Bioinspired bioactive bilayer membrane: A biodegradable adhesive membrane integrating hemostasis, antibacterial, and anti-adhesion functions for visceral repair.

Dyslipidemia is a major metabolic disorder and a key risk factor for atherosclerotic cardiovascular disease (ASCVD), particularly in the geriatric population. Elderly patients frequently present with multiple comorbidities, such as hypertension and hyperuricemia, which complicate clinical management and substantially increase cardiovascular risk. Moreover, acute conditions, including trauma-related injuries, may further disrupt metabolic control, functional capacity, and adherence to long-term therapy. This case report describes a 70-year-old male patient (RE) who presented to a primary healthcare center with swelling and intermittent pain in the right lower extremity following a fall. The patient had a known history of dyslipidemia, hypertension, and hyperuricemia. Laboratory investigations revealed elevated total cholesterol (242 mg/dL), borderline fasting plasma glucose (102 mg/dL), and uric acid level of 6.6 mg/dL. Physical examination was unremarkable except for edema and localized tenderness in the affected limb, consistent with a soft tissue injury. A holistic management approach was implemented, integrating pharmacological and non-pharmacological interventions. Statin therapy was initiated to address dyslipidemia, antihypertensive treatment was optimized, and analgesic therapy combined with limb elevation was provided to manage acute pain and edema. Non-pharmacological strategies included comprehensive lifestyle modification, encompassing dietary counseling (low saturated fat, low salt, and low purine diet), gradual resumption of physical activity following injury recovery, and structured patient–family education to improve adherence and prevent recurrent falls. Follow-up evaluation demonstrated clinical improvement, including resolution of edema, improved functional mobility, and better metabolic control. The novelty of this case lies in demonstrating how acute trauma in geriatric patients can act as a critical entry point for integrated chronic disease management within primary care settings. This case emphasizes that holistic, biopsychosocial–spiritual management not only improves lipid and blood pressure control but also enhances functional outcomes and quality of life in elderly patients with complex comorbidities.

Surface topography, surface chemistry, as well as wetting properties of dental titanium implants are decisive parameteres that modulate biological responses. Problems arise when the optimal wetting properties of as-fabricated implants are compromised by aging effects due to renewed contamination and renewed hydrophobization during storage. The primary objective of this study is to investigate the effects of plasma etching on titanium using fluorine-containing gases, focusing on submicron and nano-scale topographical changes, long-term wetting characteristics, hydrocarbon contaminations, and cellular and bacterial responses. Machined titanium reference samples (M) were either plasma-treated by reactive ion etching with CF4 and NF3 gases (MCF4, MNF3), or modified by a superimposed nanotopography (Mnano). All samples were hydrophilized by O2-plasma (new variants), further processed by 14 d storage (aged variants), and were characterized by FE-SEM, AFM, EDX, XPS, and contact angle analyses. Biological experiments were performed in vitro to evaluate possible effects of the prepared surfaces on soft and hard tissue cells by focal contact analysis, CCK8, and alizarin red staining, as well as on bacterial adhesion by crystal violet staining. CF4 and NF3 plasma treatments generated a tight network of submicron pores. MNF3 showed distinct physico-chemical non-aging properties with long-lasting hydrophilicity. The new surface of MNF3 significantly reduced the adhesion of Streptococcus gordonii. However, neither MCF4 nor MNF3 significantly improved the cellular response. In contrast, the highest number of HGF focal contacts indicating improved soft tissue attachment was observed on aged M and Mnano surfaces. Furthermore, HGF metabolic activity declined on new MCF4 and MNF3, compared to M and Mnano. This study shows promising antibacterial potential of the new NF3 plasma-etched titanium implant surface modification. However, this study also indicates that machined surfaces, due to their already promising soft tissue cellular responses, cannot simply be surpassed by novel fluorine plasma etched surface modifications. Therefore, a zonal arrangement of the transmucosal portion of implant and abutment areas with basal sealing and coronal antibacterial functionalities is suggested.

Assessment of within- and between-rater Reliability for Soft Tissue Laxity during image-based robotic assisted Total Knee Arthroplasty.

Hydrogel-based piezoelectric materials and devices for implantable bioelectronics.

Treatment of central giant cell granuloma of the jaws with intralesional denosumab: initial report.

Although various dermal substitutes are available, their use in the acute setting or for extensive surface areas is often constrained by high costs and labor-intensive application procedures. Despite these challenges, they have proven effective in treating different skin and soft tissue defects. In this prospective case series, 26 adults with acute complex deep soft tissue defects resulting from different etiologies were treated with Glyaderm. Glyaderm is a low-cost acellular dermal substitute and can be applied in either a one- or two-stage procedure with a split skin graft for epidermal coverage. Primary outcomes were graft take in percentage of the total covered wound area and time to complete wound closure. In total, 25 patients with an average age of 55.9 years completed the follow-up period. Etiologies of the acute complex wounds consisted of defects after oncological surgery (28%), debridement of soft tissue infections (28%), trauma (24%), donor site defects after free flap reconstruction (16%), and other (4%). Mean affected Total Body Surface Area was 2.2%, the mean size was 203 cm2. At 5 to 7 days post-application, the mean graft take rate was 89.7%. The average time for wound closure was 30 days. A complication occurred in 16% of cases: three patients developed wound infection resulting in incomplete graft loss, while one patient experienced complete graft loss without an identifiable cause. All cases were regrafted using Glyaderm and subsequently healed without complications. Glyaderm appears to be a valid and effective reconstructive option for acute complex wounds.

Clinical, Immunological and Microbiological Improvements With Zinc-Coated Healing Abutments During the Healing Phase.

To compare the therapeutic efficacy of miniscrew implant anchorage with that of conventional extraoral arch anchorage, both of which are combined with orthodontic-orthognathic treatment, in patients with skeletal Class II malocclusion. This prospective nonrandomised controlled study included 130 patients. In terms of treatment method and patient preference, 58 patients received conventional orthodontic-orthognathic treatment with extraoral arch anchorage (conventional group), whereas 72 patients received treatment augmented with miniscrew implant anchorage (study group). The treatment protocol for all patients followed the conventional three-stage orthodontic-orthognathic approach. The outcomes assessed included treatment effectiveness, adverse events, root resorption (volume via CT), skeletal and dental changes (via comprehensive cephalometric analysis), soft tissue profile changes, facial aesthetics, and alveolar bone morphology (via CBCT). The total effective rate was significantly greater in the study group (95.83%) than in the conventional group (74.14%) (p < 0.05). While both groups presented significant root resorption posttreatment (p < 0.05), the degree of resorption did not differ significantly between the groups (p > 0.05). Crucially, CBCT analysis revealed significantly better preservation of the palatal bone plate and alveolar bone height in the study group (p < 0.05). The study group also demonstrated significantly greater improvements in skeletal parameters (SNA, SNB, FMA, and PP-FH), dental decompensation (U1-SN, U1-NA, L1-MP, and L1-NB), soft tissue indices, and facial aesthetics (p < 0.05). The incidence of adverse events was significantly lower in the study group (34.72% vs. 75.86%, p < 0.05). Logistic analysis revealed that oral hygiene, vertical facial pattern, peri-implant swelling, and force application time were independent risk factors for miniscrew success. The integration of miniscrew implant anchorage in orthodontic-orthognathic treatment for skeletal Class II malocclusion provides superior clinical efficacy. Its primary advantage lies in enabling enhanced control over dental decompensation and skeletal correction, leading to significantly improved facial aesthetics, a more favorable mandibular position, and better alveolar bone preservation, with a lower complication profile. This represents an effective and reliable treatment option for these patients.

Occurrence and concentration of agricultural phytosanitary residues in bivalve mollusks collected from Golfo Nuevo, Argentina.

Soft tissue injuries induce lumbar instability and intervertebral disc degeneration: A mechanobiological study based on a rabbit model.

VEGF-sustained regulation and hydrogel-activated graded porous titanium scaffold for functional regeneration of the tendon-bone interface.

A high frequency ultrasound-based platform to non-destructively quantify geometric, acoustic and mechanical properties of thin, engineered soft connective tissues in vitro.

FDG-PET/MR Imaging in the Assessment of Inflammatory and Infectious Disease in Pediatric Patients.

Emerging silicate biomaterials in oral medicine.

Safflower washing medicine alleviating acute soft tissue injury via PI3K/Akt pathway.

Characterization and potential risks of microplastics in marine mollusks using the laser direct infrared (LDIR) technique.

Methylene blue-enhanced photodynamic and sonodynamic therapy againstStaphylococcus aureus: From laboratory research to clinical evaluation.

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma affecting children and young adults, but few reports describe its presentation and outcomes in Africa. We conducted a retrospective chart review of patients of all ages with RMS presenting to the Butaro Cancer Center of Excellence in Rwanda between July 2012 and June 2022. Fifty-nine patients with histopathologically confirmed RMS were treated using Intergroup RMS Study Group protocols adapted to the local context. Median age was 9.1 years (interquartile range [IQR] 3.5-16.6); 54.2% were female. Median duration from symptom onset to presentation was 5 months (IQR 4-7). Most had embryonal histology (66.1%), followed by alveolar (20.3%), pleomorphic (6.8%), and anaplastic (1.7%). At presentation, 16 patients (27.1%) had stage I, 3 (5.1%) had stage II, 22 (37.3%) had stage III, and 14 (23.7%) had stage IV disease; 4 (6.8%) were unstaged. Of the 39 patients treated with curative intent, 25 (64.1%) received local control and 16 (41.0%) completed all planned therapy. Two-year event-free survival was 23.3% (95% CI 13.5%-34.8%, n=55) overall and 61.4% (95% CI 33.3%-80.5%, n=16) among those who completed treatment. Treatment of RMS in a rural district hospital is feasible. Although outcomes remain lower than in high-income countries, survival was markedly higher in patients who completed therapy. Future efforts should focus on earlier diagnosis and support for timely transitions between specialties with the goal of optimizing completion of planned care.

“Subacromial Impingement Syndrome (SAIS)” refers to conditions disrupting the balance between structural rigidity and soft tissue inflammation, leading to irritation in the subacromial space, primarily affecting the rotator cuff and bursa. High-Intensity Laser Therapy (HILT) is a non-invasive, painless treatment that increases mobility and stimulates deeper tissues. It can be used with antiinflammatory and analgesic effects. In the present case report, a 62-year-old woman reported with right shoulder pain and limited motion for four months. Clinical metrics included a Pain Disability Index (PDI) score of 36, a Shoulder Pain and Disability Index (SPADI) score of 69%, and a Shoulder Function Index (SFInX) of 40, suggesting impingement syndrome. A high-intensity laser was applied to the site. The exercise regimen included posture improvement, pectoral and trapezius stretching, shoulder Range of Motion (ROM) exercises, gentle stretches, and finger stair exercises over four weeks. At treatment's end, significant functional improvements were noted, including reduced pain, increased ROM, and enhanced muscle strength.