Disposable Soft Contact Research Articles

Optical Characterization of Hydrogel and Silicone Hydrogel Soft Contact Lenses

Contact lenses are biomaterials that have emerged as an alternative to glasses in correcting vision defects. In this study, commercial nesofilcon A (hydrogel-Hy) and delefilcon A (silicone hydrogel-SiHy) daily disposable soft contact lenses were optically examined using UV-visible light spectroscopy. Optical absorption and transmittance measurements of the lenses were taken with a UV-visible spectrophotometer, and their properties of blocking the harmful part of the radiation to the eye and transmitting the harmless part were investigated. From the absorption spectrum, it was seen that the nesofilcon A lens absorbed ultraviolet light better. From the optical absorption coefficient spectra of nesofilcon A and delefilcon A lenses, the absorption edges were obtained as 386 and 325 nm, and the optical band gap values were 3.37 and 3.98 eV, respectively. Additionally, the refractive index profiles of the lenses were plotted. The refractive indices of the lenses at 550 nm wavelength were calculated as 1.55 and 1.77 for nesofilcon A and delefilcon A, respectively. While the delefilcon A lens transmitted visible light well, the nesofilcon A lens blocked UV light better and its refractive index was determined to be closer to the 1.40 the value specified by the manufacturer.

Characterization of tear film and wettability dynamics over two daily disposable soft contact lenses

Characterization of tear film and wettability dynamics over two daily disposable soft contact lenses

Clinical performance comparison of commercially available verofilcon A and somofilcon A daily disposable soft contact lenses

Clinical performance comparison of commercially available verofilcon A and somofilcon A daily disposable soft contact lenses

Effect of antihistamine-releasing contact lenses on ocular symptoms and treatment behavior in patients with seasonal allergic conjunctivitis: A retrospective study

PurposeThis study aimed to compare subjective allergic conjunctivitis symptoms and anti-allergic eye drop use patterns between antihistamine-releasing contact lens users and daily disposable soft contact lens users during Japan's hay fever season. MethodsThis web-based retrospective cohort study included daily disposable soft contact lens or antihistamine-releasing contact lens users with a history of seasonal allergic conjunctivitis who regularly used daily disposable soft contact lenses since the previous year. The total ocular symptom score (range 0–20) based on 5-item questionnaire scores and time from the start of the hay fever season to the initiation of anti-allergic eye drop treatment were compared between antihistamine-releasing contact lens users and daily disposable soft contact lens users. ResultsThe study included 24 participants: 17 using daily disposable soft contact lenses and 7 using antihistamine-releasing contact lenses. Antihistamine-releasing contact lens users experienced a greater reduction in total ocular symptom score from 2021 to 2022 compared with daily disposable soft contact lens users (mean total ocular symptom score [standard deviation]: daily disposable soft contact lens: −0.65 [1.4], antihistamine-releasing contact lens: −4.7 [3.6]; n = 24; Mann–Whitney U test, P = 0.010). Fourteen daily disposable soft contact lens users and five antihistamine-releasing contact lens users eventually required anti-allergic eye drops. Kaplan–Meier analysis revealed a significant delay in the initiation of anti-allergic eye drop treatment among those using antihistamine-releasing contact lenses compared with those using daily disposable soft contact lenses (median days, daily disposable soft contact lenses: 19 days, antihistamine-releasing contact lens: 57 days; n = 24; log-rank test, P = 0.045). ConclusionsAntihistamine-releasing contact lenses can potentially mitigate worsening ocular allergic responses during the hay fever season when used appropriately as a preventive measure.

Wear Experience with a daily disposable soft contact lens for astigmatism in current wearers of a reusable soft toric contact lens.

The purpose of this study was to evaluate the wear experience of satisfied wearers of a particular reusable toric soft contact lens when refit into a water surface technology daily disposable toric soft contact lens. 30 participants completed the study over three visits. At the first visit, subjects were refit into with their habitual reusable toric soft contact lens (comfilcon A) to maximize fit and vision. Subjects returned after one week and were then refit into the study daily disposable soft contact lenses (verofilcon A) and completed surveys of their initial impressions of comfort, vision, and satisfaction. Participants wore the study lenses for two weeks, and then returned for their final visit to complete a vision and ocular health check. At the final visit, subjects also completed surveys to rate their overall and end-of-day comfort, quality of vision, stability of vision, and dryness using a visual analog scale (VAS). Participants also answered questions about their wear experience with the lenses. Overall median and interquartile range (IQR) of all data and surveys was calculated. Initial impressions of the study lenses revealed a median (IQR) score of 85 (28) for vision, 91 (25) for comfort, and 87 (21) for satisfaction. Overall VAS scores after two weeks of wear found median scores of 93 (16) for quality of vision, 88 (28) for stability of vision, and 91 (20) for comfort. End-of-day median scores were 82(27) for quality of vision, 90 (35) for stability of vision, and 80 (38) for comfort. Overall dryness scores were 20(45) and end-of-day dryness was 39 (46). Median(IQR) binocular logMAR visual acuity with the study lenses was -0.16(0.1). Median rotation of the lenses was 0(4.3) degrees. Participants wearing the daily disposable study lenses for astigmatism gave high scores in vision and comfort both at initial fitting and after two weeks of lens wear. Results showed that satisfied wearers of comfilcon A reusable toric soft contact lenses can be successfully refit with verofilcon A daily disposable contact lenses.

Development of environmentally friendly soft contact lenses made from cellulose-derived hydrogel materials

With the performance improvement of soft contact lenses (SCLs) over the past few decades, their global use and market have steadily expanded. Consequently, contamination by disposable SCLs has become a potential threat to the environment. From the perspective of sustainable development goals, overcoming this issue requires the development of new biodegradable SCL materials based on plant-derived cellulose. In this study, highly transparent hydrogels based on hydroxypropyl cellulose were prepared via a radiation crosslinking technique using electron beams. By optimizing the irradiation dose and type of added monomer, excellent physicochemical properties, such as mechanical strength and transparency, and biological properties, such as low lysozyme deposition and biodegradability, were obtained. Thus, hydrogels produced by radiation crosslinking can be potentially used as human- and environment-friendly SCL materials.

Examining daily disposable soft contact lens wearers' attitudes and beliefs using the Health Belief Model.

To use the Health Belief Model (HBM) to understand daily disposable (DD) soft contact lens (SCL) wearers' attitudes and beliefs. A convenience sample of DD SCL wearers (18-33 years) was enrolled at two sites. Participants were queried about demographics, SCL wear and HBM constructs. Rasch analysis was used to assess the psychometric properties of the survey instrument and generate scores for each HBM subscale. ANOVA was used to determine relationships among HBM constructs, subject demographics and DD SCL-related health behaviours. One hundred people participated (mean ± SD), age=24.2 ± 3.9 years, 76% female. Thirty-seven percent reported sleeping in DD SCLs and 25% reported reusing DD SCLs. Self-report of reusing DD SCLs was associated with scores on the benefits: reuse (p=0.02) and barriers (p=0.007) subscales, and sleeping in lenses was associated with scores on the susceptibility (p=0.05), benefits: wear behaviours (p=0.006) and barriers (p=0.01) subscales. Rasch analysis showed some subscales demonstrated multidimensionality. Selected health belief constructs were associated with DD SCL-related behaviours including reusing and overnight wear. Increased understanding of SCL attitudes and beliefs could inform patient education and interventions to decrease risks associated with improper SCL wear.

An Unlikely Culprit for Red Eye and Elevated Intraocular Pressure: 23 Retained Daily Disposable Soft Contact Lenses

A 64-year-old woman was referred for pain, hand movements vision, and tonometry of 54 mmHg in the left eye. History included possible limbal stem cell deficiency, herpetic encephalitis, and cognitive impairment. She wore daily disposable soft contact lenses for years. Examination showed hyperemia, corneal clouding, and surprisingly, numerous stacked contacts (Fig A). Twenty-three contact lenses were removed (Fig B). Presumed infectious keratitis (Figs C and D) resolved with topical antibiotics. Testing showed absent corneal sensitivity and tonometry of 18 mmHg.

Lens wear adaptation in neophytes wearing monthly replacement soft lenses

Purpose: Many eye care professionals (ECP’s) still advocate a gradual adaptation to lens wear in neophyte soft contact lens wearers, however this approach has limited supportive evidence. This study aimed to ascertain whether this adaptation period, given modern advancements in soft lens materials, was necessary for monthly disposable soft contact lenses, in both hydrogel and silicone hydrogel materials.

Evaluation of Pollen Adhesion to Verofilcon-A Soft Contact Lenses

Purpose: A new 1-day disposable soft contact lens (SCL), verofilcon-A, constructed of silicone hydrogel material, has recently become available in Japan. This SCL has a very smooth surface produced by using the SMARTSURFACE ® Technology, and it was expected that pollen particles and protein components would not adhere easily to its surface. We examined the degree of pollen adhesion to the surface of the verofilcon-A material SCL and compared the results with those of other 1-day disposable SCLs (1DSCL). Methods: To determine the number of pollen grains attached to the surface of different types of SCLs, 0.01 mg/ml of cedar pollen solution was dropped onto the surface of 13 types of 1DSCL. After 24 h, each 1DSCL was rinsed in a shaker and washed five times with saline (n = 10 for each 1DSCL type). The number of pollen particles adhered to the 1DSCL and the percentage of surface area occupied by pollen was determined. Results: The number of pollen particles on the 1DSCLs ranged from 0 to 185 in the 200 × 200 µm area. The number of particles was lowest in the delefilcon-A and verofilcon-A SCLs with 0 particles, and the number was higher in the other 11 1DSCLs. The number of pollen particles was negatively correlated with the water content (r = −0.48), oxygen permeability (Dk; r = −0.43), oxygen transmissibility (r = −0.42), and center thickness (r = −0.33) of the 1DSCLs. The pollen adhesion area ranged from 0.0% to 3.1% and was lowest in the delefilcon-A and verofilcon-A 1DSCLs. There were significant differences in the pollen adhesion area between colored 1DSCLs (2.73 ± 1.97%) and clear 1DSCLs (1.03 ± 1.01%, P<0.001) and between hydroxyethyl methacrylate-based 1DSCLs (1.84 ± 1.45%) and silicone hydrogel-based 1DSCLs (0.05 ± 0.16%, P<0.001). Conclusion: These findings indicate that the verofilcon-A 1DSCL processed with SMARTSURFACE™ Technology is an excellent option for SCL users with allergic conjunctivitis during the high pollen season.

Evaluation of the Lubricating Effect of Hyaluronic Acid on Contact Lenses Using a Pendulum-Type Friction Tester Under Mimicking Physiological Conditions.

Objective:To evaluate the lubricating effect of hyaluronic acid (HA) on soft contact lenses (SCLs) measured using a pendulum-type friction tester.Methods:We measured the coefficient of friction (CoF) of narafilcon A, delefilcon A, and etafilcon A with polyvinylpyrrolidone (PVP), daily disposable SCL material, using a modified pendulum-type friction tester. Sample SCLs were set on an acrylic plastic half-ball and placed into the polyethylene terephthalate hemisphere cup filled with 0.4 mL of test lubricants that included saline and 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, and 0.5% (wt/vol) HA (molecular weight, 850 kDa). The viscosities of saline and HA were measured using an Ubbelohde viscometer.Results:The CoF of the SCL under a low concentration (0.05%) of HA was the lowest and significantly lower than saline in narafilcon A and delefilcon A (P<0.05, Steel multiple comparison test). Under higher HA concentrations (0.3%, 0.4%, and 0.5%), the CoF was significantly higher than that of saline (P<0.01, Steel' multiple comparison test) in all three SCLs. There were no significant differences of CoF among three SCLs in saline and all concentrations of HA. The HA viscosities increased exponentially with the concentration (Y=1.2829e9.286X).Conclusion:The viscosity of a high concentration of HA may increase the friction of SCLs, which may have a deleterious effect on the ocular surface.

Development of Environmentally Friendly Cellulose Derivative-Based Hydrogels for Contact Lenses Using a Radiation Crosslinking Technique

Although they have potential environmental pollution issues, soft contact lenses are value-added biodevices for medical use. Thus, it is important to reconsider starting materials and production methods to achieve sustainable development. In this study, hydrogels composed of hydroxypropyl cellulose (HPC) as an environmentally friendly material were produced by radiation and investigated for use in disposable soft contact lenses. HPC-based hydrogels with good mechanical properties and transparency were prepared by irradiation of electron beams on highly concentrated aqueous solutions containing HPC, polyethylene glycol #1000 dimethacrylate (23G), and 2-hydroxyethyl methacrylate (HEMA). The addition of 23G to HPC aqueous solutions resulted in an increase in the gel fraction as well as improved mechanical properties, such as tensile strength and elongation at break. The tensile strength and the elongation at break of HPC/HEMA/23G hydrogel obtained by the further addition of HEMA with HPC/23G aqueous solutions exhibited 0.2 MPa and 124%, which were approximately 2.0 and 1.8 times larger than these of the pure HPC hydrogel, respectively. The evaluation of the properties of the HPC/HEMA/23G hydrogel demonstrated its potential as a soft contact material with improved mechanical properties.

The disposable bandage soft contact lenses therapy and anterior segment optical coherence tomography for management of ocular graft-versus-host disease

PurposeTo identify the ocular surface changes of ocular graft-versus-host disease (GVHD) using anterior segment optical coherence tomography (AS-OCT) and examine the efficacy of disposable bandage soft contact lens (BSCL) treatment in ocular GVHD patients.MethodsThis study is a prospective, Phase II clinical trial. Nineteen patients diagnosed with chronic GVHD based on the NIH criteria and ocular symptoms of NIH eye score 2 or greater were enrolled. Disposable BSCL was applied to the GVHD-affected eyes with topical antibiotic coverage. Ocular exams, eye symptom surveys, and AS-OCT were performed with signed informed consent. Patients were followed for one to three months.ResultsThirty-eight eyes of 19 patients with ocular GVHD underwent BSCL treatment in this study. AS-OCT scans were done in 14 out of 19 patients. The mean best-corrected visual acuity at enrollment, 2-week, and 4-week visits was 0.180, 0.128, and 0.163 logMAR, respectively. Twenty-four out of 25 eyes (96 %) that initially presented with conjunctival inflammation, twenty-three out of 30 eyes (76.7 %) that initially presented with punctate epithelial erosion, and 8 out of 15 (53.3 %) eyes that initially presented with filamentous keratopathy showed improvement after wearing BSCL for 2 to 4 weeks. AS-OCT revealed corneal epithelial irregularity, abnormal meibomian gland orifice, and conjunctival hyperemia, in patients with ocular GVHD.ConclusionsBSCL treatment provided significant subjective and objective improvements in ocular GVHD patients. Meanwhile, we found that AS-OCT can be a promising diagnostic tool to characterize the ocular surface changes associated with ocular GVHD.

Changes in the geometry of modern daily disposable soft contact lenses during wear

The geometry of contact lenses can be altered by wear but determining the changes that occur in soft contact lenses (SCLs) is challenging. This study aimed to investigate the shape alterations of daily disposable SCLs after wear using swept-source optical coherence tomography (SS-OCT). Forty-five eyes with myopia of − 3.00 diopters (D) were enrolled. The participants wore three types of SCLs: hydrogel lens (nesofilcon A) and silicone hydrogel lenses (delefilcon A and stenfilcon A). The SCLs were scanned 3–6 min after lens removal. We found a significant decrease in the SCL anterior curvature: 0.24 ± 0.17 mm for nesofilcon A, 0.44 ± 0.21 mm for delefilcon A, and 0.53 ± 0.29 mm for stenfilcon A. The changes in the anterior curvature of SCLs correlated moderately with the mean corneal keratometry; Pearson’s correlation coefficients for nesofilcon A and delefilcon A were 0.57 and 0.52, respectively (P < 0.001). A statistically significant change in the total diameter was observed in SCL made of stenfilcon A (0.39 mm, P < 0.001). To conclude, the central radii of curvature decreased after a wearing period for all three types of daily disposable SCLs to imitate the anterior corneal surface, however, the changes in other geometrical parameters measured with SS-OCT were lens-specific.

Clinical study on the effect of multifocal contact lenses on myopia progression in myopia school children

BackgroundThe efficacy of peripheral low add multifocal soft contact lenses (SCLs) for suppressing the progression of myopia is controversial. The aim of the on-going present clinical study is to investigate whether or not multifocal SCLs with + 0.50 diopters (D) addition suppress the progression of myopia in myopic elementary school children.DesignProspective randomized controlled trial.Subjects and methodsThe study plans to include a total of 100 myopic school children. Target subjects are primary school male and female students with mild to moderate myopia. Children who have eye-related diseases other than myopia are excluded from the study, because they may affect the evaluation of the outcome. Subjects will be randomly assigned to wear daily disposable multifocal contact lenses with + 0.50D addition or daily disposable SCLs. Subjects will wear contact lenses on both eyes and will be observed for 2 years under a double-masked examination. Primary outcome is a change in the axial length over the 2-year period.ObjectivesThe purpose of this study is to identify whether or not multifocal SCLs with + 0.5D addition suppress the progression of myopia in myopic elementary school children as compared with standard SCLs.Trial registration1. UMIN (University Hospital Medical Information Network) UMIN000027940. Registered on July 21, 20172. JRCT (Japan Registry of Clinical Trials) jRCTs052180172. Registered on March 26, 2019

All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis

Electroretinogram examinations serve as routine clinical procedures in ophthalmology for the diagnosis and management of many ocular diseases. However, the rigid form factor of current corneal sensors produces a mismatch with the soft, curvilinear, and exceptionally sensitive human cornea, which typically requires the use of topical anesthesia and a speculum for pain management and safety. Here we report a design of an all-printed stretchable corneal sensor built on commercially-available disposable soft contact lenses that can intimately and non-invasively interface with the corneal surface of human eyes. The corneal sensor is integrated with soft contact lenses via an electrochemical anchoring mechanism in a seamless manner that ensures its mechanical and chemical reliability. Thus, the resulting device enables the high-fidelity recording of full-field electroretinogram signals in human eyes without the need of topical anesthesia or a speculum. The device, superior to clinical standards in terms of signal quality and comfortability, is expected to address unmet clinical needs in the field of ocular electrodiagnosis.

Adhesion of Pollen Particles to Daily Disposable Soft Contact Lenses.

PurposePollen and proteins attached to soft contact lenses (SCLs) exacerbate allergic conjunctivitis. The material of SCLs may affect the pollen adhesion to the SCLs. The factors associated with the number of pollen particles that are adherent to daily disposable SCL were investigated.MethodsPollen particles were experimentally exposed to the contact lens surface of 12 types of SCLs for 1 hour, and the SCLs were washed and rinsed with a physiological saline (n=10 for each SCL type). A total of 120 contact lenses were used in this study. The pollen particles attached to the SCL were observed and photographed under a microscope. The influence of the materials of the SCLs on the degree of pollen adhesion were investigated.ResultsThe number of residual pollen particles attached to SCLs was in the range from 0–293/area of 200×200 µm. Percentage of pollen adhesion area of the surface of the SCL was in the range from 0.01% to 3.25%. There were significant differences in both the number and adhesion area of pollen particles among the 12 types of SCLs tested (P<0.0001 and P<0.0001, respectively). The number of pollen particles adhered to SCLs was significantly higher in colored SCLs than clear SCLs (unpaired t-test, p<0.001). The portion of pollen adhesion area was the lowest in the silicone hydrogel SCLs made with delefilcon-A (0.01 ± 0.02%).ConclusionPollen adhesion in daily disposable SCLs depends on the characteristics and materials of the SCLs and was high in colored SCLs and lowest in delefilcon-A silicone hydrogel SCL. These results suggest that colored SCLs are not preferred during pollen season.

Ultraviolet radiation transmission of soft disposable contact lenses and ISO 18369: claims and compliance

ABSTRACT Clinical relevance This study was carried out to provide advice to eye care practitioners on those soft disposable contact lenses that comply with the Class 1 or Class 2 requirements of the international standard ISO 18369 for ultraviolet radiation protection. Background This study was carried out to provide advice to eye care practitioners on those soft disposable contact lenses that comply with the Class 1 or Class 2 requirements of the international standard ISO 18369 for ultraviolet radiation (UVR) protection and to validate any claims made. It is intended to be used when a patient needs or requests UVR protection. A revised ISO 18369-3 was published in 2017. There is no Australian adoption nor equivalent. Methods The direct spectral transmittance of three specimens of each of the twenty soft disposable contact lens types available in Australia in 2018 was measured in saline in a quartz cuvette with a dual beam spectrophotometer from 200-780 nm. Transmittance values for each material were averaged and scaled according to a single measurement of its transmittance in the visible spectrum (380-780 nm). Based on the ISO 18369-3:2017 criteria, lens materials were denoted as Class 1, Class 2 or non-UVR protectors. This classification was compared with any claim made by the manufacturer. Results All claims of the manufacturers for Class 1 or Class 2 were valid. There were no examples of any missed opportunity to make a claim. Some claims were so general as to be untestable. Some numerical claims appeared to hide that only a Class 2 claim could be made. Conclusions Claims of Class 1 or Class 2 were found to be appropriate. There were no missed opportunities to claim. UV protection claims that were not in the ISO 18369-3 format may be taken as Class 2 compliance but not Class 1 compliance. A two-class system of UV protectors and non-UV protectors may serve practitioners and their patients better.

A 3-year Randomized Clinical Trial of MiSight Lenses for Slowing Myopia Progression

Significance. Results of this randomized, double-masked clinical trial demonstrate the effectiveness of the MiSight soft contact lens in slowing myopia progression over multiple years.Purpose. The purpose of this study was to quantify the effectiveness of MiSight daily disposable soft contact lens in slowing the progression of juvenile-onset myopia.Methods. Myopic children (spherical equivalent refraction, −0.75 to −4.00 D; astigmatism, &lt; 1.00 D) aged 8 to 12 years with no prior contact lens experience were enrolled in a 3-year, double-masked, randomized clinical trial at four investigational sites in four countries. Subjects in each group were matched for age, sex, and ethnicity and were randomized to either a MiSight®1 day contact lens (test) or Proclear®1 day (control; omafilcon A) and worn on a daily disposable basis. Primary outcome measures were the change in cycloplegic spherical equivalent refraction and axial length.Results. Of the subjects enrolled, 75.5% (109/144) completed the clinical trial (53 test, 56 control). Unadjusted change in spherical equivalent refraction was −0.73 D (59%) less in the test group than in the control group (−0.51 ± 0.64 vs. –1.24 ± 0.61 D, P &lt; 0.001). Mean change in axial length was 0.32 mm (52%) less in the test group than in the control group (0.30 ± 0.27 vs. 0.62 ± 0.30 mm, P &lt; 0.001). Changes in spherical equivalent refraction and axial length were highly correlated (r = −0.90, P &lt; .001). Over the course of the study, there were no cases of serious ocular adverse events reported. Four asymptomatic corneal infiltrative (one test, three control) events were observed at scheduled study visits.Conclusions. Results of this clinical trial demonstrate the effectiveness of the MiSight daily disposable soft contact lens in slowing change in spherical equivalent refraction and axial length.

Clinical Performance of a Novel Daily Disposable Soft Contact Lens

Background and Objective: Verofilcon A (PRECISION1®; Alcon) silicone hydrogel daily disposable contact lenses were designed to address clinical issues associated with new wearer discontinuation, including vision quality, sustained comfort, and ease of handling. The present study assessed the objective and subjective performance of verofilcon A contact lenses in subjects needing optical correction for refractive ametropia.&#x0D; Material and Methods: Subjects aged 18 years and older with non-diseased eyes, a history of successful soft contact lens wear for distance correction in both eyes during the previous 3 months, and a best spectacle-corrected visual acuity of 20/25 or better with a manifest cylinder of ≤ 0.75 diopters in each eye were recruited. The primary endpoint was distance visual acuity. Secondary endpoints included subjective ratings of overall vision, comfort, and handling, and safety endpoints included adverse events and biomicroscopy/slit lamp examination findings.&#x0D; Results: This study recruited 70 subjects (140 eyes), aged 20–48 years, who were predominantly white (93%), non-Hispanic/Latino (94%), and female (73%); one subject discontinued due to a change in residence. Of the 140 eyes, 132 (94.3%) had 20/20 or better vision with their habitual contact lenses. Similarly, of the 138 eyes that completed the study, 136 (98.6%) had 20/20 or better vision at dispensation of verofilcon A lenses and 132 (95.7%) had 20/20 or better vision at 3 months. Mean ± SD subjective ratings of overall vision, overall comfort, and overall handling, each on a 10-point scale, were 9.4 ± 0.8, 9.4 ± 0.8, and 9.2 ± 1.3, respectively, at lens dispensing, and 9.4 ± 0.9, 9.5 ± 0.8, and 9.2 ± 1.0, respectively, at 3 months. Mean ± SD daily wear times at 1 week and 3 months were 14.71 ± 1.85 and 15.05 ± 1.27 hours, respectively, with 68.1% at 1 week and 73.9% at 3 months wearing verofilcon A lenses for 14–18 hours per day. None of the subjects experienced a serious adverse event or discontinued lens wear, with biomicroscopy/slit lamp examination showing no evidence of corneal edema or chemosis.&#x0D; Conclusion: Subjects wearing verofilcon A lenses had visual acuity similar to that when wearing their habitual lens. Verofilcon A lenses were highly rated for vision quality, comfort, and handling. Verofilcon A lenses may be an option for subjects with refractive ametropia who desire lenses that can be worn for &gt;14 hours per day and are easy to handle.