Sleep resilience is the ability to maintain effective emotional, cognitive, and physical functioning despite disruptions to sleep/circadian rhythms. While conceptually related to sleep health, no validated measure currently exists. This cross-sectional survey study aimed to validate a novel self-report measure of sleep resilience, the Sleep Resilience Questionnaire (SRQ), and examine its associations with demographic features, sleep disturbance, and sleep-related impairment. Our convenience sample included 455 adults (Mean age=45±17) in the United States who completed a demographic survey, PROMIS Sleep Disturbance (PROMIS-SD) and Sleep-Related Impairment (PROMIS-SRI), and retrospective and prospective SRQ forms (English version 1). Exploratory and confirmatory factor analyses (EFA and CFA) evaluated the SRQ's factor structure and internal consistency, and structural equation modeling examined associations with demographics, PROMIS-SD, and PROMIS-SRI. EFA and CFA supported a highly correlated two-factor retrospective SRQ structure and a unidimensional prospective SRQ structure with excellent fit and internal consistency (CFI & TLI>.99, RMSEA<.07, ω>.92). Lower sleep resilience was associated with greater sleep-related impairment (p<0.05) but not sleep disturbance. Younger age, men, higher education, greater number of dependents, and higher income were associated with lower sleep resilience in specific retrospective or prospective domains (p<0.05). Findings suggest sleep resilience is a meaningful dimension of sleep health, associated with demographic and sleep-related impairments, and the SRQ forms appear to validly measure it. Despite limitations of the cross-sectional design, the SRQ may be useful for future research aimed at identifying potential intervention targets to improve sleep-related impairments.

Urban noise pollution is a growing public health concern, particularly in rapidly developing cities where regulatory enforcement is limited. High noise levels have been linked to adverse health effects, including stress, sleep disturbances, and cardiovascular issues. However, data-driven noise monitoring remains scarce in many low-resource settings, limiting efforts to develop effective mitigation strategies. To address this gap, we designed and deployed a large-scale noise data collection pipeline in Kampala and Entebbe, Uganda. Our approach integrates mobile-based tools to capture short audio recordings, categorizations of the type of noise, and sound pressure levels at specific locations. Over the course of the study, we collected 61,821 such annotated noise samples across five divisions in Kampala and four wards in Entebbe. This is to our knowledge the largest existing urban sound dataset, and the first time that the acoustic landscape of a developing-world city has been characterized in such detail. It provides valuable insights into urban noise pollution, forming a foundation for future noise mapping and mitigation efforts.

Alcohol use disorder (AUD) represents a highly prevalent, costly, and often untreated condition in the United States. Post-traumatic stress disorder (PTSD) represents a common comorbidity with AUD which worsens outcomes and decreases functional outcomes. Suvorexant (SUV) shows clear promise as a novel therapeutic candidate to treat AUD and PTSD. This study features a promising compound (i.e., suvorexant), the application of a well-established human laboratory paradigm (i.e., alcohol cue reactivity), and a novel early efficacy laboratory model (i.e., practice quit attempt) to provide a cost/time-efficient evaluation of safety and initial efficacy of suvorexant for AUD with comorbid PTSD. Additionally, by collecting both objective and subjective sleep measures, the study provides an assessment of a putative mechanism through which suvorexant jointly addresses an intervening variable common to both AUD and PTSD. The combination of human laboratory modeling and real-world clinical outcomes provides a unique and synergistic set of data that can advance the development of suvorexant and identify its behavioral mechanisms of action. The recruitment of individuals with AUD and PTSD with sleep disturbances and who are intrinsically motivated to quit is a novel approach to screening pharmacotherapies by bridging the gap between experimental studies with non-treatment seekers and clinical trials with treatment-seeking individuals. ClinicalTrials.gov NCT06679062 "Suvorexant for Treatment of AUD and PTSD (SUV)." Registered on November 12, 2024.

The growing and pervasive use of social network sites (SNS) has raised concerns about their impact on adolescent mental health during this sensitive developmental phase. Existing longitudinal studies are constrained by methodological limitations and limited exploration of underlying mechanisms. We investigated the longitudinal associations between SNS use and depressive and anxiety symptoms in adolescents and whether sleep mediated these associations. We analysed longitudinal data from 2350 adolescents from 31 schools in London, participating in the Study of Cognition, Adolescents, and Mobile Phones (SCAMP). The exposure was self-reported duration of SNS use at baseline (aged 11-12 years). Outcomes were depressive and anxiety symptoms at follow-up, analysed as symptom severity and clinically significant symptoms (aged 13-15 years). The associations between SNS use and depressive and anxiety symptoms were assessed via multi-level ordinal logistic regression (symptom severity) and logistic regression (clinically significant symptoms). The mediation effects of insufficient sleep, sleep onset latency, and sleep disturbance were assessed by mediation analysis. Compared to 0-30 min per day, more than 3 h per day of SNS use at baseline was associated with higher severity levels of depressive and anxiety symptoms (adjusted odds ratio (OR) = 1.47, 95% CI 1.12, 1.93 and OR = 1.40, 95% CI 1.06, 1.83, respectively) and clinically significant depressive and anxiety symptoms at follow-up (OR = 1.70, 95% CI 1.19, 2.42 and OR = 1.60, 95% CI 1.11, 2.31, respectively). The associations between total and weekend SNS use and depressive symptom severity were stronger in girls than boys. Other associations were similar by gender. Insufficient sleep duration (particularly on weekdays) and sleep onset latency at baseline partly mediated the associations of SNS use and depressive and anxiety symptoms (proportion of mediation ranged between 11.1% and 33.1%). The mediation effects of sleep disturbance were less marked. In a large longitudinal cohort, we found that SNS use exceeding 3 h per day is associated with increased risks of depressive and anxiety symptoms in adolescents. Findings from mediation analysis suggest that addressing poor sleep hygiene in relation to SNS use might mitigate the negative impact of high SNS use. Our findings may inform the development of early secondary school curricula incorporating digital literacy and sleep hygiene education.

Temporomandibular disorders (TMD) and orofacial pain (OFP) are influenced by behavioural and psychosocial stressors. The Gaza Strip's prolonged conflict provides a critical context for estimating burden and correlates. To estimate the prevalence of self-reported TMD/OFP symptoms and identify independent risk factors among adults in Gaza during wartime. Cross-sectional survey of 1000 adults (500 women, 500 men) equally allocated across five governorates. A structured questionnaire captured self-reported facial/TMJ/ear pain, jaw function, parafunctional behaviours (e.g., bruxism, oral habits) and psychological symptoms (tension, mood, sleep) was used. Analyses used descriptive statistics, chi-square tests and multivariable logistic regression adjusted for sex. TMD-related pain was reported by 33.1% (n = 331). Neck pain occurred in 41.0% and morning facial stiffness in 28.2%. In bivariate analyses, men more often reported jaw dysfunction (limited opening, chewing difficulty, joint sounds), while women more often reported psychological symptoms; sex was not an independent predictor. Independent predictors were morning facial stiffness (AOR 2.57-5.27 across frequency categories), limited mouth opening (AOR 3.03; 95% CI 1.75-5.28), joint noises (AOR 3.13; 95% CI 2.08-4.72), sleep bruxism (AOR 2.33; 95% CI 1.51-3.60) and daily somatic pain elsewhere (AOR 2.99; 95% CI 1.53-5.84). Gum chewing showed an inverse association (AOR 0.62-0.31). Tension, sadness, global sleep disturbance, daytime bruxism, smoking, alcohol use, orthodontic history and governorate were not independent predictors. The multivariable model showed good performance (AUC = 0.882; Nagelkerke's R2 = 0.519). During active war, self-reported TMD and OFP symptoms are prevalent among adults in Gaza and are strongly associated with parafunctional habits and psychological distress, both potentially intensified by war-related stress. These findings underscore the need for integrated dental and mental health interventions in conflict-affected populations.

INTRODUCTIONAmyloid beta peptide (Aβ) accumulation in the brain is an Alzheimer´s disease (AD) hallmark. Sleep disturbances hamper Aβ production and clearance, thereby exacerbating the Aβ burden. The mechanisms involved remain unclear. We reported that amyloid precursor protein (APP), the Aβ source, possesses intracellular signaling that attenuates Aβ production and prevents cognitive decline in AD mice. Our follow‐up study assessed whether enhancing APP‐mediated signaling affected sleep.METHODSWe expressed a membrane‐tethered APP intracellular domain (mAICD) and a variant lacking the GαS‐interacting site in AD mouse brains. Sleep patterns, cognitive behaviors, blood–brain barrier (BBB) integrity, and gliosis were examined.RESULTSSleep, BBB integrity, and memory were strongly correlated. mAICD expression rescued sleep and cognitive function impairments, prevented BBB leakage, and promoted astrocyte redistribution surrounding the neurovascular units in AD mice. GαS interaction with mAICD was critical.DISCUSSIONAPP‐mediated signaling plays a key role in regulating sleep, maintaining BBB integrity, and preserving memory in AD.

Fezolinetant compared with elinzanetant for the treatment of vasomotor symptoms associated with menopause: A matching-adjusted indirect comparison.

The efficacy of cognitive behavioral therapy for sleep disorders following acquired brain injury: a systematic review and meta-analysis.

The impact of sleep disturbance on post-transplant recovery and quality of life: Neural mechanisms and translational management strategies.

Characteristics of sleep disturbance in Moyamoya disease.

Acceptability and feasibility of two types of asynchronous online yoga interventions in adults with moderate-to-high stress.

Rapid screening of depression and anxiety in outpatients: Symptom-based nomograms for early identification from gastrointestinal presentations.

Sleep disturbances and fatigue are significant concerns among critical care nurses due to the demanding nature of their work, which includes long shifts, high patient acuity, and constant exposure to stress. This study explores the prevalence and correlation between sleep disturbances and fatigue among critical care nurses. Using a cross-sectional design, data were collected from 104 nurses across 6 government hospitals through validated self-reported measures, including the Richards-Campbell Sleep Scale and the Fatigue Assessment Scale. Findings revealed moderate sleep disturbance, with an average sleep quality (SQ) score of 57.57 (SD=23.90). Fatigue levels were also notable, particularly physical exhaustion. While demographic factors such as experience and work shifts showed no significant effect on SQ, age and gender were significantly associated with fatigue levels. Additionally, a negative correlation (R =-0.234, P =.017) was found between SQ and fatigue, indicating that poorer SQ was linked to higher fatigue levels. These results highlight the urgent need for targeted interventions to improve sleep hygiene and reduce fatigue among critical care nurses. Implementing structured shift schedules and fatigue management strategies could enhance nurses' well-being and ultimately improve patient safety and health care outcomes.

Age, sex and mental distress as predictors of rate and deterioration of persistent physical symptoms over three and six years in a general population.

Sleep disturbance recorded via wearable sensors predicts depression severity 9years later.

Exercise and quality of life in head and neck squamous cell carcinoma patients receiving neoadjuvant immuno-chemotherapy: A randomized, open-labeled phase II trial.

Differential Diagnoses Associated with Chronic Rhinitis and Chronic Rhinosinusitis.

Background: Corticosteroids, Adrenocorticotrophic Hormone (ACTH) and vigabatrin are considered to be the first-line drug for the treatment of West Syndrome (WS). There are little consensus regarding the definitive dose, efficacy or duration of treatment of these agents in comparison to each other. So this study aimed to assess the effectiveness of low-dose ACTH in the treatment of WS. Materials and methods: A prospective observational study was conducted in the Department of Child neurology of Chattagram Maa Shishu-O-General Hospital from January 2021 to December 2022. One hundered and five children with WS aged two months to two years old enrolled in the study population. Treatment was initiated with low dose ACTH (20IU-40IU/day) and clinical and Electroencephalographic (EEG) responses were assessed at two and four weeks. Results: The mean ±SD age of the patients was 11.21 ± 7.86 months and 74.28% were male. The mean ±SD age of onset of epileptic spasm and time interval between the onset of the epileptic spasm and initiating ACTH therapy was at 6.00 ± 5.01 and 5.26 ± 4.36 months, respectively. Symptomatic epileptic spasm 76(72%) was the major category of spasm. Clinical cessation of epileptic spasm was found in 55(52.38%) and 71(67.61%) patients at two and four weeks follow-up, respectively. Cessation of hypsarrythmia in EEG was noticed in 24(27%) and 66(62.8%) patients at two and four weeks, respectively. Majority (65.71%) of the patients did not have any adverse effect. Irritability, sleep disturbance, infection and hypertension was found in 21(20%), 7(6.6%), 5(4.7%) and 3(2.8%) patients. Relapse after four weeks was found in 12 (11.4%). Conclusion: Low dose ACTH was effective in cessation of spasm and resolution of hypsarrhythmia in with children WS. Chatt Maa Shi Hosp Med Coll J; Vol.24 (1); Jan 2025; Page 87-90

Daily steps and sleep in adults: A systematic review and meta-analysis.

Trigeminal neuralgia (TN) patients are at risk for glymphatic dysfunction due to their prolonged headaches and sleep disturbances. The aim of this study is to compare the glymphatic function changes in TN patients with healthy controls, to investigate whether there are differences in glymphatic function after decompression surgery, and to examine their relationship with clinical parameters. The data for this hybrid design study were obtained from the OpenNeuro dataset titled "A large-scale dataset of pre- and post-surgical MRI data in patients with chronic trigeminal neuralgia." The DTI-ALPS index values were calculated for 62 TN patients with normal brain MRIs and 35 age- and sex-matched healthy controls, as well as for 53 TN patients who had both preoperative and postoperative diffusion tensor imaging. Statistical analyses involved nonparametric tests and Spearman correlation to assess differences between groups and relationships with clinical variables such as age, disease duration, and Sindou grading. There were no significant differences in DTI-ALPS indices between TN patients and controls. Additionally, preoperative and postoperative comparisons in the TN cohort revealed no significant changes in glymphatic function following surgery. Furthermore, no correlations were observed between DTI-ALPS indices and clinical parameters, including patient age, disease duration, or the severity of neurovascular compression. The findings of this preliminary study suggest that glymphatic dysfunction is not a contributing factor in the pathogenesis of TN and that microvascular decompression surgery does not alter glymphatic clearance. These results indicate that the underlying mechanisms of TN may be independent of glymphatic impairment, despite the presence of sleep disturbances in this population.