ILs at which synergism occurs) and volume-induced percolation threshold (ωp) have been found to influence by alkyl side-chain length, anion and polarity of ILs, and polar head group, hydrophobic moiety and content of nonionic surfactant and type of oils. Different solubilization sites of bmimCl and hmimCl have been proposed. ILs have been found to be more efficient additives than NaCl in respect of enhancing ω0,max with less [IL]max and reducing ωp. The microstructure of AOT and AOT/Brij-56 systems at different Xnonionic (=0, 0.1) has been determined by DLS and FTIR measurements in absence and presence of ILs. Droplet diameter (dh) decreases and relative population of bound water increases with increase in [IL]. An attempt has been made to correlate the solubilization capacity in presence of ILs with percolation of conductance vis-à-vis droplet dimensions and the states of confined water to underline mechanism of solubilization phenomenon in these systems.

Phase behavior and mesoscale solubilization in aqueous solutions of hydrotropes

Hydrotropes are amphiphilic molecules that are too small to spontaneously form equilibrium structures in aqueous solutions, but form dynamic, non-covalent assemblies, referred to as clusters. In the presence of a hydrophobic compound, these clusters seem to get stabilized leading to the formation of long-lived, highly stable mesoscopic droplets, a phenomenon that we call “mesoscale solubilization”. In this work, we focus on the unusual mesoscopic properties of aqueous solutions of a nonionic hydrotrope, namely tertiary butyl alcohol (TBA), on addition of various hydrophobic compounds. Aqueous TBA solutions, in about 3–8mol% TBA concentration range and about 0–25°C temperature range, show the presence of short-ranged (∼0.5nm), short-lived (tens of picoseconds) molecular clusters which result in anomalies of the thermodynamic properties. These clusters are transient but do not relax by diffusion, thus distinctly different from conventional concentration fluctuations. In this concentration and temperature range, upon the addition of a third (more hydrophobic) component to TBA–water solutions, long-lived mesoscopic droplets of about 100nm size are observed. In this work, we clarify the ambiguity behind the definition of solubility and elucidate the phenomenon of mesoscale solubilization. A systematic study of the macroscopic and mesoscopic phase behavior of three ternary systems TBA–water-propylene oxide, TBA–water-isobutyl alcohol, and TBA–water-cyclohexane has been carried out. We differentiate between molecular solubility, mesoscale solubilization, and macroscopic phase separation. We have confirmed that practically stable aqueous colloids can be created from small molecules, without addition of surfactants or polymers. Such kind of novel materials may find applications in the design of various processes and products, ranging from pharmaceuticals to cosmetics and agrochemicals.

Physicochemical investigation of mixed surfactant reverse micelles: Water solubilization and conductometric studies

Abstract Solubilization of water in mixed reverse micelles (RMs) comprising sodium bis(2-ethylhexyl) sulfosuccinate (AOT), and polyoxyethylene (20) sorbitan trioleate (Tween-85) or polyoxyethylene (20) sorbitan monooleate (Tween-80) or sorbitan trioleate (Span-85) has been studied at different compositions ( X nonionic = 0–1.0) at a total surfactant concentration, S T = 0.1 mol dm −3 in polar lipophilic oils of different chemical structures: viz., ethyl oleate (EO), isopropyl myristate (IPM) and isopropyl palmitate (IPP) at 303 K. The enhancement in water solubilization (i.e., synergism) has been evidenced by the addition of nonionic surfactant to AOT/oil(s)/water systems. The maximum water solubilization capacity ( ω 0,max ) and X nonionic,max (mole fraction at which synergism occurs) have been influenced by polar head group and hydrophobic moiety of nonionic surfactant. The standard free energy change of dissolution of water ( Δ G s 0 ) of these systems depends on water content, X Tween-85 and oil. Solubilization efficiency parameter ( S P water * ) has been evaluated to underline the efficacy of oils in obtaining maximum water solubilization capacity in mixed RMs. Conductance behavior of these systems in absence and presence of additives (bile salts and hydrotrope) has also been investigated under varied water content ( ω ) at 303 K. Volume-induced percolation threshold ( ω p ) depends on X Tween-85 , oil type, and additives. An attempt has been made to give an insight to the mechanism of solubilization phenomena, standard free energy change of dissolution of water, percolation in conductance and microstructures of these systems by dynamic light scattering (DLS) measurements, wherein the chemical structures of both nonionic surfactants and polar lipophilic oils played significant role.

Physicochemical Investigation of Biocompatible Mixed Surfactant Reverse Micelles: III. Aqueous NaCl Solubilization, Thermodynamic Parameters of Desolubilization Process and Conductometric Studies

AbstractSolubilization of water and aqueous NaCl in mixed reverse micelles (RMs) comprising sodium bis(2‐ethylhexyl) sulfosuccinate (AOT), and polyoxyethylene (20) sorbitan trioleate or polyoxyethylene (20) sorbitan monooleate has been studied at different compositions (Xnonionic = 0–1.0) at a total surfactant concentration, ST = 0.10 × 103 mol m−3 in biocompatible oils of different chemical structures; viz., ethyl oleate (EO), isopropyl myristate (IPM) and isopropyl palmitate (IPP) at 303 K. The enhancement in water solubilization (i.e., synergism) has been evidenced by the addition of nonionic surfactant to dioctyl sulfosuccinate/oil(s)/water systems. Addition of NaCl in these systems at different Xnonionic enhances their solubilization capacities further until a maximum, ωNaCl,max is reached. ωNaCl,max and [NaCl]max (concentration at which maximization of NaCl solubilization occurs) depend on type of nonionic surfactant, its content (Xnonionic) and oil. A new solubilization efficiency parameter (SP*water or SP*NaCl) has been proposed to compare solubilization phenomena in these oils. The energetic parameters of the desolubilization process of water or aqueous NaCl in single and mixed RMs have been estimated. Energetically, the water dissolution process in oil has been found to be more exothermic as well as more organized in IPP. Overall, the dissolution of water and aqueous NaCl in mixed RMs is entropically driven process. Conductance behavior of these systems in the presence of NaCl has been investigated under different [NaCl] at 303 K. An attempt has been made to give an insight to the mechanism of solubilization phenomena, percolation in conductance and microstructures vis‐à‐vis role of biocompatible oils in these systems.