Small Spot Size Research Articles

An indirect geometry crystal time-of-flight spectrometer for FRM II

We present a concept for an indirect geometry crystal time-of-flight spectrometer, which we propose for a source similar to the FRM-II reactor in Garching. Recently, crystal analyzer spectrometers at modern spallation sources have been proposed and are under construction. The secondary spectrometers of these instruments are evolutions of the flat cone multi-analyzer for three-axis spectrometers (TAS). The instruments will provide exceptional reciprocal space coverage and intensity to map out the excitation landscape in novel materials. We will discuss the benefits of combining a time-of-flight primary spectrometer with a large crystal analyzer spectrometer at a continuous neutron source. The dynamical range can be very flexibly matched to the requirements of the experiment without sacrificing the neutron intensity. At the same time, the chopper system allows a quasi-continuous variation of the initial energy resolution. The neutron delivery system of the proposed instrument is based on the novel nested mirror optics, which images neutrons from the position of the pulse cutting chopper representing a bright virtual source onto the sample. The spot size of less than 1 cm × 1 cm at the virtual source allows the realization of very short neutron pulses by the choppers, while the small and well-defined spot size at the sample position provides an excellent energy resolution of the secondary spectrometer.

Design of subsurface defect detection system based on two channels

With the continuous improvement of quality requirements for optical components, the detection of subsurface defects in optical components has become a key technology. However, there is a problem with existing detection techniques, which is that they cannot simultaneously and independently detect subsurface defects at the micrometer and nanometer levels. This article analyzes the scattering field model of subsurface scratches and conducts simulation experiments on the relationship between scattering light intensity and system aperture. Based on the simulation results, a dual channel experimental system with adjustable spot size was designed to achieve automated measurement of subsurface defects. The narrow channel was used to detect micrometer-level subsurface defects and the wide channel was used to detect nanometer-level subsurface defects. The experimental results verified the correctness of the simulation experiment. In order to improve the sensitivity of the system, we designed an aperture based on the scattering field distribution of surface and subsurface defects, which is used to block the interference signal on the sample surface and improve the signal-to-noise ratio of the subsurface defect signal. The experimental results show that this aperture plays an important role, and the detection sensitivity of the system reaches 100 nm. We used four algorithms for data processing and found that the IQR algorithm is most suitable for this system. Finally, the detection results were compared under different spot sizes, and it was found that small spot sizes have better detection effects on nanoscale subsurface defects. In practice, the spot size can be dynamically adjusted according to the detection needs to achieve the optimal configuration of detection speed and sensitivity.

Influences of Different Selective Laser Melting Machines on the Microstructures and Mechanical Properties of Co–Cr–Mo Alloys

Dental prostheses have been fabricated using various selective laser melting (SLM) machines; however, the impact of the type of machine on the microstructure and mechanical properties of Co–Cr–Mo alloys remains unclear. In this study, we prepared samples using two SLM machines (the small M100 and mid-sized M290) with different beam spot sizes (40 and 100 µm, respectively). The microstructures and tensile properties of the heated (1150 °C for 60 min) and as-built samples were evaluated. The grain sizes of the M100 samples were smaller than those of the M290 samples due to the small beam spot size of the M100 machine. Both heated samples exhibited recrystallized equiaxed grains; however, the amount of non-recrystallized grains remaining in the M290 sample exceeded that in the M100 sample. This suggests that the M100 samples recrystallized faster than the M290 samples after heating. The elongation of the M100 samples was higher than that of the M290 samples in the as-built and heated states, owing to the smaller grain size of the M100 samples. A comparison of the M100 and M290 SLM machines indicated that the M100 was suitable for producing dental prostheses owing to its good elongation and rapid recrystallization features, which shorten its post-heat-treatment duration.

Large focal length planar focusing of Dyakonov polaritons in hyperbolic metamaterial

Achieving subwavelength optical focusing is of great importance in nanophotonics. However, achieving focusing with both a small focal spot size and a large focal length remains elusive so far. Here, a large focal length planar focusing device is presented, utilizing highly oriented Dyakonov polaritons in hyperbolic metamaterial with periodic silver rings as the excitation source. Experimental results show that by controlling the size of the excitation sources, the focal length can reach 6λ0 (where λ0 is the illumination wavelength), and the focal spot size can be reduced to λ0/10. This method provides new prospects for planar polariton optical applications.

Tissue characterization using axicon probe-assisted common-path optical coherence tomography

In this work, a common-path optical coherence tomography (OCT) system is demonstrated for characterizing the tissue in terms of some optical properties. A negative axicon structure chemically etched inside the fiber tip is employed as optical probe in the OCT. This probe generates a quality Bessel beam owning a large depth-of-field, ∼700 µm and small central spot size, ∼3 µm. The OCT system is probing the sample without using any microscopic lens. For experimental validation, the OCT imaging of chicken tissue has been obtained along with estimation of its refractive index and optical attenuation coefficient. Afterwards, the cancerous tissue is differentiated from the normal tissue based on the OCT imaging, refractive index, and optical attenuation coefficient. The respective tissue samples are collected from the human liver and pancreas. This probe could be a useful tool for endoscopic or minimal-invasive inspection of malignancy inside the tissue either at early-stage or during surgery.

Cyclotron and linear accelerator generated scanning proton beams for lung cancer SBRT: Interplay effects and mitigations.

Pencil beam scanning (PBS) proton therapy for moving targets is known to be impacted by interplay effects between the scanning beam and organ motion. While respiratory motion in the thoracic region is the major cause for organ motion, interplay effects depend on the delivery characteristics of proton accelerators. To evaluate the impact of different types of PBS proton accelerators and spot sizes on interplay effects, mitigations, and plan quality for Stereotactic Body Radiation Therapy (SBRT) treatment of non-small cell lung cancer (NSCLC). Twenty NSCLC patients treated with photon SBRT were selected to represent varying tumor volumes and respiratory motion amplitudes (median: 0.6cm with abdominal compression) for this retrospective study. For each patient, plans were created using: (1) cyclotron-generated proton beams (CPB) with spot sizes of σ=2.7-7.0mm; (2) linear accelerator proton beams (LPB) (σ=2.9-5.5mm); and (3) linear accelerator proton minibeams (LPMB) (σ=0.9-3.9mm). The energy switching time is one second for CPB, and 0.005 s for LPMB and LPB. Plans were robustly optimized on the gross tumor volume (GTV) using each individual phase of four-dimensional computed tomography (4DCT) scans. Initially, single-field optimization (SFO) plans were evaluated; if the plan quality did not meet the dosimetric requirement, multi-field optimization (MFO) was used. MFO plans were created for all patients for comparisons. For each patient, all plans were normalized to have the same dose received by 99% of the GTV. Interplay effects were evaluated by computing the dose on 10 breathing phases, based on the spot distribution. Volumetric repainting (VR) was performed 2-6 times for each plan. We compared volume receiving 100% of the prescribed dose (V100%RX) of the GTV, and normal lung V20Gy. Twelve of 20 plans can be optimized sufficiently with SFO. SFO plans were less sensitive to the interplay effect compared to MFO plans in terms of target coverage for both LPB and LPMB. The following comparisons showed results utilizing the MFO technique. In the interplay evaluation without repainting, the mean V100%RX of the GTV were 99.42±0.6%, 97.52±3.9%, and 94.49±7.3% for CPB, LPB, and LPMB plans, respectively. Following VR (2 × for CPB; 3 × for LPB; 5 × for LPMB), V100%RX of the GTV were improved (on average) by 0.13%, 1.84%, and 4.63%, respectively, achieving the acceptance criteria of V100%RX>95%. Because of fast energy switch in linear accelerator proton machines, the delivery time for VR plans was the lowest for LPB plans, while delivery time for LPMB was on average 1 min longer than CPB plans. The advantage of small spot machines was better sparing in normal lung V20Gy, even when VR was applied. In the absence of repainting, proton machines with large spot sizes generated more robust plans against interplay effects. The number of VR increased with decreasing spot sizes to achieve the acceptance criteria. VR improved the plan robustness against interplay effects for modalities with small spot sizes and fast energy changes, preserving the low dose sparing aspect of the LPMB, even when motion is included.

Influence of Grid Aperture Ratio on Electron Transmittance and Electron Beam Spot Size in Field Emission Processes of Carbon Nanotubes

Field emission is an important work mode for electron sources, and carbon nanotubes (CNTs) have been extensively studied for their good emission properties. It is well known that the parameters of the grid deeply influence the field emission performance of CNTs, a relationship that requires further elucidation. Therefore, in this study, the relationship between the grid aperture ratio and electron transmittance was studied through simulations and experiments. This study’s results indicate that the electron transmittance improved as the grid aperture ratio increased. Meanwhile, electron beam spot simulations and imaging experiments indicate that an increased grid aperture ratio will expand the cathode electron divergence, leading to a larger electron beam spot size. These results demonstrate that there is a trade-off in maintaining the grid aperture ratio between high electron transmittance and relatively small electron beam spot size, and the optimum grid aperture ratio is between 75% and 85%. These results will provide a reference for the design and optimization of X-ray tubes and other electron sources.

Geant4 Simulation of Scatter Radiation Removal: Comparison and Validation of Anti-scatter Grid and Air Gap for X-ray Mammography

Abstract: X-ray mammography modality provides excellent low-contrast resolution images with low scatter radiation, making it the gold standard in diagnosing breast cancer. Anti-scatter grid and air gap techniques are typically used to further minimize the scatter radiation and improve image quality. Thus, Geant4 simulation was used to investigate the effectiveness of these techniques in removing scatter radiation in X-ray mammography. The effectiveness of an anti-scatter grid was evaluated using the Bucky factor, where it linearly increased with increasing the anti-scatter grid ratio. It was found that increasing the grid frequency affects the Bucky factor depending on the design of the grid ratio. This research proved that designing an anti-scatter grid with high grid frequency (80 lp/mm), low grid ratio (2:1), and proper orientation minimized common anti-scatter grid artifacts. The effectiveness of the air gap technique was also evaluated using the air gap dose factor. It increased non-linearly with increasing magnification. This research validated that using smaller pixel sizes and small focal spot sizes improved spatial resolution with magnification. Our simulation validated that the anti-scatter grid and air gap were effective techniques in removing scatter radiation. By comparing these techniques, the anti-scatter grid was more effective in removing scatter radiation at the expense of increasing the radiation absorbed dose with the exception of 2.0 magnification. It’s recommended to be extremely cautious when using 2.0 magnification or a grid ratio higher or equal to 8:1. These parameters may cause the radiation absorbed dose to be increased by several folds. Keywords: Geant4, Gate, X-ray mammography, Scatter removal, Anti-scatter grid, Air gap.

Process parameter optimization for laser directed energy deposition (LDED) of Ti6Al4V using single-track experiments with small laser spot size

Single-track experiments are routinely used in the optimization of process parameters in additive manufacturing processes. Most of the process parameter optimization studies use a laser spot size of 1 mm or more. Since laser spot size affects the input energy density and in turn the efficiency of the deposition process, it is important to develop process maps every time a laser of different spot sizes is used. In this work, we determine the process maps for a laser of 0.6 mm spot size. By combining the process maps and the metallographic inspection, we estimate the optimum process parameters (laser power, scan speed, powder feed rate) for building Ti6Al4V components using powder-based laser-directed energy deposition(LDED). Single-tracks corresponding to 64 different parameter combinations are deposited. After eliminating the process parameter combinations resulting in defective tracks, the optimum process parameters of 300 W laser power and 720 mm min−1 scan speed is established by considering the relationship between the process parameters and the geometrical features of the deposit. The experimental results are then used to calibrate the modeling parameters of a three-dimensional finite element model for simulating the deposition process.

Single high-energy arc proton therapy with Bragg peak boost (SHARP).

Because of the co-location of critical organs at risk, base of skull tumours require steep dose gradients to achieve the prescribed dosimetric criteria. When available, proton beam therapy (PBT) is often considered a desirable modality for these cases, but in many instances, compromises in target coverage are still required to achieve critical organ at risk (OAR) tolerance doses. A number of techniques have been proposed to further improve the penumbra of PBT. In the current study, we propose a novel, collimator-free treatment planning technique that combines high-energy shoot-through proton beams with conventional Bragg peak spot placement. The small spot size of the high-energy pencil beams provides a sharp penumbra at the target boundary, and the Bragg peak spots provide a higher linear energy transfer (LET) boost to the target centre. Three base of skull chordoma patients were retrospectively planned with three different PBT treatment planning techniques: (1) conventional intensity-modulated proton therapy (IMPT); (2) high-energy proton arc therapy (HE-PAT); and (3) the novel technique combining HE-PAT and IMPT, referred to as single high-energy arc with Bragg peak boost (SHARP). The Monaco 6 treatment planning system was used. SHARP was found to improve the PBT penumbra in the plane perpendicular to the HE-PAT beams. Minimal penumbra differences were observed in the plane of the HE-PAT beams. SHARP reduced dose-averaged LET to surrounding organs at risk. A novel PBT treatment planning technique was successfully implemented. Initial results indicate the potential for SHARP to improve the penumbra of PBT treatments for base of skull tumours.

Frequency tripled semiconductor disk laser with over 0.5 W ultraviolet output power.

Semiconductor disk lasers can produce high output power and good beam quality simultaneously. The high intracavity circulating power of about hundreds of watts, along with the flexibility of tailorable emitting wavelengths, make it an attractive light source for obtaining ultraviolet (UV) radiation from near-infrared lasers through nonlinear frequency conversion. This work reports a frequency tripled 327 nm semiconductor disk laser with record output power and wavelength tuning range by using a type-I phase-matched LiB3O5 (LBO) crystal and a type-I phase-matched β-BaB2O4 (BBO) crystal as the frequency-doubling and -tripling crystals respectively. Thanks to the obviously larger nonlinear coefficient of the type-I phase-matched BBO compared to the commonly used type-II phase-matched LBO, as well as the small spot size specifically designed at the crystal location, the maximum output power of UV lasers reaches 538 mW, corresponding to an optical-to-optical conversion efficiency from pump to UV laser of about 1.14%. A wavelength tuning range of about 8.6 nm and good power stability with a standard deviation of about 0.94 are also achieved.

On the effect of small laser spot size on the mechanical behaviour of 316L stainless steel fabricated by L-PBF additive manufacturing

This research effort experimentally investigated the influence of small laser spot size (LSS – 50 µm and 100 µm) on the mechanical behaviour of additively manufactured 316 L Stainless Steel (SS) samples produced by laser-powder bed fusion on a single metal 3D printer. The effect of main process parameters including scanning speed (1400, 1700 and 2000 mm/min), layer thickness (30, 55, and 80 µm), build direction (0°, 15° and 30°, 90 ° or flat) and printing power (100, 200, and 350 W) was analysed. Tensile tests together with scanning electron microscopy were carried out to determine the mechanical behaviour and fractography pattern of the parts produced with different parameters. When changing the build direction, the results led to a nearly isotropic mechanical behaviour in combination with the manufacturing equipment. By employing small laser sport size, the melt pool depth was increased, which in turn led to an enhancement in the mechanical performance of the fabricated 316L SS. Printed specimens displayed ultimate tensile strength values of 165–550 MPa (LSS of 50 µm) and 147–519 MPa (LSS of 100 µm), yield strengths of 137–402 MPa (LSS of 50 µm) and 120–385 MPa (LSS of 100 µm), with an elongation at break of 5–64%.

Novel 40 µm spot size 3050/3200 nm DFG laser versus CO2 laser for laser-assisted drug delivery.

The use of ablative fractional lasers to enhance the delivery of topical drugs through the skin is known as laser-assisted drug delivery. Here, we compare a novel 3050/3200 nm difference frequency generation (DFG) fiber laser (spot size: 40 µm) to a commercially used CO2 laser (spot size: 120 µm). The objective is to determine whether differences in spot size and coagulation zone (CZ) thickness influence drug uptake. Fractional ablation was performed on ex-vivo human abdominal skin with the DFG (5 mJ) and CO2 (12 mJ) lasers to generate 680 µm deep lesions. To evaluate drug delivery, 30 kDa encapsulated fluorescent dye was topically applied to the skin and histologically analyzed at skin depths of 100, 140, 200, 400, and 600 µm. Additionally, transcutaneous permeation of encapsulated and 350 Da nonencapsulated dye was assessed using Franz Cells. The DFG laser generated smaller channels (diameter: 56.5 µm) with thinner CZs (thickness: 22.4 µm) than the CO2 laser (diameter: 75.9 µm, thickness: 66.8 µm). The DFG laser treated group exhibited significantly higher encapsulated dye total fluorescence intensities after 3 h compared to the CO2 laser treated group across all skin depths (p < 0.001). Permeation of nonencapsulated dye was also higher in the DFG laser treated group vs the CO2 laser treated group after 48 h (p < 0.0001), while encapsulated dye was not detected in any group. The DFG laser treated skin exhibited significantly higher total fluorescence uptake compared to the CO2 laser. Additionally, the smaller spot size and thinner CZ of the DFG laser could result in faster wound healing and reduced adverse effects while delivering similar or greater amount of topically applied drugs.

Femtosecond reductive Laser Sintering under multiple focus conditions for rapid production of conductive copper layers

Reductive laser sintering is an advantageous alternative to conventional precious metal- or mask-based processes for the electrification of polymers and has been demonstrated in a variety of sensor applications. Ultrashort pulsed lasers promise precise control of the energy applied during sintering and ablation. Besides fine tracks, microelectronic circuits include wide contact pads, which leads to time-consuming processing with small laser spot sizes. The use of larger focal diameters, which results in wider lines and thus a higher metallization rate, is accompanied by a loss of structure resolution. We show the influence of focusing on the femtosecond reductive laser sintering of copper(II) oxide on cyclic olefin copolymers. While small focus diameters down to 23 µm provide high accuracy, increasing the laser power and the focus diameter up to 400 µm significantly accelerates the process, first by enlarging the line width and second by increasing the scanning speed due to the exposure time. Two-dimensional copper electrodes for 23 µm and 200 µm focal diameters were generated by hatching individual lines and compared with respect to their morphology. The enlarged spot can be used for high-speed generation of electrodes with a surface conductivity of 117 mΩ/sq. Hybrid processes with production under combined focusing conditions are presented for the first time.

Effect of Focal Spot Size on AlSi10Mg Alloy Parts Fabricated by Laser Powder Bed Fusion: Process Window, Mechanical Properties, and Microstructure

This study investigated the effect of the laser focal spot size on the process window, part properties, and microstructure of an AlSi10Mg alloy fabricated via the laser powder bed fusion (LPBF) process. In LPBF, process windows of different spot sizes (60 μm and 120 μm) were established to fabricate dense AlSi10Mg parts with an excellent density of 99.96% using optimal process parameters. The tensile results indicated that parts made using a large spot size had greater ductility because their coarse grain structure with an average grain size of 41 μm, as measured by the electron backscattered diffraction (EBSD) technique, reduced the resistance of dislocation movement, thus enhancing their elongation. In contrast, parts made using a small spot size had stronger yield strength because their finer grains with an average grain size of 14.6 μm enhanced their strength. The differences in their grain structures were attributed to their different cooling rates. In addition, X-ray diffraction (XRD) analysis showed a slight shift towards a lower diffraction angle at the Al-(200) peak of the parts fabricated using a smaller spot size owing to its finer grains. Moreover, the LPBF-fabricated parts using a large spot size of 120 μm exhibited a smoother surface roughness with a Sa value of 1.69 μm compared to those parts with a Sa value of 4.36 μm using a small spot size.

Ultrashort pulse ablation of printed circuit board materials using a Bessel beam

In times of digitalization, multilayer composite materials became central components in an increasing number of application fields. Thus, there is a need for optimization of the cost-intensive and time-consuming processing of multilayer composites. In this contribution, an ultrashort pulse laser-based method is presented for precise and flexible ablation of a printed circuit board base material. Therefore, an 800 nm Gaussian laser beam was transformed into a Bessel beam by an axicon to get a small spot size and an ablation result with a high aspect ratio. The influence of the average laser power, the number of exposure cycles, and the pulse duration on the geometry as well as the surface quality of ablated structures was investigated and compared to Gaussian beam ablation. Furthermore, it is shown that the results can be transferred to microdrilling processes. With the presented method, it was possible to ablate the copper top layer of the printed circuit boards as well as the FR4 layer below with a precisely adjustable depth.

Proof-of-concept for a thin conical X-ray target optimized for intensity and directionality for use in a carbon nanotube-based compact X-ray tube.

Carbon nanotube-based cold cathode technology has revolutionized the miniaturization of X-ray tubes. However, current applications of these devices required optimization for large, uniform fields with low intensity. This work investigated the feasibility and radiological characteristics of a novel conical X-ray target optimized for high intensity and high directionality to be used in a compact X-ray tube. The proposed device uses an ultrathin, conical tungsten-diamond target that exhibits significant heat loading while maintaining a small focal spot size and promoting forward-directedness of the X-ray field through preferential attenuation of oblique-angled photons. The electrostatic and thermal properties of the theoretical tube were calculated and analyzed using COMSOL Multiphysics software. The production, transport, and calculation of radiological properties associated with the resultant X-ray field were performed using the Geant4 toolkit via its wrapper, TOPAS. Heat transfer analysis of this X-ray tube demonstrated the feasibility of a 200-kV electron beam bombarding the proposed target at a maximum current of 100mA using a 1-ms symmetric duty cycle. The cathode of the X-ray tube was designed to be segmented into nine switchable electrical segments for modulation of the focal spot size from 0.4- to 10.8-mm. After importing the COMSOL-derived electron beam into TOPAS for X-ray production simulations, radiological analysis of the resultant field demonstrated high levels of intrinsic beam collimation while maintaining high intensity. A maximum dose rate of 17,887 cGy/min was calculated for 1-mm depth in water at 7-cm distance. The proposed X-ray tube design can create highly directional X-ray fields with superior fluence compared to that of current commercial X-ray tubes of comparable size.

Experimental analysis of overlap fiber laser welding for aluminum alloys: Porosity recognition and quality inspection

In recent years, laser welding has become increasingly popular in the manufacturing industry due to its advantages, including a narrow heat affected zone, low levels of distortion, the possibility of remote processing, and high welding speeds compared to conventional electric arc welding techniques. In the automotive industry, the need for overlapped joint welding, particularly for chassis assembly, has become increasingly relevant. The internal porosity detection and control in laser welding of aluminum alloys has gained significant attention. To support laser users in optimizing the welding process, this paper presents an experimental methodology followed by a phenomenological analysis of the quality of overlapped welded joints. The study focuses on the laser welding of two different aluminum alloy configurations (1.6-mm-thick AA 6061-T6 and 2-mm-thick AA 6061-T6) using three welding strategies (ScanLab remote laser welding system, Trumpf D70 laser head, and Precitec YW52 wobbling head) to evaluate single and multiple laser variants for process parameter tuning. Additionally, the paper discusses the use of X-ray technology as an offline monitoring method for porosity recognition, and analyzes laser beam characterization and beam profile shape to calculate beam distribution. Then, statistical analysis of all methods is conducted and regression analysis is performed. These findings provide valuable insights into the integration of laser welding technology in the automotive and surface transportation industries. The analysis of results indicates that as the spot size decreases, the real spot size changes more abruptly with increasing Z position, whereas with a larger spot size, the beam size remains stable up to +/- 20–30 mm in Z position due to the large lens. Porosity is mainly caused by either a too small spot size (in the absence of wobbling; ≤0.4 mm) or low travel speed (≤4.0–4.5 m/min). On the other hand, if the spot size is too large, hot cracking can occur in autogenous laser welding.

A field‐based evaluation of portable XRF to screen for toxic metals in seafood products

AbstractPortable X‐Ray Fluorescence (XRF) has become increasingly popular where traditional laboratory methods are either impractical, time consuming, and/or too costly. While the Limit of Detection (LOD) is generally poorer for XRF compared to laboratory‐based methods, recent advances have improved XRF LODs and increased its potential for field‐based studies. Portable XRF can be used to screen food products for toxic elements such as lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), manganese, (Mn), zinc (Zn), and strontium (Sr). In this study, 23 seafood samples were analyzed using portable XRF in a home setting. After XRF measurements were completed in each home, the same samples were transferred to the laboratory for re‐analysis using microwave‐assisted digestion and Inductively Coupled Plasma Tandem Mass Spectrometry (ICP‐MS/MS). Four elements (Mn, Sr, As, and Zn) were quantifiable by XRF in most samples, and those results were compared to those obtained by ICP‐MS/MS. Agreement was judged reasonable for Mn, Sr, and As, but not for Zn. Discrepancies could be due to (1) the limited time available to prepare field samples for XRF, (2) the heterogeneous nature of “real samples” analyzed by XRF, and (3) the small beam spot size (~1 mm) of the XRF analyzer. Portable XRF is a cost‐effective screening tool for public health investigations involving exposure to toxic metals. It is important for practitioners untrained in XRF spectrometry to (1) recognize the limitations of portable instrumentation, (2) include validation data for each specific analyte(s) measured, and (3) ensure personnel have some training in sample preparation techniques for field‐based XRF analyses.

The Interplay Effect and Mitigations with Cyclotron and Linac Proton Beam Scanning for Lung SBRT

To evaluate the impact of different types of pencil beam scanning proton accelerators and spot sizes on interplay effects, mitigations, and plan quality for lung cancer patients treated with SBRT. Twenty lung cancer patients (ten peripheral and ten central tumors) treated in our institution with photon SBRT were selected to represent varying tumor volumes and respiratory motion amplitudes for this retrospective study. The respiratory motion amplitude ranged from 0.1 to 1.0 cm with compression. For each patient, plans were created using: 1) cyclotron-generated proton beams (CPB) (σ: 2.7-7.0 mm); 2) linear accelerator proton beams (LPB) (σ: 2.9-5.5 mm); and 3) linear accelerator proton minibeams (LPMB) (σ: 0.9-3.9 mm). Plans were robustly optimized on the GTV using each individual 4DCT phase. Single-filed optimization (SFO) plans were the first attempt, and if the plan quality did not meet the dosimetric requirement, multi-field optimization (MFO) was used. MFO plans were created for all patients for comparison. For each patient, all plans were normalized to have the same dose to 99% of the GTV. Interplay effects were evaluated for ten scenarios of treatment delivery starting in ten breathing phases using machine generic time models and a constant breathing period of 4 seconds. Volumetric repainting (VR) was performed 2-6 times for each plan. To assess plan quality in the nominal scenario, we compared the conformity index (CI), R50, and the percentage of lung volume receiving 20 Gy (RBE) (V20Gy). CI is defined as the ratio of the 100% isodose volume to the GTV. R50 is defined as the 50% isodose volume divided by the GTV. Dmax and V18Gy of the proximal bronchial tree (PBT) were evaluated for central tumors. Twelve of 20 plans can be optimized sufficiently with SFO. In interplay effect evaluation, the mean V100%RX values of the GTV were 99.42±0.6%, 97.52±3.9%, and 94.49±7.3%for CPB, LPB, and LPMB plans respectively. After VR 2/3/5 times, the V100%RX values were improved (on average) by 0.13%/1.84%/4.63% for CPB/LPB/LPMB plans. The delivery time for VR plans was the lowest for LPB plans, while delivery time for LPMB was on average 1 minute longer than CPB plans. VR showed no effect on lung V20Gy, Dmax and V18Gy of the PBT. SFO plans were more robust against the interplay effect compared with MFO plans for LPB and LPMB. Average CIs of 1.88±0.4, 1.79±0.4, and 1.75±0.4; average R50s of 7.99±4.0, 6.68±3.0, and 5.70±2.6; and average lung V20Gy values of 2.81±1.5, 2.26±1.3, and 1.85±1.1 were obtained for CPB, LPB, and LPMB plans, respectively. Dmax and V18Gy of the PBT decreased with decreasing spot sizes. LPMB, with the smallest spot size, produced superior plan quality. In the absence of VR, proton machines with large spot sizes generated more robust plans against interplay effects. VR improved the plan robustness against interplay effects for modalities with small spot sizes and fast energy changes, preserving the low dose sparing aspect of the LPMB, even when motion is included.