Small Extension Research Articles

Risk assessment of homologous variants of biotech trait proteins using a bridging approach

ABSTRACT A transgenic protein is frequently expressed as different homologous variants in genetically modified crops due to differential processing of targeting peptides or optimization of activity and specificity. The aim of this study was to develop a science-based approach for risk assessment of homologous protein variants using dicamba mono-oxygenase (DMO) as a case study. In this study, DMO expressed in the next-generation dicamba-tolerant maize, sugar beet and soybean crops exhibited up to 27 amino acid sequence differences in the N-terminus. Structure modeling using AlphaFold, ESMFold and OpenFold demonstrates that these small N-terminal extensions lack an ordered secondary structure and do not disrupt the DMO functional structure. Three DMO variants were demonstrated to have equivalent immunoreactivity and functional activity ranging from 214 to 331 nmol/min/mg. Repeated toxicity studies using each DMO variant found no test substance-related adverse effects. These results support that homologous protein variants, which have demonstrated physicochemical and functional equivalence, can leverage existing safety data from one variant without requiring additional de novo safety assessments.

Hilbert properties under base change in small extensions

Hilbert properties under base change in small extensions

Effect of a small increase in off-premises trading hours on alcohol sales in Norway: A stepped-wedge cluster-randomized controlled trial.

Evidence of the effect of limiting off-premises alcohol trading hours is still scarce. This study tested the effect of a small extension in trading hours on alcohol sales in alcohol monopoly outlets in Norway. The extension of trading hours was implemented within a stepped-wedge cluster-randomized trial design. Eligible state monopoly outlets (n = 229) were clustered into trade districts (n = 62), which were block-randomized to one of three sequences regarding date of implementation: 1 September 2020 (n = 21 districts, 82 outlets), 1 December 2020 (n = 21 districts, 73 outlets) and 1 March 2021 (n = 20 districts, 74 outlets). Outcomes were followed-up for a 1-year period. Study participants were state monopoly outlets in urban and rural trade districts in all parts of Norway. Monthly alcohol sales in litres of pure alcohol per trade district and per outlet were measured from March 2020 to March 2022 (primary outcome). We applied a linear mixed-effect model with two-way fixed effects within a difference-in-difference framework. As a robustness check we considered the effects of cross-border trade and effects in subgroups of outlets. Trading hours in monopoly outlets were extended by 1 hour on Saturdays. The extension was permanent. Pre-intervention periods and not-yet-treated units served as control conditions. We did not find a statistically significant effect of the small extension in trading hours on monthly alcohol sales (i) per trade district [average treatment effect: -185.5litres, 95% confidence interval (CI) = -1159.9, 788.9] and (ii) per outlet (-35.3litres, 95% CI = -142.1, 72.0). These findings were consistent across estimation methods and model specifications. There is no clear evidence that a small extension in off-premises trading hours affected alcohol sales in monopoly outlets in Norway.

7025 Acute Psychosis and the Diagnosis of Cushing’s Syndrome: Lessons Learned from a Patient with a Long History of Obesity

Abstract Disclosure: S. Modi: None. L. Belalcazar: None. Background: Although the association of hypercortisolism and psychosis is well established, acute psychosis remains a very rare manifestation of Cushing’s syndrome, especially in the absence of previous psychiatric history. We present lessons learned from a patient in whom the diagnosis of Cushing’s syndrome was missed until the onset of acute psychosis helped identify his underlying endocrine disorder. Clinical Case: A 31-year-old male presented to the Emergency Department after being found down on the street. The patient had superficial lacerations that were suspected to be self-inflicted due to a suicide attempt, but later found to be the result of auditory hallucinations. He had no previous psychiatric history and no history of suicidal ideation. His medical history was positive for obesity since adolescence and a recent diagnosis of hypertension. His family noted that for the past several months he had been experiencing headache, fatigue, muscle weakness and, more recently, insomnia, restlessness, and confusion. Weight gain was noted, but of unknown magnitude. On admission, he was agitated and hallucinating. He was initially sedated with dexmedetomidine and started on quetiapine. Physical examination revealed Cushingoid features with truncal obesity (body mass index of 35 kg/m2), facial plethora, and dorsocervical fat pad; no abdominal striae were present. Labs showed mild hypokalemia. His AM cortisol was markedly elevated at > 123 ug/dL (normal 4.5-23.0 ug/dL) with an ACTH level at 144 pg/mL (normal 7.2-63.3 pg/mL). MRI Brain showed a 1.9 cm pituitary macroadenoma with small suprasellar extension. With a diagnosis of Cushing’s disease, later confirmed by pathology, he underwent transsphenoidal resection. AM cortisol on post-operative day 3 was 3.2 ug/dL (normal 4.5-23.0 ug/dL). Maintenance-dose steroids were started due to evidence of post-surgical corticotroph suppression. Notably, there was marked improvement in his anxiety, paranoia, and confusion post-operatively. Quetiapine and blood pressure medications were discontinued after discharge. Conclusion: In this patient, the diagnosis of Cushing’s syndrome was missed when initially presenting with new onset hypertension in the setting of long-standing obesity. Despite months of symptoms compatible with the diagnosis, it was not until he developed acute psychosis and a careful history was obtained, that the diagnosis of Cushing’s syndrome was entertained. Psychosis is present in only 3-8% of reported cases of Cushing’s syndrome. This case illustrates the importance of including Cushing’s syndrome in the differential diagnosis of acute psychosis, especially in patients without previous psychiatric history. It also highlights the need of excluding secondary causes of hypertension in young adults, with particular attention to Cushing’s syndrome in those who present with obesity, even if long-standing. Presentation: 6/1/2024

Morphology of Sand Dune Fields in Al-Shehabi Area, Wasit Governorate

The present research is to identify the morphological kinds of sand dunes that are deposited in Al-Shehabi area in Wasit governorate, eastern part of Iraq. The main sand dunes that are determined in the studied area are symmetrical and asymmetrical barchans, nabkha, barchanoid ridges, and sand sheet dunes as seen in the field. Dimensions of barchan dunes are 1 - 8m high, and 3 -50m side dimension, and 3 - 25m length. Nabkha dunes’ dimensions ranges between 0.5m - 3m in length, and 0.5m – 2m high. In relation to the main wind direction in Iraq, these dunes face north-west to south-east. Barchanoid ridges, which are recognized in the studied area are with 6m in average height and accumulated by few barchan dunes. Sand sheet is also recognized in the studied area with small areal extension and with ripple marks.

Socio-economic Characteristics of Farmers Practicing Rice-wheat Cropping System (RWCS) in Haryana, India: A Comparative Analysis

The Rice-Wheat Cropping System (RWCS) is a cornerstone of India's food security, particularly in the states of Haryana, Punjab, and Uttar Pradesh. However, the sustainability of RWCS is increasingly threatened by issues such as soil degradation, groundwater depletion, and climate vulnerabilities, exacerbated by the resource-intensive practices introduced during the green revolution. The study was conducted during 2023-24 using an ex-post facto research design. Multistage sampling by simple random sampling method was used to derive sample for the study and the data was collected through personal interview. This study focuses on the socio-economic profile of small and large farmers practicing RWCS in Haryana, a critical region for this cropping system. By comparing personal, economic, social, and behavioral characteristics between these two groups, the research highlights the disparities in access to resources, extension services, and agricultural technologies. These differences have significant implications for the adoption of sustainable farming practices. The study underscores the importance of targeted interventions especially for small farmers and effective extension services to bridge these gaps, thereby enhancing the sustainability and profitability of the RWCS in Haryana. Understanding the socio-economic characteristics of small and large farmers is crucial for policymakers aiming to ensure the long-term viability of this vital agricultural system.

Hydrogeological conceptual model and groundwater recharge of Avella Mts. karst aquifer (southern Italy): A literature review and update

Study regionAvella Mts., southern Italy. Study focusThe paper is focused on groundwater of Avella Mts. This aquifer has been experiencing an increasing human pressure due to periods of drought and growth in groundwater extraction. A novel hydrogeological conceptual model was developed, and groundwater recharge was estimated by two approaches. The study was carried out by an in-depth literature review and a GIS-based analysis of geological and piezometric data, ground-based meteorological and remotely sensed data. New hydrological insights for the regionThe new hydrogeological conceptual model allowed to reconstruct the aquifer lithology, its deep geometry, and, for the first time, groundwater flow scheme. Five groundwater basins were recognized with distinct outlets and subsurface outflows, suggesting a new aquifer compartmentalization in-series groundwater basins. Some basal springs are fed by autonomous basins with smaller extension, while other springs have dried up completely. The groundwater recharge varies from 7.30 to 6.90 m3/s as estimated by Turc formula and MODIS data, respectively; the values are comparable among them, confirming mutually the validity of approaches used. The comparison with previous studies highlights variations and changes for both the hydrogeological conceptual model and water balance, linked to natural and anthropogenic factors. The results obtained represent a way for supporting sustainable management of groundwater, waterwork systems security and groundwater-dependent ecosystems protection of a large sector of Campania region.

Low energy impact damage characteristics of epoxy coating on the surface of sandwich composites

AbstractWhen composite honeycomb sandwich structures are subjected to low energy impacts, the upper panel or the honeycomb core often suffers large damages, which are invisible, but affects the structural safety. To achieve non‐destructive detection of these damages, an epoxy resin film (ERF) was designed as a functional coating to display the internal failure features on structure surface. The effect of low energy impacts on the damage modes of the ERF was first investigated, and then the correspondence between the ERF damage characteristics and the structural internal failure was established. Simulation and experimental results showed that with the increase of impact energy, cracks on the ERF expanded from the radial radiation with a small extension range to the circumferential pattern with an increased damage area. Meanwhile, localized delamination appeared inside the upper panel, while the degree of flexure and crushing damage to the core continued to increase. Based on the analysis of the crack extension pattern of the ERF and the damage state of the upper panel and honeycomb core, a specific link between the ERF crack characteristics and the internal damages to the sandwich structure was obtained, which might offer a novel non‐destructive testing method for composite impact damages.Highlights Low energy impact damage in honeycomb sandwich structures was a concern. Impact damage response of epoxy resin film on sandwich composites was studied. Crack extension of the film showed a particular change from radial to annular. Specific link between film crack and sandwich structure damage was established. The results would be helpful for damage detection in sandwich composites.

Designing the geometry of compact tension specimens for easy fracture toughness measurement using reinforcement learning

Abstract For composite laminates, a rising R-curve is observed for their fracture toughness under Mode I stress, which is important for a comprehensive failure analysis of the materials. Since it is laborious to measure the R-curve due to its dependence on both the load and the crack extension, we put forward a novel compact tension specimen by modifying its geometry to eliminate the relation between fracture toughness and crack extension, so as to simplify the experimental process of the R-curve measurement by only recording the load history. Two machine learning models were developed for the optimum sample design based on the finite element analysis of the effect of sample geometries on the R-curve. A simple neural network model was built for designing tapered specimen and a reinforcement learning model was created for further finding the best design from a broader design space. The results showed that, in contrast to the specimens with a tapered shape, which only ensure the independence between the R-curve and crack extension in the case of a small extension, the design provided by the reinforcement learning provides such independence across a wider range of crack length and an improved accuracy.

Breaking the baryon-dark matter degeneracy in a model-independent way through the Sunyaev-Zeldovich effect

Context. In cosmological fits, it is common to fix the baryon density ωb via the cosmic microwave background. We here constrain ωb by means of a model-independent interpolation of the acoustic parameter from correlated baryonic acoustic oscillations. Aims. The proposed technique is used to alleviate the degeneracy between baryonic and dark matter abundances. Methods. We propose a model-independent Bézier parametric interpolation and applied it to intermediate-redshift data. We first interpolated the observational Hubble data to extract cosmic bounds over the (reduced) Hubble constant h0 and interpolated the angular diameter distances, D(z), of the galaxy clusters, inferred from the Sunyaev-Zeldovich effect, to constrain the spatial curvature, Ωk. Through the Hubble points and D(z) determined in this way, we interpolated uncorrelated data of baryonic acoustic oscillations bounding the baryon ωb and total matter ωm densities, reinforcing the constraints on h0 and Ωk with the same technique. Finally, to remove the matter sector degeneracy, we obtained ωb by interpolating the acoustic parameter from correlated baryonic acoustic oscillations. Results. Monte Carlo Markov chain simulations agree at 1σ confidence level with the flat ΛCDM model and are roughly suitable at 1σ with its nonflat extension, while the Hubble constant appears in tension up to the 2σ confidence levels. Conclusions. Our method excludes very small extensions of the standard cosmological model, and on the Hubble tension side, seems to match local constraints slightly.

Revision Strategy for Proximal Junctional Failure: Combined Effect of Proximal Extension and Focal Correction.

Retrospective review of a prospectively-collected multicenter database. The objective of this study was to determine optimal strategies in terms of focal angular correction and length of proximal extension during revision for PJF. 134 patients requiring proximal extension for PJF were analyzed in this study. The correlation between amount of proximal junctional angle (PJA) reduction and recurrence of proximal junctional kyphosis (PJK) and/or PJF was investigated. Following stratification by the degree of PJK correction and the numbers of levels extended proximally, rates of radiographic PJK (PJA >28° & ΔPJA >22°), and recurrent surgery for PJF were reported. Before revision, mean PJA was 27.6° ± 14.6°. Mean number of levels extended was 6.0 ± 3.3. Average PJA reduction was 18.8° ± 18.9°. A correlation between the degree of PJA reduction and rate of recurrent PJK was observed (r = -.222). Recurrent radiographic PJK (0%) and clinical PJF (4.5%) were rare in patients undergoing extension ≥8 levels, regardless of angular correction. Patients with small reductions (<5°) and small extensions (<4 levels) experienced moderate rates of recurrent PJK (19.1%) and PJF (9.5%). Patients with large reductions (>30°) and extensions <8 levels had the highest rate of recurrent PJK (31.8%) and PJF (16.0%). While the degree of focal PJK correction must be determined by the treating surgeon based upon clinical goals, recurrent PJK may be minimized by limiting reduction to <30°. If larger PJA correction is required, more extensive proximal fusion constructs may mitigate recurrent PJK/PJF rates.

The correlation of the drain-source capacitance variation and the P-pillar structures in a 4H-SiC quasi super junction MOSFET

In order to improve the trade-off between the 4H-SiC planar Metal-Oxide-Semiconductor Field-Effect Transistor (MOSFET) and super junction MOSFET (SJ-MOSFET), particularly on the drain to source capacitance (Cds) which affects the switching performance, this study investigates the Cds of the quasi SJ-MOSFETs with various P-pillar widths, depths, and concentrations. The measured results show (1) when the N-type region between the P-pillars (Epi-1 region) is fully depleted, the Cds value abruptly drops, (2) when the N-type drift region beneath the P-pillar (Epi-2 region) is fully depleted, the slope of the Cds-Vds curve slowly changes because of the small extension of the depletion region in the P-type region. This is because the wider P-pillar width will increase the magnitude of the abrupt drop of the Cds and make the drop occur earlier; the abrupt drop of the Cds will occur later and the magnitude increases when the P-pillar depth is deeper due to the larger P-type region; Moreover, increasing the P-pillar concentration not only initiates the abrupt drop earlier and increases the magnitude, but also increases the minimum saturation value of the Cds at a higher reverse bias. This study also reveals that the mechanism of the Cds formation in a quasi SJ-MOSFET is different from the planar MOSFET and SJ-MOSFET. Finally, the simulated results are used to validate the influence of the P-pillar structures on the Cds – Vds curves in a quasi SJ-MOSFET.

Smallest quasi-transitive extensions

Quasi-transitivity is a weakening of transitivity that has some attractive features, such as the important role it plays in the context of path-independent choice. However, the property suffers from the shortcoming that it does not allow for the existence of a closure operator. This paper examines the question to what extent an alternative operator can be defined that may then be used to ameliorate some of the limitations of quasi-transitivity imposed by the absence of a well-defined closure. To do so, we define the concept of a smallest quasi-transitive extension. A novel weakening of quasi-transitivity turns out to be necessary and sufficient for the existence of such a smallest extension. As an illustration, we apply the notion of a smallest quasi-transitive extension in the context of rational choice on arbitrary domains.

C2 Nerve Sheath Tumors: An Analysis of Radiological – Intraoperative Concordance for Intradural Extension and Systematic Review

Background: Nerve sheath tumors (NSTs) of C2 nerve-root are clinically and radiologically distinct from NSTs of rest of the spine. On imaging, they appear to have a major intradural component in addition to the large extradural part. Thus, they may require durotomy with its possible added complications. Objective: The aim of this study is to evaluate the radiological – intra-operative discordance for intradural component and need for tailored durotomy for complete resection of C2 NSTs. Material and Methods: We retrospectively analyzed 14 consecutively operated patients of C2 NSTs over the past 10 years (2013-2023). Dura was opened in patients where there was a radiological or intra-operative suspicion of intradural extension. Results: Mean(±SD) age at presentation was 37.5(±13) years, with no gender predominance (Male:Female-1.3:1). Dura was opened in 7(50%) patients. On preoperative radiological study, all the patients had a dominant extradural tumor, while 7(50%) patients appeared to have an intradural tumor extension also. Intra-operatively, 5(35.7%) of these 7 patients had only extradural component, while 2(14.3%) patients had an intradural extension. 7(50%) patients had extradural tumor radiologically, while only one patient was found to have a small intradural extension intraoperatively. Thus, only 21.4% of the patients (n=3) were found to have an intradural extension as against 50%(n=7) predicted on imaging. Post-operatively there was clinical improvement in all 14 patients (100%). Conclusions: Due to radiological and intra-operative discordance in intradural tumor extension, decision for midline durotomy should be taken following excision of extradural component. Thus, limiting the number of unnecessary midline-durotomies.

Revision of the GeV γ-Ray Emission in the Region of HESS J1813-178 with Fermi-LAT

HESS J1813-178 is one of the brightest and most compact TeV γ-ray sources, and whether its γ-ray emission is associated with supernova remnant (SNR), pulsar wind nebula (PWN), or young stellar cluster (YSC) is still under debate. By analyzing the GeV γ-ray data in the field of HESS J1813-178 using 14 yr of PASS 8 data recorded by the Fermi Large Area Telescope (Fermi-LAT), we report the discovery of three different sources with different spectra in this region. The hard source with a PL spectral index of 2.11 ± 0.08 has a small size extension, which is spatially and spectrally coincident with the TeV γ-ray emission from HESS J1813-178. CO observations display the dense molecular clouds surrounding HESS J1813-178 in the velocity range of 45–60 km s−1. The possible origins of the γ-ray emission from HESS J1813-178 are discussed, including SNR G12.820.02, the PWN driven by the energetic X-ray pulsar PSR J1813-1749 and YSC Cl 1813-178. However, none of them can be ruled out clearly. Note that the maximum energy of protons in the hadronic model should exceed a few hundred TeV, which makes HESS J1813-178 a promising PeVatron. A detailed LHAASO data analysis about the morphology and spectrum would be helpful to investigate the origin of the γ-ray emission in this region and test its PeVatron nature.

An Adaptable Charge Source Enabled by Mode‐Switchable TENG for Efficient Self‐Repairing Coating

AbstractSelf‐repairing coatings have received widespread attention due to their ability to repair damaged surfaces. However, film‐forming molecules can only be fixed on the metal surface through relatively weak physical and chemical adsorption. This drawback limits its self‐repairing ability. Here, a mode‐switchable TENG (MS‐TENG) is developed, which has the ability to switch between AC and DC outputs as an adjustable charge source for self‐repairing coatings. Besides the normal sector electrodes of rotational TENG, MS‐TENG has a special design of external electrodes (small extension electrodes on rotator and inner/outer orbit electrodes on stator) and achieves charge accumulation through an excitation circuit and DC output through air breakdown on external electrodes with advantage of the complete release of accumulated charges. Compared with traditional air breakdown TENG, its current output has been improved. In addition, the air breakdown process occurs in the external electrode framework independent of the TENG body. Therefore, the negative impact of air breakdown is suppressed. Finally, MS‐TENG is used to achieve rapid electrostatic adsorption of charged film‐forming molecules through charge injection. MS‐TENG as a charge source effectively improves the performance of self‐repairing coatings, with a corrosion inhibition rate of 96.9%.

Spanish as a resource in the acquisition of English as a second language

The use of the mother tongue in foreign language lessons has always generated a wide debate on whether the use of L1 prevents students from learning a L2. This research shows what teachers of English as L2 in Spain think about this topic. First, we review the reasons to exclude the use of Spanish, as well as the reasons for its inclusion. This approach includes linguistic, social, and cultural factors intrinsic to the teaching/learning process. Information is collected using a mixed method approach. On the one hand, a questionnaire is designed to identify patterns and trends regarding the use of Spanish in the English classroom considering factual, behavioural, and attitudinal data. Each section is linked to research objectives. On the other, three specific qualitative methods are used: personal interviews, small focus group discussions and extension written narratives, where 12 questions are composed as a basis for the realisation of these three methods. The results of the study suggest that a prudent and judicious use of Spanish does not prevent or hinder the development of English learning in students. On the contrary, in many cases, it facilitates it since it provides the teacher with a powerful pedagogical resource. The study posits that the judicious employment of Spanish within the classroom setting yields positive outcomes and advocates for increased flexibility in its utilisation. However, it simultaneously points to the imperative that this flexibility should not detract from the primary objective of English language acquisition. This study has theoretical and practical implications in the design of formation syllabi for in-service and future teachers of L2 in L1 contexts.

Characterization of a secreted aminopeptidase of M28 family from B. fragilis and its possible role in protein metabolism in the gut

Products of microbial protein metabolism in the gut can influence the health of the host in many ways. Members of the Bacteriodales, major commensals of the human colon have been associated with long-term intake of high-protein diets. Undigested proteins or peptides that reach the colon can be hydrolyzed by extra-cellular proteases found in some Bacteroides species into amino acids and peptides which can be further catabolized. In this communication, we have characterized one such secreted aminopeptidase (BfAP) from Bacteroides fragilis belonging to the M28 family which is capable of degrading peptides released from soybean protein after predigestion in the small intestine. The BfAP enzyme was cloned, expressed in E. coli, and purified to homogeneity. It is a metallopeptidase requiring Co2+ ion for optimum activity at 55 °C and pH 8 and preferentially cleaves neutral aliphatic (Met/Leu) and positively charged (Arg/Lys) amino acids from the N-terminus of peptides. It showed high specificity for long peptides as well as proteins like β-casein. Structural analysis of BfAP and its orthologues using AlphaFold2 reveal a shared highly conserved M28 domain, but vary with respect to their N-terminal region with some of them possessing an additional cap domain which may be important for regulation of substrate binding. Although BfAP lacks the typical cap domain, it shows small extensions that can form a loop adjacent to the proposed active site and may affect substrate binding. We suggest that this secreted enzyme may play an important role in protein metabolism in the colon where Bacteroides species are abundant.

Inversion points of the accretion flows onto super-spinning Kerr attractors

We study the accretion flows towards a central Kerr super-spinning attractor, discussing the formation of the flow inversion points, defined by condition uϕ=0\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$u^{\\phi }=0$$\\end{document} on the particles flow axial velocity. We locate two closed surfaces, defining inversion coronas (spherical shells), surrounding the central attractor. The coronas analysis highlights observational aspects distinguishing the central attractors and providing indications on their spin and the orbiting fluids. The inversion corona is a closed region, generally of small extension and thickness, which is for the counter-rotating flows of the order of ≲1.4M\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\lesssim 1.4 M$$\\end{document} (central attractor mass) on the vertical rotational axis. There are no co-rotating inversion points (from co-rotating flows). The results point to strong signatures of the Kerr super-spinars, provided in both accretion and jet flows. With very narrow thickness, and varying little with the fluid initial conditions and the emission process details, inversion coronas can have remarkable observational significance for primordial Kerr super-spinars predicted by string theory. The corona region closest to the central attractor is the most observably recognizable and active part, distinguishing black holes solutions from super-spinars. Our analysis expounds the Lense–Thirring effects and repulsive gravity effects in the super-spinning ergoregions.

Alaska's emergent fisheries processes

Under climate change, shifts in distributions of commercialized marine species challenge livelihoods and management in some fisheries and create opportunities in others. Whether existing management processes can enable fishers to access emergent fisheries – efforts by fishers to commercialize species – is unclear. Thus far, the literature has largely focused on reactive management processes that lead to overharvest and conflicts over fisheries allocations under species distributional shifts. We examine the progress and outcomes of 144 emergent fisheries in the state waters of Alaska, illustrating the historical diversity of management mechanisms, regions, species, and gears in the state's unique system of permitting and data collection for emergent fisheries. We further examine 28 emergent fisheries' roles in fishing portfolios through a métier analysis, finding that most are small extensions to existing portfolio strategies instead of novel opportunities for specialization. Together, these findings underscore challenges in adapting current processes to future shifts in marine species distributions, reflecting the need for large scale reconsiderations of scale, tradeoffs and a more holistic approach.