Clinical and instrumental comparison between insufficient sleep syndrome and narcolepsy type 1.

Outcomes from a combined cognitive behavioral therapy for insomnia (CBT-I) and sleep-related medication and substance use reduction treatment.

Introduction Grounded in belongingness theory, the goal of this study is to understand the consequences of ghosting (an approach to ending relationships that involves ending all forms of communication with someone without explanation) on objective and subjective sleep quality in young adults seeking romantic relationships. Methods Data for this experimental study comes from emerging adults recruited from a university in the Southern Central United States ( N = 112) who were told that they would be put into a dating pool and matched with a romantic partner. All participants were randomly assigned to one of three conditions: ghosting ( N = 40), courteous ending ( N = 35), or a control condition ( N = 37). In the ghosting condition, participants received a text message initiating conversation with a romantic partner “match” (laboratory confederate), but the conversation was abruptly ended after 2 hours. In the courteous ending group, participants conversed with a laboratory confederate, but after two hours the confederate politely ended the conversation and said that they would reach out to them in the future. The control condition received no text message. Participants wore Oura rings for two days and completed a sleep diary for two consecutive mornings (i.e., pre- and post-experimental manipulation) to capture objective and subjective sleep. Results Contrary to our hypothesis, we did not observe any influence of acute experimental ghosting on objective or subjective sleep measures. Discussion This study is unique in that it aimed to experimentally elicit relationship stress using a novel low-investment ghosting protocol to assess the influence of relationship stress on objective and subjective sleep parameters. In addition, the study demonstrates the feasibility and limitations of a controlled experimental protocol for modeling ghosting in early-stage romantic contexts, providing a foundation for future experimental research on relational disengagement.

Introduction Sufficient sleep is integral to overall health whereas suboptimal sleep puts athletes at greater risk for injury, lengthens their recovery time, and decreases their performance. Our purpose was to compare sleep across training days (i.e., competition, practice, and rest) in adolescent athletes, specifically identifying differences between nights before and after training. Methods Participants [ n = 33 (14 male, 19 female), aged 15.6 ± 1.0 years] wore an activPAL accelerometer continuously for 14 consecutive days and completed a sleep log noting training day status (i.e., competition, practice, rest). Results Athletes slept less on the day after competition compared to after practice and rest days [Sleep Duration (mean ± SD ) after competition: 7.9 ± 1.6 h, after practice: 8.6 ± 0.8 h, after rest: 9.2 ± 1.4 h, interaction effect p < 0.001]. The time athletes went to bed tended to be later before and after rest days compared with competition and practice days [Time in Bed Start (hr:min, mean ± SD ) before competition: 22:02 ± 0:58, after competition: 22:19 ± 1:03, before practice: 22:20 ± 0:49, after practice: 22:06 ± 0:40, before rest: 22:55 ± 1:09, after rest: 23:13 ± 0:58, p = 0.080]. Athletes woke up the latest on and after rest days (before competition: 6:52 ± 1:16, after competition: 6:11 ± 1:21, before practice: 6:59 ± 0:43, after practice: 6:43 ± 0:42, before rest: 7:35 ± 1:09, after rest: 8:26 ± 1:22, p < 0.001). Conclusion In conclusion, athletes slept less the day after a competition compared with the day after a practice or rest day. While sleep start times did not differ by training day, athletes woke up later before and after rest days. Understanding factors influencing athletes’ sleep may enable health care providers and coaches to help athletes stay healthy and optimize their performance.

To descriptively compare sleep outcomes between fire agencies utilizing different shift configurations. Firefighters employed by three departments utilizing a 24/48, 48/96, 4 Platoon system (4P) and a control group of day shift first responders completed the Emergency Service Sleep Diary and Pittsburgh Sleep Quality Index (PSQI) to compare sleep quantity and quality outcomes. After controlling for differences in nighttime emergency call volume, the 24/48 resulted in less on-duty sleep time than the 48/96, whereas the 4P was similar to 24/48. The 24/48 displayed greater total PSQI scores than all other shift configurations. Sleep quantity and quality were worse among firefighters working a 24/48 shift compared to some shifts. Many firefighters across shifts did not obtain the recommended amount of sleep on- and off-duty.

Endogenous circadian rhythm sleep disorders through the lens of nonparametric variables of actigraphy: an exploratory study in myotonic dystrophy type 1.

ABSTRACT Objectives To review the efficacy of lemborexant (LEM), a dual orexin-receptor antagonist approved in multiple countries for treatment of insomnia in adults, by assessing the consistency of the available LEM objective and subjective evidence. Methods Data from 2 pivotal phase 3, randomized, double-blind, parallel-group, placebo (PBO)-controlled studies are reviewed. Study 304 (1-month) and Study 303 (12-months; only first 6 months included here) evaluated the efficacy/safety of LEM 5 mg (LEM5) and LEM 10 mg (LEM10) in adults with insomnia disorder. Objective sleep onset (latency to persistent sleep [LPS]) and sleep maintenance (wake after sleep onset [WASO] and total sleep time [TST]) were assessed with polysomnography in Study 304. Subjective sleep onset latency (sSOL) and sleep maintenance (sWASO and sTST) were assessed with sleep diaries in both studies. Other patient-reported efficacy measures included Insomnia Severity Index-total score (ISI-TS), ISI-daytime functioning (ISI-DF), Fatigue Severity Scale (FSS), and Patient Global Impression-Insomnia (PGI-I). Results Compared with PBO, significantly larger decreases (improvements) from baseline in LPS, sSOL, WASO, and sWASO and significantly larger increases (improvements) from baseline in TST and sTST were observed within the first week of LEM treatment (as early as within the first 1–2 nights) and were sustained throughout the treatment period (1–6 months) (all p < 0.05, except for sWASO at Month 1). These improvements aligned with significantly larger decreases (improvements) from baseline in ISI-TS, ISI-DF, and PGI-I (all p < 0.05). Significantly larger decreases (improvement) from baseline in FSS scores were observed at 3 and 6 months (both p < 0.05). Conclusion LEM showed concordance in its ability to improve objective and subjective measures of nighttime sleep, as well as daytime functioning and patient perception of nighttime sleep. These findings demonstrate that LEM is effective both objectively and from the patient’s perspective, supporting LEM as a valuable treatment option for adults with insomnia.

Sleep disorders in children managed in the pediatric palliative care unit of a tertiary hospital.

Traumatic brain injury (TBI) is associated with sleep disturbances and cognitive impairment, with limited effective therapeutic strategies. Our previous work showed dietary supplementation with branched chain amino acids (BCAAs; isoleucine, leucine, valine), the primary substrate for de novo glutamate/GABA synthesis in the CNS, restored normal sleep-wake patterns and improved cognitive function in rodents. Our recent pilot work in humans showed preliminary feasibility/acceptability and limited efficacy for BCAAs to improve sleep in Veterans with TBI. However, these pilot data were limited in sample size, treatment dosages/duration, and therefore unable to establish efficacy or provide insight into dosing/duration parameters. The present study, SmART-TBI (supplementation with amino acid rehabilitative therapy in TBI: NCT04603443), represents a placebo-controlled, double-masked randomized clinical trial (target n = 120). Covariate adaptive randomization controlling for age, sex, TBI recency, pain, depression, and PTSD, allocated participants 1:1:1:1 to four groups comprising 3 BCAA doses b.i.d. ("high" 30g; "medium" 20g; and "low" 10g) and one placebo-control (rice protein, 10g b.i.d.). Outcomes were assessed following a 2-week baseline period; after 4weeks, 8weeks, and 12weeks of intervention; and after 4weeks and 12weeks post-intervention. The primary outcomes are overall feasibility/acceptability metrics, and secondarily, preliminary efficacy for BCAAs to improve subjective sleep as assessed by the Insomnia Severity Index. Additional sleep measures were obtained for future analyses using a combination of actigraphy, mattress-sensors, sleep diaries, as well as pre-/post-BCAA overnight polysomnography. Additional exploratory outcomes included sweat-based biomarkers. Analyses of primary outcome measures indicated high feasibility and acceptability for this fully protocol.

ABSTRACT Background: Most individuals with posttraumatic stress disorder (PTSD) report sleep disturbances. Yet, results on the impact of trauma-focused therapy on subjective and objective sleep disturbances are inconsistent. Objectives: This study conducted secondary analyses from a randomized controlled trial (RCT; German Clinical Trials Registration: DRKS00005578) to investigate changes in both subjective and objective sleep over the course of trauma-focused therapy and whether these changes differed for dialectical behaviour therapy for PTSD (DBT-PTSD) or cognitive processing therapy (CPT). Methods: Women with PTSD related to childhood abuse were randomized to receive DBT-PTSD or CPT. Sleep was assessed in n = 180 women using the Pittsburgh Sleep Quality Index (PSQI), sleep diaries, and actigraphy at baseline, 6 and 12 months into treatment, with sleep monitoring for 1 week at each assessment. Results: Subjective sleep disturbances improved significantly from pre- to post-treatment, reflected in better PSQI scores (d = 0.76), sleep quality (d = 0.69), and total sleep time (d = 0.11) in sleep diary entries with no differences between treatment groups. No significant changes were observed in actigraphy measures. In total, 76% of participants still met the clinical cut-off of 5 on the PSQI, indicating clinically significant subjective sleep disturbances. Conclusions: PTSD treatments were linked to improvements in subjective sleep quality, but objective sleep measures remained unaffected. A high percentage of participants with persistent clinical sleep disturbances after treatment highlight the need for further research on the efficacy of PTSD treatments on sleep disturbances. To reduce the burden of sleep disturbances, sleep-specific treatment components may need to be added to trauma-focused treatments.

Assessment of sleep quality in clinical practice remains constrained by tools that are either subjective or impractical for routine use. Self-report instruments, such as the Pittsburgh Sleep Quality Index (PSQI) and sleep diaries, are vulnerable to recall bias and demonstrate limited correspondence with objective neurophysiological measures. Polysomnography (PSG), while the gold standard, is costly, labor-intensive, and disruptive to natural sleep, rendering it unsuitable for longitudinal or outpatient monitoring. Recent advances in quantitative electroencephalography (qEEG), event-related potential (ERP) analysis, and source localization have created opportunities to bridge this gap. These methods enable scalable, objective evaluation of neurophysiological processes underpinning sleep architecture, cognitive function, and emotional regulation. This review synthesizes emerging evidence that EEG-derived biomarkers (e.g., spectral power ratios (delta/alpha, theta/ beta), cross-frequency coupling, and ERP dynamics) can serve as sensitive indices of sleep quality and neural health. We highlight the BrainView platform as an exemplar of this translational shift. BrainView is an FDA-cleared system combining qEEG, ERP, source localization, and normative comparison to quantify brain function non-invasively and longitudinally. By integrating neurophysiological data with actigraphy, self-report, and behavioral outcomes, EEG-based platforms such as BrainView may redefine how clinicians and researchers monitor sleep, treatment response, and neurocognitive resilience.

Insomnia represents a significant risk factor for impaired daytime functioning and various chronic health conditions, emerging as a growing public health concern in Malaysia. The absence of standardized local guidelines complicates treatment decisions. This consensus aimed to develop pharmacological treatment recommendations for insomnia in Malaysia using a modified Delphi approach. An eight-member expert panel of sleep medicine, psychiatry, neurology, and pharmacology specialists reviewed high-level evidence on insomnia’s neurobiology, diagnosis, and treatment. A 31-item consensus statement survey addressing insomnia's definition, diagnosis, and pharmacological management was conducted, with agreement evaluated on a 5-point Likert scale. The consensus recommendations were finalized after two Delphi rounds and a final vote, with at least 75% agreement with each statement. Results underscored the need for tailored treatment strategies in Malaysia, combining nonpharmacological and pharmacological interventions. Insomnia was recognized as a chronic condition diagnosed primarily through subjective criteria, with sleep diaries and questionnaires recommended for assessment. Benzodiazepines, Z-class drugs, and dual orexin receptor agonists (DORAs) are effective, although concerns about long-term safety and dependency were noted. DORAs show promise in managing sleep onset and maintenance, highlighting lemborexant as a promising pharmacological option. The meeting emphasized the need for individualized treatment plans and careful risk assessment, especially for older adults, and provided practical recommendations for managing insomnia. Integration of Cognitive Behavioral Therapy for Insomnia (CBT-I) with pharmacotherapy was strongly advocated. These consensus statements provide a practical foundation for future national guidelines to improve insomnia care in Malaysia’s primary care settings.

Background and Objective Chronotype, sleep, and diet are interconnected. Social demands, such as work or school, often hinder alignment with biological rhythms, potentially harming dietary habits and health. This study investigated the association between chronotype and social jetlag in undergraduate students and their impact on diet.Methods Sixty-three young adults (40 females), who studied at night and worked during the week, participated. Chronotype, social jetlag, sleep quality, and daytime sleepiness were assessed through validated questionnaires. A 1-week sleep and food diary evaluated sleep and dietary intake.Results Most students were classified as good sleepers, despite excessive daytime sleepiness. The majority had an intermediate chronotype and social jetlag exceeding 1 hour (median: 1.57 h; range: 0.05–4.02 h). On free days, participants woke later, slept longer, and had later sleep midpoints compared to workdays (p&lt;0.001). Social jetlag was negatively correlated with chronotype (p=0.009), but not with sleep quality, efficiency, or daytime sleepiness. Negative correlations were observed between protein, lipid, and energy intake and sleep latency on day 1. On day 4, higher carbohydrate, lipid, and energy intake were associated with later bedtimes, and lipid and energy intake were negatively correlated with sleep latency. Social jetlag was also negatively correlated with weekly average intake of carbohydrates (p=0.05), protein (p=0.03), and energy (p=0.03).Conclusions Social demands affected biological rhythms, leading to social jetlag exceeding one hour in most participants, especially in evening chronotypes. While no clear links were found with sleep quality, observed diet–sleep correlations suggest dietary intake may influence sleep timing and latency.

The Simons Sleep Project (SSP) is an open-science resource designed to accelerate digital health research into sleep and daily behaviors of autistic children. The SSP contains data from Dreem3 EEG headbands, multi-sensor EmbracePlus smartwatches and Withings' sleep mats, as well as parent questionnaires and daily sleep diaries. It contains data from >3,600 days and nights collected from 102 children (aged 10-17 years) with idiopathic autism and 98 of their nonautistic siblings, and enables access to whole-exome sequencing for all participants. Here we present the breadth of available harmonized data and show that digital devices have higher accuracy and reliability compared to parent reports. The data show that autistic children have longer sleep-onset latencies than their siblings and longer latencies are associated with behavioral difficulties in all participants, regardless of diagnosis. The results highlight the advantages of using digital devices and demonstrate the opportunities afforded by the SSP to study autism and develop broad digital phenotyping techniques.

Children and adolescents with HIV previously taking ritonavir-boosted lopinavir (LPV/r)-based antiretroviral therapy (ART) were recently programmatically transitioned to dolutegravir (DTG)-based ART in Lesotho, southern Africa. We investigated associated changes in treatment satisfaction and potential side effects. This single-center prospective cohort study enrolled participants <18 years transitioned from LPV/r- to DTG-based ART during the national programmatic DTG rollout in 2022-2023. Virally suppressed participants ≥6 years able to handle a sleep diary and actigraphy were eligible for additional sleep monitoring. Enrollment occurred 2 weeks before (with actigraphy) or at (without actigraphy) transition with follow-up until 4 weeks post-transition. Co-primary endpoints were i) change in treatment satisfaction, using the HIV Treatment Satisfaction Questionnaire change version (HIVTSQc; Teen and Parent versions) at 4 weeks, and ii) difference in mean sleep period length over a two-week period before and after transition (only actigraphy participants). Secondary endpoints assessed treatment satisfaction status, gastrointestinal symptoms, depressive symptoms, and additional sleep measures. Among 245 participants with transition and 4-week data, 115 (47%) were female and median age was 11.1 (interquartile range 8.9-13.6) years. HIVTSQc outcomes favored DTG, with 88/92 (96%) HIVTSQc-Teen and 149/151 (99%) HIVTSQc-Parent responses indicating being "much more satisfied now" post-transition. Among 69 (28%) actigraphy participants, mean sleep period length was 9.0 hours (standard deviation [SD] 1.0) before and 9.2 hours (SD 1.0) 2-4 weeks post-transition (mean difference 0.2, 95% CI 0.0-0.4). Secondary outcomes did not change meaningfully. Observed treatment satisfaction and tolerability support the rollout of DTG in pediatric HIV care.

BackgroundWearable devices enable continuous measurement of physical activity, sedentary behavior, sleep, and heart rate under free-living conditions. However, most validation studies rely on small, homogeneous samples; are conducted under laboratory conditions; or lack gold standard ground-truth measurements, limiting the generalizability and accuracy of derived metrics. There is a pressing need for open-access, large-scale, free-living validation datasets that include multisensor data from diverse body locations and participant demographics to aid in model development.ObjectiveThe Oxford Wearable ECG, Activity, Circadian Rhythm, and Sleep Validation Study (OxWEARS) aims to (1) validate accelerometer-based measurement of physical behaviors across 5 body sites against annotated camera data; (2) validate measurements of sleep and sleep staging from 5 different body sites against polysomnography; (3) validate wrist-worn photoplethysmography heart rate measurements against chest-worn electrocardiogram; and (4) generate a comprehensive, annotated, and anonymized dataset for open-access research use.MethodsThis cross-sectional study will recruit approximately 160 adults (aged ≥40 years) stratified by age, sex, and BMI from the Oxford BioBank. Over 3 days and 4 nights, participants will wear sensors on the wrists, chest, hip, thigh, and ankle. Ground-truth measures will be obtained from a chest electrocardiogram patch for heart rate, a first-person camera for activity annotation, an ankle-worn accelerometer for step count, and at-home polysomnography for sleep. An under-mattress sensor will collect measures of sleep, respiration rate, and bedtime, and a subjective sleep diary will also be obtained. Signals from different wear locations will be compared against the ground truth using precision, recall, F1-score, κ, and agreement metrics.ResultsRecruitment commenced in November 2024, with 15 participants enrolled by May 2025. Overall, 50% of eligible adults contacted were happy to consent to the study, with excellent compliance with the protocol observed to date. Data collection is ongoing and expected to conclude in 2026, with the final annotated dataset made publicly available as soon as possible thereafter.ConclusionsThe OxWEARS study will generate an openly accessible dataset containing more than 10,000 annotated hours from a stratified sample of adults. This will directly support scalable, generalizable human activity recognition efforts, while also enabling robust development and benchmarking of wearable-derived health metrics.

BackgroundPersons with mild cognitive impairment (PwMCI) and caregivers commonly experience low quality sleep which is associated with increased stress. Tai Chi has shown tremendous promise for stress reduction and improving sleep quality in older adults and those with MCI. Our objective was to test the feasibility of a Tai Chi for sleep intervention among PwMCI and their caregivers.MethodParticipants were 12 PwMCI (3 female, 50% African American/Black, M = 75.4 years) diagnosed from Emory's Cognitive Neurology Clinic and their 12 spousal caregivers (8 female, 50% African American/Black, M = 74.6 years). Participants used a bed sensor, an Oura ring, and completed morning and evening sleep diaries for 10 days. The evening diary included an embedded 10‐minute Tai Chi video curated by a Tai Chi master. Data were analyzed using descriptive statistics (see Table 1) and paired t‐tests to assess feasibility according to acceptability, demand, implementation, and preliminary efficacy.ResultAcceptability: Participants reacted positively to each of the intervention components and the study overall. Participants enjoyed Tai Chi, the bed sensors were easy to deploy, participants enjoyed using the Oura ring, and post‐participation study enjoyment ratings were high.Demand: High interest in study participation among PwMCI and caregivers was supported by greater than 55% of nightly Tai Chi participation. However, caregivers were more likely than PwMCI to complete Tai Chi.Implementation: The study components were largely executed as planned. Diary completion rates across the morning and evening forms were very high for PwMCI (85.83%) and caregivers (96.25%). The bed sensors were successfully self‐installed for five dyads and Oura ring use was near‐perfect across all participants.Preliminary efficacy: Although limited, sleep and stress data from our diverse convenience sample supports employing our intervention approach and methods in a larger study focused on quantifying and improving sleep for PwMCI and their caregivers. Nightly stress was lower on average after completing Tai Chi compared to before for PwMCI and was significantly lower for caregivers (t(74) = 5.08, p = < .001).ConclusionOur Tai Chi for sleep intervention was feasible for PwMCI and their caregivers. This approach warrants further exploration for improving sleep quality and stress reduction.

IntroductionChronic insomnia is a pressing public health issue that significantly affects patients’ quality of life. In China, Prolong Life With Nine Turn-Method (PLWNT) Qigong exercise has long been used to improve sleep quality, yet evidence that supports its efficacy for chronic insomnia treatment remains lacking. The aim of this study is to evaluate the effectiveness and safety of the PLWNT qigong exercise for treating chronic insomnia and its relationship with hyperarousal.Methods and analysisThis multi-centre randomised controlled trial will recruit 348 eligible patients from three hospitals in Shanghai. Participants will be randomly assigned to either the treatment group (PLWNT qigong exercise) or the control group (cognitive behavioural therapy). The treatment will occur once a week for 12 weeks, followed by an 8-week follow-up phase. The primary outcome is the change in the total Pittsburgh Sleep Quality Index (PSQI) score from baseline to week 12. The secondary outcomes are the scores on the Hyperarousal Scale (HAS), Insomnia Severity Index (ISI), Multidimensional Fatigue Inventory 20 (MFI-20), Hospital Anxiety and Depression (HADS), Medical Outcome Trust 36–Item Short Form Health Survey (SF–36) and Gastrointestinal Symptom Rating Scale (GSRS), gut microbiota, actigraphy, sleep diary, cortisol, adrenocorticotrophic hormone, corticotropin-releasing hormone, polysomnography and functional MRI. All adverse events during the trial will be promptly recorded and assessed. The PSQI, HAS, ISI, MFI-20, HADS, SF–36 and GSRS will be evaluated at baseline, 6 weeks post-treatment and 12 weeks post-treatment, as well as at the 4- week and 8- week follow-ups. Other outcomes will only be evaluated at baseline and 12 weeks post-treatment.Ethics and disseminationThe trial has been approved by the Ethics Committee of the Shanghai Municipal Hospital of Traditional Chinese Medicine (2024SHL-KY-92–01). Written informed consent was obtained from all participants before their involvement in the trial. Results of this study will be published in peer-reviewed journals or at conferences.Trial registration numberITMCTR2024000534.

Disruptions in sleep and circadian rhythms have been consistently linked to higher mortality rates in the general population. Among cancer patients, these disruptions are not only prevalent but may significantly influence prognosis. Despite this, sleep and circadian trajectories remain unexplored in the context of cancer, particularly related to prognostic outcomes in modern therapies such as immune checkpoint inhibitors (ICIs), which are rapidly transforming oncological care. In this pioneering report, we examined how trajectories of sleep and circadian rhythms relate to prognostic outcomes in patients with non-small cell lung cancer (NSCLC), offering novel insights into their potential role as modifiable biomarkers of clinical outcomes. Forty-nine treatment-naïve NSCLC patients were enrolled in this prospective longitudinal study. Continuous 24-h recordings of circadian function (Circadian Function Index [CFI]) were collected over the first 5 months of treatment, alongside weekly assessments of insomnia severity (Insomnia Severity Index [ISI]) and estimations of total sleep time (TST) derived from sleep diaries every 3 weeks. Follow-up data, time to treatment discontinuation, disease progression, and cancer-related death were obtained from medical records. We estimated hazard ratios (HRs) for these outcomes based on ISI, TST, and CFI, analyzed as continuous variables and median-split. Cox regression analyses indicated that patients with trajectories portraying circadian robustness below the median had a higher risk of earlier progression (HR = 3.75, 95% confidence interval [CI] = [1.475-9.536], p = 0.005) and death (HR = 3.07, 95% CI = [1.128-8.360], p = 0.028). No significant associations were found between insomnia severity, TST, and the prognostic outcomes. Patients with more pronounced declines in circadian robustness demonstrated significantly elevated risks of disease progression and mortality. As the circadian rhythm is modifiable, these findings, if replicated, underscore the need for interventional studies aimed at stabilizing circadian rhythms to further explore potential improvements in patient outcomes and efficacy of cancer therapies.

Objectives: Insomnia is a prevalent sleep disorder characterised by challenges in initiating, maintaining or achieving restorative sleep, resulting in compromised daytime functionality. Traditional therapeutic modalities frequently encompass pharmacological treatments, which may have adverse effects and potential for dependency. Numerous patients pursue alternative methodologies, such as homoeopathy, which is attributed to its personalised, holistic and non-invasive treatment framework. This thorough examination assesses the effectiveness of homoeopathy in promoting better sleep quality and overall wellness in people with insomnia by analysing randomised controlled trials (RCTs). Material and Methods: This meta-analysis sought to ascertain whether homoeopathy induces a statistically significant enhancement in the management of insomnia, concentrating on aspects of sleep quality, duration and general well-being. All RCTs addressing insomnia treated with homoeopathic interventions were included in this review. All studies were meticulously documented in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Three evaluators independently reviewed and compiled the literature, extracting comprehensive details regarding participants, study designs, therapeutic interventions and follow-up pertaining to homoeopathic treatment. The primary outcome of the investigation was disease assessment based on sleep diary scores, with an additional outcome being the enhancement of quality of life. Results: The analysis revealed that homoeopathic remedies exhibited statistically significant improvement over placebo in the management of insomnia. The overall pooled effect size, standardised mean difference (random), was −0.60, standard error (random) was 0.42 and confidence interval (random) at 95% ranged from −0.93 to −0.26. The risk of bias was assessed for all studies. Conclusion: This meta-analysis shows that homoeopathic remedies are effective in treating insomnia, but more studies are required for accuracy.