Event Abstract Back to Event Behavioural effect of continuous Theta Burst Stimulation in macaque parietal cortex Lara Merken1, Maria C. Romero1, 2*, Peter Janssen1 and Marco Davare2 1 Laboratory for Neuro- and Psychophysiology, Doctoral School of Biomedical Sciences, KU Leuven, Belgium 2 Movement Control and Neuroplasticity Research Group, Department of Kinesiology, Biomedical Sciences Group, KU Leuven, Belgium Theta-burst stimulation (TBS), a well-known type of repetitive Transcranial Magnetic Stimulation (TMS), is a powerful neuromodulation tool due to its ability to induce long-term changes in brain activity. However, behavioural results in human volunteers are still highly variable. Recently, Romero et al. (FENS Forum of Neuroscience Berlin, 2018; Abstract No. D037) showed that continuous TBS (cTBS; triplets of pulses at 50 Hz, applied every 200 ms, during 20 sec) induces a robust reduction in neuronal excitability of parietal neurons in rhesus monkeys. Here, we studied the effect of cTBS on the macaque parietal cortex, by measuring the grasping times (GT) during a visually-guided grasping (VGG) task. Monkeys were trained to perform the VGG under six different conditions, combining the grasping of two objects (large and small cylinder, i.e. power grip and precision grip, respectively) under three different stimulation conditions: no stimulation (NS), low stimulation (LS) - 40% of the resting motor threshold (rMT) -, and high stimulation (HS) - 80% of the rMT -. Data were obtained from two rhesus monkeys (3 sessions per condition, average of 797 trials/session in monkey 1 and 862 trials/session in monkey 2). cTBS induced significant changes (p < 0.05 two-tailed) in GT in both monkeys. In the power grip sessions of monkey 1, high stimulation cTBS significantly increased the GT from 20 min to at least 120 min post-cTBS by up to 20% compared to NS (p < 0.001, two-tailed). In contrast, for precision grip, cTBS caused a significant reduction in the GT after 100 min to at least 120 min post-cTBS (5% reduction compared to NS, p < 0.001, two-tailed). For monkey 2, we also observed opposite effects for both objects. For power grip, the GT was significantly reduced from 20 min to at least 120 min post cTBS (max of 12% reduction compared to NS, p < 0.05 two-tailed), while for precision grip cTBS significantly increased the GT from 80 min post cTBS to at least 120 min (up to 11% increase compared to NS, p < 0.05, two-tailed). Interestingly, in each condition and in each monkey, low stimulation cTBS increased or decreased the GT in the opposite direction compared to the effect of high stimulation. A two-way ANOVA for grip type (power/precision grip) and stimulation type (high/low/no) as factors, showed significant interactions for all tested time intervals in both monkeys (p < 0.01). These findings demonstrate long-lasting changes of cTBS on behaviour, which are strongly dependent on the applied stimulation intensity. Keywords: TMS, transcranial magnetic stimulation, Theta-burst stimulation (TBS), Visually-guided grasping, Power grip, macaque, Precision Grip Conference: 13th National Congress of the Belgian Society for Neuroscience , Brussels, Belgium, 24 May - 24 May, 2019. Presentation Type: Poster presentation Topic: Behavioral/Systems Neuroscience Citation: Merken L, Romero MC, Janssen P and Davare M (2019). Behavioural effect of continuous Theta Burst Stimulation in macaque parietal cortex. Front. Neurosci. Conference Abstract: 13th National Congress of the Belgian Society for Neuroscience . doi: 10.3389/conf.fnins.2019.96.00075 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Apr 2019; Published Online: 27 Sep 2019. * Correspondence: PhD. Maria C Romero, Laboratory for Neuro- and Psychophysiology, Doctoral School of Biomedical Sciences, KU Leuven, Leuven, Belgium, mela.romero@kuleuven.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lara Merken Maria C Romero Peter Janssen Marco Davare Google Lara Merken Maria C Romero Peter Janssen Marco Davare Google Scholar Lara Merken Maria C Romero Peter Janssen Marco Davare PubMed Lara Merken Maria C Romero Peter Janssen Marco Davare Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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