Abstract Background: Cervical cancer is still a major threat in the Caribbean region. Stigma may be a contributor to low screening and HPV vaccination practices, but it has been understudied in the region. The study aims to assess stigma among a Caribbean non- patient population in Jamaica, Grenada and Trinidad and Tobago. Methods: A cross-sectional study involving 1207 participants was conducted using a trans-created Cancer Stigma Scale for the Caribbean context and additional measures on cervical cancer and HPV vaccine knowledge and beliefs were added. Cancer stigma was assessed across six sub-domains Severity, Personal Responsibility, Awkwardness, Avoidance, Policy Opposition and Financial Discrimination. The data were collected online between October 2022 and March 2023. Descriptive statistics for characteristics of socio- demographic and variables associated with cancer stigma were run. ANOVA tests compared factor scores with multi categorised variables using SPSS. Results: Levels of cancer stigma were low but varied across the six domains with the severity domain showing high scores (40.1%-77.4%). The majority of the participants disagreed with banks refusing to give loans to people with cancer (85.1%). Under policy opposition (93.0%) agreed that more government funding should be spent on cancer care and treatment. Social rejection was significantly higher in Grenada when compared to both Jamaica and Trinidad and Tobago. More than a third of the participants (35.6%) agreed that the fear of family reaction and rejection may discourage women from getting a further diagnosis after an abnormal Pap smear. Younger participants showed less stigma than older participants. Those aged 18-25 also differed from those aged 26-35 and 56-65 for the factors of Policy Opposition and Severity respectively. In all cases the older age group had higher mean scores. Social impact factors of shame and social rejection are predictors of cancer stigma with p < 0.001 and p = 0.050 respectively. Married/cohabiting individuals had more negative responses than divorced persons across all three factors of Shame, Social Rejection and Social Isolation. The majority of our participants were female 81.4% and fell between the ages of 18-35 years (56.8%). Discussion: Cancer stigma is understudied in the Americas. Our results show that cancer stigma varies by several important factors including stigma domain, and participant demographics e.g. age and gender. The findings indicate that interventions and educational efforts targeting cancer stigma ought to be included in cancer prevention and control efforts. Targeted evidenced-based strategies for reducing stigma include featuring cancer survivors especially prominent survivors like celebrities, and employing mass media public health campaigns. A reduction in cancer stigma may lead to increased prevention, screening, and treatment of cervical cancer. Citation Format: Diadrey-Anne Sealy, Kamilah Thomas- Purcell, Althea Bailey, Gaole Song, Kimlin Ashing. Cervical cancer stigma in the Caribbean: Implications for prevention [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B113.
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