Social Losses Research Articles

회상요법을 활용한 집단미술치료가 독거노인의 노화태도와 삶의 질에 미치는 영향

This study examines the effects of reminiscence-based group art therapy on the attitudes toward aging and the quality of life of elderly individuals living alone. The study participants were 24 elderly individuals living alone, aged 65 and older, who use a senior care facility in K City. They were divided into two groups: an exp. group of 12 and a control group of 12. The experimental group underwent 12 sessions of group art therapy once a week from September 5, 2023, to December 12, 2023. The Aging Attitudes Questionnaire(AAQ-21) and the Quality of Life in Ageing Scale(CASP-19) were used as research tools. Differences between groups were analyzed using Analysis of Covariance. The results are as follows. First, the experimental group showed significant improvements in their attitudes towards aging, particularly in aspects related to social loss, physical and psychological changes, and growth. Second, the quality of life in terms of autonomy, pleasure, and self-realization also significantly improved in the experimental group. These findings suggest that reminiscence-based group art therapy can be an effective intervention for enhancing aging attitudes and quality of life among elderly living alone.

Now or Later? Examining Social and Financial Decision-Making in Middle-to-Older Aged Adults.

Contextually driven decision-making is multidimensional, as individuals need to contend with prioritizing both competing and complementary demands. However, data is limited as to whether temporal discounting rates vary as a function of framing (gains vs. loss) and domain (monetary vs. social) in middle-to-older aged adults. It is also unclear whether socioaffective characteristics like social isolation and loneliness are associated with temporal discounting. Temporal discounting rates were examined across monetary gain, monetary loss, social gain, and social loss conditions in 140 adults aged 50-90 during the Omicron stage of the pandemic. Self-report measures assessed loneliness and social isolation levels. Results found evidence of steeper temporal discounting rates for gains as compared to losses in both domains. Social outcomes were also more steeply discounted than monetary outcomes, without evidence of an interaction with the framing condition. Socioeconomic and socioaffective factors were unexpectedly not associated with temporal discounting rates. Community-dwelling middle-to-older aged adults showed a preference for immediate rewards and devalued social outcomes more than monetary outcomes. These findings have implications for tailoring social and financial incentive programs for middle to later adulthood.

Internalization of External Cost in the Thermal Power Generation on Social Welfare Maximization

For decades, Kenya has incorporated thermal power technology into its grid to generate electrical energy using fossil fuels such as petroleum, natural gas, and coal. The burning of fossil fuels has become a major source of air pollutants and is associated with several undesirable side effects on the environment and human health. However, the impact of pollutants on environmental sustainability and public welfare has yet to be evaluated. Therefore, the purpose of this study is to evaluate the external cost of electricity generated by thermal power plants in Kenya. Both survey data and secondary data were used. The analysis was conducted using externality valuation and welfare maximization approaches, and the research hypotheses were tested using a negative binomial regression model. The annual external cost ($/2022) was determined to be $ 1,333,904,970.76, with the following distribution: environmental at $ 993,488,336.26, Public health at $ 86,760,038.01, and socio-economic at $ 253,656,596.49. Equally, the thermal power generation marginal social cost ($/2022) was determined to be 1.22 $cents/kWh with the following distribution: Marginal Private Cost (MPC) at 0.01 $cents/kWh and Marginal External Cost (MEC) at 1.21 $cents/kWh. The established marginal social cost (MSC) (i.e. Σ MPC+MEC) was 1.22 ($cents/kWh). Thus, MSC is significantly greater than the established social marginal benefit (SMB) of 0.089 ($ cents/kWh); hence, we conclude that the burden of social welfare loss is highly significant, making thermal power a non-sustainable and economic energy source.

Experiences and impacts of out-of-pocket healthcare expenditure on remote Aboriginal families.

Aboriginal Australians face significant health disparities, with hospitalisation rates 2.3 times greater, and longer hospital length of stay, than non-Indigenous Australians. This additional burden impacts families further through out-of-pocket healthcare expenditure (OOPHE), which includes additional healthcare expenses not covered by universal taxpayer insurance. Aboriginal patients traveling from remote locations are likely to be impacted further by OOPHE. The objective of this study was to examine the impacts and burden of OOPHE for rurally based Aboriginal individuals. Participants were recruited through South Australian community networks to participate in this study. Decolonising methods of yarning and deep listening were used to centralise local narratives and language of OOPHE. Qualitative analysis software was used to thematically code transcripts and organise data. A total of seven yarning sessions were conducted with 10 participants. Seven themes were identified: travel, barriers to health care, personal and social loss, restricted autonomy, financial strain, support initiatives and protective factors. Sleeping rough, selling assets and not attending appointments were used to mitigate or avoid OOPHE. Government initiatives, such as the patient assistance transport scheme, did little to decrease OOPHE burden on participants. Family connections, Indigenous knowledges and engagement with cultural practices were protective against OOPHE burden. Aboriginal families are significantly burdened by OOPHE when needing to travel for health care. Radical change of government initiative and policies through to health professional awareness is needed to ensure equitable healthcare access that does not create additional financial hardship in communities already experiencing economic disadvantage.

The role of social support among caregivers of people with cancer from Chinese and Arabic communities: a qualitative study

PurposeCancer caregivers from culturally and linguistically diverse (CALD) communities have reported significant unmet emotional support needs. This study aimed explore the role of social support to manage emotional wellbeing among cancer caregivers from Arabic and Chinese communities in Australia.MethodsSemi-structured interviews were conducted with Chinese (n = 12) and Arabic (n = 12) speaking cancer caregivers. Participants’ mean age was 40.6 years; majority were female (83%) and providing care to a parent (41.67%).ResultsUsing thematic analysis to analyse interview data, five overarching themes emerged describing caregivers’ perspectives on social support. Themes were related to the following: (1) receiving emotional support from social networks, (2) barriers to accessing emotional support from social networks, (3) isolation and loss of connection following the cancer diagnosis, (4) faith as a source of support, and (5) utility of support groups and caregiver advocates. Several caregivers relied on social networks for emotional support; however, caregivers identified key cultural and generational barriers to seeking support from their social networks which prevented caregivers from disclosing their emotions and caregiving situation. Caregivers also reported being isolated from their support system.ConclusionEmpirical testing of culturally appropriate strategies that improve social support seeking among caregivers from CALD communities is recommended.

A spectral assessment for instant preliminary evaluation of structures after seismic events

This article introduces a simple, efficient spectral-based approach for rapid preliminary seismic assessment of earthquake-affected structures. Performance is validated using data from three highly earthquake-affected structures in New Zealand, where visual inspection with subjective outcomes missed damage, resulting in inaccurate and delayed decisions with significant social and economic losses. The three structures considered include (1) the instrumented Bank of New Zealand (BNZ) building; (2) the un-instrumented Queensgate Mall (QM) Complex; and (3) the un-instrumented Canterbury Television (CTV) building. This study uses these cases to highlight the importance of structural health monitoring (SHM) instrumentation and reliable quantified post-earthquake assessment methods in earthquake-prone areas, where each damaging earthquake and subsequent further-damaging aftershocks demand continuous monitoring to continuously assess damage and life safety risk. The simple, low-cost spectral analyses in this study clearly show the existence of damage and deterioration not fully discovered with standard visual inspection methods. This outcome highlights the importance of sensor networks and SHM instrumentation so quantitative, post-event analysis can rapidly augment and target further, more subjective visual inspection results.

Safety evaluation for regulation changes on commercial vehicle operation using multilevel Bayesian methods

Truck-involved crashes cause serious social and economic losses, and the crash severity is higher compared to ordinary vehicles. Driver fatigue is a major crash causation, especially have a larger impact on truck drivers. Therefore, mandating a truck rest-break is one of the road safety management strategies for reducing both truck-involved crash frequency and severity. This paper analyses the change in safety performance according to the revision of the truck rest-break time on highways. Because spatial heterogeneity and homogeneity should be considered to estimate safety effects precisely after executing crash countermeasures, this study estimates the safety effect after the revision of the Trucking Transport Business Act, by developing a model based on the Multilevel Full-Bayes before and after the study. The safety performance function was developed in different section units and distributions, and the crash modification factor was calculated for the most suitable model. As a result of the analysis, the performance of the Multilevel Bayesian Poisson-gamma model was the highest, and it was found that there was a crash reduction effect after the revision of the truck break time. The results of this study can be referred to when preparing measures for road safety regulations.

Understanding Intimate Partner Femicide and Attempted Intimate Partner Femicide During and After COVID-19: A Comprehensive Strain-Based Approach

Intimate partner femicide (IPF) and attempted intimate partner femicide (AIPF) are severe forms of violence and global phenomena occurring in all societies worldwide. However, explaining IPF and AIPF is a complex and challenging endeavor. This article delves into the evolution of IPF and AIPF in Portugal during and after COVID-19, seeking to comprehend the underlying explanatory factors through a comprehensive strain-based approach. IPF rates during the COVID-19 pandemic have remained relatively stable, comparable to those observed before the pandemic, following a pattern akin to that documented in other countries. However, a significant increase in AIPF occurred during the COVID-19 pandemic, and a slight uptick in IPF indicators was noted toward the end of the pandemic period (2022). Perpetrators faced various strains, such as separation and financial difficulties, along with experiencing emotions like anger, jealousy, anxiety, and depression, leading to instances of IPF and AIPF. The COVID-19 crisis and associated restrictions introduced additional strains, including social isolation, economic losses, anxiety, and widespread fear, which may contribute to psychological distress, stress, and depression, thereby heightening the likelihood of committing IPF and AIPF. The pandemic restrictions also resulted in limited access to support and protection services, hindering victims from seeking help. Establishing a contingency plan for use in future crises (including pandemics) is imperative to promote support for victims and prevent situations of IPF and AIPF.

Evaluating and strengthening low-rise reinforced concrete buildings constructed in Nepal

In Nepal, the reinforced concrete (RC) frame system is commonly used to construct low-rise buildings. In last three decades, a significant number of such buildings were proportioned and constructed in accordance with Nepal National Building Code NBC 205:1994 and NBC 205:2012—also known as the Mandatory Rule of Thumb (MRT). In the aftermath of 2015 Gorkha Earthquake (Mw 7.8) which resulted in large scale social and economic losses, the efforts to formulate improved seismic design provisions led to the development of NBC 105:2020. Considering that MRT-designed low-rise RC frame buildings still constitute a significant part of existing building stock, this study is aimed to conduct a comparative seismic performance evaluation of several case study structures under a comprehensive set of ground motions. Using the nonlinear analysis and seismic fragility assessment of four low-rise RC frame buildings (designed using all three code versions), it is shown that the structural performance and seismic losses can be significantly reduced by following NBC 105:2020 provisions. Several retrofitting solutions are also explored to improve the seismic performance of buildings designed using MRT. It is shown that the concrete or steel jacketing of RC columns can significantly increase the lateral strength and energy dissipation, and reduce the damage probability of such buildings. Lastly, based on the developed results, a machine learning approach is employed to correlate the peak ground acceleration with structural drifts for convenient practical applications.

Education of Internally Displaced Children in the Context of the Health Crisis Linked to the COVID 19 Pandemic in the Zamai Cultural Universe

Objective: The aim of this article is to analyse compliance with barrier measures in the fight against the Covid 19 pandemic in a context where internally displaced school-age children under the weight of forced displacement as a result of conflict crises (Boko Haram) and natural disasters are also forced to comply with barrier measures linked to the fight against the Covid 19 or Zamai Coronavirus pandemic. Method: Qualitative data was collected using standard anthropological data collection techniques, including in-depth individual interviews and focus group discussions (FGDs). An interview guide and a discussion guide corresponding to each of the targets were used to collect qualitative data. Direct observation was used to collect data on the environment of the informants, their behaviour and attitudes, their level of knowledge about the education of displaced school-age children and Covid 19. Discussion: Impoverishment refers to the loss of natural capital, man-made material capital, human capital and social capital. Nine risks or processes are at the root of the impoverishment of displaced persons: not having land, not having a job, not having a house, marginalisation, food insecurity, increased morbidity and mortality, loss of access to public goods and services, fraying of the social fabric and loss of educational opportunities. Conclusion: In various towns in the Far North Region, in this case Zamai, concentration camps have been set up to house IDPs. Initially intended as short-stay camps, most of them are confined there, sometimes for long periods, in generally difficult living conditions.

Indicating landslide hazard from tree rings – Ecosystem service provided by an alder forest in the hengduan Mts, Sichuan, China

Landslides are destructive geomorphological processes that cause economic and social losses. This stimulates the development of new tools related to landslide hazard. Recently, trees, their growth rings and dendrochronology have become widely used in landslide studies. Thus, this study aims to explore the potential of trees in providing landslide-monitoring ecosystem services through dendrochronology. In our opinion, establishing such an idea would help promote empirical evidence on the efficiency of tree-ring-based tools to decision-makers. We use the example of a landslide in the Moxi basin, Sichuan, China and present results of dendrochronological analysis of growth eccentricity in 48 Nepalese alder (Alnus nepalensis) trees. This analysis provided data on event timing and magnitudes, average frequency and recurrence interval for reactivation of the study landslide, as well as spatial variability of landslide active. Based on dendrochronological data we were also able to determine the current slope balance and general hazard of landslide reactivation on the study slope. Our study shows that trees and dendrochronology can provide data on the activity of landslides that can complement and improve the results of standard engineering methods. Moreover, dendrochronology itself can provide the full information needed for landslide hazard assessment, monitoring and prediction.

STABILITY AND POTENTIAL OF COMMUNITIES IN THE CONDITIONS OF WAR: THREATS AND COUNTERMEASURES

Goal. In the conditions of war, the stability of the community becomes a decisive factor for its survival and further development. War exacerbates existing threats and creates new ones, requiring communities to rapidly adapt and develop resilience. The main goal of this article is to identify the key threats to communities in war conditions and to develop countermeasures. Method. A combination of quantitative and qualitative methods was used for the research, including case studies of local communities that have already faced military actions, as well as methods of comparative analysis, systemic-structural, generalization, economic-statistical, abstract-logical, monographic, methods of analysis and synthesis. The results. The invasion of the Russian army on the territory of Ukraine on February 24, 2022 caused terrible destruction, including the civil infrastructure of Ukraine. Significant damage to civil infrastructure has a negative impact on the functioning and development of the national economy, regions and communities. Russia's armed aggression today is also the main threat to the stability and security of the country in general and its regions and territorial communities in particular. This requires an immediate response at various levels of state administration and public activity. In addition to military action and political diplomatic pressure, an important aspect of countermeasures is economic stability. The stability of the economy, in particular, requires the strengthening of internal capacities capable of compensating for the economic and social losses that may arise as a result of military operations and require an understanding of countermeasures against threats. The main areas of sustainability are: Social cohesion: Threats: Division of communities, loss of trust, spread of fear and uncertainty. Countermeasures: Formation of mutual aid networks, provision of clear and truthful communication, organization of social events to preserve the community. Economic stability: Threats: Decrease in economic activity, increase in unemployment, drop in local budgets. Countermeasures: Creation of support funds for local enterprises, development of alternative sales channels, promotion of domestic and foreign investments. Psychological endurance: Threats: Spread of stress, injuries, mental disorders among the population. Countermeasures: Provision of psychological assistance, creation of specialized support centers, conducting trainings on psychological stability. Local self-government: Threats: Destruction of management infrastructure, loss of control over territories. Countermeasures: Development of local authorities, involvement of citizens in decision-making processes, creation of high-speed communication networks for communication between different levels of government. Scientific news. An analysis is made of how strategies to counter threats can be integrated into the daily functioning of the community and increase their recovery potential and resilience in the long term. Practical significance. The conclusions and suggestions of the article can be useful in optimizing community resources and developing strategies for their recovery and development in the post-war period.

Biofilm in Cochlear Implant: A Surgeon’s Diagnosis

Biofilms in a cochlear implant can lead to severe intracranial complications like meningitis, and it can cause implant failure, thus requiring an explant, leading to financial and social loss. Meticulous sterility in the intraoperative period and proper hygiene in the postoperative period need to be emphasized in a cochlear implant Patient. We report a case of a 4-year-old girl child who presented with recurrent episodes of wound dehiscence through the cochlear implant site following the asymptomatic period after a course of antibiotics, and finally treated with debridement and flap reconstruction under general anaesthesia. We sought to use novel agents with antimicrobial activity in addition to debridement, vascularized soft tissue cover, and oral rifampicin after surgery. The child underwent serial surgeries, and finally, the use of medical grade Manuka honey and rifampicin demonstrated a successful response to biofilm up to a two-month follow-up period. This case revealed that biofilm is primarily a surgeon’s diagnosis.

Review of anatomical and histological alterations in the brain of patients with autism

Autism spectrum disorder is a developmental illness which interferes with communication and behavior. autism can be detected at any age but symptoms become clinically evident in the first 2 years of life. The main symptoms are associated with social communication, interaction, monotonus actions and loss of enjoyment in objects and events. In addition it is linked to other psychological disorder like attention-deficit hyperactivity and epilepsy in the early years of life. Early diagnosis of the disorder with successive interference is very helpful to refine verbal outcomes and upgrade critical symptoms. Nowadays it is evident the neuroanatomical involvement in this disorder in early childhood and teenage groups like the cortical tissue of frontal, temporal and parietal lobes, amygdala and hippocampus, in the inferior cerebellar vermis and left cerebellar lobule. In conclusion: Autism is a neurodevelopmental disorder which characterized by diminished communication skills, behavioral disturbances and cognitive impairment issues which definitely associated with neuroanatomical and microstructural changes in the brain cortex. In addition to genetic role in its etiology.

Metaverse: Virtual Currencies as a Mechanism for Employee Engagement and Retention

Virtual currencies, including cryptocurrencies and non-fungible tokens (NFT’s), are increasingly used as rewards in virtual environments. Traditional reward systems have been effective in improving employee satisfaction and retention but with the shift to hybrid or remote work post-COVID-19, organisations need adapted reward systems. However, the problem of this research is that it’s unclear how virtual currencies can be effectively utilised as a reward system, in the Metaverse, and their impact on employee motivation and engagement. This study explores this by reviewing literature, analysing reward mechanisms, and proposing a conceptual model to evaluate the feasibility of such a reward system. The study considers factors like social comparison and loss aversion as well as rewards known to boost motivation and engagement. The flexibility of virtual currencies for conversion or exchange into rewards offers numerous possibilities, with specific reward choices left to organisations’ discretion. This study offers promise to organisations seeking to retain and motivate their employees, ultimately contributing to increased productivity. In turn, employees can benefit from improved job satisfaction and reduced work-related pressures. The study’s conclusion assesses the usefulness of this research and outlines potential areas for future research.

Impact of Forest and Land Fires on Environmental Pollution and Public Health in Sungai Raya Sub-District, Kubu Raya District

Forest and land fires in Sungai Raya District, Kubu Raya Regency, severely impact environmental pollution and public health. This condition causes quite significant ecological and social losses. First, the smoke produced from these fires contains various dangerous substances, such as carbon monoxide, dust particles, and toxic chemicals. Continuous exposure to these substances can cause respiratory problems, respiratory tract diseases, and other health problems in local communities. Apart from that, forest fires also result in the loss of natural habitat for various species of flora and fauna. Disrupted ecosystems can cause biodiversity loss and affect local food chains. Recovery of fire-affected ecosystems takes a long time, and some species may experience local extinction due to habitat loss. Furthermore, preventing and responding to forest fires requires significant resources in terms of personnel and equipment. Funds allocated for firefighting can disrupt local government budgets that should be used for infrastructure development and community welfare programs. Therefore, forest fires harm the environment and health and impose an economic burden on the people of Sungai Raya District. Efforts to prevent forest and land fires and educate the public regarding the risks of prevention are essential to overcome these negative impacts. Sustainable measures such as law enforcement against illegal forest burning, sustainable land management, and increasing public awareness of the importance of preserving the environment can help reduce fire risks and protect public health.

The Influence of Comic Media Education “SIMEBA” (Siap Menghadapi Banjir) on the Self-Efficacy Level of Flood Disaster Preparedness Among Mts Muhammadiyah Sirau Students in 2023

Background: Floods cause various kinds of losses in the form of property losses and social losses. Floods in Sirau Village routinely occur every year because of the village's geographical location which is concave, but the community is always not ready to make any preparations if a flood occurs, such as planning evacuation locations, carrying out evacuation simulation exercises, not preparing a first aid box or preparing a special place to store archives. important. People need to have good self-efficacy and knowledge to overcome problems in order to avoid their impacts. Method: This research used a pre-experimental design with one group pretest-posttest. The sample was 46 respondents using proportional random sampling technique. Then the Wilcoxon test is used for statistical tests. This research instrument uses a questionnaire to collect data, and comic media as an educational intervention. Results: This research shows that the majority of respondents received a good category after the intervention with a Self Efficacy level of 73.9%. The p value obtained from the Wilcoxon test is 0.00 < 0.05. This means that there is a significant influence on the level of self-ability on preparedness for flood disasters. Conclusion: Good Self Efficacy will influence the Respondent's abilities and skills in managing or dealing with uncontrollable situations such as disasters.

Economic Policy of Renewable Energy Adoption, Economic Policy of Digital Technology, Human Resource Management, Business Decision

Energy fluctuations and global economic directly hit Indian Subcontinent (Geopolitically, it generally includes the countries of Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan and Sri Lanka) economy and social welfare, which are the net importer of energy sources. This study investigates the relationship between strategic petroleum reserve and welfare losses for Indian Subcontinent. The breakdown of crude oil energy supply has a significant impact on energy security & welfare losses. Oil supply security was quantified in terms of the Indian Subcontinent's oil vulnerability index (which accounts for 84 percent of global oil imports), and welfare losses based on oil supply disruption were calculated. Afghanistan is the most susceptible country in the Indian Subcontinent in terms of energy reserves, as per the composite index results, whereas India is the lowest vulnerable. Empirical findings pointed to a 30% deficit of oil supply as the cause of the most volatile pattern of oil pricing, which exacerbates the estimated welfare loss by a 40% drop in GDP, which is around $700 in the Indian Subcontinent & $9000 in the top oil-consuming countries. According to this analysis, the Indian Subcontinent should keep at least a hundred days' worth of strategic oil resources to avert social and economic losses due to oil price fluctuations.

Economic value of diastasis repair with the use of mesh compared to no intervention in Italy

AimRectus abdominal diastasis (RAD) can cause mainly incontinence and lower-back pain. Despite its high incidence, there is no consensus regarding surgical indication. We aimed at comparing RAD repair (minimally invasive technique with mesh implant) with no treatment (standard of care – SOC) through cost-effectiveness and budget impact analyses from both National Healthcare Service (NHS) and societal perspectives in Italy.MethodsA model was developed including social costs and productivity losses derived by the online administration of a socio-economic questionnaire, including the EuroQol for the assessment of quality of life. Costs for the NHS were based on reimbursement tariffs.ResultsOver a lifetime horizon, estimated costs were 64,115€ for SOC and 46,541€ for RAD repair in the societal perspective; QALYs were 19.55 and 25.75 for the two groups, respectively. Considering the NHS perspective, RAD repair showed an additional cost per patient of 5,104€ compared to SOC, leading to an ICUR of 824€. RAD repair may be either cost-saving or cost-effective compared to SOC depending on the perspective considered. Considering a current scenario of 100% SOC, an increased diffusion of RAD repair from 2 to 10% in the next 5 years would lead to an incremental cost of 184,147,624€ for the whole society (87% borne by the NHS) and to incremental 16,155 QALYs.ConclusionIn light of the lack of economic evaluations for minimally invasive RAD repair, the present study provides relevant clinical and economic evidence to help improving the decision-making process and allocating scarce resources between competing ends.

Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

BackgroundEpisodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain unclear. Therefore, further investigation is necessary.MethodsWe investigated the effects of AD-like tau pathology by Tandem mass tag proteomic and phosphoproteomic analysis, social behavioural tests, hippocampal electrophysiology, immunofluorescence staining and in vivo optical fibre recording of GCaMP6f and iGABASnFR. Additionally, we utilized optogenetics and administered ursolic acid (UA) via oral gavage to examine the effects of these agents on social memory in mice.ResultsThe results of proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1 (vCA1) under both physiological conditions and AD-like tau pathology. As tau progressively accumulated, vCA1, especially its excitatory and parvalbumin (PV) neurons, were fully filled with mislocated and phosphorylated tau (p-Tau). This finding was not observed for dorsal hippocampal CA1 (dCA1). The overexpression of human tau (hTau) in excitatory and PV neurons mimicked AD-like tau accumulation, significantly inhibited neuronal excitability and suppressed distinct discrimination-associated firings of these neurons within vCA1. Photoactivating excitatory and PV neurons in vCA1 at specific rhythms and time windows efficiently ameliorated tau-impaired social memory. Notably, 1 month of UA administration efficiently decreased tau accumulation via autophagy in a transcription factor EB (TFEB)-dependent manner and restored the vCA1 microcircuit to ameliorate tau-impaired social memory.ConclusionThis study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau accumulation. Notably, our novel findings regarding the efficacy of UA in reducing tau load and targeting the vCA1 microcircuit may provide a promising strategy for treating AD in the future.