Fluid-structure interactions (FSI) of multiple cylindrical structures frequently occur in crossflows. Due to the different wake interference regions of flexible cylinders with different diameters, the interaction between multiple cylinders is complicated and sensitive to the centre-to-centre spacing ratio and diameter ratio. Limited information has been presented on the flow-induced vibration (FIV) of two unequal-diameter flexible cylinders in a tandem arrangement. In this paper, an experimental investigation was carried out in a towing tank to study the FIV of two tandem flexible cylinders with different diameters that can vibrate in both the cross-flow (CF) and in-line (IL) directions. There were two IL spacing ratios (T/d = 12.0 and 6.0, where T is the centre-to-centre distance between two cylinders, and d is the diameter of the small cylinder), and the diameter ratio (d/D, where D is the diameter of the large cylinder) was nearly 0.5. The aspect ratios/mass ratios of the small cylinder and the large cylinder were 350/1.90 and 181/1.47, respectively. The towing velocity varied from 0.05 to 1.00 m/s with an interval of 0.05 m/s. The Reynolds numbers for the small and large cylinder were 800–16000 and 1600–32000, respectively. The CF vibration of the upstream large cylinder with T/d = 6.0 was suppressed at Vrs = 16.28–18.79, whereas the CF vibration of the large cylinder with T/d = 12.0 was not influenced. The downstream cylinder exhibited more complicated behaviour due to the significant wake effect from the upstream cylinder, which is consistent with the two equal-diameter cylinders. The FIV response of the downstream small cylinder was more sensitive to the IL spacing ratio. Because of the wake shielding effect of the large cylinder, the downstream small cylinder vibrated at low IL dominant frequencies, and the IL to CF frequency ratio (fIL/fCF) was approximately 1.0. Moreover,wake-induced flutter was observed on the downstream small cylinder.
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