BACKGROUND Breast cancer is one of the most prevalent causes of morbidity and mortality worldwide, presenting an increasing public health challenge, particularly in low-income and middle-income countries. However, data on the knowledge, attitudes, and preventive practices regarding breast cancer and the associated factors among females in Wollo, Ethiopia, remain limited. AIM To assess the impact of family history (FH) of breast disease on knowledge, attitudes, and breast cancer preventive practices among reproductive-age females. METHODS A community-based cross-sectional study was conducted in May and June 2022 in Northeast Ethiopia and involved 143 reproductive-age females with FH of breast diseases and 209 without such a history. We selected participants using the systematic random sampling technique. We analyzed the data using Statistical Package for Social Science version 25 software, and logistic regression analysis was employed to determine odds ratios for variable associations, with statistical significance set at P < 0.05. RESULTS Among participants with FH of breast diseases, the levels of knowledge, attitudes, and preventive practices were found to be 83.9% [95% confidence interval (CI): 77.9-89.9], 49.0% (95%CI: 40.8-57.1), and 74.1% (95%CI: 66.9-81.3), respectively. In contrast, among those without FH of breast diseases, these levels were significantly decreased to 10.5% (95%CI: 6.4-14.7), 32.1% (95%CI: 25.7-38.4), and 16.7% (95%CI: 11.7-21.8), respectively. This study also indicated that knowledge, attitudes, and preventive practices related to breast cancer are significantly higher among participants with FH of breast diseases compared to those without HF breast diseases. CONCLUSION Educational status, monthly income, and community health insurance were identified as significant factors associated with the levels of knowledge, attitudes, and preventive practices regarding breast cancer among reproductive-age females.
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